CDK
Os inibidores das quinases dependentes de ciclinas (CDK) são compostos que bloqueiam a atividade das CDKs, um grupo de quinases de proteínas que regulam o ciclo celular, a transcrição e outros processos celulares. As CDKs são ativadas pela ligação às ciclinas, e sua atividade é crucial para a progressão das células através das diferentes fases do ciclo celular. Inibir as CDKs pode interromper a divisão celular, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas onde as CDKs frequentemente estão desreguladas. Os inibidores de CDK são amplamente utilizados na pesquisa do câncer e têm potencial terapêutico no tratamento de vários tipos de câncer. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de CDK de alta qualidade para apoiar sua pesquisa em controle do ciclo celular, câncer e desenvolvimento terapêutico.
Foram encontrados 535 produtos de "CDK"
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NVP-2
CAS:NVP-2 selectively inhibits CDK9 (IC50: 0.514 nM), prompts apoptosis, and affects other CDKs (IC50: 0.584-0.706 μM).Fórmula:C27H37ClN6O2Pureza:99.13%Cor e Forma:SolidPeso molecular:513.07Ref: TM-T16363
1mg55,00€2mg79,00€5mg119,00€10mg202,00€25mg439,00€50mg648,00€100mg924,00€1mL*10mM (DMSO)135,00€Trilaciclib hydrochloride
CAS:Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).Fórmula:C24H32Cl2N8OPureza:99.69% - 99.89%Cor e Forma:SolidPeso molecular:519.47Cyclin K degrader 1
Cyclin K degrader 1 is a Cyclin K degrader.Cyclin K degrader 1 is a degrader converted from AT-7519.Cyclin K degrader 1 has weak degrading activity against Cyclin K but does not result in a sustained decrease in degradation affinity.Cyclin K degrader 1 is a degrader converted from AT-7519.Fórmula:C23H17Cl2N5O2Pureza:99.76%Cor e Forma:SolidPeso molecular:466.32Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Fórmula:C23H26O7Pureza:99.13% - 99.92%Cor e Forma:SolidPeso molecular:414.45CDK4/6-IN-2
CAS:CDK4/6-IN-2 是一种CDK4和CDK6抑制剂，IC50分别为 2.7 和 16 nM。Fórmula:C27H32F2N8Pureza:99.47%Cor e Forma:SolidPeso molecular:506.59(R)-CR8
CAS:<p>(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.</p>Fórmula:C24H29N7OPureza:98.41%Cor e Forma:SolidPeso molecular:431.53Ca2+ channel agonist 1
CAS:Ca2+ channel agonist 1 activates N-type Ca2+ channels and inhibits Cdk2 (EC50: 14.23 μM/3.34 μM) for motor nerve issues.Fórmula:C19H26N6OPureza:97.71%Cor e Forma:SolidPeso molecular:354.45Ref: TM-T10659
1mg97,00€5mg188,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.130,00€1mL*10mM (DMSO)217,00€hSMG-1 inhibitor 11j
CAS:<p>hSMG-1 inhibitor 11j: pyrimidine, IC50=0.11 nM, >455x selective vs. mTOR/PI3Kα/γ/CDK1/CDK2; cancer research use.</p>Fórmula:C27H28ClN7O3SPureza:99.22% - 99.65%Cor e Forma:SolidPeso molecular:566.07(±)-Enitociclib
CAS:(±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152. BAY-1251152 is highly selective inhibitor of PTEF/CDK9.Fórmula:C19H18F2N4O2SPureza:99.29%Cor e Forma:SolidPeso molecular:404.43Ref: TM-T13467
1mg37,00€5mg88,00€10mg120,00€25mg216,00€50mg354,00€100mg567,00€200mg805,00€1mL*10mM (DMSO)87,00€XPW1
CAS:XPW1 is a CDK9 inhibitor with antitumor activity, inhibits DNA repair procedures, and can be used for the research of clear cell renal cell carcinoma.Fórmula:C36H39ClFN7O2Pureza:98.08%Cor e Forma:SoildPeso molecular:656.19CDKI-73
CAS:CDKI-73: strong CDK9 blocker, Ki 4 nM, kills CLL cells selectively, aids cisplatin.Fórmula:C15H15FN6O2S2Pureza:98.11%Cor e Forma:SolidPeso molecular:394.45Ref: TM-T14919
1mg143,00€2mg188,00€5mg293,00€10mg420,00€25mg695,00€50mg938,00€100mg1.320,00€1mL*10mM (DMSO)306,00€Samuraciclib hydrochloride
CAS:Samuraciclib HCl is an oral CDK7 inhibitor (IC50: 41 nM), 45-230x selective over CDK1/2/5/9, inhibiting breast cancer growth (GI50: 0.2-0.3 μM).Fórmula:C22H31ClN6OPureza:98.99% - 99.8%Cor e Forma:SolidPeso molecular:430.97Ref: TM-T10898
1mg108,00€2mg147,00€5mg222,00€10mg335,00€25mg595,00€50mg847,00€100mg1.153,00€1mL*10mM (DMSO)245,00€GSK-3 inhibitor 4
CAS:Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.Fórmula:C22H15F2N5OPureza:99.82%Cor e Forma:SoildPeso molecular:403.38Ref: TM-T77341
1mg315,00€5mg873,00€10mg1.080,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg3.537,00€Ribociclib succinate
CAS:Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Fórmula:C27H36N8O5Pureza:99.9%Cor e Forma:SolidPeso molecular:552.63Ref: TM-T15732
2mg34,00€5mg49,00€10mg70,00€25mg92,00€50mg109,00€100mg165,00€200mg258,00€500mg459,00€1mL*10mM (DMSO)60,00€CDK2-IN-4
CAS:CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A.Fórmula:C23H18N6O2SPureza:97.24% - 99.10%Cor e Forma:SolidPeso molecular:442.49Ref: TM-T14916
1mg82,00€5mg192,00€10mg304,00€25mg522,00€50mg713,00€100mg1.018,00€1mL*10mM (DMSO)212,00€Amantadine hydrochloride
CAS:Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.Fórmula:C10H18ClNPureza:99.98%Cor e Forma:Solid CrystallinePeso molecular:187.71Cirtuvivint
CAS:Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor that can be used to study arthritis.Fórmula:C24H25N7OPureza:99.95% - 99.96%Cor e Forma:SolidPeso molecular:427.5BRD6989
CAS:BRD6989, a cortistatin A analog, inhibits CDK8/19, enhances IL-10, and binds CDK8 with a 200 nM IC50.Fórmula:C16H16N4Pureza:99.43%Cor e Forma:SolidPeso molecular:264.33Ref: TM-T14778
1mg34,00€5mg66,00€10mg92,00€25mg177,00€50mg268,00€100mg398,00€200mg575,00€1mL*10mM (DMSO)73,00€Lerociclib dihydrochloride
CAS:Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3 and CDK4/Fórmula:C26H36Cl2N8OPureza:97.4%Cor e Forma:SolidPeso molecular:547.52NU6140
CAS:NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).Fórmula:C23H30N6O2Pureza:98.33%Cor e Forma:SolidPeso molecular:422.52Ref: TM-T16359
2mg39,00€5mg60,00€10mg92,00€25mg177,00€50mg285,00€100mg414,00€200mg580,00€1mL*10mM (DMSO)67,00€
