Trombina
Os inibidores de trombina são compostos que bloqueiam a trombina, uma enzima envolvida no processo de coagulação do sangue e que também desempenha um papel na promoção da angiogênese. A trombina pode estimular a formação de novos vasos sanguíneos em tumores, ajudando em seu crescimento e metástase. Ao inibir a trombina, esses compostos podem reduzir a angiogênese e a progressão tumoral. Os inibidores de trombina são importantes tanto na pesquisa do câncer quanto no estudo de doenças vasculares. Na CymitQuimica, oferecemos uma seleção de inibidores de trombina de alta qualidade para apoiar sua pesquisa em hemostasia, oncologia e angiogênese.
Foram encontrados 47 produtos de "Trombina"
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Dabigatran ethyl ester hydrochloride
CAS:<p>Dabigatran prevents blood clots, inhibiting NQO2 and thrombin with IC50 0.8 μM.</p>Fórmula:C27H30ClN7O3Pureza:99.65%Cor e Forma:SolidPeso molecular:536.03Dabigatran etexilate
CAS:<p>Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation.</p>Fórmula:C34H41N7O5Pureza:98.19% - 99.98%Cor e Forma:White PowderPeso molecular:627.73Ichorcumab
CAS:<p>Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Cor e Forma:LiquidThrombin inhibitor 13
<p>Thrombin inhibitor 13 (Compound 13a) acts as a covalent reversible inhibitor of thrombin (thrombin, FIIa) with an IC50 of 0.7 nM. This compound prolongs activated partial thromboplastin time (aPTT) and prothrombin time (PT), demonstrating both antithrombotic and anticoagulant properties.</p>Fórmula:C16H17ClN6OSCor e Forma:SolidPeso molecular:376.864Thrombin (MW 37kDa)
CAS:<p>Thrombin (MW 37kDa) is a trypsin-like allosteric serine protease.</p>Pureza:98%Cor e Forma:SolidPeso molecular:37kDaH-Gly-Arg-pNA dihydrochloride
CAS:<p>H-Gly-Arg-pNA 2HCl, a peptide, binds 1,2 thrombin; colorimetric quantification at 405 nm indicates thrombin activity.</p>Fórmula:C14H23Cl2N7O4Pureza:99.14%Cor e Forma:SolidPeso molecular:424.28Fibrinopeptide B, human
CAS:<p>Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer.</p>Fórmula:C66H93N19O25Pureza:98%Cor e Forma:SolidPeso molecular:1552.56Platelet aggregation-IN-1
<p>Platelet aggregation-IN-1 (Compound 10e) acts as an inhibitor of platelet aggregation and can achieve complete (100%) inhibition of thrombin-induced platelet aggregation at a concentration of 50 μM.</p>Fórmula:C18H13N3O4Peso molecular:335.09061Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Cor e Forma:Odour SolidSulodexide
CAS:<p>Sulodexide is an orally administered combination of glycosaminoglycans, consisting of low molecular weight heparin (80%) and dermatan sulfate (20%). It demonstrates antithrombotic properties by interacting with antithrombin III (AT III) and heparin cofactor II (HC II), and by inhibiting thrombin formation. Additionally, sulodexide enhances profibrinolytic activity by releasing tissue plasminogen activator (tPA). It also offers endothelial protection, possesses anti-inflammatory effects, and alleviates chronic venous disease.</p>Cor e Forma:SolidBefovacimab
CAS:<p>Befovacimab, a human IgG2 antibody, targets TFPI for hemophilia A/B research.</p>Cor e Forma:LiquidPM 102
CAS:<p>Peptide that reverses the anticoagulant effect of heparin. Potently binds heparin (Kd = 36 nM in vitro).</p>Fórmula:C235H425N111O64Pureza:98%Cor e Forma:SolidPeso molecular:5830Metolazone
