DYRK
Os inibidores de DYRK (quinase regulada por fosforilação de tirosina de dupla especificidade) são compostos que têm como alvo a família de quinasas DYRK, que estão envolvidas na regulação do ciclo celular, no desenvolvimento neuronal e na apoptose. As quinasas DYRK têm dupla especificidade, o que significa que podem fosforilar resíduos de tirosina e serina/treonina. Inibir as quinasas DYRK pode afetar vários processos celulares, incluindo a progressão do ciclo celular e a diferenciação. Os inibidores de DYRK são ferramentas importantes na pesquisa sobre câncer, doenças neurodegenerativas e sinalização celular. Na CymitQuimica, oferecemos uma seleção de inibidores de DYRK de alta qualidade para apoiar sua pesquisa no controle do ciclo celular, neurobiologia e desenvolvimento terapêutico.
Foram encontrados 47 produtos para "DYRK".
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GSK-626616
CAS:GSK-626616: strong, oral DYRK3 inhibitor (IC50: 0.7 nM), affects DYRK family, may treat anemia.Fórmula:C18H10Cl2N4OSPureza:98.27%Cor e Forma:SolidPeso molecular:401.27AZ-Dyrk1B-33
CAS:AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.Fórmula:C19H16N4Pureza:99.91%Cor e Forma:SolidPeso molecular:300.36Ref: TM-T14364
1mg44,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg147,00€25mg289,00€50mg419,00€100mg583,00€200mg787,00€BT173
CAS:BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.Fórmula:C18H12BrN3O2Pureza:98.24%Cor e Forma:SolidPeso molecular:382.21GNF2133
CAS:GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.Fórmula:C24H30N6O2Pureza:98.51%Cor e Forma:SolidPeso molecular:434.53Ref: TM-T40187
1mg123,00€5mg295,00€1mL*10mM (DMSO)339,00€10mg447,00€25mg745,00€50mg1.108,00€100mg1.558,00€KTD-092
KTD-092, a DYRK1A inhibitor, exhibits an IC50 of 22 nM against human DYRK1A. It is applicable in research related to Down syndrome (DS), Alzheimer's disease (AD), autism spectrum disorder (ASD), diabetes, and other neurodegenerative diseases.Dyrk1A-IN-7
Dyrk1A-IN-7 (Compound 29) is a selective DYRK1A kinase inhibitor with notable kinase selectivity, exhibiting an IC50 value of 28 nM for DYRK1A and a Kd of 17.5 nM for CLK2. This selective inhibitor is applicable in research related to cancer, type II diabetes, and neurological disorders.Fórmula:C19H13F3N4OCor e Forma:SolidPeso molecular:370.10415DYR684
CAS:DYR684 is a PROTAC designed to target the protein kinase DYRK1A, promoting its rapid, efficient, potent, and selective degradation in cellular assays.Fórmula:C58H58FN15O5Cor e Forma:SolidPeso molecular:1064.18Mirk-IN-1
CAS:Mirk-IN-1 is an effective inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A (IC50: 68±48 nM and 22±8 nM respectively).Fórmula:C23H17Cl2N5O4Pureza:98%Cor e Forma:SolidPeso molecular:498.32Protein kinase inhibitors 1 hydrochloride
CAS:Protein Kinase Inhibitors 1 Hydrochloride effectively inhibits HIPK2, demonstrating high potency with IC50 values of 136 nM for HIPK1 and 74 nM for HIPK2,Fórmula:C18H18ClN5O3SCor e Forma:SolidPeso molecular:419.88LDN-192960
CAS:LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).Fórmula:C18H20N2O2SPureza:99.01% - 99.51%Cor e Forma:Yellow SolidPeso molecular:328.43Ref: TM-TQ0111
