IAP
Os inibidores das proteínas inibidoras da apoptose (IAP) são compostos que bloqueiam a atividade das IAPs, uma família de proteínas que previnem a apoptose, inibindo caspases e outros componentes da maquinaria apoptótica. Os inibidores de IAP promovem a apoptose em células cancerígenas ao neutralizar esses sinais de sobrevivência, tornando-os ferramentas importantes na pesquisa e terapia contra o câncer. Na CymitQuimica, oferecemos uma ampla gama de inibidores de IAP de alta qualidade para apoiar sua pesquisa em oncologia, apoptose e desenvolvimento terapêutico.
Foram encontrados 66 produtos de "IAP"
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MV1
CAS:<p>MV1 is an IAP antagonist. When combined with HaloTag ligand, MV1 causes protein knockdown of HaloTag-fused proteins.</p>Fórmula:C33H44N4O5Pureza:99.86%Cor e Forma:SolidPeso molecular:576.73SM-164 Hydrochloride (957135-43-2 free base)
<p>SM-164 Hydrochloride: cell-permeable, binds to XIAP (BIR2/3 domains), IC50 of 1.39 nM, potent XIAP antagonist.</p>Fórmula:C62H85ClN14O6Pureza:98%Cor e Forma:SolidPeso molecular:1157.88S2/IAPinh
<p>S2/IAPinh is a conjugate composed of an inhibitor of apoptosis proteins inhibitor (IAPinh) and a ligand of sigma 2 SW43. It demonstrates anti-proliferative and apoptosis-inducing activity by degrading inhibitor of apoptosis proteins (clAP-1).</p>Fórmula:C52H75Cl2FN6O6SPeso molecular:1000.48299N-Deshydroxyethyl Dasatinib
CAS:<p>N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP</p>Fórmula:C20H22ClN7OSPureza:95.96%Cor e Forma:SolidPeso molecular:443.95XIAP BIR2/BIR2-3 inhibitor-3
CAS:<p>XIAP BIR2/BIR2-3 Inhibitor-3 functions as a dual inhibitor targeting both BIR2 and BIR2-3 domains, exhibiting potent activity with IC50 values below 1 nM. This compound is utilized in cancer research [1].</p>Fórmula:C86H106N18O16S2Cor e Forma:SolidPeso molecular:1712XIAP BIR2/BIR2-3 inhibitor-1
CAS:<p>XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) serves as a potent dual inhibitor targeting BIR2 and BIR2-3 domains, with IC50 values of 1.9 nM and 0.8 nM, respectively. This compound is utilized in cancer research studies [1].</p>Fórmula:C72H96N16O14Cor e Forma:SolidPeso molecular:1409.63SBP-0636457
CAS:<p>SBP-0636457: SMAC mimetic, IAP inhibitor, binds BIR-domains (Ki=0.27μM), potential in tumor/cancer research.</p>Fórmula:C25H36N4O4Cor e Forma:SolidPeso molecular:456.587CST626
CAS:<p>CST626 is a PROTAC degrader that targets XIAP, cIAP1, and cIAP2.</p>Fórmula:C61H82N8O9SPureza:95.87%Cor e Forma:SolidPeso molecular:1103.42Anti-CD47 Antibody (8A121)
<p>Anti-CD47 Antibody (8A121) is a Mouse antibody targeting CD47. Anti-CD47 Antibody (8A121) can be used in ELISA.</p>Cor e Forma:Odour LiquidAnti-CD47 Antibody-PE (9X161)
<p>Anti-CD47 Antibody-PE (9X161) is a PE-conjugated Mouse antibody targeting CD47. Anti-CD47 Antibody-PE (9X161) can be used in FCM.</p>Cor e Forma:Odour LiquidAnti-CD47 Antibody (8K78)
<p>Anti-CD47 Antibody (8K78) is a Rabbit antibody targeting CD47. Anti-CD47 Antibody (8K78) can be used in WB,ELISA,IP.</p>Cor e Forma:Odour LiquidAnti-CD47 Antibody (4E249)
<p>Anti-CD47 Antibody (4E249) is a Rabbit antibody targeting CD47. Anti-CD47 Antibody (4E249) can be used in ELISA.</p>Cor e Forma:Odour LiquidAnti-CD47 Antibody (5R542)
<p>Anti-CD47 Antibody (5R542) is a Mouse antibody targeting CD47. Anti-CD47 Antibody (5R542) can be used in ELISA.</p>Cor e Forma:Odour LiquidAnti-CD47 Antibody (5K435)
