PLK
Os inibidores de quinases Polo-like (PLK) têm como alvo as PLKs, uma família de quinases serina/treonina essenciais para várias fases da divisão celular, incluindo entrada na mitose, montagem do fuso e citocinese. As PLKs são críticas para a execução adequada do ciclo celular, e sua desregulação é frequentemente associada ao câncer. Inibir as PLKs pode induzir parada do ciclo celular e apoptose em células cancerígenas, tornando esses inibidores ferramentas importantes na pesquisa e terapia do câncer. Na CymitQuimica, oferecemos uma gama de inibidores de PLK de alta qualidade para apoiar sua pesquisa em mitose, controle do ciclo celular e oncologia.
Foram encontrados 28 produtos de "PLK"
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Centrinone
CAS:<p>Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).</p>Fórmula:C26H25F2N7O6S2Pureza:98.76%Cor e Forma:SolidPeso molecular:633.65TTK/PLK1-IN-1
CAS:<p>TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.</p>Fórmula:C30H33N7O2Pureza:97.39%Cor e Forma:SolidPeso molecular:523.63RP-1664
CAS:<p>RP-1664,PLK4 inhibitor (IC50=3 nM). Disrupts centriole biogenesis. Antitumor activity in breast cancer, neuroblastoma.</p>Fórmula:C23H24F2N8O2SPureza:99.04%Cor e Forma:SoildPeso molecular:514.55PLK1-IN-12
<p>PLK1-IN-12 is a highly selective, orally active PLK1 inhibitor with an IC50 of 20 nM. It demonstrates greater selectivity for PLK1 over PLK2 (IC50: >10000 nM) and PLK3 (IC50: 3953 nM). PLK1-IN-12 exhibits anticancer efficacy across a wide range of cell lines and is applicable to anti-leukemia research.</p>Cor e Forma:Odour SolidPLK1-IN-14
<p>PLK1-IN-14 (Compound Hit-4) is a selective PLK1 inhibitor with an IC50 of 22.61 pM for PLK1, and an IC50 of 0.09 nM for inhibiting the proliferation of DU-145 prostate cancer cells. It is applicable in prostate cancer research.</p>Cor e Forma:Odour SolidSP27
<p>SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].</p>Fórmula:C40H40F2N12O5Pureza:98%Cor e Forma:SolidPeso molecular:806.82PLK1 Protein, Mouse, Recombinant (His)
<p>PLK1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:70.6 kDa (predicted); 65 kDa (reducing conditions)Poloxime
CAS:<p>Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.</p>Fórmula:C10H13NO2Pureza:98%Cor e Forma:SolidPeso molecular:179.22PLK1 Protein, Human, Recombinant (His)
<p>PLK1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.</p>Pureza:96.8%Cor e Forma:Lyophilized PowderPeso molecular:70.5 kDa (predicted); 66 kDa (reducing conditions)5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS:<p>5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.</p>Fórmula:C8H13N3SPureza:99.03%Cor e Forma:SolidPeso molecular:183.27Poloxin
CAS:<p>Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).</p>Fórmula:C18H19NO3Pureza:99.19%Cor e Forma:SolidPeso molecular:297.35HMN-214
CAS:<p>HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.</p>Fórmula:C22H20N2O5SPureza:98% - >99.99%Cor e Forma:SolidPeso molecular:424.47TAK-960
CAS:<p>TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.</p>Fórmula:C27H34F3N7O3Pureza:97.06%Cor e Forma:SolidPeso molecular:561.6Ro3280
CAS:<p>Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).</p>Fórmula:C27H35F2N7O3Pureza:97.1% - >99.99%Cor e Forma:SolidPeso molecular:543.61GSK461364
CAS:<p>GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.</p>Fórmula:C27H28F3N5O2SPureza:99% - 99.73%Cor e Forma:SolidPeso molecular:543.6MLN0905
CAS:<p>MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).</p>Fórmula:C24H25F3N6SPureza:97.17% - 98%Cor e Forma:SolidPeso molecular:486.56(1E)-CFI-400437 dihydrochloride
CAS:<p>(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.</p>Fórmula:C29H30Cl2N6O2Pureza:97.08%Cor e Forma:SolidPeso molecular:565.5HMN-176
CAS:<p>HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).</p>Fórmula:C20H18N2O4SPureza:98.92% - 98.99%Cor e Forma:SolidPeso molecular:382.43Ocifisertib(CFI-400945 free base)
CAS:<p>Ocifisertib (CFI-400945 free base) is a potent, selective and orally active inhibitor of polo-like kinase 4.Cost-effective and quality-assured.</p>Fórmula:C33H34N4O3Pureza:98.53% - 99.04%Cor e Forma:SolidPeso molecular:534.65Cyclapolin 9
CAS:<p>Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.</p>Fórmula:C9H4F3N3O4SPureza:99.5%Cor e Forma:SolidPeso molecular:307.21
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