Trombina
Os inibidores de trombina são compostos que bloqueiam a trombina, uma enzima envolvida no processo de coagulação do sangue e que também desempenha um papel na promoção da angiogênese. A trombina pode estimular a formação de novos vasos sanguíneos em tumores, ajudando em seu crescimento e metástase. Ao inibir a trombina, esses compostos podem reduzir a angiogênese e a progressão tumoral. Os inibidores de trombina são importantes tanto na pesquisa do câncer quanto no estudo de doenças vasculares. Na CymitQuimica, oferecemos uma seleção de inibidores de trombina de alta qualidade para apoiar sua pesquisa em hemostasia, oncologia e angiogênese.
Foram encontrados 53 produtos de "Trombina"
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Dabigatran etexilate
CAS:Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation.Fórmula:C34H41N7O5Pureza:98.19% - 99.98%Cor e Forma:White PowderPeso molecular:627.73Dabigatran ethyl ester hydrochloride
CAS:Dabigatran prevents blood clots, inhibiting NQO2 and thrombin with IC50 0.8 μM.Fórmula:C27H30ClN7O3Pureza:99.65%Cor e Forma:SolidPeso molecular:536.03Metolazone
CAS:<p>Metolazone (SR-720-22) is a quinazoline-sulfonamide derived diuretic that inhibits sodium chloride symporters.</p>Fórmula:C16H16ClN3O3SPureza:98.14% - 98.5%Cor e Forma:Crystals From Ethanol SolidPeso molecular:365.83Knob A peptide GPRPFPAC
CAS:Knob A peptide GPRPFPAC is a fibrin knob peptide. The PEGylated form of Knob A peptide GPRPFPAC exhibits enhanced anticoagulant activity.Fórmula:C38H57N11O9SCor e Forma:SolidPeso molecular:843.99Hirudin (55-65) (sulfated)
CAS:Hirudin (55-65) (sulfated), a fragment of Hirudin, is a thrombin inhibitor with anticoagulant effects and blood anticoagulant properties.Fórmula:C64H90N12O27SCor e Forma:SolidPeso molecular:1491.53Thrombin inhibitor 13
Thrombin inhibitor 13 (Compound 13a) acts as a covalent reversible inhibitor of thrombin (thrombin, FIIa) with an IC50 of 0.7 nM. This compound prolongs activated partial thromboplastin time (aPTT) and prothrombin time (PT), demonstrating both antithrombotic and anticoagulant properties.Fórmula:C16H17ClN6OSCor e Forma:SolidPeso molecular:376.864Thrombin (MW 37kDa)
CAS:Thrombin (MW 37kDa) is a trypsin-like allosteric serine protease.Pureza:98%Cor e Forma:SolidPeso molecular:37kDaIchorcumab
CAS:<p>Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Cor e Forma:LiquidProtease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Cor e Forma:Odour SolidRef: TM-L1100
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarHirudin (54-65) (TFA)
Hirudin (54-65) TFA, a segment of the 65-amino-acid protein Hirudin, exhibits anticoagulant properties [1].Cor e Forma:Odour SolidSulodexide
CAS:Sulodexide is an orally administered combination of glycosaminoglycans, consisting of low molecular weight heparin (80%) and dermatan sulfate (20%). It demonstrates antithrombotic properties by interacting with antithrombin III (AT III) and heparin cofactor II (HC II), and by inhibiting thrombin formation. Additionally, sulodexide enhances profibrinolytic activity by releasing tissue plasminogen activator (tPA). It also offers endothelial protection, possesses anti-inflammatory effects, and alleviates chronic venous disease.Cor e Forma:SolidPlatelet aggregation-IN-1
Platelet aggregation-IN-1 (Compound 10e) acts as an inhibitor of platelet aggregation and can achieve complete (100%) inhibition of thrombin-induced platelet aggregation at a concentration of 50 μM.Fórmula:C18H13N3O4Peso molecular:335.09061Fibrinopeptide B, human
CAS:Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer.Fórmula:C66H93N19O25Pureza:98%Cor e Forma:SolidPeso molecular:1552.56Idarucizumab
CAS:Idarucizumab, a humanized monoclonal antibody fragment, serves as the first reversal agent for direct oral anticoagulants (DOACs).Cor e Forma:LiquidFibrinogen-Binding Peptide
CAS:Fibrinogen-binding peptide mimics vitronectin site and activates platelets; thrombin turns it to fibrin.Fórmula:C25H39N7O8Pureza:98%Cor e Forma:SolidPeso molecular:565.62H-Gly-Arg-pNA dihydrochloride
CAS:H-Gly-Arg-pNA 2HCl, a peptide, binds 1,2 thrombin; colorimetric quantification at 405 nm indicates thrombin activity.Fórmula:C14H23Cl2N7O4Pureza:99.14%Cor e Forma:SolidPeso molecular:424.28PM 102
CAS:Peptide that reverses the anticoagulant effect of heparin. Potently binds heparin (Kd = 36 nM in vitro).Fórmula:C235H425N111O64Pureza:98%Cor e Forma:SolidPeso molecular:5830Acetyl-Hirudin (54-65) (sulfated)
CAS:Acetyl-Hirudin (54-65) (sulfated) binds thrombin-rHCII(L444R), blocking rHCII's N-terminal/thrombin exosite I interaction, stabilizing the complex.Fórmula:C68H95N13O29SCor e Forma:SolidPeso molecular:1590.63Befovacimab
CAS:Befovacimab, a human IgG2 antibody, targets TFPI for hemophilia A/B research.Cor e Forma:LiquidAnti-Coagulation Factor II Antibody (8M286)
Anti-Coagulation Factor II Antibody (8M286) is a Rabbit antibody targeting Coagulation Factor II. Anti-Coagulation Factor II Antibody (8M286) can be used in ELISA.Cor e Forma:Odour Liquid