<p>Anti-CD47 Antibody (5K435) is an antibody targeting CD47. Anti-CD47 Antibody (5K435) can be used in ELISA, WB, IHC, IF.</p>Cor e Forma:Odour LiquidCD47 Protein, Mouse, Recombinant (rFc)
<p>CD47 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:39.9 kDa (predicted)Anti-CD47 Antibody (5S892)
<p>Anti-CD47 Antibody (5S892) is a Mouse antibody targeting CD47. Anti-CD47 Antibody (5S892) can be used in IHC-P.</p>Cor e Forma:Odour LiquidAnti-CD47 Antibody (9X161)
<p>Anti-CD47 Antibody (9X161) is a Mouse antibody targeting CD47. Anti-CD47 Antibody (9X161) can be used in FCM.</p>Cor e Forma:Odour LiquidAnti-CD47 Antibody-FITC (9X161)
<p>Anti-CD47 Antibody-FITC (9X161) is a FITC-conjugated Mouse antibody targeting CD47. Anti-CD47 Antibody-FITC (9X161) can be used in FCM.</p>Cor e Forma:Odour LiquidAnti-CD47 Antibody (4C168)
<p>Anti-CD47 Antibody (4C168) is a Mouse antibody targeting CD47. Anti-CD47 Antibody (4C168) can be used in IHC-P.</p>Cor e Forma:Odour LiquidAnti-CD47 Antibody (6T428)
<p>Anti-CD47 Antibody (6T428) is a Rabbit antibody targeting CD47. Anti-CD47 Antibody (6T428) can be used in ELISA.</p>Cor e Forma:Odour LiquidAnti-CD47 Antibody (5E321)
<p>Anti-CD47 Antibody (5E321) is a Rabbit antibody targeting CD47. Anti-CD47 Antibody (5E321) can be used in ELISA.</p>Cor e Forma:Odour LiquidAnti-CD47 Antibody (1F304)
<p>Anti-CD47 Antibody (1F304) is an antibody targeting CD47. Anti-CD47 Antibody (1F304) can be used in ELISA, FCM.</p>Cor e Forma:Odour LiquidAZD5582
CAS:AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.Fórmula:C58H78N8O8Pureza:98.75%Cor e Forma:SolidPeso molecular:1015.29CD47 Protein, Mouse, Recombinant (His)
<p>CD47 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Pureza:SDS-PAGE: 98.3%; SEC-HPLC: 98.5%Cor e Forma:Lyophilized PowderPeso molecular:15.3 kDa (predicted); 34-44 kDa (reducing condition, due to glycosylation)Alkaline Phosphatase/PLAP Protein, Human, Recombinant (His)
<p>Most importantly, placental alkaline phosphatase (ALPP), an ectoenzyme that locates on cell surface with catalytic domains outside the plasma membrane and is</p>Pureza:92.7%Cor e Forma:Lyophilized PowderPeso molecular:54.1 kDa (predicted); 66 kDa (reducing conditions)CD47 Protein, Human, Recombinant (Avi & His), Biotinylated
<p>CD47 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:30-40 KDa (reducing condition)CD47 Protein, Human, Recombinant (hFc)
<p>CD47 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>Pureza:> 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC - > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLCCor e Forma:Lyophilized PowderPeso molecular:40.5 kDa (predicted); 55-65 kDa (reducing condition, due to glycosylation)CD47 Protein, Human, Recombinant (mFc)
<p>CD47 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:48-65 KDa (reducing condition)CD47 Protein, Rhesus macaque, Recombinant (hFc)
<p>CD47 Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:60-90 KDa (reducing condition)CD47 Protein, Human, Recombinant (aa 19-139, His)
<p>CD47 Protein, Human, Recombinant (aa 19-139, His) is expressed in HEK293 mammalian cells with His tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:14.5 kDa (predicted); 40-55 kDa (reducing conditions)Alkaline phosphatase (Intestinal type) /ALPI Protein, Human, Recombinant (His & Flag)
<p>Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletal</p>Cor e Forma:Lyophilized PowderPeso molecular:54.5 kDa (predicted). Due to glycosylation, the protein migrates to 63-73 kDa based on Tris-Bis PAGE result.CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated
