Caspase
Os inibidores de caspases são compostos que bloqueiam a atividade das caspases, uma família de proteases que são executores centrais da apoptose. As caspases clivam substratos específicos dentro da célula para desencadear o processo apoptótico, levando à morte celular programada. Os inibidores de caspases são usados para estudar os mecanismos da apoptose, bem como para prevenir a morte celular indesejada em vários modelos de pesquisa. Esses inibidores também são explorados em contextos terapêuticos para proteger as células da apoptose em doenças como a neurodegeneração. Na CymitQuimica, oferecemos uma ampla gama de inibidores de caspases de alta qualidade para apoiar sua pesquisa em apoptose, morte celular e áreas relacionadas.
Foram encontrados 163 produtos para "Caspase".
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BOC-D-FMK
CAS:Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).Fórmula:C11H18FNO5Pureza:97.02%Cor e Forma:SolidPeso molecular:263.26Ref: TM-T10580
1mg50,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg167,00€25mg326,00€50mg462,00€100mg640,00€200mg884,00€Z-VDVA-(DL-Asp)-FMK
CAS:Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.Fórmula:C32H46FN5O11Cor e Forma:SolidPeso molecular:695.742Perfluorodecanoic acid
CAS:Perfluorodecanoic acid is a biochemical.Fórmula:C10HF19O2Cor e Forma:SolidPeso molecular:514.08Ac-VDQQD-pNA
CAS:Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).Fórmula:C31H43N9O14Cor e Forma:SolidPeso molecular:765.73Ac-AAVALLPAVLLALLAPVAD-CHO TFA
Ac-AAVALLPAVLLALLAPVAD-CHO (TFA) is a complex of Ac-VAD-CHO. It acts as a non-selective caspase inhibitor and features a hydrophobic sequence derived from K-FGF that enables cell penetration.CIB-1476
CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.Fórmula:C28H28N2O6SCor e Forma:SolidPeso molecular:520.6Trehalose-6,6'-dibehenate
CAS:Trehalose-6,6'-dibehenate, a bioactive glycolipid, is applicable for the preparation of vaccine adjuvant [1].Fórmula:C56H106O13Cor e Forma:SolidPeso molecular:987.43Reproxalap
CAS:Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.Fórmula:C12H13ClN2OPureza:99.4% - 99.97%Cor e Forma:SolidPeso molecular:236.7Protease Inhibitor Library
A unique collection of xnum protease and proteasome inhibitors for research in chemical genomics, and drug screening;Cor e Forma:Odour SolidRef: TM-L1100
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarTD1092
TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.Fórmula:C55H70N8O9Cor e Forma:SolidPeso molecular:987.19Biotin-DEVD-CHO TFA
Biotin-DEVD-CHO (TFA) is the biotin-conjugated form of the caspase-3 and caspase-7 inhibitor Ac-DEVD-CHO. It can be utilized for affinity purification of active caspase-3, -6, -7, and -8 and is also applicable for in vitro detection of active caspase-3.Cor e Forma:Odour SolidIRF1-IN-2
CAS:IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.Fórmula:C18H20N2O4SPureza:99.85%Cor e Forma:SolidPeso molecular:360.43Ac-AAVALLPAVLLALLAP-YVAD-CHO
CAS:Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1 exhibiting antitumor activity [1].Fórmula:C97H160N20O24Pureza:98%Cor e Forma:SolidPeso molecular:1990.43TNF-α-IN-11
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.Fórmula:C24H26N2O5Cor e Forma:SolidPeso molecular:422.47Ac-IETD-AFC TFA
Ac-IETD-AFC TFA is a synthetic fluorescent substrate used for the specific detection of Caspase-8 enzyme activity. It contains the fluorescent group AFC (7-amino-4-trifluoromethylcoumarin), which becomes free and emits fluorescence (Ex=~400 nm; Em=~505 nm) when Caspase-8 cleaves the amide bond following the IETD sequence. [INDO 1 pentasodium].Cor e Forma:Odour SolidDiethylnorspermine HCl
CAS:Diethylnorspermine HCl (N1,N11-Diethylnorspermine tetrahydrochloride) potently induces SSAT (spermidine/spermine N1-acetyltransferase) mRNA and effectivelyFórmula:C13H36Cl4N4Pureza:99.79% - 99.86%Cor e Forma:SolidPeso molecular:390.26Roxatidine
CAS:Roxatidine, a metabolite of Roxatidine acetate, is a H2-receptor antagonist that prevents ulcers and has anti-inflammatory properties.Fórmula:C17H26N2O3Cor e Forma:SolidPeso molecular:306.4δ-secretase inhibitor 11
CAS:δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.Fórmula:C10H12N4O2Pureza:99.57% - 99.84%Cor e Forma:Red SolidPeso molecular:220.23Sarglaroids F
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+Fórmula:C38H44O12Pureza:98%Cor e Forma:SolidPeso molecular:692.75NLRP3-IN-84
NLRP3-IN-84 (Compound 32) is an inhibitor of the NLRP3 inflammasome. It interferes with the oligomerization of NLRP3 by inhibiting the activity of NLRP3ATPase (IC50= 158.4 nM). NLRP3-IN-84 also inhibits Caspase-1 (IC50= 27.7 nM), the release of IL-1β in PBMC (IC50= 19.5 nM) and mPBMC (IC50= 24.2 nM), and ASC speck formation (IC50= 131 nM). It shows no inhibitory activity against the NLRC4 and AIM2 inflammasomes. NLRP3-IN-84 exhibits significant in vivo anti-inflammatory effects in a mouse acute peritonitis model, making it useful for studying NLRP3-related inflammatory diseases.
