Microtúbulo associado
Os inibidores de proteínas associadas aos microtúbulos têm como alvo as proteínas que interagem com os microtúbulos, os componentes estruturais do citoesqueleto da célula que são essenciais para a divisão celular. Essas proteínas regulam a estabilidade e a dinâmica dos microtúbulos durante a mitose. A inibição de proteínas associadas aos microtúbulos pode interromper a função dos microtúbulos, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas de rápida divisão. Esses inibidores são amplamente utilizados na pesquisa do câncer e no desenvolvimento de medicamentos. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteínas associadas aos microtúbulos de alta qualidade para apoiar sua pesquisa em divisão celular, dinâmica do citoesqueleto e terapia do câncer.
Foram encontrados 262 produtos de "Microtúbulo associado"
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Bepranemab
CAS:<p>Bepranemab (UCB 0107) - humanized IgG4 monoclonal antibody targeting tau (235-250) for Alzheimer's research.</p>Pureza:99% (SDS-PAGE); 96.8% (SEC-HPLC) - 99% (SDS-PAGE); 96.8% (SEC-HPLC)Cor e Forma:LiquidTilavonemab
CAS:<p>Tilavonemab (ABBV-8E12), a humanized anti-tau antibody, halts tau uptake in neurons and may help with Alzheimer's research.</p>Pureza:95.2% (SDS-PAGE); 96.6% (SEC-HPLC) - 95.2% (SDS-PAGE); 96.6% (SEC-HPLC)Cor e Forma:LiquidZagotenemab
CAS:<p>Zagotenemab: humanized antibody targeting tau protein to study neurological disorders, including Alzheimer's.</p>Pureza:95% - > 95%Cor e Forma:LiquidPeso molecular:145.3 kDaDM4
CAS:<p>DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.</p>Fórmula:C38H54ClN3O10SPureza:98.15%Cor e Forma:SolidPeso molecular:780.37Verubulin hydrochloride
CAS:<p>Verubulin hydrochloride (MPC-6827 hydrochloride) is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxic</p>Fórmula:C17H18ClN3OPureza:98.29% - 99.77%Cor e Forma:SolidPeso molecular:315.8BNC105
CAS:<p>BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.</p>Fórmula:C20H20O7Pureza:96.57%Cor e Forma:SolidPeso molecular:372.37Tirbanibulin Mesylate
CAS:<p>Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).</p>Fórmula:C27H33N3O6SPureza:99%Cor e Forma:SolidPeso molecular:527.63Entasobulin
CAS:<p>Entasobulin is an inhibitor of β-tubulin polymerization. It has a potential anticancer activity.</p>Fórmula:C26H18ClN3O2Pureza:98.40%Cor e Forma:SolidPeso molecular:439.89AC 7739
CAS:<p>AC 7739 is a microtubule protein binding agent with anticancer and antitumor activity that inhibits advanced solid tumors and in situ transplanted tumors.</p>Fórmula:C18H22ClNO4Pureza:99.38% - 99.55%Cor e Forma:SoildPeso molecular:351.83Tubulin inhibitor 6
CAS:<p>Tubulin inhibitor 6 (iHAP1) is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.</p>Fórmula:C20H14ClNO2SPureza:99.05%Cor e Forma:SolidPeso molecular:367.85Tubulin Polymerization-IN-1 prodrug
CAS:<p>Tubulin Polymerization-IN-1 prodrug (Compound 2b) is a microtubule polymerization inhibitor prodrug mediated by Pd. Developed from colchicine-binding site inhibitors (CBSIs), it aims to reduce toxicity and enhance targeted release. Compared to the parent compound, its cytotoxicity is decreased by 68.3 times, but can be in situ restored in the presence of Pd resin. Mechanistic studies show it retains the same antitumor activity as CBSIs. In vivo tests demonstrate that, once activated by Pd resin, it significantly suppresses tumor growth (63.2% inhibition rate). Tubulin Polymerization-IN-1 prodrug is a promising candidate for cancer research.</p>Fórmula:C22H23FN2O4Cor e Forma:SolidPeso molecular:398.43Anticancer agent 270
<p>Anticanceragent 270 (Compound 8e) is a microtubule protein inhibitor with an IC50 of 1.02 μM against MCF-7 breast cancer cells. It exerts significant antiproliferative activity on breast cancer cells through a dual mechanism of inducing apoptosis and destabilizing microtubules. Anticanceragent 270 is useful for cancer research.</p>Cor e Forma:Odour SolidPironetin
CAS:<p>Pironetin, from Streptomyces, inhibits microtubule polymerization and tumor growth, and causes cell cycle arrest.</p>Fórmula:C19H32O4Pureza:98%Cor e Forma:SolidPeso molecular:324.45Sudocetaxel
CAS:<p>Sudocetaxel is a compound that serves as a microtubule depolymerization inhibitor, specifically designed for the pH-sensitive delivery of docetaxel.</p>Fórmula:C48H59NO16Cor e Forma:SolidPeso molecular:905.98Tubulin polymerization-IN-44
<p>Tubulinpolymer-in-44 (compound 7w) effectively inhibits Tubulin with an IC50 value of 0.21 μM and induces apoptosis by arresting the G2/M phase, making it</p>Fórmula:C19H15Cl2N3O3SCor e Forma:SolidPeso molecular:436.31Tubulin inhibitor 21
<p>Compound 6f, a chalcone-melatonin hybrid, is a potent tubulin inhibitor with IC50=0.26μM in SW480 cells, less toxic to non-cancer cells.</p>Fórmula:C28H25N3O4SCor e Forma:SolidPeso molecular:499.58PM050489
CAS:<p>PM050489, a polyketone inhibitor from Lithoplocamia lithistoides, halts mitosis at 26.4 nM IC50 and aids cancer research.</p>Fórmula:C31H44ClN3O7Cor e Forma:SolidPeso molecular:606.15TTBK1-IN-2
CAS:<p>TTBK1-IN-2, a TTBK1 inhibitor with IC50s of 0.24/4.22 µM, lowers TDP-43 phosphorylation in vitro and in mice.</p>Fórmula:C18H13ClN4OPureza:99.83%Cor e Forma:SoildPeso molecular:336.77Tubulin inhibitor 48
CAS:<p>Tubulin inhibitor 48 (compound 16) is an anticancer agent targeting microtubules. It exhibits IC50 values of 0.1 μM and 0.07 μM against LN-229 and Capan-1 cells, respectively.</p>Fórmula:C21H22N4OCor e Forma:SolidPeso molecular:346.43Larotaxel dihydrate
