IAP

MV1 is an IAP antagonist. When combined with HaloTag ligand, MV1 causes protein knockdown of HaloTag-fused proteins.

PROTAC KRAS G12C degrader-2 (compound 432) is a targeted modulator of K-Ras protein hydrolysis that functions as a bifunctional PROTAC molecule, incorporating a cereblon inhibitor of apoptosis proteins (IAP) ligand on one terminus and a KRAS-binding moiety on the opposite end, thereby enabling selective recruitment of mutant KRAS G12C to the ubiquitin–proteasome system for controlled degradation and mechanistic investigation of KRAS-driven oncogenic signaling pathways.

MDM2/XIAP-IN-1 (compound 14) is an orally active dual inhibitor of MDM2 and XIAP, exhibiting anti-cancer activity with an IC50 of 0.3 μM and potential

SM-164 Hydrochloride: cell-permeable, binds to XIAP (BIR2/3 domains), IC50 of 1.39 nM, potent XIAP antagonist.

SBP-0636457: SMAC mimetic, IAP inhibitor, binds BIR-domains (Ki=0.27μM), potential in tumor/cancer research.

XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) serves as a potent dual inhibitor targeting BIR2 and BIR2-3 domains, with IC₅₀ values of 1.9 nM and 0.8 nM, respectively. This compound is utilized in cancer research studies [1].

PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective PROTAC-based degrader targeting TEAD1 and cIAP1, with DC50 values of 14 nM and 270 nM, respectively. This compound facilitates the ubiquitination and degradation of TEAD1 and cIAP1, and it reduces the expression of the TEAD-dependent gene CTGF. Additionally, PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma.

IAP ligand 9 is a SMAC mimetic and binds to the IAP (inhibitor of apoptosis protein) BIR domains, selectively targeting cIAP1-BIR3 and XIAP-BIR3, while showing minimal affinity for XIAP-BIR2, with SPR pKD values of 7.0, 8.0, and 5.0, respectively. As an IAP ligand module, it can be conjugated via linkers with degraders targeting the TEAD1 P site to form IAP-recruiting proteolysis-targeting chimeras (PROTACs/IPDs). This IPD recruits the IAPE3 ubiquitin ligase to form the TEAD1-IPD-IAP ternary complex, mediating ubiquitination and proteasome-dependent degradation of TEAD1 and inducing autodegradation of cIAP1. IAP ligand 9 and related degraders are useful in the study of solid tumors such as malignant pleural mesothelioma associated with abnormal activation of the Hippo pathway.

S2/IAPinh is a conjugate composed of an inhibitor of apoptosis proteins inhibitor (IAPinh) and a ligand of sigma 2 SW43. It demonstrates anti-proliferative and apoptosis-inducing activity by degrading inhibitor of apoptosis proteins (clAP-1).

XIAP BIR2/BIR2-3 Inhibitor-3 functions as a dual inhibitor targeting both BIR2 and BIR2-3 domains, exhibiting potent activity with IC₅₀ values below 1 nM. This compound is utilized in cancer research [1].

XIAP BIR2/BIR2-3 Inhibitor-2 is a dual inhibitor of BIR2 and BIR2-3 with IC₅₀ values less than 1 nM. It can be used in the study of cancers [1].

CST626 is a PROTAC degrader that targets XIAP, cIAP1, and cIAP2.

PROTAC TEAD1/IAP degrader-2 is an IAP-recruiting TEAD1 PROTAC degrader with a DC50 of 170 nM for TEAD1 in NCI-H2052 cells. It exhibits moderate antiproliferative activity in mesothelioma cells that depend on the Hippo pathway. PROTAC TEAD1/IAP degrader-2 also inhibits CTGF expression, though less effectively than the TEAD inhibitor VT-107, and is applicable for mesothelioma research.

APG-1387 inhibits IAPs, degrades cIAP1/2, XIAP, boosts chemosensitivity, and induces apoptosis in NPC.

Anti-CD47 Antibody-FITC (9X161) is a FITC-conjugated Mouse antibody targeting CD47. Anti-CD47 Antibody-FITC (9X161) can be used in FCM.

AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.

CD47 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

Anti-CD47 Antibody-PE (9X161) is a PE-conjugated Mouse antibody targeting CD47. Anti-CD47 Antibody-PE (9X161) can be used in FCM.

Anti-CD47 Antibody (8A121) is a Mouse antibody targeting CD47. Anti-CD47 Antibody (8A121) can be used in ELISA.

Anti-CD47 Antibody (1F304) is an antibody targeting CD47. Anti-CD47 Antibody (1F304) can be used in ELISA, FCM.