CDK
Os inibidores das quinases dependentes de ciclinas (CDK) são compostos que bloqueiam a atividade das CDKs, um grupo de quinases de proteínas que regulam o ciclo celular, a transcrição e outros processos celulares. As CDKs são ativadas pela ligação às ciclinas, e sua atividade é crucial para a progressão das células através das diferentes fases do ciclo celular. Inibir as CDKs pode interromper a divisão celular, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas onde as CDKs frequentemente estão desreguladas. Os inibidores de CDK são amplamente utilizados na pesquisa do câncer e têm potencial terapêutico no tratamento de vários tipos de câncer. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de CDK de alta qualidade para apoiar sua pesquisa em controle do ciclo celular, câncer e desenvolvimento terapêutico.
Foram encontrados 542 produtos de "CDK"
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Cdc7-IN-17
CAS:Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1].Fórmula:C13H15N5OSCor e Forma:SolidPeso molecular:289.36K 00546
CAS:K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).Fórmula:C15H13F2N7O2S2Pureza:99.12%Cor e Forma:SolidPeso molecular:425.44CDK8-IN-7
CAS:CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.Fórmula:C30H40N2Cor e Forma:SolidPeso molecular:428.65Cdc7-IN-15
CAS:Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].Fórmula:C12H14N4OSCor e Forma:SolidPeso molecular:262.33CDK9-IN-15
CAS:CDK9-IN-15: potent CDK9 inhibitor, blocks P-TEFb phosphorylation, inhibits transcription, reduces mRNA, induces tumor cell apoptosis.Fórmula:C16H11N3OSPureza:99.32%Cor e Forma:SolidPeso molecular:293.34Ref: TM-T60619
5mg46,00€10mg71,00€25mg126,00€50mg180,00€100mg260,00€200mg364,00€1mL*10mM (DMSO)44,00€CDK4/6-IN-12
CAS:CDK4/6-IN-12 inhibits CDK4/6 with IC50s of 592.3 nM & 3090 nM, useful in cancer research.Fórmula:C12H10N6Cor e Forma:SolidPeso molecular:238.25CDK8-IN-10
CAS:CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.Fórmula:C25H15ClF3N5O3Cor e Forma:SolidPeso molecular:525.87RP-106
CAS:RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.Fórmula:C17H19N3OPureza:98%Cor e Forma:SolidPeso molecular:281.35MFH290
CAS:MFH290 is a selective CDK12/13 inhibitor, covalently bonding with CDK12 Cys-1039, blocks Pol II CTD phosphorylation, and enhances olaparib's efficacy.Fórmula:C26H31N5O3S2Cor e Forma:SolidPeso molecular:525.69BS-181
CAS:BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.Fórmula:C22H32N6Pureza:98%Cor e Forma:SolidPeso molecular:380.53CDK5 inhibitor 20-223
CAS:CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.Fórmula:C19H19N3OCor e Forma:SolidPeso molecular:305.37(E/Z)-BIO-acetoxime
CAS:(E/Z)-BIO-acetoxime: potent GSK-3 α/β inhibitor; IC50: GSK-3α/β 10nM, CDK5/p25 2.4μM, CDK2/A 4.3μM, CDK1/B 63μM.Fórmula:C18H12BrN3O3Cor e Forma:SolidPeso molecular:398.21NSC 693868
CAS:CDKs and GSK-3 inhibitorFórmula:C9H7N5Pureza:98%Cor e Forma:SolidPeso molecular:185.19FN-1501
CAS:FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).
Fórmula:C22H25N9OPureza:97.4%Cor e Forma:SolidPeso molecular:431.49SNX2-1-108
CAS:SNX2-1-108 is a selective CDK8 and CDK19 inhibitor.Fórmula:C21H16N4Pureza:98%Cor e Forma:SolidPeso molecular:324.38Metralindole HCl
CAS:Metralindole is a reversible monoamine oxidase A (RIMA) inhibitor, it was investigated as a potential antidepressant.Fórmula:C15H18ClN3OPureza:98%Cor e Forma:SolidPeso molecular:291.78CGP60474
CAS:CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.Fórmula:C18H18ClN5OPureza:98.81%Cor e Forma:SolidPeso molecular:355.82Ref: TM-T14943
1mg34,00€2mg46,00€5mg71,00€10mg92,00€25mg177,00€50mg314,00€100mg518,00€1mL*10mM (DMSO)78,00€CDK4/6-IN-8
CAS:CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).Fórmula:C18H18N6O5Cor e Forma:SolidPeso molecular:398.37CLK1-IN-2
CLK1-IN-2: Metabolically stable, Clk1-selective inhibitor; IC50=1.7nM; useful in tumor, Duchenne MD, HIV-1, influenza research.Fórmula:C16H12Cl2N2O2SCor e Forma:SolidPeso molecular:367.25Metralindole
CAS:Metralindole is a reversible inhibitor of monoamine oxidase A (RIMA).Fórmula:C15H17N3OCor e Forma:SolidPeso molecular:255.32