CAS:<p>Larotaxel dihydrate possesses antineoplastic activity.</p>Fórmula:C45H57NO16Pureza:98%Cor e Forma:SolidPeso molecular:867.93Anticancer agent 139
<p>Compound 6h (Anticancer Agent 139) exhibits potent anticancer activity, engaging in a π-cationic interaction with Lys352 of Tubulin and demonstrating high</p>Fórmula:C16H12F3N3OCor e Forma:SolidPeso molecular:319.28Microtubule stabilizing agent-1
<p>Compound 3l, a paclitaxel derivative known as Microtubule Stabilizing Agent-1, effectively enhances tubulin polymerization and demonstrates antitumor efficacy [</p>Fórmula:C45H55NO13Cor e Forma:SolidPeso molecular:817.92PROTAC tubulin-Degrader-1
<p>PROTAC tubulin-Degrader-1 (Compound W13) functions as an inhibitor of PROTAC tubulin and exhibits anti-tumor activity against human lung cancer.</p>Cor e Forma:Odour SolidAnhydrovinblastine sulfate
Anhydrovinblastine sulfate is a monoterpene indole alkaloid that can be extracted from the leaves of Catharanthus roseus.Fórmula:C46H60N4O16S2Peso molecular:988.34457Vinzolidine
CAS:<p>Vinzolidine is a semi-synthetic vinca alkaloid. It exerts cytotoxic effects on tumor cells by inhibiting cell division through disruption of tubulin polymerization. Vinzolidine can be utilized in research to investigate synergy with other chemotherapy or biotherapy drugs, as well as cancer cell tolerance or resistance, and to explore strategies to overcome these challenges.</p>Fórmula:C48H58ClN5O9Cor e Forma:SolidPeso molecular:884.46Tubulin inhibitor 50
<p>Tubulin inhibitor 50 (compound 07) is a microtubule protein inhibitor that enhances mitochondrial reactive oxygen species levels. It exhibits anticancer activity in HeLa cells with an IC50 value of 0.46 μM, while showing low toxicity in normal cell lines.</p>Fórmula:C16H10ClFN2O2Cor e Forma:SolidPeso molecular:316.04148KIF18A-IN-12
CAS:<p>KIF18A-IN-12 (compound 9), a potent KIF18A inhibitor, exhibits an IC 50 of 45.54 nM and is utilized in cancer research.</p>Fórmula:C30H39F2N5O4SCor e Forma:SolidPeso molecular:603.72TBL-100
<p>TBL-100 is a human monoclonal antibody (mAb) that targets Tau. It is applicable for research in Alzheimer's disease (AD) and progressive supranuclear palsy.</p>Cor e Forma:Odour LiquidAntiproliferative agent-66
Antiproliferative agent-66 (Compound B3) is an antiproliferative compound that induces apoptosis and causes cell cycle arrest. It demonstrates IC50 values ranging from 2.03 to 3.6 µM against SH-SY5Y neuroblastoma, HT-29 colorectal adenocarcinoma, and fibroblasts. Additionally, Antiproliferative agent-66 functions as a microtubule polymerization inhibitor with an IC50 of 0.79 µM.Fórmula:C18H15N3SCor e Forma:SolidPeso molecular:305.397ALB-109564 dihydrochloride
CAS:<p>ALB-109564 dihydrochloride: Semi-synthetic, vinblastine-derived, microtubule inhibitor, arrests tumor cells in G2/M phase.</p>Fórmula:C47H62Cl2N4O9SPureza:98%Cor e Forma:SolidPeso molecular:929.99T-808
CAS:<p>T-808 is a tau tracer which may be used in radiographic labeling of Tau aggregates during Alzheimer's disease.</p>Fórmula:C17H19FN4Cor e Forma:SolidPeso molecular:298.36KGP591
<p>KGP591, a tubulin polymerization inhibitor with an IC50 of 0.57 µM, effectively induces G2/M arrest, inhibits cell migration, and disrupts microtubule structure</p>Fórmula:C24H21NO5Cor e Forma:SolidPeso molecular:403.43Combretastatin A-1 phosphate tetrasodium
CAS:<p>OXi-4503, a prodrug of Combretastatin A-1, disrupts tubulin, inhibits Wnt/β-catenin and AKT, and has anti-tumor/vascular effects.</p>Fórmula:C18H18Na4O12P2Cor e Forma:SolidPeso molecular:580.24cis-trismethoxy Resveratrol
CAS:<p>cis-trismethoxy Resveratrol ((Z)-3,5,4'-Trimethoxystilbene) inhibits tubulin polymerization (IC50 = 4 μM) and has anti-mitotic effects.</p>Fórmula:C17H18O3Pureza:99.88%Cor e Forma:SolidPeso molecular:270.32Dihydrocephalomannine
CAS:<p>Dihydrocephalomannine is similar to paclitaxel, showing reduced cytotoxicity and tubulin binding.</p>Fórmula:C45H55NO14Pureza:98%Cor e Forma:SolidPeso molecular:833.928Trimethylcolchicinic acid
CAS:<p>Trimethylcolchicinic acid is an orally available colchicine analog that binds to tubulin and inhibits its polymerization into microtubules,potential antitumor.</p>Fórmula:C19H21NO5Pureza:>99.99%Cor e Forma:SoildPeso molecular:343.3720-O-Demethyl-AP3
CAS:<p>20-O-Demethyl-AP3, a derivative of the microtubule-inhibiting antitumor agent Ansamitocin P-3, is a secondary metabolite.</p>Fórmula:C31H41ClN2O9Cor e Forma:SolidPeso molecular:621.12Tubulin inhibitor 38
<p>Tubulin Inhibitor 38 (Compound 14), a tetrazole-based agent, demonstrates significant antiproliferative effects by inducing mitotic arrest and blocking the cell</p>Fórmula:C17H13ClN6OSCor e Forma:SolidPeso molecular:384.84MT189
CAS:<p>MT189 (Antiproliferative agent-14) inhibits tubulin polymerization (IC50 3.41 μM), arrests G2/M cell cycle, and is highly antiproliferative.</p>Fórmula:C21H18FN3O2Pureza:98.52%Cor e Forma:SoildPeso molecular:363.38Phomopsin A
CAS:<p>Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis.</p>Fórmula:C36H45ClN6O12Pureza:98%Cor e Forma:SolidPeso molecular:789.23Tubulin polymerization-IN-78
<p>Tubulin polymerization-IN-78 (compound 10a) is an inhibitor of tubulin polymerization, with an IC50 value of 2.69 μM. It exhibits antiproliferative activity.</p>Cor e Forma:Odour SolidEpothilone F
