Chk
Os inibidores da quinase de checkpoint (Chk) têm como alvo as quinasas Chk1 e Chk2, que são reguladoras-chave da resposta aos danos no DNA e dos pontos de verificação do ciclo celular. Essas quinasas interrompem a progressão do ciclo celular em resposta a danos no DNA, permitindo tempo para reparo. Inibir as quinasas Chk pode impedir a parada do ciclo celular, forçando as células danificadas a prosseguir no ciclo e, eventualmente, sofrer apoptose. Os inibidores de Chk são particularmente valiosos na pesquisa do câncer, onde podem sensibilizar as células tumorais a agentes que causam danos ao DNA. Na CymitQuimica, oferecemos uma variedade de inibidores de Chk de alta qualidade para apoiar sua pesquisa em resposta a danos no DNA, regulação do ciclo celular e oncologia.
Foram encontrados 48 produtos de "Chk"
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CHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Fórmula:C18H19BrClN7O2Pureza:99.29%Cor e Forma:SoildPeso molecular:480.75Monalizumab
CAS:Monalizumab, a humanized antibody, enhances NK cell function by inhibiting NKG2A; used in HNSCC studies.Pureza:95% - >95.0% (SDS-PAGE); 100% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:147 kDaCCT241533 dihydrochloride
CAS:Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.Fórmula:C23H29Cl2FN4O4Cor e Forma:SolidPeso molecular:515.41CHK1-IN-9
CHK1-IN-9 (compound 11) is an orally active CHK1 inhibitor with an IC50 of 0.55 nM. It enhances the effects of DNA-damaging agents on tumor cells and exhibits synergistic anticancer activity with Gemcitabine.WAY-230563
CAS:WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cellsFórmula:C17H12N2O2SPureza:98.40%Cor e Forma:SolidPeso molecular:308.35Chk1-IN-6
CAS:Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.
Fórmula:C16H18F3N7Cor e Forma:SolidPeso molecular:365.364CBP501 Affinity Peptide
CAS:CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].Fórmula:C68H119N21O25SCor e Forma:SolidPeso molecular:1662.86PROTAC Chk1 degrader-1
CAS:Compound PROTAC-2, also known as PROTAC Chk1 degrader-1, is a potent degrader of Chk1, exhibiting a DC50 of 1.33 μM. It is utilized in cancer research [1].Fórmula:C43H44N14O9Cor e Forma:SolidPeso molecular:900.9CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.Fórmula:C19H19N7O2Cor e Forma:SolidPeso molecular:377.16002GDC-0425
CAS:GDC-0425 (RG-7602), an oral selective ChK1 inhibitor, targets multiple cancers.Fórmula:C18H19N5OCor e Forma:SolidPeso molecular:321.38CCT244747
CAS:CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .Fórmula:C20H24N8O2Pureza:99.17%Cor e Forma:SolidPeso molecular:408.46PD 407824
CAS:PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).Fórmula:C20H12N2O3Pureza:98.02%Cor e Forma:SolidPeso molecular:328.32GDC-0575 dihydrochloride
CAS:GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is a selective, orally active CHK1 inhibitor (IC50: 1.2 nM) that exhibits antitumour effects.Fórmula:C16H22BrCl2N5OCor e Forma:SolidPeso molecular:451.19Rabusertib
CAS:Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.
Fórmula:C18H22BrN5O3Pureza:98.86% - 99.87%Cor e Forma:SolidPeso molecular:436.3GDC0575 monohydrochloride
CAS:GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Fórmula:C16H21BrClN5OPureza:97.85%Cor e Forma:SolidPeso molecular:414.73Ref: TM-T27407
1mg43,00€2mg55,00€5mg80,00€10mg103,00€25mg177,00€50mg255,00€100mg356,00€200mg520,00€1mL*10mM (DMSO)93,00€CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Fórmula:C16H16F3N7OPureza:98.28% - 99.93%Cor e Forma:SolidPeso molecular:379.34Ref: TM-T7080
1mg37,00€2mg49,00€5mg79,00€10mg113,00€25mg213,00€50mg350,00€100mg523,00€1mL*10mM (DMSO)87,00€Baricitinib
CAS:Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Fórmula:C16H17N7O2SPureza:99% - >99.99%Cor e Forma:SolidPeso molecular:371.42Ref: TM-T2485
5mg48,00€10mg70,00€25mg95,00€50mg109,00€100mg137,00€200mg178,00€500mg295,00€1mL*10mM (DMSO)65,00€ML367
CAS:ML367 inhibits ATAD5 stabilization with low micromolar activity, serving as a probe molecule.Fórmula:C19H12F2N4Pureza:99.39%Cor e Forma:SolidPeso molecular:334.32GDC-0575
CAS:GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).Fórmula:C16H20BrN5OPureza:≥95%Cor e Forma:SolidPeso molecular:378.27AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Fórmula:C17H19FN4O2SPureza:98.96% - 99.19%Cor e Forma:SolidPeso molecular:362.42Ref: TM-T6093
1mg35,00€2mg50,00€5mg77,00€10mg90,00€25mg167,00€50mg265,00€100mg424,00€1mL*10mM (DMSO)84,00€
