ASK
Os inibidores da quinase reguladora de apoptose (ASK) têm como alvo a família de quinases ASK, que são reguladores críticos das vias de apoptose e resposta ao estresse. As quinases ASK estão envolvidas na ativação da apoptose em resposta a vários sinais de estresse, incluindo estresse oxidativo e danos ao DNA. Ao inibir ASK, esses compostos podem modular a sinalização apoptótica, fornecendo ferramentas valiosas para pesquisas sobre morte celular, câncer e doenças neurodegenerativas. Na CymitQuimica, oferecemos uma gama de inibidores de ASK de alta qualidade para apoiar sua pesquisa em apoptose, sinalização celular e mecanismos de doenças.
Foram encontrados 13 produtos para "ASK".
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dASK1-VHL
dASK1-VHL is an orally active PROTAC degrader targeting ASK1. It effectively binds to VHL, promoting the selective degradation of ASK1. By reducing ASK1 protein levels, dASK1-VHL inhibits the activation of p38 MAPK and decreases liver lipid content, offering new insights for MASH research.Cor e Forma:Odour SolidASK1-IN-12
ASK1-IN-12 is an ASK1 inhibitor with an IC50 of 6.3 nM. It effectively suppresses the activation of the ASK1-p38/JNK pathway induced by TNF-α. Additionally, ASK1-IN-12 reduces cholesterol elevation and lipid droplet accumulation induced by free fatty acids, improving hepatic steatosis. This compound is valuable for research on non-alcoholic steatohepatitis (NASH).dASK1
CAS:dASK1 is a selective CRBN-based PROTAC degrader targeting apoptosis signal-regulating kinase 1 (ASK1). It forms a stable ternary complex with ASK1, facilitating its rapid and sustained degradation via the ubiquitin-proteasome pathway. dASK1 exhibits strong ASK1 degradation capabilities and is applicable for hepatitis research.Fórmula:C38H38F2N10O8Cor e Forma:SolidPeso molecular:800.77Anti-DBF4 Antibody (2Q22)
Anti-DBF4 Antibody (2Q22) is an antibody targeting DBF4. Anti-DBF4 Antibody (2Q22) can be used in ELISA, WB, IF Recommended dilution: WB:1:500-1:2000, IF:1:50-1:200.Cor e Forma:Odour LiquidASK1-IN-1
CAS:ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.Fórmula:C19H19N9O2Pureza:99.92%Cor e Forma:White SolidPeso molecular:405.41MSC 2032964A
CAS:MSC 2032964A: Potent, selective ASK1 inhibitor, IC50=93 nM, oral, brain-permeable, curbs neuroinflammation, blocks LPS-induced ASK1/p38 activation.Fórmula:C16H13F3N6OPureza:99.76%Cor e Forma:SolidPeso molecular:362.31Ref: TM-T33514
1mg79,00€2mg92,00€5mg149,00€1mL*10mM (DMSO)168,00€10mg227,00€25mg371,00€50mg530,00€100mg713,00€200mg982,00€ASK1 ligand 1
CAS:ASK1ligand 1 is a binding ligand for ASK1 and can be utilized to synthesize PROTACs such as dASK1-VHL.Fórmula:C17H16F2N6OCor e Forma:SolidPeso molecular:358.35ASK1-IN-8
CAS:ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM. In a mouse liver injury model induced by Acetaminophen, ASK1-IN-8 significantly reduces plasma alanine aminotransferase (ALT) levels, offering liver protection. This compound is useful for research in liver disease-related fields.Fórmula:C26H32N8O2Cor e Forma:SolidPeso molecular:488.585CDK8/19-IN-1
CAS:CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).Fórmula:C19H18N4O4S2Pureza:98%Cor e Forma:SolidPeso molecular:430.5ASK1-IN-9
CAS:ASK1-IN-9 (Compound 3) is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of less than 200 nM. It is applicable for inflammation research.Fórmula:C21H20N6O2Peso molecular:388.43ASK1-IN-11
CAS:ASK1-IN-11 (Compound 7) is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of less than 200 nM. It also exhibits inhibitory activity against TNF-α, MYLK/MLCK kinase, and the hERG potassium ion channel. ASK1-IN-11 can be utilized in inflammation research.Fórmula:C23H22N6O3Peso molecular:430.47ASK1-IN-10
CAS:ASK1-IN-10 (Compound 27) is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of less than 200 nM. It also exhibits inhibitory activity on the hERG potassium channel. ASK1-IN-10 is utilized in inflammation research.Fórmula:C22H19N7OPeso molecular:397.44ASK1-IN-7
CAS:ASK1-IN-7 (Compound 4c) is an ASK1 inhibitor and a derivative of the ASK1 inhibitor scaffold 5-(5-Phenyl-furan-2-ylmethylene)-2-thioxo-thiazolidin-4-one. This compound is potentially applicable in research involving ASK1 signaling pathways, including studies on cellular stress response, inflammatory response, neurodegenerative diseases, and cardiovascular diseases.Fórmula:C13H8N2O2S2Cor e Forma:SolidPeso molecular:288.345
