Chk
Os inibidores da quinase de checkpoint (Chk) têm como alvo as quinasas Chk1 e Chk2, que são reguladoras-chave da resposta aos danos no DNA e dos pontos de verificação do ciclo celular. Essas quinasas interrompem a progressão do ciclo celular em resposta a danos no DNA, permitindo tempo para reparo. Inibir as quinasas Chk pode impedir a parada do ciclo celular, forçando as células danificadas a prosseguir no ciclo e, eventualmente, sofrer apoptose. Os inibidores de Chk são particularmente valiosos na pesquisa do câncer, onde podem sensibilizar as células tumorais a agentes que causam danos ao DNA. Na CymitQuimica, oferecemos uma variedade de inibidores de Chk de alta qualidade para apoiar sua pesquisa em resposta a danos no DNA, regulação do ciclo celular e oncologia.
Foram encontrados 49 produtos para "Chk".
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Baricitinib
CAS:Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Fórmula:C16H17N7O2SPureza:99% - >99.99%Cor e Forma:SolidPeso molecular:371.42Ref: TM-T2485
5mg48,00€1mL*10mM (DMSO)65,00€10mg70,00€25mg95,00€50mg109,00€100mg137,00€200mg178,00€500mg295,00€CCT245737
CAS:CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.Fórmula:C16H16F3N7OPureza:98.28% - 99.93%Cor e Forma:SolidPeso molecular:379.34Ref: TM-T7080
1mg37,00€2mg49,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg113,00€25mg213,00€50mg350,00€100mg523,00€SAR-020106
CAS:SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.Fórmula:C19H19ClN6OPureza:97.78%Cor e Forma:SolidPeso molecular:382.85Zimistobart
CAS:Zimistobart (BMS-986315) is a fully human IgG1 antibody that targets and binds to NKG2A. It is applicable in research for non-small cell lung cancer (NSCLC). For an isotype control, refer to HumanIgG1kappa, Isotype Control.Cor e Forma:LiquidNSC 109555 ditosylate
CAS:Chk2 inhibitor,ATP-competitiveFórmula:C26H32N10O4SPureza:98%Cor e Forma:SolidPeso molecular:580.66SC-203885
CAS:SC-203885 is a checkpoint kinase 2 inhibitor.Fórmula:C15H13N5O2Pureza:98%Cor e Forma:SolidPeso molecular:295.3CCT245737(S)
CAS:CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor.Fórmula:C16H16F3N7OCor e Forma:SolidPeso molecular:379.34PV-1115
CAS:PV-1115 is an effective and highly selective inhibitor of the Chk2.Fórmula:C20H19N7O3Pureza:98%Cor e Forma:SolidPeso molecular:405.41VRX-0466617
CAS:VRX-0466617 is a novel selective Chk2 inhibitor.Fórmula:C19H20BrN5O2SCor e Forma:SolidPeso molecular:462.36TCS 2312
CAS:checkpoint kinase 1 (chk1) inhibitorFórmula:C25H24N4O2Pureza:98%Cor e Forma:SolidPeso molecular:412.48M443
CAS:M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.Fórmula:C31H30F3N7O2Pureza:98.95%Cor e Forma:White SolidPeso molecular:589.61AZD7762 HCl
CAS:AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.Fórmula:C17H20ClFN4O2SPureza:98%Cor e Forma:SolidPeso molecular:398.88PV-1019
CAS:PV-1019 (NSC 744039), a potent Chk2 inhibitor, has an IC50 of 24 nM and blocks Chk2 autophosphorylation and IR-induced apoptosis.Fórmula:C18H17N7O3Cor e Forma:SolidPeso molecular:379.37NR2F6 modulator-1
CAS:NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.Fórmula:C23H17NO5SPureza:98.31%Cor e Forma:White SolidPeso molecular:419.45Ref: TM-T62204
1mg87,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg268,00€25mg502,00€50mg703,00€100mg982,00€CHK1-IN-3
CAS:CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Fórmula:C20H23N9OPureza:98.78%Cor e Forma:SolidPeso molecular:405.46Ref: TM-T10791
1mg168,00€2mg231,00€5mg371,00€1mL*10mM (DMSO)423,00€10mg558,00€25mg868,00€50mg1.153,00€100mg1.575,00€200mg2.125,00€PD-321852
CAS:PD-321852, a Chk1 inhibitor, boosts gemcitabine's effect in pancreatic cancer cells, varying from minimal in Panc1 to >30-fold in MiaPaCa2.Fórmula:C24H19Cl2N3O3Cor e Forma:SolidPeso molecular:468.33CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Fórmula:C23H27FN4O4Pureza:98%Cor e Forma:SolidPeso molecular:442.48CCT241533 hydrochloride
CAS:CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Fórmula:C23H28ClFN4O4Pureza:99.90%Cor e Forma:SolidPeso molecular:478.95Ref: TM-T10718L
1mg70,00€2mg90,00€5mg150,00€1mL*10mM (DMSO)158,00€10mg227,00€25mg487,00€50mg807,00€100mg1.198,00€500mg2.412,00€MU-380
CAS:MU-380 is an effective and selective inhibitor of CHK1.Fórmula:C15H15BrF3N7Cor e Forma:SolidPeso molecular:430.23VER-00158411
CAS:VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).Fórmula:C31H34N6O3Pureza:98%Cor e Forma:SolidPeso molecular:538.64
