Canal de iões
Os canais iônicos são proteínas especializadas que formam poros nas membranas celulares, permitindo a passagem seletiva de íons como sódio, potássio, cálcio e cloreto. Esses canais desempenham um papel crítico em vários processos fisiológicos, incluindo a transmissão de impulsos nervosos, a contração muscular e a regulação da homeostase celular. Os canais iônicos são alvos essenciais na descoberta de medicamentos, especialmente no tratamento de distúrbios neurológicos, doenças cardiovasculares e no manejo da dor. Na CymitQuimica, oferecemos uma ampla gama de proteínas de canais iônicos de alta qualidade e reagentes relacionados para apoiar seus projetos de pesquisa e desenvolvimento de medicamentos.
Foram encontrados 106 produtos para "Canal de iões".
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Picrotoxin - Bio-X ™
CAS:Picrotoxin is a GABA-A receptor antagonist that is used to relieve respiratory distress. This drug also is used as an antidote from poisoning by CNS depressants. Picrotoxin works by blocking the GABA activated chloride ionophore.Fórmula:C15H18O7·C15H16O6Pureza:Min. 95%Cor e Forma:PowderPeso molecular:602.58 g/molVincamine
CAS:Peripheral vasodilator; nootropic agentFórmula:C21H26N2O3Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:354.44 g/molGlimepiride - Bio-X ™
CAS:Glimepiride is a sulfonylurea drug that is used in the treatment of type 2 diabetes mellitus. This drug works by inhibiting ATP-sensitive potassium channels by binding non-specifically to the B sites of both sulfonylurea receptor-1 (SUR1) and sulfonylurea receptor-2A (SUR2A) subunits. As a result, this promotes insulin secretion from beta cells.
Fórmula:C24H34N4O5SPureza:Min. 95%Cor e Forma:PowderPeso molecular:490.62 g/molAniracetam - Bio-X ™
CAS:Aniracetam is a nootropic drug that is used to alleviate memory disturbances caused by cerebrovascular disease and brain disorders. This drug has anti-depressive and anxiolytic properties and is said to target serotonin and dopamine receptors.
Fórmula:C12H13NO3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:219.24 g/molFonturacetam
CAS:Produto ControladoPiracetam analog; AMPA receptor allosteric modulator
Fórmula:C12H14N2O2Pureza:Min. 99 Area-%Peso molecular:218.25 g/molOndansetron hydrochloride - Bio-X ™
CAS:Ondansetron is a serotonin 5-HT3 receptor antagonist that has been shown to inhibit the effects of serotonin in the gastrointestinal tract, thereby preventing nausea and vomiting that is caused by cancer chemotherapy. Chemotherapy and radiotherapy are associated with the release of serotonin (5-HT) from enterochromaffin cells of the small intestine, initiating a vomiting reflex through stimulation of 5-HT3 receptors located on vagal afferents. Ondansetron blocks the initiation of this reflex. The drug binds to receptors on cells in the gastrointestinal tract that are normally activated by serotonin, thereby blocking its effect.Fórmula:C18H20N3OClPureza:Min. 95%Cor e Forma:PowderPeso molecular:329.82 g/molNBQX
CAS:Competitive antagonist of ionotropic glutamate receptors of AMPA and kainate subfamilies. Reported anti-convulsant activity in seizures models induced by electrostimulation, drugs or genetic predisposition. Pro-convulsant effects in Theiler's murine encephalomyelitis virus-induced (TMEV) seizure model.Fórmula:C12H8N4O6SPureza:Min. 95%Cor e Forma:PowderPeso molecular:336.28 g/molNateglinide - Bio-X ™
CAS:Nateglinide is used to treat type 2 diabetes mellitus as an oral hypoglycemic, insulinotropic agent. It is a blocker of ATP-dependent potassium channels and works by increasing the body's production of insulin, which lowers blood glucose levels. Nateglinide has been shown to be effective in reducing postprandial blood glucose levels in patients with type 2 diabetes who have not responded well to other treatments. The effects of nateglinide are reversible.Fórmula:C19H27NO3Pureza:Min. 95%Peso molecular:317.42 g/molIfenprodil tartrate
CAS:Produto ControladoNMDA receptor antagonist
Fórmula:C21H27NO2Pureza:Min. 98.5%Cor e Forma:White SolidPeso molecular:800.98 g/molAR-R 17779 hydrochloride
CAS:AR-R 17779 is a selective agonist for α7 nicotinic acetylcholine receptors (nAChRs) (Ki value = 190 nM for rat α7 receptor). This compound has use as a tool to study the function of α7 nicotinic receptors. One such study revealed a role for α7 nicotinic receptors in nicotine-mediated excitatory effects on hippocampal learning and memory. AR-R17779 reduces formation of atherosclerotic plaques and abdominal aortic aneurysms in apolipoprotein E-deficient mice.Fórmula:C9H14N2O2•HClPureza:Min. 95%Cor e Forma:White PowderPeso molecular:218.68 g/mol(+)-Bicuculline - Bio-X ™
CAS:Bicuculline is a phthalide-isoquinoline compound and is a competitive GABA receptor antagonist. It blocks GABA’s inhibitory action, mimicking epilepsy. This compound is used in research to better study epilepsy.
