Ferroptose
A ferroptose é uma forma de morte celular regulada caracterizada pelo acúmulo de peróxidos lipídicos e estresse oxidativo dependente de ferro. Ao contrário da apoptose, a ferroptose não é impulsionada por caspases, mas pelo fracasso das defesas antioxidantes celulares, levando à morte celular. Inibidores e indutores de ferroptose são críticos para estudar essa via única de morte celular, que está implicada em várias doenças, incluindo câncer, neurodegeneração e lesão por isquemia-reperfusão. Na CymitQuimica, oferecemos uma ampla gama de moduladores de ferroptose de alta qualidade para apoiar sua pesquisa em mecanismos de morte celular, estresse oxidativo e patologia de doenças.
Foram encontrados 229 produtos para "Ferroptose".
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Deferitazole
CAS:Deferitazole (FBS 0701) is a novel and orally active, selective and high affinity iron chelator.Fórmula:C18H25NO7SPureza:99.48%Cor e Forma:SolidPeso molecular:399.46BCP-T.A
CAS:BCP-T.A is an iron death inducer that acts by binding to GPX4.Fórmula:C23H19Cl2N3OSPureza:99.94%Cor e Forma:White SolidPeso molecular:456.39Erastin2
CAS:Erastin2 is an iron death inducer that induces cell death by binding to the lipophilic free radical trapping antioxidant ferrostatin-1 or the iron chelator DFO.Fórmula:C36H35ClN4O4Pureza:99.87%Cor e Forma:SolidPeso molecular:623.14Ref: TM-T35994
1mg70,00€5mg152,00€1mL*10mM (DMSO)202,00€10mg236,00€25mg356,00€50mg465,00€100mg602,00€FA16
FA16 is a selective, metabolically stable ferroptosis inducer with an IC50 value of 1.26 μM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16Fórmula:C22H27F3N4O2SPureza:99.44%Cor e Forma:SolidPeso molecular:468.54HBED
CAS:HBED (CHELII) is an iron chelator and can be used in research on the treatment of chronic iron overload and acute iron poisoning.Fórmula:C20H24N2O6Pureza:97.35% - 98.58%Cor e Forma:SolidPeso molecular:388.41Cerivastatin
CAS:Cerivastatin is an HMG-CoA reductase inhibitor with anticancer and lipid-lowering effects and can be used to study primary hyperlipidemia.Fórmula:C26H34FNO5Pureza:97.80% - 99.56%Cor e Forma:SolidPeso molecular:459.55Ferroptosis inducer-5
CAS:Ferroptosisinducer-5 (compound 20a) is an inducer of ferroptosis.Fórmula:C15H14N2O4SCor e Forma:SolidPeso molecular:318.35CP-24879 hydrochloride
CAS:CP-24879 HCl, a Δ5D/Δ6D dual-inhibitor, reduces liver lipid buildup and inflammation.Fórmula:C11H18ClNOPureza:98.08%Cor e Forma:SolidPeso molecular:215.72FerroLOXIN-1
CAS:FerroLOXIN-1 is a potent inhibitor of 15LOX-2, selectively blocking the production of ferroptosis-promoting HOO-ETE-PE and preventing RSL3-induced ferroptosis (ferroptosis). It interacts closely and specifically with 15LOX-2, particularly engaging with Y154, N155, and W158.Fórmula:C23H16F5N3Cor e Forma:SolidPeso molecular:429.39Ogremorphin
CAS:Ogremorphin (GPR68-IN-1) is a potent inhibitor of GPR68, exhibiting an EC50 of 170 nM.it is utilized in the study of autoimmune chronic inflammatory diseases [1Fórmula:C21H17N3OSPureza:99.65% - 99.65%Cor e Forma:SolidPeso molecular:359.44viFSP1
CAS:viFSP1, a species-independent FSP1 inhibitor, effectively induces ferroptosis in FSP1-dependent cells by targeting the highly conserved NAD(P)H binding pocket of FSP1, directly inhibiting its activity. This action results in lipid peroxidation and exhibits anticancer activity [1].Fórmula:C16H17N3O3SCor e Forma:SolidPeso molecular:331.39Docebenone
CAS:Docebenone is a selective and orally active inhibitor of 5-LO.Fórmula:C21H26O3Cor e Forma:SolidPeso molecular:326.43Ferroptosis-IN-6
CAS:Ferroptosis-IN-6 is an efficient ferroptosis inhibitor, protecting cells from cell death induced by ferroptosis inducers, and inhibiting STY-BODIPY oxidation.Fórmula:C15H17NOPureza:99.84%Cor e Forma:Blue SolidPeso molecular:227.3Ref: TM-T86417
1mg54,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg177,00€25mg356,00€50mg573,00€100mg888,00€CAR-2
CAS:CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LD). It exhibits phototoxicity against breast cancer cells with an IC50 of 0.01-0.02 μM and demonstrates antitumor efficacy in a 4T1 xenograft mouse model.Fórmula:C27H23BF2I2N4O2Cor e Forma:SolidPeso molecular:738.114Microtubule inhibitor 2
Microtubule inhibitor 2: potent, selective, oral, induces ferroptosis, strong antitumor effect.Fórmula:C20H23NO7Cor e Forma:SolidPeso molecular:389.4GPX4-IN-3
CAS:GPX4-IN-3 is a selective GPX4 inhibitor inducing ferroptosis (71.7% inhibition at 1 μM).Fórmula:C29H24ClN3O3SPureza:99.91%Cor e Forma:White SolidPeso molecular:530.04Cetzole
CAS:Cetzole (Compound 1) acts as an inducer of ferroptosis (iron-dependent cell death) through the accumulation of ROS, leading to cell death. The compound exhibits varying half-maximal cytotoxic concentrations (CC50) against several cell lines: 2.56 μM in NCI-H522, 10.31 μM in NCI-H522 GFP-SCL7A11 #8, 2.71 μM in NCI-H522 RV-GFP, 3.07 μM in HT-1080, 14.9 μM in NARF2, and 6.28 μM in MDA-MB-231. This highlights Cetzole's potential for research in cancer therapeutics.Fórmula:C11H11NOSCor e Forma:SolidPeso molecular:205.28DL-Buthionine-(S,R)-sulfoximine hydrochloride
DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent and specific glutamylcysteine synthetase biosynthesis inhibitorFórmula:C8H19ClN2O3SCor e Forma:SolidPeso molecular:258.77Ferroptosis-IN-18
CAS:Ferroptosis-IN-18 (51) is a phenothiazine derivative known for its potent anti-ferroptotic and antioxidant properties. It is useful for research related to intracerebral hemorrhage (ICH).Fórmula:C25H27N3SCor e Forma:SolidPeso molecular:401.567Nur77 agonist-1
CAS:Nur77 agonist-1 (Compound 8f) is an orally active Nur77 agonist. It induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, while decreasing GPX4 protein expression. Nur77 agonist-1 binds with affinity to the ligand binding domain of Nur77, with a KD of 13.80 μM. It demonstrates significant antiproliferative activity against various breast cancer cells (IC50: 2.15-3.26 μM) and exhibits low cytotoxicity towards normal cells. This compound is useful for breast cancer research.Fórmula:C24H18ClN5O2Cor e Forma:SolidPeso molecular:443.885