<p>CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:60-70 KDa (reducing condition)Alkaline phosphatase (Intestinal type) /ALPI Protein, Mouse, Recombinant (His)
<p>Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletal</p>Cor e Forma:Lyophilized PowderPeso molecular:53.10 kDa (predicted). Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.CD47 Protein, Rhesus macaque, Recombinant (His & Flag)
<p>CD47, also known as Integrin‑Associated Protein (IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily.</p>Cor e Forma:Lyophilized PowderPeso molecular:33-55 KDa (reducing condition)CD47 Protein, Mouse, Recombinant (His & Avi), Biotinylated
<p>CD47 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:17.1 kDa (predicted); 38.8 kDa (reducing conditions)Alkaline phosphatase Protein, Human, Recombinant (hFc)
<p>Alkaline phosphatase Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:79.5 kDa (predicted); 90-95 kDa (reducing condition, due to glycosylation)CD47 Protein, Human, Recombinant (aa 1-139, His)
<p>CD47 Protein, Human, Recombinant (aa 1-139, His) is expressed in HEK293 mammalian cells with His tag.</p>Pureza:SDS-PAGE: 98.4%; SEC-HPLC: 97.6%Cor e Forma:Lyophilized PowderPeso molecular:15.2 kDa (predicted); 35-44 kDa (reducing condition, due to glycosylation)CD47 Protein, Human, Recombinant (His)
<p>CD47 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag.</p>Pureza:Greater than 95% as determined by reducing SDS-PAGE. - SDS-PAGE: 100%; SEC-HPLC: 97%Cor e Forma:Lyophilized PowderPeso molecular:30-45 KDa (reducing condition)CD47 Protein, Human, Recombinant, Biotinylated
<p>CD47 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells.</p>Pureza:97.6%Cor e Forma:Lyophilized PowderPeso molecular:14.5 kDa (predicted)CD47 Protein, Mouse, Recombinant
<p>CD47 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 13.8 kDa and the accession number is E5Q371.</p>Cor e Forma:Lyophilized PowderPeso molecular:13.8 kDa (predicted)CD47 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
<p>CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene.</p>Cor e Forma:Lyophilized PowderPeso molecular:15 kDa (predicted). Due to glycosylation, the protein migrates to 45-65 kDa based on Tris-Bis PAGE result.CD47 Protein, Mouse, Recombinant (hFc)
<p>CD47 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:40.6 kDa (predicted)CD47 Protein, Human, Recombinant
<p>CD47 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3.</p>Pureza:97.8%Cor e Forma:Lyophilized PowderPeso molecular:14.5 kDa (predicted); 35 kDa (reducing condition, due to glycosylation)Alkaline phosphatase Protein, Human, Recombinant (His)
<p>Alkaline phosphatase Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Pureza:98.4%Cor e Forma:Lyophilized PowderPeso molecular:54 kDa (predicted); 66 kDa (reducing condition, due to glycosylation)Embelin
CAS:<p>Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).</p>Fórmula:C17H26O4Pureza:97.07% - 99.88%Cor e Forma:SolidPeso molecular:294.39GDC-0152
CAS:<p>GDC-0152 is a potent inhibitor of IAPs.</p>Fórmula:C25H34N6O3SPureza:97.18% - 99.32%Cor e Forma:SolidPeso molecular:498.64Birinapant
CAS:<p>Birinapant (TL32711) is a synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of</p>Fórmula:C42H56F2N8O6Pureza:97.08% - ≥95%Cor e Forma:SolidPeso molecular:806.94ASTX660
CAS:<p>Tolinapant (ASTX660) is an orally bioavailable cIAP1/2 and XIAP antagonist.Cost-effective and quality-assured.</p>Fórmula:C30H42FN5O3Pureza:98.33% - 99.85%Cor e Forma:SolidPeso molecular:539.68Xevinapant
