PERK
Os inibidores de PERK (Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase) têm como alvo a via PERK, que está envolvida na resposta celular ao estresse do retículo endoplasmático (ER) e na regulação da apoptose. PERK desempenha um papel crítico na resposta a proteínas mal enoveladas (UPR), interrompendo a tradução de proteínas e promovendo a sobrevivência celular sob condições de estresse. No entanto, a ativação prolongada de PERK pode levar à apoptose. A inibição de PERK pode modular essas respostas ao estresse, tornando esses inibidores valiosos na pesquisa de doenças neurodegenerativas, câncer e distúrbios metabólicos. Na CymitQuimica, oferecemos uma gama de inibidores de PERK de alta qualidade para apoiar sua pesquisa em apoptose, estresse do RE e homeostase celular.
Foram encontrados 26 produtos de "PERK"
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eIF4E-IN-4
CAS:<p>eIF4E-IN-4 (Compound 33) is a selective inhibitor of the eukaryotic initiation factor 4E (eIF4E) with a biochemical activity value of 95 nM. It inhibits cap-dependent mRNA translation with an IC50 of 2.5 μM and is applicable in research on breast cancer, colon cancer, and head and neck cancer.</p>Fórmula:C20H19ClN5O5PCor e Forma:SolidPeso molecular:475.822eIF4A-IN-1
CAS:eIF4A-IN-1 is an eIF4A inhibitor used in tumor research.Fórmula:C31H33N3O5Cor e Forma:SolidPeso molecular:527.61HC-7366
CAS:HC-7366 (GCN2 modulator-1) is an orally active GCN2 kinase activator with antitumor activity, inducing tumor growth inhibition.Fórmula:C20H15ClF2N6O4SPureza:99.84%Cor e Forma:SolidPeso molecular:508.89HC-5404-Fu
CAS:HC-5404-Fu is an inhibitor of PERK with anti-tumor activity. This compound inhibits the signaling pathway of the endoplasmic reticulum stress response. Additionally, HC-5404-Fu increases the sensitivity of renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). It holds potential for research into renal cell carcinoma, stomach cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors.Fórmula:C28H28F2N4O7Cor e Forma:SolidPeso molecular:570.54HR-19011
CAS:HR-19011 (Compound 40) is an inducer of eIF2α phosphorylation that increases expression levels of downstream proteins ATF and CHOP,antiproliferative.Fórmula:C25H19F6N3O3Pureza:99.89%Cor e Forma:SolidPeso molecular:523.43Ref: TM-T63665
2mg90,00€5mg137,00€10mg219,00€25mg440,00€50mg704,00€100mg1.103,00€200mg1.499,00€1mL*10mM (DMSO)157,00€HC-5404
CAS:HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.Fórmula:C24H24F2N4O3Pureza:99.33%Cor e Forma:SolidPeso molecular:454.47