1mg49,00€2mg64,00€5mg92,00€1mL*10mM (DMSO)104,00€10mg152,00€25mg295,00€50mg477,00€100mg763,00€200mg1.018,00€Harmine
CAS:Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.Fórmula:C13H12N2OPureza:98.29% - 99.92%Cor e Forma:White SolidPeso molecular:212.25Protein kinase inhibitors 1
CAS:Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.Fórmula:C18H17N5O3SPureza:98%Cor e Forma:SolidPeso molecular:383.42GNF4877
CAS:GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.Fórmula:C25H27FN6O4Pureza:98.68% - 99.40%Cor e Forma:SolidPeso molecular:494.52Harmine hydrochloride
CAS:Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.Fórmula:C13H13ClN2OPureza:99.61% - >99.99%Cor e Forma:Yellow SolidPeso molecular:248.71LDN-192960 hydrochloride
CAS:LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively.Fórmula:C18H22Cl2N2O2SPureza:98%Cor e Forma:SolidPeso molecular:401.35AZ191
CAS:AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor.Fórmula:C24H27N7OPureza:98.04% - 99.65%Cor e Forma:SolidPeso molecular:429.52ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Fórmula:C10H12N6OPureza:99.69%Cor e Forma:White SolidPeso molecular:232.24GNF2133 hydrochloride
CAS:GNF2133 hydrochloride: selective oral DYRK1A inhibitor (IC50: 0.0062 μM), boosts β-cell growth and insulin, potential for type 1 diabetes research.Fórmula:C24H31ClN6O2Cor e Forma:SolidPeso molecular:471.02-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi
CAS:2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine serves as an intermediate.Fórmula:C6H6N4OPureza:99.21% - 99.39%Cor e Forma:SolidPeso molecular:150.14ID-8
CAS:ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.Fórmula:C16H14N2O4Pureza:99.32%Cor e Forma:White SolidPeso molecular:298.29JH-XIV-68-3
CAS:JH-XIV-68-3: Selective DYRK1A/B inhibitor; effective in HNSCC cell lines.Fórmula:C21H17F3N8OCor e Forma:SolidPeso molecular:454.41Dyrk1A-IN-5
CAS:Potent DYRK1A inhibitor with IC50s: 6 nM overall, 0.5 μM SF3B1, 2.1 μM tau phosphorylation. Useful for Down syndrome studies.Fórmula:C16H9IN2O2Cor e Forma:SolidPeso molecular:388.16AnnH31
CAS:AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm theFórmula:C15H13N3OPureza:99.99%Cor e Forma:Yellow SolidPeso molecular:251.28Dyrk1A-IN-3
CAS:Dyrk1A-IN-3 is a selective DYRK1A inhibitor with an IC50 of 76 nM, useful for neurodegenerative disease research.Fórmula:C18H16N6Cor e Forma:SolidPeso molecular:316.36tBID
CAS:tBID is a selective homeodomain-interacting protein kinase 2 (HIPK2) inhibitor (IC50 of 0.33 μM)Fórmula:C11H3Br4N3O2Pureza:98%Cor e Forma:SolidPeso molecular:528.78DYRKi
CAS:DYRKi is a nontoxic, DYRK1-selective inhibitor.Fórmula:C20H13F3N4O2SCor e Forma:SolidPeso molecular:430.4FINDY
CAS:FINDY selectively inhibits DYRK1A at 35 μM IC50, blocking Ser97 autophosphorylation, useful for neurological disorder research.Fórmula:C16H17NO2S2SiCor e Forma:SolidPeso molecular:347.53CLK-IN-T3
CAS:CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.Fórmula:C28H30N6O2Pureza:99.61%Cor e Forma:SolidPeso molecular:482.58Ref: TM-T14980
1mg47,00€2mg62,00€5mg92,00€10mg160,00€25mg289,00€50mg505,00€100mg787,00€200mg1.063,00€INDY
CAS:INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.Fórmula:C12H13NO2SPureza:99.26%Cor e Forma:Green SolidPeso molecular:235.3YK-2-69