CAS:<p>Epothilone F, an active metabolite of Epothilone D with a hydroxymethyl on thiazole, disrupts cell division, shows promise over taxanes, and is water-soluble.</p>Fórmula:C27H41NO7SCor e Forma:SolidPeso molecular:523.68KIF18A-IN-2
CAS:<p>KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.</p>Fórmula:C25H34N4O5S2Pureza:99.64%Cor e Forma:SolidPeso molecular:534.69Cys-McMMAF
CAS:<p>Cys-McMMAF, a microtubule-disrupting agent linked to an anti-5T4 antibody, shows antitumor effects in mouse models.</p>Fórmula:C52H83N7O13SCor e Forma:SolidPeso molecular:1046.3210-Oxo Docetaxel
CAS:10-Oxo Docetaxel is a Docetaxel intermediate having remarkable antitumor properties.Fórmula:C43H51NO14Pureza:98%Cor e Forma:SolidPeso molecular:805.874Aβ-IN-1 TFA
<p>Aβ-IN-1 TFA inhibits and reverses different types of protein aggregation.</p>Fórmula:C37H50F3NO2Pureza:99.82%Cor e Forma:SoildPeso molecular:597.79Tubulin polymerization-IN-50
<p>Tubulin Polymerization-IN-50 (compound 7n) serves as an inhibitor of tubulin polymerization, exhibiting an IC50 of 5.05 μM in SK-Mel-28 cells and inducing cell</p>Fórmula:C24H20FN3O3Cor e Forma:SolidPeso molecular:417.43Microtubule destabilizing agent-1
CAS:<p>Compound 12b is a hydroxamic acid-based MDA with stable metabolism, high bioavailability, and strong antitumor properties.</p>Fórmula:C22H26N4O4Cor e Forma:SolidPeso molecular:410.47Cy5-Paclitaxel
Cy5-Paclitaxel is a Cy5-labeled paclitaxel conjugate. Cy5 is a cyanine dye (with an approximate wavelength of 662 nm) utilized in molecular labeling and microscopy imaging. Paclitaxel stabilizes tubulin polymerization, causing mitotic arrest and apoptotic death. It also induces autophagy.Fórmula:C93H104N4O16Peso molecular:1533.84Microtubule-associated protein tau (26-44)
<p>Microtubule-associated protein tau (26-44) is a synthetic peptide with an amino group conjugated to glutamine and a carboxyl group conjugated to lysine.</p>Fórmula:C83H127N25O34SPureza:98%Cor e Forma:SolidPeso molecular:2051.11Tubulin inhibitor 36
<p>Tubulin Inhibitor 36 (Compound 10) serves as a potent novel inhibitor of tubulin polymerization, which consequently induces apoptosis in glioblastoma cells,</p>Fórmula:C16H13ClN6SCor e Forma:SolidPeso molecular:356.83N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide
CAS:<p>N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide, a TAU cytotoxicity inhibitor, inhibits LDH leakage of M17-TAU P301L cells with EC50 of 325nM</p>Fórmula:C24H18ClN3OPureza:99.93%Cor e Forma:SoildPeso molecular:399.87Tubulin polymerization-IN-46
<p>Tubulin polymerization-IN-46 (compound 9q) is a microtubule/tubulin inhibitor that impedes tubulin polymerization, induces apoptosis, and arrests MCF-7 breast</p>Fórmula:C22H25NO6Cor e Forma:SolidPeso molecular:399.44Vinflunine Tartrate
CAS:<p>Vinflunine Tartrate, a uniquely fluorinated vinca alkaloid, exhibits mitotic-arresting and tubulin-interacting properties.</p>Fórmula:C45H54F2N4O8·xC4H6O6Pureza:98%Cor e Forma:SolidPeso molecular:967.02Diminutol
CAS:<p>Diminutol, a purine derivative, inhibits NQO1 (Ki=1.72μM), affects tubulin polymerization, and disrupts mitosis at 50μM without impacting Cdk1 or actin.</p>Fórmula:C19H26N6OSCor e Forma:SolidPeso molecular:386.51Tubulin polymerization-IN-47
CAS:<p>Tubulin polymerization-IN-47 is a tubulin polymerization inhibitor and mitotic inhibitor with antitumor activity and inhibitory effects on neuroblastoma cancer</p>Fórmula:C22H21N3O3Pureza:99.64%Cor e Forma:SoildPeso molecular:375.42Ceratamine A
CAS:<p>Ceratamine A, from Pseudoceratina sponge, is a cytotoxic, microtubule-stabilizing antimitotic alkaloid.</p>Fórmula:C17H16Br2N4O2Pureza:98%Cor e Forma:SolidPeso molecular:468.14Bifidenone
CAS:<p>Bifidenone is an effective tubulin polymerization inhibitor.</p>Fórmula:C21H26O5Cor e Forma:SolidPeso molecular:358.43Anti-α-Tubulin Antibody, AF555 conjugate
<p>Anti-α-Tubulin Antibody, AF555 conjugate, is a mouse-derived monoclonal antibody conjugated with the red fluorescent dye Alexa Fluor 555, designed for the</p>Cor e Forma:SolidSPA107
CAS:<p>SPA107 (Hemiasterlin methyl ester) is an analogue of Hemiasterlin. It inhibits tubulin polymerization, exhibiting antimitotic activity with an IC50 of 0.5 nM. SPA107 also shows cytotoxicity against p53 mutated MCF-7 cells, with an IC50 of 0.5 nM.</p>Fórmula:C31H48N4O4Cor e Forma:SolidPeso molecular:540.74Tubulin polymerization-IN-55
CAS:<p>Tubulin polymerisation-IN-55 is a Tubulin Polymerization inhibitor that displays antiproliferative effects on A549, K562, HepG2, MDA-MB-231 and HFL-1.</p>Fórmula:C22H24N2O4Pureza:98.68%Cor e Forma:SoildPeso molecular:380.44TNIR7-1A
CAS:<p>TNIR7-1A is a fused cycloheptatriene-BODIPY derivative that is optimized for near-infrared (NIR) imaging characteristics (Ex/Em = 600/774 nm in PBS) and exhibits high affinity and specificity for neurofibrillary tangles (NFT) in vitro. Additionally, TNIR7-1A can effectively penetrate the blood-brain barrier.</p>Fórmula:C23H20BF2N3Cor e Forma:SolidPeso molecular:387.23T-900607
CAS:<p>T-900607 is a novel microtubule protein active agent that disrupts microtubule polymerization through a unique mechanism of action. t-900607 is cardiotoxic.</p>Fórmula:C14H10F5N3O4SPureza:98.84%Cor e Forma:SolidPeso molecular:411.37-Epi-docetaxel
CAS:<p>7-Epi-10-oxo-docetaxel (7-Epitaxotere) is a impurity of docetaxel.</p>Fórmula:C43H53NO14Pureza:98%Cor e Forma:SolidPeso molecular:807.88Tubulin inhibitor 24
CAS:<p>Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization.</p>Fórmula:C22H21N3O3Pureza:99.99%Cor e Forma:SolidPeso molecular:375.42Phomopsinamine
