PLK
Os inibidores de quinases Polo-like (PLK) têm como alvo as PLKs, uma família de quinases serina/treonina essenciais para várias fases da divisão celular, incluindo entrada na mitose, montagem do fuso e citocinese. As PLKs são críticas para a execução adequada do ciclo celular, e sua desregulação é frequentemente associada ao câncer. Inibir as PLKs pode induzir parada do ciclo celular e apoptose em células cancerígenas, tornando esses inibidores ferramentas importantes na pesquisa e terapia do câncer. Na CymitQuimica, oferecemos uma gama de inibidores de PLK de alta qualidade para apoiar sua pesquisa em mitose, controle do ciclo celular e oncologia.
Foram encontrados 25 produtos de "PLK"
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SP27
CAS:SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].Fórmula:C40H40F2N12O5Pureza:98%Cor e Forma:SolidPeso molecular:806.82RP-1664
CAS:RP-1664,PLK4 inhibitor (IC50=3 nM). Disrupts centriole biogenesis. Antitumor activity in breast cancer, neuroblastoma.Fórmula:C23H24F2N8O2SPureza:99.04%Cor e Forma:SoildPeso molecular:514.55PLK1-IN-12
PLK1-IN-12 is a highly selective, orally active PLK1 inhibitor with an IC50 of 20 nM. It demonstrates greater selectivity for PLK1 over PLK2 (IC50: >10000 nM) and PLK3 (IC50: 3953 nM). PLK1-IN-12 exhibits anticancer efficacy across a wide range of cell lines and is applicable to anti-leukemia research.Cor e Forma:Odour SolidPLK1-IN-14
PLK1-IN-14 (Compound Hit-4) is a selective PLK1 inhibitor with an IC50 of 22.61 pM for PLK1, and an IC50 of 0.09 nM for inhibiting the proliferation of DU-145 prostate cancer cells. It is applicable in prostate cancer research.Cor e Forma:Odour SolidPLK1 Protein, Mouse, Recombinant (His)
PLK1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:70.6 kDa (predicted); 65 kDa (reducing conditions)Poloxime
CAS:Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.Fórmula:C10H13NO2Pureza:98%Cor e Forma:SolidPeso molecular:179.22PLK1 Protein, Human, Recombinant (His)
PLK1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Pureza:96.8%Cor e Forma:Lyophilized PowderPeso molecular:70.5 kDa (predicted); 66 kDa (reducing conditions)5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS:5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.Fórmula:C8H13N3SPureza:99.03%Cor e Forma:SolidPeso molecular:183.27MLN0905
CAS:MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).Fórmula:C24H25F3N6SPureza:98% - 99.92%Cor e Forma:SolidPeso molecular:486.56GSK461364
CAS:GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.Fórmula:C27H28F3N5O2SPureza:99% - 99.73%Cor e Forma:SolidPeso molecular:543.6Ref: TM-T6282
1mg37,00€2mg52,00€5mg74,00€10mg124,00€25mg207,00€50mg374,00€100mg557,00€200mg797,00€500mg1.216,00€HMN-176
CAS:HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).Fórmula:C20H18N2O4SPureza:98.92% - 98.99%Cor e Forma:SolidPeso molecular:382.43Ref: TM-T3643
1mg43,00€2mg56,00€5mg88,00€10mg119,00€25mg188,00€50mg350,00€100mg522,00€500mg1.130,00€1mL*10mM (DMSO)79,00€(1E)-CFI-400437 dihydrochloride
CAS:(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.Fórmula:C29H30Cl2N6O2Pureza:97.08%Cor e Forma:SolidPeso molecular:565.5Ref: TM-T22288
1mg81,00€5mg169,00€10mg250,00€25mg416,00€50mg582,00€100mg825,00€1mL*10mM (DMSO)208,00€Poloxin
CAS:Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).Fórmula:C18H19NO3Pureza:99.19%Cor e Forma:SolidPeso molecular:297.35HMN-214
CAS:HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.Fórmula:C22H20N2O5SPureza:98% - >99.99%Cor e Forma:SolidPeso molecular:424.47Ref: TM-T2438
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg505,00€500mg1.121,00€1mL*10mM (DMSO)92,00€TAK-960
CAS:TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.Fórmula:C27H34F3N7O3Pureza:97.06%Cor e Forma:SolidPeso molecular:561.6Ref: TM-T7200
1mg64,00€2mg89,00€5mg120,00€10mg170,00€25mg294,00€50mg490,00€100mg710,00€1mL*10mM (DMSO)170,00€Ro3280
CAS:Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).Fórmula:C27H35F2N7O3Pureza:97.1% - >99.99%Cor e Forma:SolidPeso molecular:543.61Centrinone-B
CAS:Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative breast cancer.Fórmula:C27H27F2N7O5S2Pureza:98.71%Cor e Forma:SolidPeso molecular:631.67Cyclapolin 9
CAS:Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.Fórmula:C9H4F3N3O4SPureza:99.64%Cor e Forma:SolidPeso molecular:307.21Ref: TM-T22700
1mg92,00€5mg216,00€10mg338,00€25mg540,00€50mg747,00€100mg1.017,00€500mg2.043,00€1mL*10mM (DMSO)240,00€Poloxin-2
CAS:Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.Fórmula:C16H15NO3Pureza:99.67%Cor e Forma:SolidPeso molecular:269.3TC-S 7005
CAS:TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).Fórmula:C21H17N3O3Pureza:99.516%Cor e Forma:SolidPeso molecular:359.38Ref: TM-T17008
1mg57,00€2mg84,00€5mg125,00€10mg188,00€25mg354,00€50mg532,00€100mg712,00€500mgA consultar1mL*10mM (DMSO)138,00€
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