FAK
Os inibidores da quinase de adesão focal (FAK) têm como alvo a FAK, uma quinase envolvida na adesão celular, migração e angiogênese. A FAK é frequentemente superexpressa em tumores e contribui para a formação de novos vasos sanguíneos que fornecem nutrientes ao tumor. Inibir a FAK pode interromper esses processos, tornando os inibidores de FAK ferramentas valiosas na terapia do câncer e na pesquisa de angiogênese. Na CymitQuimica, oferecemos uma gama abrangente de inibidores de FAK de alta qualidade para apoiar sua pesquisa em biologia celular, câncer e angiogênese.
Foram encontrados 71 produtos para "FAK".
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FAK-IN-8
CAS:FAK-IN-8 (compound 5h), a FAK inhibitor with an IC50 of 5.32 μM, exhibits potent anti-proliferative activity, making it suitable for use in cancer research [1].Fórmula:C15H9Cl2N3O2SCor e Forma:SolidPeso molecular:366.22FAK inhibitor 5
CAS:FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.Fórmula:C20H21N3O2SPureza:98%Cor e Forma:SolidPeso molecular:367.46ProMMP-9 inhibitor-3c
CAS:ProMMP-9 inhibitor-3c hinders MMP-9 homodimers, blocks proMMP-9/α4β1 integrin/CD44 binding, and detaches EGFR.Fórmula:C18H20FN3O2SCor e Forma:SolidPeso molecular:361.43Adhesamine
CAS:Adhesamine, a dumbbell molecule, enhances cell adhesion, growth, neuron differentiation, and survival via MAPK/FAK.Fórmula:C24H32Cl4N8O2S2Cor e Forma:SolidPeso molecular:670.51FLT3-IN-17
CAS:FLT3-IN-17: FAK inhibitor, IC50 of 12 nM; blocks CYPs, FLT3 mutants; IC50 <0.5 nM for D835Y in cancer studies.Fórmula:C23H24N6O2S2Cor e Forma:SolidPeso molecular:480.61TG53
CAS:TG53 is a tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction inhibitor.Fórmula:C21H22ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:411.88NAMI-A
CAS:NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.Fórmula:C8H15Cl4N4ORuSPureza:98%Cor e Forma:Orange SolidPeso molecular:458.18Ref: TM-T16266
1mgA consultar5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar200mgA consultarDefactinib hydrochloride
CAS:Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.Fórmula:C20H22ClF3N8O3SPureza:98.06% - 98.78%Cor e Forma:SolidPeso molecular:546.95Roslin 2 bromide
CAS:Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.Fórmula:C13H19BrN4Pureza:99.34%Cor e Forma:SolidPeso molecular:311.22Ref: TM-T24730
2mg42,00€5mg62,00€1mL*10mM (DMSO)67,00€10mg93,00€25mg140,00€50mg202,00€100mg298,00€200mg429,00€FC 11
CAS:FC 11 is a reversible FAK PROTAC Degrader with DC50 of 40-370 pM and degrades pFAKtyr397 in TM3 cells within 3 hours at 100 nM.Fórmula:C41H42F3N13O9SCor e Forma:SolidPeso molecular:949.91Ifebemtinib
CAS:Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.Fórmula:C28H28F4N6O4Pureza:98.47% - 99.93%Cor e Forma:White SolidPeso molecular:588.55Ref: TM-T64167
1mg146,00€5mg245,00€1mL*10mM (DMSO)316,00€10mg369,00€25mg572,00€50mg882,00€100mg1.243,00€FAK-IN-6
FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.Fórmula:C25H31ClN5O6PSCor e Forma:SolidPeso molecular:596.04FAK-IN-26
CAS:FAK-IN-26 is a blood-brain barrier-penetrating inhibitor of Focal Adhesion Kinase (FAK) with an IC50 of 0.87 nM. It significantly reduces tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 exhibits potent anticancer activity, achieving tumor inhibition rates of 59.15% and 57.9% in A549 and SKOV-3 tumor mouse models, respectively.Fórmula:C20H19BrFN5O2Cor e Forma:SolidPeso molecular:460.30Pyk2-IN-2
CAS:Pyk2-IN-2 (compound 13j) acts as a Pyk2 inhibitor, exhibiting an IC 50 value of 0.608 μM for FAK kinase [1].Fórmula:C27H27N7OCor e Forma:SolidPeso molecular:465.55FAK-IN-21
CAS:FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.Fórmula:C22H22F2N8O3SCor e Forma:SolidPeso molecular:516.52JP-153
CAS:JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.Fórmula:C21H19NO5Cor e Forma:SolidPeso molecular:365.379OXA-11
CAS:OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.Fórmula:C37H49F3N7O5PPureza:98.70% - 99.20%Cor e Forma:White SolidPeso molecular:759.8FAK-IN-23
CAS:FAK-IN-23 (Compound II) is an inhibitor of focal adhesion kinase (FAK).Fórmula:C32H38F3N5O8Cor e Forma:SolidPeso molecular:677.668Ifebemtinib tosylate
CAS:Ifebemtinib (tosylate) (BI-853520 (tosylate); IN-10018 (tosylate)) is a highly selective PTK2 kinase inhibitor with anti-tumor properties. It inhibits FAK autophosphorylation in prostate cancer cells and suppresses spheroid formation and in situ tumor growth in vivo. Ifebemtinib (tosylate) is applicable in cancer research, including studies on solid tumors, breast cancer, and malignant pleural mesothelioma.Fórmula:C35H36F4N6O7SCor e Forma:SolidPeso molecular:760.76FAK inhibitor 6
CAS:Compound 26F: potent enzyme inhibitor (IC50=28.2nM), low cytotoxicity (IC50=3.32μM), induces dose-dependent apoptosis in MDA-MB-231, blocks G0/G1 phase.Fórmula:C25H24FN5O2SCor e Forma:SolidPeso molecular:477.55FAK-IN-3
FAK-IN-3 inhibits FAK, reduces PA-1 cell migration/invasion, and tumor growth, with no major side effects.Fórmula:C28H28N6O4Cor e Forma:SolidPeso molecular:512.56
