Chk
Os inibidores da quinase de checkpoint (Chk) têm como alvo as quinasas Chk1 e Chk2, que são reguladoras-chave da resposta aos danos no DNA e dos pontos de verificação do ciclo celular. Essas quinasas interrompem a progressão do ciclo celular em resposta a danos no DNA, permitindo tempo para reparo. Inibir as quinasas Chk pode impedir a parada do ciclo celular, forçando as células danificadas a prosseguir no ciclo e, eventualmente, sofrer apoptose. Os inibidores de Chk são particularmente valiosos na pesquisa do câncer, onde podem sensibilizar as células tumorais a agentes que causam danos ao DNA. Na CymitQuimica, oferecemos uma variedade de inibidores de Chk de alta qualidade para apoiar sua pesquisa em resposta a danos no DNA, regulação do ciclo celular e oncologia.
Foram encontrados 46 produtos de "Chk"
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GDC-0575
CAS:<p>GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).</p>Fórmula:C16H20BrN5OPureza:≥95%Cor e Forma:SolidPeso molecular:378.27GDC0575 monohydrochloride
CAS:GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Fórmula:C16H21BrClN5OPureza:97.85%Cor e Forma:SolidPeso molecular:414.73AZD7762 HCl
CAS:AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.Fórmula:C17H20ClFN4O2SPureza:98%Cor e Forma:SolidPeso molecular:398.88SC-203885
CAS:<p>SC-203885 is a checkpoint kinase 2 inhibitor.</p>Fórmula:C15H13N5O2Pureza:98%Cor e Forma:SolidPeso molecular:295.3VRX-0466617
CAS:VRX-0466617 is a novel selective Chk2 inhibitor.Fórmula:C19H20BrN5O2SCor e Forma:SolidPeso molecular:462.36TCS 2312
CAS:checkpoint kinase 1 (chk1) inhibitorFórmula:C25H24N4O2Pureza:98%Cor e Forma:SolidPeso molecular:412.48PV-1115
CAS:PV-1115 is an effective and highly selective inhibitor of the Chk2.Fórmula:C20H19N7O3Pureza:98%Cor e Forma:SolidPeso molecular:405.41NSC 109555 ditosylate
CAS:Chk2 inhibitor,ATP-competitiveFórmula:C26H32N10O4SPureza:98%Cor e Forma:SolidPeso molecular:580.66PV-1019
CAS:PV-1019 (NSC 744039), a potent Chk2 inhibitor, has an IC50 of 24 nM and blocks Chk2 autophosphorylation and IR-induced apoptosis.Fórmula:C18H17N7O3Cor e Forma:SolidPeso molecular:379.37CCT245737(S)
CAS:CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor.Fórmula:C16H16F3N7OCor e Forma:SolidPeso molecular:379.34M443
CAS:M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.Fórmula:C31H30F3N7O2Pureza:98.95%Cor e Forma:SolidPeso molecular:589.61CHK1-IN-3
CAS:CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Fórmula:C20H23N9OPureza:98.78%Cor e Forma:SolidPeso molecular:405.46NR2F6 modulator-1
CAS:NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.Fórmula:C23H17NO5SPureza:98.31%Cor e Forma:SolidPeso molecular:419.45MU-380
CAS:MU-380 is an effective and selective inhibitor of CHK1.Fórmula:C15H15BrF3N7Cor e Forma:SolidPeso molecular:430.23CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Fórmula:C23H27FN4O4Pureza:98%Cor e Forma:SolidPeso molecular:442.48VER-00158411
CAS:VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).Fórmula:C31H34N6O3Pureza:98%Cor e Forma:SolidPeso molecular:538.64PD-321852
CAS:PD-321852, a Chk1 inhibitor, boosts gemcitabine's effect in pancreatic cancer cells, varying from minimal in Panc1 to >30-fold in MiaPaCa2.Fórmula:C24H19Cl2N3O3Cor e Forma:SolidPeso molecular:468.33CCT241533 hydrochloride
CAS:CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Fórmula:C23H28ClFN4O4Pureza:97.13%Cor e Forma:SolidPeso molecular:478.95CHK1-IN-2
CAS:CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).Fórmula:C20H22N4OSPureza:98%Cor e Forma:SolidPeso molecular:366.48CHK-IN-1
CAS:CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.Fórmula:C18H19ClFN5OSPureza:>99.99%Cor e Forma:SolidPeso molecular:407.89