CAS:<p>Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP, binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3.</p>Fórmula:C32H43N5O4Pureza:98% - 99.94%Cor e Forma:SolidPeso molecular:561.71LCL161
CAS:<p>LCL161 is a SMAC mimetic, an IAP antagonist with oral activity that inhibits XIAP and cIAP1. LCL161 has potential antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C26H33FN4O3SPureza:99.13% - 99.87%Cor e Forma:SolidPeso molecular:500.63Isolinderalactone
CAS:<p>Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.</p>Fórmula:C15H16O3Pureza:99.62%Cor e Forma:SolidPeso molecular:244.29Polygalacin D
CAS:<p>Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced</p>Fórmula:C57H92O27Pureza:98.95% - ≥98%Cor e Forma:SolidPeso molecular:1209.44-Methylsalicylic acid
CAS:<p>4-Methylsalicylic acid is used to inhibit the medium chain acyl-CoA synthetase.</p>Fórmula:C8H8O3Pureza:99.64%Cor e Forma:Solid Solid CrystallinePeso molecular:152.15SM-164
CAS:<p>SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains (IC50: 1.39 nM). It acts as an extremely potent antagonist of XIAP.</p>Fórmula:C62H84N14O6Pureza:98.53% - 99.92%Cor e Forma:SolidPeso molecular:1121.42MX69
CAS:<p>MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.</p>Fórmula:C27H26N2O4SPureza:97.27% - 99.57%Cor e Forma:SolidPeso molecular:474.57BV6
CAS:<p>BV6 is an antagonist of c-IAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family.</p>Fórmula:C70H96N10O8Pureza:97.46% - 99.82%Cor e Forma:SolidPeso molecular:1205.57AZD5582 acetate (1258392-53-8 free base)
<p>AZD5582 acetate is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively.</p>Fórmula:C60H82N8O10Pureza:97.76%Cor e Forma:SolidPeso molecular:1075.36T-3256336
CAS:<p>T-3256336 is an oral IAP blocker targeting cIAP-1, cIAP-2, and XIAP.</p>Fórmula:C31H45F2N5O5Pureza:98%Cor e Forma:SolidPeso molecular:605.72MX107
CAS:<p>MX107 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation.</p>Fórmula:C24H28N2O2Cor e Forma:SolidPeso molecular:376.49A 410099.1
CAS:<p>A 410099.1 is a BIRC (baculoviral IAP repeat-containing protein) inhibitor with EC50 values of 4.6, 9.2, 15.6, 19.9, and 93.9 nM for BIRC2/3/4/7/8.</p>Fórmula:C27H41ClN4O3Pureza:99.30%Cor e Forma:SolidPeso molecular:505.1MDM2/XIAP-IN-3
CAS:<p>MDM2/XIAP-IN-3 (compound 3e), a dual inhibitor of MDM2/XIAP, diminishes MDM2 and XIAP protein levels while augmenting p53 expression, consequently suppressing</p>Fórmula:C29H30N2O5SCor e Forma:SolidPeso molecular:518.62CUDC-427
CAS:<p>CUDC-427 (GDC-0917) is an orally bioactive and pan antagonist of inhibitor of apoptosis proteins(IAPs). CUDC-427 can be used in research on cancers.</p>Fórmula:C29H36N6O4SPureza:99.92%Cor e Forma:SolidPeso molecular:564.7Anticancer agent 128
CAS:<p>Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, exhibiting IC50 values of 24.9 nM, 19</p>Fórmula:C26H38N4O4Pureza:98%Cor e Forma:SolidPeso molecular:470.6Anticancer agent 127
CAS:<p>Anticancer agent 127 (142D6), an IAP inhibitor, covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, with IC50 values of 12 nM, 14 nM, and 9 nM,</p>Fórmula:C26H37FN4O6SPureza:98%Cor e Forma:SolidPeso molecular:552.66XIAP degrader-1
<p>XIAP degrader-1 is a small primary amine molecule that promotes the degradation of X-linked apoptosis inhibitory protein (XIAP).</p>Fórmula:C34H45N5O4Cor e Forma:SolidPeso molecular:587.75XIAP/cIAP1 antagonist-1
<p>Potent oral XIAP/cIAP1 inhibitor with EC50s: XIAP 5.1 nM, cIAP1 0.32 nM; curbs tumor growth in vivo.</p>Cor e Forma:Solid
