CDK
Os inibidores das quinases dependentes de ciclinas (CDK) são compostos que bloqueiam a atividade das CDKs, um grupo de quinases de proteínas que regulam o ciclo celular, a transcrição e outros processos celulares. As CDKs são ativadas pela ligação às ciclinas, e sua atividade é crucial para a progressão das células através das diferentes fases do ciclo celular. Inibir as CDKs pode interromper a divisão celular, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas onde as CDKs frequentemente estão desreguladas. Os inibidores de CDK são amplamente utilizados na pesquisa do câncer e têm potencial terapêutico no tratamento de vários tipos de câncer. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de CDK de alta qualidade para apoiar sua pesquisa em controle do ciclo celular, câncer e desenvolvimento terapêutico.
Foram encontrados 541 produtos de "CDK"
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SR-4835
CAS:SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (Fórmula:C21H20Cl2N10OPureza:98.09% - >99.99%Cor e Forma:SolidPeso molecular:499.36LY3405105
CAS:LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-Fórmula:C26H39N7O3Pureza:99.66%Cor e Forma:SolidPeso molecular:497.63PHA-767491 hydrochloride
CAS:PHA-767491 (CAY-10572) is a potent Cdc7/CDK9 inhibitor (IC50: 10/34 nM), selective against GSK3-β, CDK1/2, CDK5, MK2, CHK2, PLK1.Fórmula:C12H12ClN3OPureza:99.56% - 99.92%Cor e Forma:SolidPeso molecular:249.69Fadraciclib
CAS:Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).Fórmula:C21H31N7OPureza:99.75%Cor e Forma:SolidPeso molecular:397.52Ref: TM-TQ0053
1mg42,00€2mg55,00€5mg88,00€10mg145,00€25mg260,00€50mg414,00€100mg583,00€1mL*10mM (DMSO)87,00€PF-562271
CAS:PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).Fórmula:C21H20F3N7O3SPureza:97.17% - >99.99%Cor e Forma:SolidPeso molecular:507.49MSC2530818
CAS:MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).Fórmula:C18H17ClN4OPureza:98.93%Cor e Forma:SolidPeso molecular:340.81Ref: TM-TQ0266
1mg63,00€5mg137,00€10mg215,00€25mg462,00€50mg692,00€100mg964,00€1mL*10mM (DMSO)150,00€Amantadine
CAS:Amantadine (1-Aminoadamantane), an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release and blocks dopamine reuptake.
Fórmula:C10H17NPureza:99.73% - 99.94%Cor e Forma:Hexakistetrahedral Crystals By Sublimation SolidPeso molecular:151.25TC11
CAS:TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosisFórmula:C20H22N2O2Pureza:97.86%Cor e Forma:SolidPeso molecular:322.4AT7519 Hydrochloride
CAS:AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.Fórmula:C16H18Cl3N5O2Pureza:99.66% - 99.9%Cor e Forma:SolidPeso molecular:418.71Desmethylglycitein
CAS:Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which hasFórmula:C15H10O5Pureza:97.93%Cor e Forma:SolidPeso molecular:270.24JSH-150
CAS:JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).Fórmula:C24H33ClN6O2SPureza:99.96% - 99.96%Cor e Forma:SolidPeso molecular:505.08Dalpiciclib
CAS:Dalpiciclib (SHR-6390) selectively inhibits CDK4/6 (IC50: 12.4/9.9 nM), is orally available, and impedes esophageal cancer growth.
Fórmula:C25H30N6O2Pureza:99.69%Cor e Forma:SolidPeso molecular:446.54NG 52
CAS:NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.Fórmula:C16H19ClN6OPureza:98% - 99.34%Cor e Forma:SolidPeso molecular:346.81SCH900776 (S-isomer)
CAS:SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Fórmula:C15H18BrN7Pureza:99.88%Cor e Forma:SolidPeso molecular:376.25Ref: TM-T3700
1mg49,00€2mg70,00€5mg96,00€10mg155,00€25mg264,00€50mg424,00€100mg627,00€1mL*10mM (DMSO)114,00€BUR1
CAS:BUR1 is a Saccharomyces cerevisiae cyclin-dependent kinase (CDK) and is homologous to mammalian Cdk9, which functions in transcriptional elongation.Fórmula:C16H17N5Pureza:90%Cor e Forma:SolidPeso molecular:279.34CC-671
CAS:CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.Fórmula:C28H28N6O4Pureza:98.66% - 98.8%Cor e Forma:SolidPeso molecular:512.56Ref: TM-T4482
1mg50,00€5mg105,00€10mg170,00€25mg340,00€50mg512,00€100mg733,00€500mg1.513,00€1mL*10mM (DMSO)120,00€HQ461
CAS:HQ461, a molecular glue, boosts CDK12-DDB1 binding, lowers cyclin K, impedes CDK12 phosphorylation, hinders DNA repair genes, and induces cell death.Fórmula:C15H15N5OS2Pureza:98.11%Cor e Forma:SolidPeso molecular:345.44Ref: TM-T9849
1mg46,00€2mg59,00€5mg87,00€10mg153,00€25mg338,00€50mg567,00€100mg810,00€500mg1.644,00€1mL*10mM (DMSO)96,00€THZ1 Hydrochloride
THZ1 Hydrochloride: selective covalent CDK7 inhibitor, IC50 of 3.2 nM; affects CDK12/13 & lowers MYC expression.Fórmula:C31H29Cl2N7O2Cor e Forma:SolidPeso molecular:602.51Purvalanol A
CAS:Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.Fórmula:C19H25ClN6OPureza:98.13% - 99.68%Cor e Forma:PowderPeso molecular:388.89(E/Z)-Zotiraciclib citrate
(E/Z)-Zotiraciclib ((E/Z)-TG02) citrate is a potent inhibitor of CDK2, JAK2 and FLT3 and can be used in cancer research.Fórmula:C29H32N4O8Cor e Forma:SolidPeso molecular:564.59
