CDK
Os inibidores das quinases dependentes de ciclinas (CDK) são compostos que bloqueiam a atividade das CDKs, um grupo de quinases de proteínas que regulam o ciclo celular, a transcrição e outros processos celulares. As CDKs são ativadas pela ligação às ciclinas, e sua atividade é crucial para a progressão das células através das diferentes fases do ciclo celular. Inibir as CDKs pode interromper a divisão celular, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas onde as CDKs frequentemente estão desreguladas. Os inibidores de CDK são amplamente utilizados na pesquisa do câncer e têm potencial terapêutico no tratamento de vários tipos de câncer. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de CDK de alta qualidade para apoiar sua pesquisa em controle do ciclo celular, câncer e desenvolvimento terapêutico.
Foram encontrados 542 produtos de "CDK"
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Olomoucine II
CAS:Olomoucine II, a CDK inhibitor effective on Cdk1/2/4/7/9, also inhibits ERK2, ABCB1, and various virus replications, not effective on measles/influenza.Fórmula:C19H26N6O2Pureza:99.94%Cor e Forma:SolidPeso molecular:370.45Aloisine A
CAS:Aloisine A, a CDK/GSK-3 inhibitor with IC50: Cdk1/B-150nM, Cdk2/A-120nM, Cdk2/E-400nM, Cdk5/25-200nM, Cdk5/35-160nM, GSK-3α-500nM, GSK-3β-650nM, JNK-3-10μM.Fórmula:C16H17N3OPureza:98%Cor e Forma:SolidPeso molecular:267.33SLM6
CAS:SLM6, an inhibitor of cyclin-dependent kinase-9 (CDK9), exhibits potent anti-multiple myeloma activity.Fórmula:C12H17N7O4Cor e Forma:SolidPeso molecular:323.31CDK9/10/GSK3β-IN-1
CAS:CDK9/10/GSK3β-IN-1 is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3β, HsCDK9/CyclinT, HsCDK5/p25 and HsCDK2/CyclinA with IC50Fórmula:C29H24ClN3O4SCor e Forma:SolidPeso molecular:546.04TP1287
CAS:TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib.Fórmula:C21H21ClNO8PCor e Forma:SolidPeso molecular:481.82SMAPP1
CAS:SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells.Fórmula:C27H25N5O5S2Pureza:98%Cor e Forma:SolidPeso molecular:563.65SLK/STK10-IN-1
CAS:SLK/STK10-IN-1 is a selective and potent inhibitor of SLK and STK10 with potential antitumor activity.Fórmula:C17H13ClN2O3Pureza:99.34%Cor e Forma:SolidPeso molecular:328.75GW8510
CAS:GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.Fórmula:C21H15N5O3S2Pureza:99.32%Cor e Forma:SolidPeso molecular:449.51β-catenin-IN-3
CAS:β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces theFórmula:C19H20Br2N2OSCor e Forma:SolidPeso molecular:484.25Atuveciclib S-Enantiomer
CAS:Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.Fórmula:C18H18FN5O2SPureza:98%Cor e Forma:SolidPeso molecular:387.43Alsterpaullone, 2-Cyanoethyl
CAS:Alsterpaullone, 2-Cyanoethyl is a selective dual inhibitor of Cdk1/cyclin B and GSK-3β.Fórmula:C19H14N4O3Cor e Forma:SolidPeso molecular:346.34CDK-IN-10
CAS:CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.Fórmula:C18H18N4O2Pureza:97.07%Cor e Forma:SolidPeso molecular:322.36Zotiraciclib HCl
CAS:Zotiraciclib (TG02/SB1317) is a CDK/JAK2/FLT3 inhibitor potentially treating Myc-overexpressing cancers, including glioblastoma.Fórmula:C23H26Cl2N4OCor e Forma:SolidPeso molecular:445.388AG-012986
CAS:AG-012986: a selective CDK inhibitor with in vitro and in vivo antitumor effects; low IC50 in 14/18 cancer cell types; CAS# 486414-35-1.Fórmula:C22H23F2N5O2SCor e Forma:SolidPeso molecular:459.51Aloisine B
CAS:Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.Fórmula:C15H14ClN3Pureza:95.15%Cor e Forma:SolidPeso molecular:271.74CDK8-IN-4
CAS:CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).Fórmula:C20H18N4OCor e Forma:SolidPeso molecular:330.38CDK12-IN-3
CAS:CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.Fórmula:C23H28F2N8OPureza:99.85%Cor e Forma:SolidPeso molecular:470.52Ref: TM-T14990
1mg123,00€5mg295,00€10mg485,00€25mg1.018,00€50mg1.701,00€100mg2.250,00€1mL*10mM (DMSO)326,00€BAY-958
CAS:BAY-958 is a potent and selective inhibitor of PTEFb/CDK9.Fórmula:C17H16FN5O3SPureza:98%Cor e Forma:SolidPeso molecular:389.4Cdc7-IN-1
CAS:Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.Fórmula:C21H16ClN3O4Cor e Forma:SolidPeso molecular:409.82Cdc7-IN-4
CAS:Cdc7-IN-4 is a potent inhibitor of Cdc7 kinase.Fórmula:C22H24F3N5O4Pureza:98%Cor e Forma:SolidPeso molecular:479.45