CAS:<p>Metolazone (SR-720-22) is a quinazoline-sulfonamide derived diuretic that inhibits sodium chloride symporters.</p>Fórmula:C16H16ClN3O3SPureza:98.14% - 98.5%Cor e Forma:Crystals From Ethanol SolidPeso molecular:365.83Coagulation Factor II Protein, Rat, Recombinant (His)
<p>Coagulation Factor II Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:69.5 kDa (predicted)Anti-Coagulation Factor II Antibody (2P591)
<p>Anti-Coagulation Factor II Antibody (2P591) is a Rabbit antibody targeting Coagulation Factor II. Anti-Coagulation Factor II Antibody (2P591) can be used in WB.</p>Cor e Forma:Odour LiquidAnti-Coagulation Factor II Antibody (8M286)
<p>Anti-Coagulation Factor II Antibody (8M286) is a Rabbit antibody targeting Coagulation Factor II. Anti-Coagulation Factor II Antibody (8M286) can be used in ELISA.</p>Cor e Forma:Odour LiquidDabigatran ethyl ester
CAS:<p>Dabigatran ethyl ester (Dabigatran (ethyl ester)) is an emerging oral anticoagulant and it also is a direct inhibitor of thrombin activity.</p>Fórmula:C27H29N7O3Pureza:99.98%Cor e Forma:SolidPeso molecular:499.56Coagulation Factor II Protein, Mouse, Recombinant (His)
<p>Coagulation Factor II Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:69.3 kDa (predicted); 85 kDa (reducing conditions)TRAP-6
CAS:<p>TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).</p>Fórmula:C34H56N10O9Pureza:>99.99%Cor e Forma:SolidPeso molecular:748.87Lusutrombopag
CAS:<p>Lusutrombopag (Mulpleta) is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with</p>Fórmula:C29H32Cl2N2O5SPureza:99.96%Cor e Forma:SolidPeso molecular:591.55Avatrombopag
CAS:<p>Avatrombopag (YM477) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation</p>Fórmula:C29H34Cl2N6O3S2Pureza:99.01% - 99.63%Cor e Forma:SolidPeso molecular:649.65Dabigatran
CAS:<p>Dabigatran (BIBR 953ZW), a thrombin inhibitor, prevents thrombus formation, reducing stroke and embolism risk in nonvalvular atrial fibrillation patients.</p>Fórmula:C25H25N7O3Pureza:97.44% - 98.7%Cor e Forma:Tan SolidPeso molecular:471.51Enoxaparin sodium
CAS:<p>Enoxaparin, a low-weight heparin approved by FDA for STEMI, enhances antithrombin and prevents clotting by inhibiting factors XIa, IXa, Xa, IIa.</p>Fórmula:C42H59N3Na4O35S2Pureza:98%Cor e Forma:SolidPeso molecular:1322AEBSF hydrochloride
CAS:<p>AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.</p>Fórmula:C8H11ClFNO2SPureza:98% - 99.81%Cor e Forma:White PowderPeso molecular:239.69H-D-Phe-Pip-Arg-pNA dihydrochloride
CAS:<p>H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238) is a sensitive and accurate thrombin detection substrate for measuring antithrombin-heparin cofactor (AT-III).</p>Fórmula:C27H38Cl2N8O5Pureza:99.47%Cor e Forma:SolidPeso molecular:625.55Bivalirudin
CAS:<p>Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting</p>Fórmula:C98H138N24O33Pureza:98.8% - >99.99%Cor e Forma:White To Off-White PowderPeso molecular:2180.29Dabigatran Etexilate Mesylate
CAS:<p>Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor.</p>Fórmula:C34H41N7O5·CH4O3SPureza:99.91%Cor e Forma:SolidPeso molecular:723.84Argatroban Monohydrate
CAS:<p>Argatroban Monohydrate is a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.</p>Fórmula:C23H38N6O6SPureza:99.51%Cor e Forma:SolidPeso molecular:526.65Edoxaban Tosylate Monohydrate
CAS:<p>Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.</p>Fórmula:C31H40ClN7O8S2Pureza:99.86% - 99.91%Cor e Forma:SolidPeso molecular:738.27Cycloolivil