CAS:<p>Phomopsinamine, a phomopsin A derivative, hampers microtubule assembly in sheep brain tubulin (IC50: 0.53-0.59 μM).</p>Fórmula:C32H43ClN6O8Cor e Forma:SolidPeso molecular:675.17Vinblastine
CAS:<p>Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.</p>Fórmula:C46H58N4O9Pureza:97.42%Cor e Forma:PowderPeso molecular:810.97Tubulin polymerization-IN-69
<p>Tubulin polymerization-IN-69 (compound 6c) exhibits significant inhibition of microtubule assembly in vitro, with an inhibition rate of 78.3% and an IC50 value of 6.53 μM. It rapidly induces apoptosis and G2/M phase cell cycle arrest in MCF-7 cells.</p>Cor e Forma:Odour SolidAlestramustine
CAS:<p>Alestramustine: a cancer drug that targets microtubules in estrogen receptor-positive cells, impeding cell division.</p>Fórmula:C26H36Cl2N2O4Cor e Forma:SolidPeso molecular:511.48Modified MMAF
CAS:<p>Modified MMAF, an ADC cytotoxin, aids in ADC synthesis for targeted cancer research.</p>Fórmula:C45H73N7O8Cor e Forma:SolidPeso molecular:840.1Tubulin inhibitor 37
<p>Tubulin Inhibitor 37 (Compound 12) effectively impedes tubulin aggregation (IC50 = 1.3 µM) and demonstrates antiproliferative activity against human tumor cell</p>Fórmula:C16H10Cl2N6OCor e Forma:SolidPeso molecular:373.2AADvac 1 TFA
AADvac 1 TFA is an active tau peptide vaccine utilized in Alzheimer's disease research. It is formed by conjugating the regulatory peptide 294KDNIKHVPGGGS305, which drives tau oligomerization, with keyhole limpet hemocyanin (KLH), and is formulated with aluminum hydroxide.Tubulin/PARP-IN-1
<p>Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with anti-endometrial cancer activity. It exhibits inhibitory concentration (IC50) values of 74 nM for PARP1, 109 nM for PARP2, and 1.4 μM for microtubules/tubulin. Tubulin/PARP-IN-1 induces apoptosis and autophagy, causing cell cycle arrest at the G2/M phase.</p>Fórmula:C19H13FO3Peso molecular:308.08487Tubulin polymerization-IN-49
<p>Tubulin polymerization-IN-49 (compound 12d), a potent inhibitor of tubulin polymerization, binds to the colchicine site on tubulin, subsequently inducing cell</p>Fórmula:C20H24O5Cor e Forma:SolidPeso molecular:344.4Tubulin inhibitor 45
<p>Tubulin inhibitor 45 (compound 5) functions as an inhibitor of the active site of tubulin. It exhibits IC50 values of 11 μM for MCF7 cancer cells and 13 μM for HePG2 cancer cells.</p>Fórmula:C19H18N2O2SPeso molecular:338.1089Tubulin polymerization-IN-48
<p>Tubulin polymerization-IN-48 (Compound 4k) is an inhibitor of tubulin polymerization, moderately disrupting the microtubule network.</p>Fórmula:C20H15Cl2N3OCor e Forma:SolidPeso molecular:384.267-Epi-10-oxo-docetaxel
CAS:<p>7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) is an impurity of docetaxel detected by HPLC.</p>Fórmula:C43H51NO14Pureza:98%Cor e Forma:SolidPeso molecular:805.86Tubulin polymerization-IN-53
<p>Tubulin polymerization-IN-53 (compound 4b) serves as an inhibitor of β-tubulin polymerization and is capable of arresting the cell cycle at the G2/M stage.</p>Cor e Forma:Odour SolidTrifluralin
CAS:<p>Trifluralin (Treflan) is an agricultural herbicide with mild toxicity. Trifluralin is a novel pollutant that can interfere with mitochondrial respiration.</p>Fórmula:C13H16F3N3O4Pureza:99.84%Cor e Forma:Yellow-Orange Crystalline SolidPeso molecular:335.28PhosTAC7
CAS:<p>PhosTAC7 successfully induced ternary protein complex formation of Halo-FOXO3a in a dose-dependent manner.</p>Fórmula:C58H87ClN2O17Pureza:98.96%Cor e Forma:SolidPeso molecular:1119.77Oryzalin
CAS:<p>Oryzalin is a selective pre-emergence herbicide belonging to the dinitroaniline class, which exerts its effect by inhibiting cell division in weeds.</p>Fórmula:C12H18N4O6SPureza:99.86%Cor e Forma:SolidPeso molecular:346.36Avanbulin
CAS:<p>Avanbulin hinders tubulin polymerization, has unique antitumor properties, and is effective against various human tumors at low concentrations.</p>Fórmula:C20H17N7O2Cor e Forma:SolidPeso molecular:387.39TTBK1-IN-1
CAS:<p>TTBK1-IN-1 (compound 31) is a potent and selective TTBK1 inhibitor with CNS penetration that inhibits tau phosphorylation , Alzheimer's disease.</p>Fórmula:C18H19N5O2Cor e Forma:SolidPeso molecular:337.38colchiceine
CAS:<p>colchiceine has a wide range of applications in life science related research.</p>Fórmula:C21H23NO6Pureza:99.38%Cor e Forma:SolidPeso molecular:385.41Amiprofos methyl
CAS:<p>Amiprofos methyl (BAY-NTN 6867) is an organophosphorus herbicide that specifically and competitively inhibits microtubule polymerization in plant cells.</p>Fórmula:C11H17N2O4PSPureza:99.66%Cor e Forma:SolidPeso molecular:304.30BSc3094
CAS:<p>BSc3094 is a potent Tau aggregation inhibitor that demonstrates the potential for Alzheimer's disease (AD) research.</p>Fórmula:C17H12N6O3SCor e Forma:SolidPeso molecular:380.38Ombrabulin hydrochloride
CAS:<p>Ombrabulin hydrochloride is a synthetic, selective CA-4 phosphate ester or derivative of Ombrabulin to disrupt the tubulin cytoskeleton of endothelial cells and</p>Fórmula:C21H27ClN2O6Pureza:98%Cor e Forma:SolidPeso molecular:438.9Tirbanibulin dihydrochloride
CAS:<p>Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).</p>Fórmula:C26H31Cl2N3O3Pureza:98%Cor e Forma:SolidPeso molecular:504.45N-Phenylbenzylamine
CAS:<p>A series of N-Phenylbenzylamine (Benzenemethanamine) as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization</p>Fórmula:C13H13NPureza:98.75%Cor e Forma:Colorless To Pale Yellow Crystalline PowderPeso molecular:183.25Soblidotin