Fórmula:C20H17NO6Pureza:Min. 99 Area-%Cor e Forma:PowderPeso molecular:367.35 g/molTraxoprodil
CAS:Produto ControladoNMDA glutamate receptor antagonist; anti-depressant
Fórmula:C20H25NO3Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:327.42 g/molTropisetron hydrochloride
CAS:5-HT3 receptor antagonist; alpha-7 nicotinic acetylcholine receptor partial agonist
Fórmula:C17H20N2O2•HClPureza:Min. 95%Peso molecular:320.81 g/molIvacaftor
CAS:Activates CFTR channelsFórmula:C24H28N2O3Pureza:Min. 95%Cor e Forma:White To Off-White SolidPeso molecular:392.49 g/molNAP
CAS:NAP is a neuroprotective peptide, which is derived from activity-dependent neuroprotective protein (ADNP), with a mechanism involving microtubule stabilization and neuronal protection. It exhibits the ability to protect neurons from various types of damage, including oxidative stress and conditions mimicking neurodegenerative diseases. NAP enhances axonal transport and increases the resilience of neurons to insults that would typically result in cell death. This peptide has shown promise in preclinical studies for its potential to halt or reverse cognitive decline, making it a focal point for research into therapeutic strategies for disorders like Alzheimer's disease and other tauopathies. The peptide operates by binding to microtubules, promoting stability, and facilitating efficient transport of cellular components. Studies have highlighted its role in traversing the blood-brain barrier, which makes it a viable candidate for central nervous system-targeted therapies. Researchers continue to explore its efficacy and possible applications in improving cognitive function and providing neuroprotection in aging populations.Pureza:(Hplc-Ms) Min. 98 Area-%Mibefradil hydrochloride
CAS:Mibefradil is a calcium channel antagonist with the highest selectivity for T- and L-type channels, but also effective for N-, Q-, and R-type calcium channels at micromolar range. It decreases smooth muscle proliferation in response to vascular injury and causes vessel dilatation.Fórmula:C29H38FN3O3·2HClPureza:Min. 95%Cor e Forma:PowderPeso molecular:568.55 g/molFG 7142
CAS:Partial inverse agonist of benzodiazepine sites of the GABAA receptors with anxiogenic properties. FG 7142 is a pharmacological stressor which generates anxiety in humans and in experimental animals such as rhesus monkeys and rodents. FG 7142 also reduces food intake and frequency of feeding in male and female rats.Fórmula:C13H11N3OPureza:Min. 95%Cor e Forma:Yellow PowderPeso molecular:225.25 g/molAMTB hydrochloride
CAS:Selective TRPM8 channel blocker. Inhibits icillin-induced store-operated Ca2+ entry, hence TRPM8 activation, in pulmonary vasculature. Reduces frequency of volume-induced contraction of bladder. Reduces micturition and nociceptive reflex actions in the bladder, suggesting therapeutic potential for bladder hypersensitivity disorders.
Fórmula:C23H26N2O2SHClPureza:Min. 95%Cor e Forma:SolidPeso molecular:430.99 g/molL 838417
CAS:Selective partial GABAA receptor antagonist of subtypes α1, α2, α3, α5 subunits. Non-sedative anxiolytic effects demonstrated in vivo, without compromising motor activity. Anti-nociceptive and anti-inflammatory activities also demonstrated in vivo.Fórmula:C19H19F2N7OPureza:Min. 95%Cor e Forma:White/Off-White SolidPeso molecular:399.4 g/molVecuronium bromide
CAS:Antagonist of nicotinic acetylcholine receptors; nondepolarising muscle relaxant
Fórmula:C34H57BrN2O4Pureza:Min. 95%Peso molecular:637.73 g/mol
