PERK
Os inibidores de PERK (Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase) têm como alvo a via PERK, que está envolvida na resposta celular ao estresse do retículo endoplasmático (ER) e na regulação da apoptose. PERK desempenha um papel crítico na resposta a proteínas mal enoveladas (UPR), interrompendo a tradução de proteínas e promovendo a sobrevivência celular sob condições de estresse. No entanto, a ativação prolongada de PERK pode levar à apoptose. A inibição de PERK pode modular essas respostas ao estresse, tornando esses inibidores valiosos na pesquisa de doenças neurodegenerativas, câncer e distúrbios metabólicos. Na CymitQuimica, oferecemos uma gama de inibidores de PERK de alta qualidade para apoiar sua pesquisa em apoptose, estresse do RE e homeostase celular.
Foram encontrados 26 produtos de "PERK"
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Daraxonrasib
CAS:Daraxonrasib is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.Fórmula:C44H58N8O5SPureza:98.24% - 99.96%Cor e Forma:SolidPeso molecular:811.05PERK-IN-6
CAS:PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).Fórmula:C23H22N6OPureza:99.62% - 99.92%Cor e Forma:SolidPeso molecular:398.46PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Fórmula:C24H19F4N5OPureza:99.44% - 99.49%Cor e Forma:SolidPeso molecular:469.43Claturafenib
CAS:Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.Fórmula:C18H15Cl2F2N5O3SPureza:98.68% - 99.85%Cor e Forma:SolidPeso molecular:490.31EIF2α activator 2
CAS:EIF2α activator 2 is an activator of eIF2α phosphorylation, anti-proliferative in SRB, K562, and PBMC cells, suitable for cancer research.Fórmula:C21H20F6N2O2Pureza:98.86%Cor e Forma:SolidPeso molecular:446.39Ref: TM-T62637
1mg62,00€5mg130,00€10mg203,00€25mg380,00€50mg556,00€100mg799,00€200mg1.094,00€1mL*10mM (DMSO)144,00€2BAct
CAS:2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress responseFórmula:C19H16ClF3N4O3Pureza:97.97% - 99.04%Cor e Forma:SolidPeso molecular:440.8Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Fórmula:C27H19ClFN5O3SPureza:98.27%Cor e Forma:SolidPeso molecular:547.99Ref: TM-T22436
1mg92,00€2mg128,00€5mg178,00€10mg268,00€25mg439,00€50mg610,00€100mg820,00€200mg1.099,00€1mL*10mM (DMSO)243,00€ONO-8130
CAS:ONO-8130 is an orally available antagonist of EP1 receptor.Fórmula:C25H28N2O5S2Pureza:97.82%Cor e Forma:SolidPeso molecular:500.63GSK621
CAS:GSK621 is a specific and potent AMPK activator.Fórmula:C26H20ClN3O5Pureza:97.02% - 97.05%Cor e Forma:SolidPeso molecular:489.91Ref: TM-T6854
1mg52,00€2mgA consultar5mg106,00€10mg180,00€25mg311,00€50mg502,00€100mg743,00€200mg1.026,00€IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Fórmula:C17H18Cl2N6Pureza:98.8%Cor e Forma:SolidPeso molecular:377.27GSK2606414
CAS:GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase（PERK）inhibitor.Cost-effective and quality-assured.Fórmula:C24H20F3N5OPureza:98% - >99.99%Cor e Forma:SolidPeso molecular:451.44Bufotalin
CAS:<p>1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.</p>Fórmula:C26H36O6Pureza:99.45% - 99.91%Cor e Forma:White To Off-White SolidPeso molecular:444.56SHP099
CAS:SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cellsFórmula:C16H19Cl2N5Pureza:98.73% - 99.4%Cor e Forma:SolidPeso molecular:352.26Ref: TM-T3564
1mg34,00€2mg49,00€5mg74,00€10mg94,00€25mg165,00€50mg213,00€100mg388,00€1mL*10mM (DMSO)57,00€ISRIB (trans-isomer)
CAS:ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.Fórmula:C22H24Cl2N2O4Pureza:97.86% - 99.27%Cor e Forma:SolidPeso molecular:451.34GSK2656157
CAS:GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Fórmula:C23H21FN6OPureza:98.59% - >99.99%Cor e Forma:SolidPeso molecular:416.45Ref: TM-T2654
2mg35,00€5mg50,00€10mg81,00€25mg142,00€50mg259,00€100mg467,00€200mg632,00€1mL*10mM (DMSO)56,00€SHP389
CAS:SHP389 is a highly effective allosteric inhibitor of SHP2, inhibiting SHP2 and p-ERK, used in cancer research.Fórmula:C23H29ClN8O2Pureza:98.24%Cor e Forma:SolidPeso molecular:484.98DNL343
CAS:DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 dipeptide repeat.Fórmula:C20H19ClF3N3O4Pureza:99.96%Cor e Forma:SolidPeso molecular:457.83eIF4A3-IN-1
CAS:<p>eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A3 (eIF4A3). eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.</p>Fórmula:C29H23BrClN5O2Pureza:99.49% - 99.89%Cor e Forma:SolidPeso molecular:588.88PF-07284892
CAS:PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.Fórmula:C21H22ClN7SPureza:97.77%Cor e Forma:SolidPeso molecular:439.96GCN2-IN-6
CAS:GCN2-IN-6: Potent, oral GCN2/PERK inhibitor; IC50s - GCN2: 1.8 nM (enzymatic), 9.3 nM (cellular); PERK: 0.26 nM (enzymatic), 230 nM (cellular).Fórmula:C19H12Cl2F2N4O3SPureza:95.04% - 98%Cor e Forma:SolidPeso molecular:485.29eIF4E-IN-4
CAS:<p>eIF4E-IN-4 (Compound 33) is a selective inhibitor of the eukaryotic initiation factor 4E (eIF4E) with a biochemical activity value of 95 nM. It inhibits cap-dependent mRNA translation with an IC50 of 2.5 μM and is applicable in research on breast cancer, colon cancer, and head and neck cancer.</p>Fórmula:C20H19ClN5O5PCor e Forma:SolidPeso molecular:475.822eIF4A-IN-1
CAS:eIF4A-IN-1 is an eIF4A inhibitor used in tumor research.Fórmula:C31H33N3O5Cor e Forma:SolidPeso molecular:527.61HC-7366
CAS:HC-7366 (GCN2 modulator-1) is an orally active GCN2 kinase activator with antitumor activity, inducing tumor growth inhibition.Fórmula:C20H15ClF2N6O4SPureza:99.84%Cor e Forma:SolidPeso molecular:508.89HC-5404-Fu
CAS:HC-5404-Fu is an inhibitor of PERK with anti-tumor activity. This compound inhibits the signaling pathway of the endoplasmic reticulum stress response. Additionally, HC-5404-Fu increases the sensitivity of renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). It holds potential for research into renal cell carcinoma, stomach cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors.Fórmula:C28H28F2N4O7Cor e Forma:SolidPeso molecular:570.54HR-19011
CAS:HR-19011 (Compound 40) is an inducer of eIF2α phosphorylation that increases expression levels of downstream proteins ATF and CHOP,antiproliferative.Fórmula:C25H19F6N3O3Pureza:99.89%Cor e Forma:SolidPeso molecular:523.43Ref: TM-T63665
2mg90,00€5mg137,00€10mg219,00€25mg440,00€50mg704,00€100mg1.103,00€200mg1.499,00€1mL*10mM (DMSO)157,00€HC-5404
CAS:HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.Fórmula:C24H24F2N4O3Pureza:99.33%Cor e Forma:SolidPeso molecular:454.47