CAS:<p>Soblidotin (TZT-1027) (Auristatin PE) is an inhibitor of tubulin polymerization. It is also a novel synthetic Dolastatin 10 derivative.</p>Fórmula:C39H67N5O6Pureza:99.89%Cor e Forma:SolidPeso molecular:701.98LP-261
CAS:<p>LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.</p>Fórmula:C22H19N3O4SPureza:99.91%Cor e Forma:SolidPeso molecular:421.47Parbendazole
CAS:<p>Parbendazole (SKF 29044) is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine.</p>Fórmula:C13H17N3O2Pureza:99.60%Cor e Forma:Physical Description Crystals Or Fine White Powder (Ntp 1992)Peso molecular:247.29T807
CAS:<p>T807 (AV-1451) is a novel tracer of tau positron emission tomography (PET).</p>Fórmula:C16H10FN3Pureza:99.72%Cor e Forma:SolidPeso molecular:263.27MAP4343
CAS:<p>Map4343, a 3-methyl ether pregnenolone derivative, binds MAP2, boosts tubulin polymerization, spurs neurite growth, and guards neurons.</p>Fórmula:C22H34O2Pureza:97.024%Cor e Forma:SolidPeso molecular:330.5Tirbanibulin
CAS:<p>Tirbanibulin (KX2-391) is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of a variety of cancers.</p>Fórmula:C26H29N3O3Pureza:99.43% - 99.67%Cor e Forma:SolidPeso molecular:431.53Estramustine
CAS:<p>Estramustine (LEO-275), a nitrogen mustard-estradiol compound, treats prostate cancer and protects against radiation.</p>Fórmula:C23H31Cl2NO3Pureza:98.09%Cor e Forma:SolidPeso molecular:440.4MMAD
CAS:<p>MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).</p>Fórmula:C41H66N6O6SPureza:99.25% - 99.91%Cor e Forma:SolidPeso molecular:771.06Plinabulin
CAS:<p>Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM).</p>Fórmula:C19H20N4O2Pureza:98.69% - >99.99%Cor e Forma:SolidPeso molecular:336.39MMAF
CAS:<p>MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.</p>Fórmula:C39H65N5O8Pureza:97.00% - 99.88%Cor e Forma:SolidPeso molecular:731.96D-64131
CAS:<p>D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.</p>Fórmula:C16H13NO2Pureza:99.48% - 99.67%Cor e Forma:SolidPeso molecular:251.28Albendazole sulfoxide
CAS:Albendazole sulfoxide (Ricobendazole) is a metabolite of Albendazole, an anthelmintic.Fórmula:C12H15N3O3SPureza:97.29%Cor e Forma:White To Off-White PowderPeso molecular:281.33Valecobulin
CAS:Valecobulin is a potent β-tubulin polymerization inhibitor. Valecobulin is a valine prodrug of (S516) and an avascular disrupting compound.Fórmula:C26H28N6O5SPureza:98%Cor e Forma:SolidPeso molecular:536.6Suprafenacine
CAS:<p>Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) is a cell-permeable microtubule destabilizer that induces</p>Fórmula:C16H18N4OPureza:99.91%Cor e Forma:SolidPeso molecular:282.34Tau protein (592-597), Human TFA
<p>Tau protein (592-597), Human (TFA) is a peptide fragment of human Tau protein.</p>Fórmula:C36H63F3N10O11Pureza:>99.99%Cor e Forma:SolidPeso molecular:868.94Vindesine sulfate
CAS:<p>Vindesine sulfate, a vinca alkaloid derived from vinblastine, binds to spindle microtubules, causing cell death.</p>Fórmula:C43H57N5O11SPureza:97.51%Cor e Forma:Amorphous SolidPeso molecular:852Curvulin
CAS:<p>Curvulin is the active metabolite isolated from Paraphoma sp. VIZR 1.46. Curvularin inhibits iNOS expression and microtubule assembly.</p>Fórmula:C12H14O5Pureza:98.65%Cor e Forma:SolidPeso molecular:238.24Clanfenur
CAS:<p>Clanfenur belongs to a new group of substituted benzoylphenylureas. The drug shows both in vitro and in vivo antitumour activity.</p>Fórmula:C16H15ClFN3O2Pureza:99.93%Cor e Forma:SolidPeso molecular:335.764-Isopropoxybenzoic acid
CAS:<p>4-Isopropoxybenzoic acid (AI3 12104) is a Centromere-Associated Protein E inhibitor.</p>Fórmula:C10H12O3Pureza:99.88%Cor e Forma:White To Off-White PowderPeso molecular:180.2TN-16
CAS:<p>TN-16 is a microtubule polymerization inhibitor (IC50 :0.4-1.7 μM)</p>Fórmula:C19H18N2O2Pureza:99.54%Cor e Forma:SolidPeso molecular:306.36Spastazoline
CAS:<p>Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99 nM ).</p>Fórmula:C20H30N8Pureza:99.23%Cor e Forma:SolidPeso molecular:382.51NQTrp
CAS:<p>NQTrp is an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects.</p>Fórmula:C21H16N2O4Pureza:98.35%Cor e Forma:SolidPeso molecular:360.36Gosuranemab
CAS:<p>Gosuranemab (BMS-986168), a humanized IgG4 mAb, targets tau residues 15-22, and may aid in Alzheimer’s research.</p>Pureza:95% - 95%Cor e Forma:LiquidST-401
CAS:<p>ST-401, a microtubule-targeting agent (MTA), functions as a brain-penetrant microtubule (MT) assembly inhibitor. It disrupts microtubule (MT) function by gently and reversibly reducing MT assembly, which leads to mitotic delay and interphase cell death. ST-401 demonstrates potent antitumor activity.</p>Fórmula:C24H20N2OCor e Forma:SolidPeso molecular:352.43Posdinemab
CAS:<p>Posdinemab, a humanized IgG1κ antibody, targets the microtubule-associated protein tau (MAPT) [1].</p>Cor e Forma:LiquidSemorinemab
CAS:<p>Semorinemab (RG6100) is a humanised monoclonal antibody targeting the N-terminal domain of tau protein with a Kd of 3.8 nM, suitable for Alzheimer's disease.</p>Pureza:95% - 95%Cor e Forma:Liquid4-Desacetylvinblastine hydrazide
CAS:<p>Deacetylvinblastine hydrazide, a cytotoxic vinca alkaloid often conjugated with folic acid to produce EC145, a novel folate-receptor targeted agent.</p>Fórmula:C43H56N6O7Cor e Forma:SolidPeso molecular:768.94Tubulin polymerization-IN-2
CAS:<p>Tubulin-IN-2, anticancer β-tubulin binder, IC50 0.92 μM, effective against various cancers.</p>Fórmula:C17H12F2N2O2Cor e Forma:SolidPeso molecular:314.29Auristatin F
