Caspase
Os inibidores de caspases são compostos que bloqueiam a atividade das caspases, uma família de proteases que são executores centrais da apoptose. As caspases clivam substratos específicos dentro da célula para desencadear o processo apoptótico, levando à morte celular programada. Os inibidores de caspases são usados para estudar os mecanismos da apoptose, bem como para prevenir a morte celular indesejada em vários modelos de pesquisa. Esses inibidores também são explorados em contextos terapêuticos para proteger as células da apoptose em doenças como a neurodegeneração. Na CymitQuimica, oferecemos uma ampla gama de inibidores de caspases de alta qualidade para apoiar sua pesquisa em apoptose, morte celular e áreas relacionadas.
Foram encontrados 163 produtos para "Caspase".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Roxatidine
CAS:Roxatidine, a metabolite of Roxatidine acetate, is a H2-receptor antagonist that prevents ulcers and has anti-inflammatory properties.Fórmula:C17H26N2O3Cor e Forma:SolidPeso molecular:306.4Protease Inhibitor Library
A unique collection of xnum protease and proteasome inhibitors for research in chemical genomics, and drug screening;Cor e Forma:Odour SolidRef: TM-L1100
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarBiotin-DEVD-CHO TFA
Biotin-DEVD-CHO (TFA) is the biotin-conjugated form of the caspase-3 and caspase-7 inhibitor Ac-DEVD-CHO. It can be utilized for affinity purification of active caspase-3, -6, -7, and -8 and is also applicable for in vitro detection of active caspase-3.Cor e Forma:Odour SolidPerfluorodecanoic acid
CAS:Perfluorodecanoic acid is a biochemical.Fórmula:C10HF19O2Cor e Forma:SolidPeso molecular:514.08Ac-AAVALLPAVLLALLAP-LEVD-CHO
CAS:Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-permeable inhibitor of caspase-4 that exhibits antitumor activity [1].Fórmula:C96H164N20O25Pureza:98%Cor e Forma:SolidPeso molecular:1998.45Ac-AAVALLPAVLLALLAPVAD-CHO TFA
Ac-AAVALLPAVLLALLAPVAD-CHO (TFA) is a complex of Ac-VAD-CHO. It acts as a non-selective caspase inhibitor and features a hydrophobic sequence derived from K-FGF that enables cell penetration.VCP/p97 IN-3
VCP/p97 IN-3 is an allosteric inhibitor of VCP/p97. It exhibits inhibitory activity against VCP, with an IC50 of 9 nM, and shows IC50 values of 12 nM (N660K) and 19 nM (V474A/D649A) for mutant VCP proteins. VCP/p97 IN-3 increases the levels of K48 ubiquitination and caspase-3. It activates endoplasmic reticulum stress and the unfolded protein response (UPR). In a subcutaneous xenograft mouse model with RPMI-8226 cells, VCP/p97 IN-3 suppresses tumor growth. This compound is applicable for research in multiple myeloma.Cor e Forma:Odour SolidBOC-D-FMK
CAS:Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).Fórmula:C11H18FNO5Pureza:97.02%Cor e Forma:SolidPeso molecular:263.26Ref: TM-T10580
1mg50,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg167,00€25mg326,00€50mg462,00€100mg640,00€200mg884,00€TNF-α-IN-11
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.Fórmula:C24H26N2O5Cor e Forma:SolidPeso molecular:422.47PQ401
CAS:PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Fórmula:C18H16ClN3O2Pureza:99.77%Cor e Forma:SolidPeso molecular:341.79Ac-LEHD-AMC
CAS:Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.Fórmula:C33H41N7O11Cor e Forma:SolidPeso molecular:711.729Ac-VDVAD-CHO TFA
Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.Cor e Forma:Odour SolidDiethylnorspermine HCl
CAS:Diethylnorspermine HCl (N1,N11-Diethylnorspermine tetrahydrochloride) potently induces SSAT (spermidine/spermine N1-acetyltransferase) mRNA and effectivelyFórmula:C13H36Cl4N4Pureza:99.79% - 99.86%Cor e Forma:SolidPeso molecular:390.26Pralnacasan
CAS:Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).Fórmula:C26H29N5O7Pureza:98%Cor e Forma:SolidPeso molecular:523.54Ac-IEPD-AFC
CAS:Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.Fórmula:C32H38F3N5O11Pureza:99.16%Cor e Forma:White SolidPeso molecular:725.67Ac-LEVD-CHO
CAS:Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].Fórmula:C22H36N4O9Cor e Forma:SolidPeso molecular:500.54Z-VDVA-(DL-Asp)-FMK
CAS:Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.Fórmula:C32H46FN5O11Cor e Forma:SolidPeso molecular:695.742Boc-Asp(OBzl)-CMK
CAS:Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].Fórmula:C17H22ClNO5Cor e Forma:SolidPeso molecular:355.81Z-WEHD-FMK
CAS:Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).Fórmula:C37H42FN7O10Pureza:98%Cor e Forma:SolidPeso molecular:763.78IRF1-IN-2
CAS:IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.Fórmula:C18H20N2O4SPureza:99.85%Cor e Forma:SolidPeso molecular:360.43
