PERK
Os inibidores de PERK (Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase) têm como alvo a via PERK, que está envolvida na resposta celular ao estresse do retículo endoplasmático (ER) e na regulação da apoptose. PERK desempenha um papel crítico na resposta a proteínas mal enoveladas (UPR), interrompendo a tradução de proteínas e promovendo a sobrevivência celular sob condições de estresse. No entanto, a ativação prolongada de PERK pode levar à apoptose. A inibição de PERK pode modular essas respostas ao estresse, tornando esses inibidores valiosos na pesquisa de doenças neurodegenerativas, câncer e distúrbios metabólicos. Na CymitQuimica, oferecemos uma gama de inibidores de PERK de alta qualidade para apoiar sua pesquisa em apoptose, estresse do RE e homeostase celular.
Foram encontrados 34 produtos para "PERK".
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Daraxonrasib
CAS:Daraxonrasib is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.Fórmula:C44H58N8O5SPureza:98.24% - 99.98%Cor e Forma:White SolidPeso molecular:811.05ISR-IN-3
ISR-IN-3 (Compound 7a) is an eIF2B activator with a pEC50 value of 7.3. It also exhibits significant hERG inhibitory activity, with a pIC50 value of 5.7. ISR-IN-3 is applicable in research related to Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis (als).eIF4E-IN-3
CAS:eIF4E-IN-3 is an eIF4E inhibitor that blocks cap-dependent translation and is used in cancer-related mechanism studies.Fórmula:C34H30ClF3N6O4SCor e Forma:SolidPeso molecular:711.16PERK-IN-6
CAS:PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).Fórmula:C23H22N6OPureza:99.62% - 99.97%Cor e Forma:SolidPeso molecular:398.46PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Fórmula:C24H19F4N5OPureza:99.44% - 99.49%Cor e Forma:SolidPeso molecular:469.4342Claturafenib
CAS:Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.Fórmula:C18H15Cl2F2N5O3SPureza:98.68% - 99.85%Cor e Forma:SolidPeso molecular:490.31ML-291
CAS:ML-291 is a potent UPR inducer; activates PERK/eIF2α/CHOP apoptotic arm; cancer cell death research tool.Fórmula:C16H16ClN3O6SPureza:99.79%Cor e Forma:White SolidPeso molecular:413.833EIF2α activator 2
CAS:EIF2α activator 2 is an activator of eIF2α phosphorylation, anti-proliferative in SRB, K562, and PBMC cells, suitable for cancer research.Fórmula:C21H20F6N2O2Pureza:98.86%Cor e Forma:White SolidPeso molecular:446.39GSK2656157
CAS:GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Fórmula:C23H21FN6OPureza:98.59% - >99.99%Cor e Forma:SolidPeso molecular:416.4508IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Fórmula:C17H18Cl2N6Pureza:98.8%Cor e Forma:SolidPeso molecular:377.271GSK2606414
CAS:GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase（PERK）inhibitor.Cost-effective and quality-assured.Fórmula:C24H20F3N5OPureza:98% - >99.99%Cor e Forma:White SolidPeso molecular:451.44Bufotalin
CAS:1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.Fórmula:C26H36O6Pureza:99.45% - 99.91%Cor e Forma:SolidPeso molecular:444.5604ONO-8130
CAS:ONO-8130 is an orally available antagonist of EP1 receptor.Fórmula:C25H28N2O5S2Pureza:97.82% - 98.94%Cor e Forma:White SolidPeso molecular:500.632BAct
CAS:2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress responseFórmula:C19H16ClF3N4O3Pureza:97.61% - 99.04%Cor e Forma:SolidPeso molecular:440.804GSK621
CAS:GSK621 is a specific and potent AMPK activator.Fórmula:C26H20ClN3O5Pureza:97.02% - 97.05%Cor e Forma:SolidPeso molecular:489.907ISRIB (trans-isomer)
CAS:ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.Fórmula:C22H24Cl2N2O4Pureza:97.86% - 99.27%Cor e Forma:SolidPeso molecular:451.34Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Fórmula:C27H19ClFN5O3SPureza:98.27%Cor e Forma:Yellow SolidPeso molecular:547.988PERK/eIF2α activator 1
CAS:Compound V8 (PERK/eIF2α activator 1), a flavonoid, exhibits anti-tumor properties by inducing apoptosis and activating the PERK-eIF2α-ATF4 pathway. It effectively inhibits the proliferation of HepG2 cells, with an IC 50 value of 23 μM [1].Fórmula:C24H29NO7Cor e Forma:SolidPeso molecular:443.49DNL343
CAS:DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 dipeptide repeat.Fórmula:C20H19ClF3N3O4Pureza:99.96%Cor e Forma:SolidPeso molecular:457.83eIF4A3-IN-1
CAS:eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A3 (eIF4A3). eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.Fórmula:C29H23BrClN5O2Pureza:99.49% - 99.89%Cor e Forma:SolidPeso molecular:588.882