CAS:<p>Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.</p>Fórmula:C40H67N5O8Pureza:98.41% - 99.25%Cor e Forma:SolidPeso molecular:745.99Sabeluzole
CAS:<p>Sabeluzole (R-58735) has antiepileptic and cognitive enhancing properties and may be used in the study of Alzheimer's disease.</p>Fórmula:C22H26FN3O2SPureza:98.51%Cor e Forma:SolidPeso molecular:415.52AM-5308
CAS:<p>AM-5308 is a kinesin KIF18A inhibitor that can be used to study cancer.</p>Fórmula:C26H35N5O5SPureza:98.06% - 99.58%Cor e Forma:SolidPeso molecular:529.65Tau protein aggregation-IN-1
CAS:<p>Tau Protein Aggregation-IN-1 (Compound 0c) serves as an inhibitor of Tau protein aggregation, applicable in research related to protein folding disorders</p>Fórmula:C17H11BrN2O2Cor e Forma:SolidPeso molecular:355.19OSIP-486823
CAS:<p>OSIP-486823（CP248） is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.</p>Fórmula:C29H28FNO4Pureza:98.59%Cor e Forma:SolidPeso molecular:473.54IQTub4P
CAS:<p>IQTub4P is a potent inhibitor of microtubules. IQTub4P exhibits cytotoxicity in HeLa cells (EC50: 170 nM).</p>Fórmula:C19H18NNa2O8PCor e Forma:SolidPeso molecular:465.305Tubulin polymerization-IN-42
CAS:<p>Tubulin polymerization-IN-42 (compound 10j), an indole-substituted furanone, inhibits tubulin polymerization and exhibits anti-cancer properties [1].</p>Fórmula:C22H21NO5Cor e Forma:SolidPeso molecular:379.41Alyssin
CAS:<p>Alyssin: sulforaphane analog, antioxidant; boosts Nrf2 and phase II enzymes in cancer cells; lowers PAH metabolism, reducing cancer risk in vitro.</p>Fórmula:C7H13NOS2Pureza:98%Cor e Forma:SolidPeso molecular:191.31Tubulozole
CAS:<p>Tubulozole blocks mitosis by inhibiting microtubule dynamics, leading to cell cycle arrest and apoptosis.</p>Fórmula:C23H23Cl2N3O4SPureza:98%Cor e Forma:SolidPeso molecular:508.42Sirt1/2-IN-1
CAS:<p>Sirt1/2-IN-1 inhibits SIRT1 (IC50: 1.81 μg/mL) and SIRT2 (2.10 μg/mL), less on SIRT3 (20.5 μg/mL), with anticancer properties.</p>Fórmula:C22H13ClN2OS2Cor e Forma:SolidPeso molecular:420.93Amphethinile
CAS:<p>Amphethinile is an anti-tubulin agent. The Ka of Amphethinile with tubulin is 1.3 μM.</p>Fórmula:C15H11N3SPureza:98%Cor e Forma:SolidPeso molecular:265.33Microtubule inhibitor 3
CAS:<p>Compounds 17o and 17p with furan have IC50s of 14.0 and 2.9 nM, respectively, against NCI-H460 cancer cells.</p>Fórmula:C26H23FN4O3Cor e Forma:SolidPeso molecular:458.48Microtubule inhibitor 1
CAS:<p>Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity(IC50 = 9-16 nM, in cancer cells).</p>Fórmula:C21H19NO3Pureza:98%Cor e Forma:SolidPeso molecular:333.38Anticancer agent 48
CAS:<p>Compound 48: broad-spectrum, anti-proliferative, inhibits microtubules, active in vivo, with potential for tumor research.</p>Fórmula:C26H25N3O4Cor e Forma:SolidPeso molecular:443.49Tubulin polymerization-IN-39
<p>Tubulin-IN-39 inhibits polymerization (IC50: 4.9 μM), blocks colchicine site, stops cancer growth.</p>Fórmula:C21H21N5O5Cor e Forma:SolidPeso molecular:423.42Tubulin inhibitor 28
CAS:<p>Compound 2g, a tubulin inhibitor with an IC50 of 1.2 μM, inhibits MCF-7 cell proliferation.</p>Fórmula:C12H8Br2S2Cor e Forma:SolidPeso molecular:376.13Tubulin inhibitor 7
CAS:<p>Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines (tubulin polymerization (IC50: 0.52 μM), K562 cell growth (</p>Fórmula:C21H14N2O4Pureza:98%Cor e Forma:SolidPeso molecular:358.35MT-7
CAS:<p>MT-7 is a tubulin polymerization inhibitor.</p>Fórmula:C22H17N3O2Pureza:98%Cor e Forma:SolidPeso molecular:355.39Anticancer agent 49
CAS:<p>Anticancer agent 49, also 69, hinders cell growth and microtubule aggregation, with potential in solid and blood cancer research.</p>Fórmula:C26H25N3O4Cor e Forma:SolidPeso molecular:443.49Tubulin polymerization-IN-19
CAS:<p>Tubulin aggregation-IN-19 (compound 4) is a potent tubulin aggregation inhibitor that has shown potential in breast cancer and drug-resistant colon cancer.</p>Fórmula:C25H25NO5Cor e Forma:SolidPeso molecular:419.47DJ101
CAS:<p>DJ101: A stable tubulin inhibitor that bypasses multidrug resistance efflux pumps.</p>Fórmula:C23H20N4O3Pureza:98%Cor e Forma:SolidPeso molecular:400.43Tubulin polymerization-IN-27
CAS:<p>Compound 5j inhibits tubulin polymerization, arrests cell cycle at G2/M phase, and induces apoptosis.</p>Fórmula:C22H20N2O2Cor e Forma:SolidPeso molecular:344.41Aha1/Hsp90-IN-1
CAS:<p>Aha1/Hsp90-IN-1 (Compound 17) inhibits Aha1/Hsp90, preventing tau aggregation; IC50 = 3.32 μM.</p>Fórmula:C22H17F3N4O2Cor e Forma:SolidPeso molecular:426.39MG-2119
CAS:<p>MG-2119 is a potent inhibitor of monomeric tau and α-syn aggregation and can be used to study neurological diseases.</p>Fórmula:C27H29N5O4Cor e Forma:SolidPeso molecular:487.55isoCA-4
CAS:<p>isoCA-4 is a Combretastatin A4 derivative. isoCA-4 is a tubulin polymerization inhibitor with anti-proliferative activities [1].</p>Fórmula:C18H20O5Cor e Forma:SolidPeso molecular:316.35Tubulin polymerization-IN-29
CAS:<p>Tubulin polymerization-IN-29 inhibits microtubule assembly, has anti-proliferative properties, and arrests HeLa cells at G2/M.</p>Fórmula:C25H20FNO6Cor e Forma:SolidPeso molecular:449.43BNC105P
CAS:<p>BNC105P, a prodrug VDA, converts to BNC105, blocks tubulin polymerization, disrupts tumor vessels, and evades P-glycoprotein resistance.</p>Fórmula:C20H21O10PCor e Forma:SolidPeso molecular:452.3485Microtubule inhibitor 4
CAS:<p>Microtubule inhibitor 4 (Compound 2) blocks polymerization, toxic to HT-29 cells (IC50: 2.1 nM).</p>Fórmula:C25H23FN4O3Cor e Forma:SolidPeso molecular:446.47Tubulin inhibitor 27
