Ferroptose
A ferroptose é uma forma de morte celular regulada caracterizada pelo acúmulo de peróxidos lipídicos e estresse oxidativo dependente de ferro. Ao contrário da apoptose, a ferroptose não é impulsionada por caspases, mas pelo fracasso das defesas antioxidantes celulares, levando à morte celular. Inibidores e indutores de ferroptose são críticos para estudar essa via única de morte celular, que está implicada em várias doenças, incluindo câncer, neurodegeneração e lesão por isquemia-reperfusão. Na CymitQuimica, oferecemos uma ampla gama de moduladores de ferroptose de alta qualidade para apoiar sua pesquisa em mecanismos de morte celular, estresse oxidativo e patologia de doenças.
Foram encontrados 229 produtos para "Ferroptose".
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UAMC-3203
CAS:UAMC-3203 is a potent and selective Ferroptosis inhibitor (IC50: 12 nM).Fórmula:C25H37N5O2SPureza:97.05% - 99.72%Cor e Forma:White SolidPeso molecular:471.66FINO2
CAS:FINO2, a strong ferroptosis trigger, blocks GPX4, oxidizes Fe2+, stable in different pH, causes lipid peroxidation.Fórmula:C15H28O3Pureza:97.27%Cor e Forma:SolidPeso molecular:256.38Anti-Mouse IL-1b Antibody (B122)
Anti-Mouse IL-1b Antibody (B122) is a mab inhibitor, blocks IL-1β signaling, reducing monocyte infiltration and alleviating T cell exhaustion.Cor e Forma:Transparent LiquidFrataxin-IN-1
CAS:Frataxin-IN-1 inhibits the mitochondrial protein Frataxin with IC50 45 μM and is used in Friedreich’s ataxia research linked to mitochondrial defects.Fórmula:C20H23NO6Pureza:99.34%Cor e Forma:SolidPeso molecular:373.4Microtubule inhibitor 8
CAS:Microtubule Inhibitor 8 (MP-HJ-1b) serves as a potent disruptor of microtubule function, inducing cell death via ferroptosis and demonstrating anti-tumor effects [1] [2].Fórmula:C21H15N3O2SCor e Forma:SolidPeso molecular:373.43JKE-1716
CAS:JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 . 1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)Fórmula:C20H20Cl2N4O4Cor e Forma:SolidPeso molecular:451.3Pioglitazone-D4
CAS:Pioglitazone D4 is a deuterium labeled Pioglitazone. Pioglitazone is a agonist of PPARγ .Fórmula:C19H20N2O3SPureza:98%Cor e Forma:SolidPeso molecular:360.46Ferroptosis-IN-17
Ferroptosis-IN-17 (Compound 18) is an inhibitor of ferroptosis with an EC50 value of 0.57 μM. It effectively reduces the accumulation of intracellular ferrous ions and lipid peroxidation while restoring levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4). In rat plasma, Ferroptosis-IN-17 demonstrates good solubility and notable metabolic stability. This compound holds potential for research in tumor suppression, neurodegenerative diseases, and cardiovascular disorders.Fórmula:C21H26N4O5SCor e Forma:SolidPeso molecular:446.52Anticancer agent 147
CAS:Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROSFórmula:C32H40BrN3O2Pureza:98%Cor e Forma:SolidPeso molecular:578.58NPD4928
CAS:NPD4928 boosts cancer cell sensitivity to GPX4 inhibitors, hinting at therapeutic potential through ferroptosis.Fórmula:C29H32N2O6Cor e Forma:SolidPeso molecular:504.57Roxadustat-D5
CAS:Roxadustat-d5 is a reference standard for GC/LC-MS quantification of a HIF-PH inhibitor, distinct from other dioxygenases.Fórmula:C19H11D5N2O5Cor e Forma:SolidPeso molecular:357.37Ferroptosis-IN-4
CAS:Ferroptosis-IN-4 (compound 6k), an inhibitor of ferroptosis, exhibits an EC50 of 20 μM and lacks significant cytotoxicity. It demonstrates a protective role in glycerol-induced RM-AKI mice by alleviating kidney dysfunction [1].Fórmula:C17H24ClN3O2Peso molecular:337.84CN128 hydrochloride
CAS:CN128 hydrochloride is an oral, selective hydroxypyridone iron chelator for β-thalassemia research.Fórmula:C15H18ClNO3Cor e Forma:SolidPeso molecular:295.76Ferroptosis inducer-1
CAS:Ferroptosis inducer-1 is a Ferroptosis inducer with antitumor potential .Fórmula:C25H21ClN2O5Cor e Forma:SolidPeso molecular:464.9Tubulin inhibitor 30
CAS:Tubulin Inhibitor 30, exhibiting an IC50 value of 0.52 μM, functions as an inhibitor of tubulin assembly. Additionally, it can induce ferroptosis.Fórmula:C22H19N3O5Cor e Forma:SolidPeso molecular:405.4IM-93
CAS:IM-93 inhibits ferroptosis and NETosis with an IC< sub>50 of 0.45 μM for cell death inhibition [1].Fórmula:C21H28N4O2Cor e Forma:SolidPeso molecular:368.47CGP 65015
CAS:CGP 65015 is an oral iron chelator and can mobilize iron deposits.Fórmula:C14H15NO4Pureza:98%Cor e Forma:SolidPeso molecular:261.27YL-939
YL-939 is a potent inhibitor of ferroptosis, targeting the PHB2/ferritin/iron axis to impede this form of cell death.Fórmula:C25H26N6OCor e Forma:SolidPeso molecular:426.51W1131
CAS:W1131 is a potent STAT3 inhibitor and ferroptosis trigger, reducing cancer progression and 5-FU resistance.Fórmula:C23H19N5O4Cor e Forma:SolidPeso molecular:429.43Utreloxastat
CAS:Utreloxastat (PTC857) is a novel 15-lipoxygenase inhibitor that can be used to study amyotrophic lateral sclerosis .Fórmula:C18H28O2Pureza:99.81%Cor e Forma:Yellow SolidPeso molecular:276.41Ref: TM-T60507
1mg96,00€5mg205,00€1mL*10mM (DMSO)224,00€10mg295,00€25mg505,00€50mg745,00€100mg1.305,00€200mg1.755,00€
