Cinesina
Os inibidores de cinesina têm como alvo as proteínas motoras cinesinas, que são responsáveis pelo transporte de carga celular ao longo dos microtúbulos e desempenham um papel crucial na divisão celular, particularmente durante a mitose. As cinesinas estão envolvidas no movimento de cromossomos e outras organelas durante a divisão celular. Inibir as cinesinas pode interromper esses processos, levando à parada do ciclo celular e possível morte celular, tornando esses inibidores valiosos na pesquisa do câncer. Na CymitQuimica, oferecemos uma gama diversificada de inibidores de cinesina de alta qualidade para apoiar sua pesquisa em biologia celular, mitose e terapia do câncer.
Foram encontrados 87 produtos de "Cinesina"
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Paprotrain
CAS:Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.Fórmula:C16H11N3Pureza:99.91%Cor e Forma:SolidPeso molecular:245.28Ref: TM-T12359
5mg48,00€10mg62,00€25mg97,00€50mg169,00€100mg250,00€200mg373,00€500mg612,00€1mL*10mM (DMSO)52,00€BOS-172722
CAS:BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).Fórmula:C24H30N8OPureza:99.37%Cor e Forma:SolidPeso molecular:446.55Mps1-IN-3
CAS:Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).Fórmula:C26H31N7O4SPureza:99.25%Cor e Forma:SolidPeso molecular:537.63Ref: TM-T16130
2mg37,00€5mg57,00€10mg92,00€25mg158,00€50mg269,00€100mg405,00€200mg568,00€1mL*10mM (DMSO)67,00€KIF18A-IN-2
CAS:KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.Fórmula:C25H34N4O5S2Pureza:99.64%Cor e Forma:SolidPeso molecular:534.69Ref: TM-T60026
1mg74,00€5mg172,00€10mg245,00€25mg383,00€50mg507,00€100mg672,00€200mg910,00€1mL*10mM (DMSO)202,00€KIF18A-IN-11
KIF18A-IN-11 (Compound 13) is an effective inhibitor of KIF18A, exhibiting IC50 values below 100 nM in OVCAR3 and MDA-MB-157 cells. It is applicable for cancer research.Fórmula:C28H38F2N6O4SPeso molecular:592.26433Anticancer agent 190
Anticancer agent 190 (compound 3e) is an inhibitor targeting KSP (Kinesin) and PI3Kδ, demonstrating efficacy against breast cancer.Fórmula:C21H13ClF2N2OSPeso molecular:414.04052KIF18A-IN-6
CAS:KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor that suppresses KIF18A microtubule-dependent ATPase activity with an IC50 of 0.016 μM.Fórmula:C28H37N3O5S2Pureza:97.59%Cor e Forma:SolidPeso molecular:559.74Ref: TM-T73049
1mg69,00€5mg147,00€10mg231,00€25mg394,00€50mg522,00€100mg728,00€1mL*10mM (DMSO)177,00€Solidagonic acid
CAS:Solidagonic acid inhibits HSET, prevents fission yeast cell death, and hinders L. sativa and L. multiflorum seedling growth.Fórmula:C22H34O4Cor e Forma:SolidPeso molecular:362.5TTK/PLK1-IN-1
CAS:TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.Fórmula:C30H33N7O2Pureza:97.39%Cor e Forma:SolidPeso molecular:523.63(S)-AM-9022
CAS:(S)-AM-9022 is the S-enantiomer of AM-9022, which is a potent and selective KIF18A inhibitor with oral bioavailability, applicable in cancer research.Fórmula:C27H36F2N6O4SCor e Forma:SolidPeso molecular:578.67CENP-E-IN-2
CENP-E-IN-2 (compound 3) is a photocontrollable CENP-E inhibitor exhibiting a pIC50 of 6.82 in the absence of light and a pIC50 of 5.85 under 365 nm light exposure. This compound also demonstrates antitumor activity.Filanesib TFA
CAS:<p>Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.</p>Fórmula:C22H23F5N4O4SPureza:98%Cor e Forma:SolidPeso molecular:534.5(S)-Monastrol
CAS:Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Fórmula:C14H16N2O3SPureza:98%Cor e Forma:SolidPeso molecular:292.35Eg5-IN-3
Eg5-IN-3 (5) is an Eg5 inhibitor targeting a novel allosteric site (α4/α6/L11). It disrupts tubulin assembly, leading to abnormal and irregular formations, which subsequently causes typical mitotic arrest, akin to the effects of Monastrol.Fórmula:C23H23N7O2Peso molecular:429.1913211H-Benzo[a]carbazole
CAS:11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.Fórmula:C16H11NPureza:99.14%Cor e Forma:SolidPeso molecular:217.27Mps1-IN-6
Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].Fórmula:C35H39N9O3Cor e Forma:SolidPeso molecular:633.74KIF18A-IN-12
CAS:KIF18A-IN-12 (compound 9), a potent KIF18A inhibitor, exhibits an IC 50 of 45.54 nM and is utilized in cancer research.Fórmula:C30H39F2N5O4SCor e Forma:SolidPeso molecular:603.72KIF2C-IN-1
KIF2C-IN-1 (Compound 7S9) is a selective and potent small molecule inhibitor of KIF2C. It stabilizes the interaction between KIF2C and microtubule proteins, preventing the depolymerization of polyglutamylated microtubules. KIF2C-IN-1 enhances the cytotoxicity of Paclitaxel in Paclitaxel-resistant triple-negative breast cancer (TNBC) cells and, when combined with Paclitaxel, significantly reduces tumor growth in mouse models.Fórmula:C36H39ClN4O9SCor e Forma:SolidPeso molecular:738.21263Mitotic kinesin-IN-3 hydrochloride
Mitotic kinesin-IN-3 (Page 135, fourteenth) hydrochloride is an inhibitor of the mitotic motor protein (Mitotickinesin). It interferes with cell proliferation by inhibiting mitosis. This compound can be utilized in research relating to cancer, cardiac hypertrophy, immune and inflammatory diseases, as well as fungal infections.Cor e Forma:Odour SolidEg5-IN-1
Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.Fórmula:C23H16ClFN4OPureza:99.65%Cor e Forma:SolidPeso molecular:418.85
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