CAS:<p>DYT-1 Tubulin inhibitor 27, IC50: 25.6 μM, hinders tubulin polymerization, displays anti-angiogenic and antitumor effects.</p>Fórmula:C21H19NO4Cor e Forma:SolidPeso molecular:349.38Tubulin polymerization-IN-21
CAS:<p>Tubulin polymerization-IN-21 disrupts microtubules, affects glucose metabolism, and has anticancer properties.</p>Fórmula:C30H29NO7Cor e Forma:SolidPeso molecular:515.55Tubulin polymerization-IN-10
CAS:<p>Tubulin polymerization-IN-10 inhibits tubulin polymerization with 4.25 μM IC50 and has anti-tumor properties.</p>Fórmula:C18H21NO6SCor e Forma:SolidPeso molecular:379.43Neuroinflammatory-IN-3
CAS:<p>Neuroinflammatory-IN-3 is a potent tubulin inhibitor with anti-neuroinflammatory and antitumor properties.</p>Fórmula:C19H19ClO3Cor e Forma:SolidPeso molecular:330.81Tubulin polymerization-IN-36
CAS:<p>Tubulin polymerization-IN-36, a cancer research agent for lymphomas, inhibits tubulin at the colchicine site with IC50 of 2.8 µM.</p>Fórmula:C18H18N2O3Cor e Forma:SolidPeso molecular:310.35Tubulin polymerization-IN-16
CAS:<p>Compound 5g is a potent tubulin aggregation inhibitor, disrupting microtubules and causing G2/M arrest in SGC-7901 cells.</p>Fórmula:C24H27N5O5Cor e Forma:SolidPeso molecular:465.5O-GlcNAcase-IN-4
CAS:<p>O-GlcNAcase-IN-4, an inhibitor from patent WO2018140299A1, may aid in neurodegenerative disease research.</p>Fórmula:C16H22FN5O3SCor e Forma:SolidPeso molecular:383.44Tubulin polymerization-IN-18
CAS:Tubulin aggregation-IN-18 (compound 3) is a potent tubulin aggregation inhibitor with potential for breast cancer and drug-resistant colon cancer studies.Fórmula:C25H25NO6Cor e Forma:SolidPeso molecular:435.47Synstab A
CAS:<p>Synstab A is a microtubule stabilizer.</p>Fórmula:C15H13BrCl3N3O3SCor e Forma:SolidPeso molecular:501.61Microtubule inhibitor 7
CAS:<p>Compounds 17o and 17p have IC50s of 14.0 nM and 2.9 nM respectively, in NCI-H460 cancer cells, showing potent activity.</p>Fórmula:C25H19FN2O5Cor e Forma:SolidPeso molecular:446.43(S)-Dolaphenine hydrochloride
CAS:<p>(S)-Dolaphenine hydrochloride is a useful componet of compound synthesis.</p>Fórmula:C11H13ClN2SPureza:98%Cor e Forma:SolidPeso molecular:240.75Deox B 7,4
CAS:<p>Deox B 7,4 is a reversible microtubule inhibitor that acts by increasing lysosomal V-ATPase activity and lysosome acidity.</p>Fórmula:C18H18O5Cor e Forma:SolidPeso molecular:314.33Tubulin polymerization-IN-30
CAS:<p>Compound 6e inhibits tubulin polymerization, disrupts microtubules, halts G2/M phase, and targets HeLa, SGC-7901, A549 with low IC50.</p>Fórmula:C22H25N5O3Cor e Forma:SolidPeso molecular:407.47Tubulin inhibitor 29
CAS:<p>Compound 3c, a tubulin inhibitor, blocks assembly at colchicine site with IC50 of 1.2 μM; anti-proliferative IC50 7.5 μM in MCF-7 cells.</p>Fórmula:C12H8F2O2S2Cor e Forma:SolidPeso molecular:286.32Microtubule inhibitor 6
CAS:<p>Compound 17o inhibits microtubules, toxic to NCI-H460, BxPC-3, HT-29 cells (IC50: 14.0, 6.6, 7.0 nM), blocks polymerization.</p>Fórmula:C24H19FN2O5Cor e Forma:SolidPeso molecular:434.42Tubulin inhibitor 31
<p>Tubulin inhibitor 31: potent with 4 µM IC50, anti-proliferative, inhibits HUVEC migration.</p>Fórmula:C22H19NO2Cor e Forma:SolidPeso molecular:329.39Tubulin polymerization-IN-7
CAS:<p>Tubulin aggregation-IN-7 is a potent tubulin aggregation inhibitor that has shown research potential for cancer diseases.</p>Fórmula:C28H24N4O6SCor e Forma:SolidPeso molecular:544.58Anticancer agent 60
CAS:<p>Anticancer agent 60 hinders HepG2 cell growth with IC50 of 4.13 μM and suppresses tumors in HepG2 mouse model.</p>Fórmula:C27H33N5O4SCor e Forma:SolidPeso molecular:523.65SB26019
CAS:<p>SB26019: Potent anti-neuroinflammation; inhibits NF-κB via α-tubulin monomers preventing p65 translocation.</p>Fórmula:C24H20O4Cor e Forma:SolidPeso molecular:372.41AMXI-5001
CAS:<p>AMXI-5001: potent oral parp1/2 inhibitor, blocks microtubules, strong anti-cancer effects, lower IC50s, and can shrink large tumors.</p>Fórmula:C25H20FN5O3Cor e Forma:SolidPeso molecular:457.46Tubulin inhibitor 20
CAS:<p>Tubulin inhibitor 20 (compound 1) shows the potential for the cancer research that is a potent tubulin inhibitor [1].</p>Fórmula:C19H18O4Cor e Forma:SolidPeso molecular:310.34Tubulin inhibitor 26
CAS:<p>Compound 3c, a potent indazole-based tubulin inhibitor, halts G2/M phase and induces apoptosis in various cancers without weight loss in mice.</p>Fórmula:C17H19N3O3Cor e Forma:SolidPeso molecular:313.35Microtubule inhibitor 5
CAS:<p>Compound 17f, a potent microtubule inhibitor, shows strong cytotoxicity in NCI-H460 cells with an IC50 of 154.5 nM and high cell permeability.</p>Fórmula:C22H15FN2O4Cor e Forma:SolidPeso molecular:390.36Tubulin polymerization-IN-37
CAS:<p>Tubulin polymerization-IN-37 inhibits tubulin polymerization at the colchicine site (IC50: 2.3 μΜ), potentially aiding lymphoma research.</p>Fórmula:C19H20N2O4Cor e Forma:SolidPeso molecular:340.37THK-5117
CAS:<p>THK-5117, a tau PET probe, has a high tau fibril affinity (Ki 10.5 nM) and binds well to AD brain aggregates.</p>Fórmula:C19H19FN2O2Cor e Forma:SolidPeso molecular:326.36OXi8007
CAS:<p>OXi8007, a water-soluble prodrug for OXi8006, disrupts vasculature and exhibits strong cytotoxicity against DU-145 cancer cells.</p>Fórmula:C26H24NNa2O10PCor e Forma:SolidPeso molecular:587.428Hydromethylthionine HBr