CAS:<p>Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity present in olive trees.</p>Fórmula:C20H24O7Pureza:98%Cor e Forma:SolidPeso molecular:376.4NQ301
CAS:<p>NQ301, an antithrombotic agent, inhibits collagen-challenged rabbit platelet aggregation (IC50: 10 mg/mL).</p>Fórmula:C18H12ClNO3Pureza:99.74% - 99.76%Cor e Forma:SolidPeso molecular:325.75Ximelagatran
CAS:<p>Ximelagatran, oral direct thrombin inhibitor, transforms to active melagatran in body.</p>Fórmula:C24H35N5O5Pureza:95.48% - 99.60%Cor e Forma:SolidPeso molecular:473.57MNS
CAS:<p>MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.</p>Fórmula:C9H7NO4Pureza:98.53%Cor e Forma:Yellow PowderPeso molecular:193.16Argatroban
CAS:<p>Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.</p>Fórmula:C23H36N6O5SPureza:99.77% - >99.99%Cor e Forma:White To Off-White Crystalline SolidPeso molecular:508.63Efegatran sulfate
CAS:<p>Efegatran sulfate (LY294468 sulfate) is a potent thrombin inhibitor used in the treatment of thrombotic disorders.</p>Fórmula:C21H34N6O7SPureza:≥98% - ≥98%Cor e Forma:SolidPeso molecular:514.6OM-189
CAS:<p>OM-189 is a selective inhibitor of synthetic thrombin.</p>Fórmula:C24H36N6O3SPureza:98%Cor e Forma:SolidPeso molecular:488.65Atopaxar Hydrobromide
CAS:<p>Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.</p>Fórmula:C29H39BrFN3O5Pureza:98%Cor e Forma:SolidPeso molecular:608.54Flovagatran
CAS:<p>Flovagatran (TGN 255) is a potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.</p>Fórmula:C27H36BN3O7Pureza:99.56%Cor e Forma:SolidPeso molecular:525.4Atopaxar
CAS:<p>Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.</p>Fórmula:C29H38FN3O5Pureza:97.07% - 98.07%Cor e Forma:SolidPeso molecular:527.63Melagatran
CAS:<p>Melagatran is an orally available, direct synthetic thrombin inhibitor that does not require endogenous cofactors other than thrombin.Cost-effective and quality-assured.</p>Fórmula:C22H31N5O4Pureza:98.29% - >99.99%Cor e Forma:SolidPeso molecular:429.51NP-313
CAS:<p>NP-313 (NSC-4264) is a potent antithrombotic that blocks platelet aggregation via thromboxane A2 synthesis inhibition and targets SOCC-mediated Ca2+ efflux.</p>Fórmula:C12H8ClNO3Pureza:98.97%Cor e Forma:SolidPeso molecular:249.65SCH79797 dihydrochloride
CAS:<p>SCH79797 dihydrochloride is a PAR1 antagonist with IC50 70 nM, Ki 35 nM, antiproliferative, and pro-apoptotic properties.</p>Fórmula:C23H27Cl2N5Pureza:99.5%Cor e Forma:SolidPeso molecular:444.4Thrombin inhibitor 1
CAS:<p>Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).</p>Fórmula:C22H20Cl2F2N4O3Pureza:98%Cor e Forma:SolidPeso molecular:497.32Odiparcil
CAS:<p>Odiparcil is an orally active beta-d-thioxyloside analog.</p>Fórmula:C15H16O6SPureza:98%Cor e Forma:SolidPeso molecular:324.35LK-732
CAS:<p>LK-732 is a thrombin inhibitor with antithrombotic activity. It exhibits dose-dependent inhibition in models of hypercoagulability, with an IC50 value of 1.3 mg/kg. LK-732 is used in cardiovascular and cerebrovascular research.</p>Fórmula:C25H29N5O3SCor e Forma:SolidPeso molecular:479.59SAR107375
CAS:<p>SAR107375 is a potent, orally active dual inhibitor of thrombin and factor Xa, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively [1].</p>Fórmula:C24H30ClN5O5S2Cor e Forma:SolidPeso molecular:568.11Antiplatelet agent 3
CAS:<p>Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.</p>Fórmula:C38H32N2O5Cor e Forma:SolidPeso molecular:596.671