CAS:YK-2-69 selectively blocks DYRK2 at Lys-231 and Lys-234, outperforming enzalutamide in prostate cancer treatment.Fórmula:C25H27FN8OSPureza:99.03% - 99.64%Cor e Forma:SolidPeso molecular:506.6ARN25068
CAS:ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.Fórmula:C19H18N6SPureza:99.75%Cor e Forma:SolidPeso molecular:362.45ProINDY
CAS:ProINDY (Pro-indy) is a potent DYRK inhibitor that activates NFAT for the study of Down syndrome.Fórmula:C14H15NO3SPureza:97.19%Cor e Forma:Yellow SolidPeso molecular:277.34DYRKs-IN-2
CAS:DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.Fórmula:C32H38ClN9O3Pureza:98%Cor e Forma:SolidPeso molecular:632.16Norharmine
CAS:Norharmine is an analogue of harman and functions as an alkaloid. It serves as an inhibitor of both monoamine oxidase A (MAO-A) and DYRK1A. While it exhibits weak inhibitory activity against MAO-A, it has certain inhibitory effects on DYRK1A.Fórmula:C12H10N2OCor e Forma:SolidPeso molecular:198.221DYRK1-IN-1
CAS:DYRK1-IN-1: Selective DYRK1A inhibitor with IC50 of 220 nM, good permeability, CNS penetrant for research, no P-glycoprotein issues.Fórmula:C12H12N6Cor e Forma:SolidPeso molecular:240.26Dyrk1A/α-synuclein-IN-2
Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM).Fórmula:C21H16N4O4SCor e Forma:SolidPeso molecular:420.44DYRKs-IN-1 hydrochloride
CAS:DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) & DYRK1B (8 nM IC50) with antitumor properties.Fórmula:C30H31Cl2N7O4Cor e Forma:SolidPeso molecular:624.52Dyrk1A-IN-2
Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.Fórmula:C27H32N6O4Cor e Forma:SolidPeso molecular:504.58Dyrk1A-IN-4
CAS:Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.Fórmula:C14H13F3N6Cor e Forma:SolidPeso molecular:322.29Dyrk1A/α-synuclein-IN-1
Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM).Fórmula:C20H21N5O3SCor e Forma:SolidPeso molecular:411.48DYRKs-IN-1
CAS:DYRKs-IN-1 has antitumor activity.Fórmula:C30H30ClN7O4Pureza:98%Cor e Forma:SolidPeso molecular:588.06Dyrk1A-IN-8
CAS:Dyrk1A-IN-8 is an active molecule that can be used in life science related research. The CAS number of Dyrk1A-IN-8 is 101578-13-6.Fórmula:C17H21N3OCor e Forma:SolidPeso molecular:283.37DYR530
CAS:DYR530 is a ligand for the target protein (protein kinase DYRK1A) of PROTAC.Fórmula:C23H24FN7Cor e Forma:SolidPeso molecular:417.48Dyrk1A-IN-11
CAS:Dyrk1A-IN-11 (compound 166) is an effective inhibitor targeting dual-specificity tyrosine phosphorylation-regulated 1A (DYRK1A) with an EC50 of 0.0021 µM. Additionally, this compound inhibits the phosphorylation of Tau (Thr212) with an EC50 of 0.0361 µM.Fórmula:C23H23F5N8OCor e Forma:SolidPeso molecular:522.47Dyrk1A-IN-12
CAS:Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).Fórmula:C22H16FN3O2SCor e Forma:SolidPeso molecular:405.445Dyrk1A-IN-1
Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity, aggregation of tau and α-syn oligomers, with an IC50 value of 119 nM for Dyrk1A kinase.Fórmula:C23H20N4O3SCor e Forma:SolidPeso molecular:432.49Dyrk1A/B-IN-1
Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.Fórmula:C21H17N3O2S2Cor e Forma:SolidPeso molecular:407.51
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