CAS:<p>Hydromethylthionine (LMTM/Leucomethylene Blue) inhibits tau in Alzheimer's/frontotemporal dementia and improves brain function.</p>Fórmula:C16H21Br2N3SCor e Forma:SolidPeso molecular:447.233(R)-TTBK1-IN-1
CAS:<p>(R)-TTBK1-IN-1: potent, selective brain-penetrant TTBK1 inhibitor, studies Alzheimer’s & tauopathies.</p>Fórmula:C18H19N5O2Cor e Forma:SolidPeso molecular:337.38Tubulin polymerization-IN-25
CAS:<p>Tubulin polymerization-IN-25 inhibits tubulin (IC50: 1.11 μM) & FTase (IC50: 0.39 μM), and is cytotoxic to cancer cells, halting growth.</p>Fórmula:C24H18N2O3SCor e Forma:SolidPeso molecular:414.48Tubulin polymerization-IN-15
CAS:<p>Tubulin polymerization-IN-15 (compound 4) is a highly effective inhibitor of tubulin polymerization, with significant potential in cancer research [1].</p>Fórmula:C18H17N3O4Cor e Forma:SolidPeso molecular:339.35Tubulin polymerization-IN-20
CAS:<p>Tubulin aggregation-IN-20, a potent inhibitor, may be studied for breast and drug-resistant colon cancers.</p>Fórmula:C25H24FNO5Cor e Forma:SolidPeso molecular:437.46Tubulin inhibitor 18
CAS:<p>"Tubulin inhibitor 18 (5j), a potent chalcone, uniquely structured for cancer research."</p>Fórmula:C22H26O5Cor e Forma:SolidPeso molecular:370.44Tubulin/MMP-IN-1
<p>Tubulin/MMP-IN-1 inhibits tubulin, MMP, and cancer cell growth; disrupts cell cycles and induces apoptosis.</p>Fórmula:C38H44NO9PCor e Forma:SolidPeso molecular:689.73Tubulin inhibitor 12
CAS:<p>New tubulin inhibitor 12 (Hit 9); potent anti-cancer agent; IC50=25.3 μM; strong anti-tumor effect.</p>Fórmula:C24H20N2OCor e Forma:SolidPeso molecular:352.43Tau tracer 1
CAS:<p>Tau tracer 1 is a radiopharmaceutical for imaging Tau aggregates linked to neurodegenerative disease diagnosis.</p>Fórmula:C34H23N5O2Cor e Forma:SolidPeso molecular:533.591Iso-Fludelone
CAS:<p>Iso-Fludelone: a stable, soluble, potent, 3rd-gen epothilone B inhibiting cell division and inducing apoptosis, with low toxicity.</p>Fórmula:C27H36F3NO6Cor e Forma:SolidPeso molecular:527.57Antitumor agent-68
CAS:<p>Potent Antitumor-68 inhibits tubulin, IC50: 3.6μM HeLa, 3.8μM MCF-7; also scavenges ROS/DPPH dose-dependently.</p>Fórmula:C17H11NO2Cor e Forma:SolidPeso molecular:261.27Antitumor agent-71
CAS:<p>Antitumor Agent-71 inhibits tubulin aggregation; IC50 of 3.98-15.70 μM against cancer cells.</p>Fórmula:C26H31N5O4SCor e Forma:SolidPeso molecular:509.62IDT
CAS:<p>IDT, an oral TNFα modulator, changes neutrophil levels, boosts cognition, and reduces tau/amyloid in 3xTgAD mice.</p>Fórmula:C8H5NS2Pureza:98%Cor e Forma:SolidPeso molecular:179.26DHNQ
CAS:<p>DHNQ is a novel inhibitor of the PI3K enzyme activity and transcriptional as well as translational expression levels in colorectal cancer (CRC).</p>Fórmula:C18H14N2OCor e Forma:SolidPeso molecular:274.32D011-2120
CAS:<p>D011-2120: Antiviral that blocks microtubule growth, disrupts Golgi, and hinders viral egress.</p>Fórmula:C17H15NO3Pureza:98%Cor e Forma:SolidPeso molecular:281.31DAT1
CAS:<p>DAT1 is an antimitotic and antiangiogenic that acts by binding to the colchicine binding site of tubulin.</p>Fórmula:C17H15N3O2SPureza:98%Cor e Forma:SolidPeso molecular:325.38Acodazole
CAS:<p>Acodazole is a synthetic imidazoquinoline. It has antimicrobial and antineoplastic properties. It also has been shown to treat arrhythmias.</p>Fórmula:C20H19N5OPureza:98%Cor e Forma:SolidPeso molecular:345.4Acodazole hydrochloride
CAS:<p>Acodazole hydrochloride: synthetic imidazoquinoline with antineoplastic activity; disrupts DNA replication by intercalation.</p>Fórmula:C20H20ClN5OPureza:98%Cor e Forma:SolidPeso molecular:381.86LDN-193665
CAS:LDN-193665 is a potent inhibitor of tau kinase. It acts by targeting CDK5/p25 and GSK3β.Fórmula:C15H11FN4OSPureza:98%Cor e Forma:SolidPeso molecular:314.34GF 15
CAS:<p>GF 15 is a potent inhibitor of centrosomal clustering in tumor cells.</p>Fórmula:C23H21ClO6Pureza:98%Cor e Forma:SolidPeso molecular:428.86TOK-8801
CAS:<p>TOK-8801 is a dihydroimidazole thiazole carboxamide with immunomodulatory activity.</p>Fórmula:C17H21N3OSPureza:99.97%Cor e Forma:SolidPeso molecular:315.43Mivobulin
CAS:<p>Mivobulin is an inhibitor of tubulin .</p>Fórmula:C17H19N5O2Pureza:98%Cor e Forma:SolidPeso molecular:325.37S-methyl DM1
CAS:<p>S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization.</p>Fórmula:C36H50ClN3O10SPureza:98%Cor e Forma:SolidPeso molecular:752.31Cevipabulin
CAS:<p>Cevipabulin (TTI-237) is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell</p>Fórmula:C18H18ClF5N6OPureza:99.53%Cor e Forma:SolidPeso molecular:464.82Tau-aggregation and neuroinflammation-IN-1
CAS:<p>Potent tau aggregate inhibitor, anti-inflammatory, low cytotoxicity, reverses memory impairment in rats.</p>Fórmula:C25H20N2O7Pureza:99.85%Cor e Forma:SolidPeso molecular:460.44CCB02
CAS:CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity.Fórmula:C14H9N3OPureza:98.38%Cor e Forma:SolidPeso molecular:235.24S516
CAS:<p>S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.</p>Fórmula:C21H19N5O4SPureza:98%Cor e Forma:SolidPeso molecular:437.47Tubulin inhibitor 8
CAS:<p>Tubulin inhibitor 8 blocks tubulin polymerization, stunts K562 cancer cell growth; IC50: 0.73 μM, 14 nM.</p>Fórmula:C21H14N2O3Pureza:98.51% - 99.87%Cor e Forma:SolidPeso molecular:342.35LY3372689
CAS:<p>LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor for tau protein-based disorders including Alzheimer's disease.</p>Fórmula:C16H22FN5O3SPureza:99.43% - 99.53%Cor e Forma:SolidPeso molecular:383.44
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