PKC
Os inibidores de PKC (Proteína Cinase C) têm como alvo a família de cinases serina/treonina PKC, que estão envolvidas em uma ampla gama de processos celulares, incluindo regulação do ciclo celular, apoptose e diferenciação. A PKC desempenha um papel crucial nas vias de transdução de sinais que influenciam a proliferação e sobrevivência celular. Inibir a PKC pode levar a alterações na progressão do ciclo celular, tornando esses inibidores valiosos na pesquisa relacionada ao câncer, neurobiologia e doenças cardiovasculares. Na CymitQuimica, oferecemos uma seleção diversificada de inibidores de PKC de alta qualidade para apoiar sua pesquisa em transdução de sinais, regulação do ciclo celular e desenvolvimento terapêutico.
Foram encontrados 126 produtos de "PKC"
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Aurothiomalate tetramer sodium
Aurothiomalate tetramer sodium, a tetrameric form of Aurothiomalate sodium, functions as an anti-arthritis gold agent. It also acts as a potent and selective inhibitor of the oncogenic PKCι signaling pathway.Cor e Forma:Odour SolidPKCδ Peptide Substrate
CAS:PKCδ Peptide Substrate is a highly specific substrate for the δ-type of Protein kinase C, composed of a sequence that mirrors murine eEF-1α (422-443) andFórmula:C109H191N35O29SCor e Forma:SolidPeso molecular:2487.97Protein kinase C α peptide TFA
CAS:Protein Kinase C (alpha) Peptide (TFA) is a PKC-α-associated peptide functioning as a lipid-dependent serine/threonine protein kinase.Fórmula:C68H115F3N24O26SCor e Forma:SolidPeso molecular:1773.85NPC-15437 dihydrochloride
CAS:NPC-15437 dihydrochloride is a PKC inhibitor blocking enzyme activity and phorbol ester binding, selective over other kinases, in cellular signaling research.Fórmula:C25H52Cl2N4O2Cor e Forma:SolidPeso molecular:511.62K-252b
CAS:K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor.
Fórmula:C26H19N3O5Pureza:98%Cor e Forma:Ready-To-Use SolutionPeso molecular:453.45(±)-1,2-Diolein
CAS:(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.Fórmula:C39H72O5Cor e Forma:SolidPeso molecular:620.99PKC-θ inhibitor
CAS:PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.Fórmula:C20H25F3N6O3Pureza:99.46%Cor e Forma:SolidPeso molecular:454.45Ref: TM-T5423
1mg101,00€5mg236,00€10mg313,00€25mg442,00€50mg580,00€100mg893,00€200mg1.198,00€1mL*10mM (DMSO)259,00€Protein kinase inhibitor H-7 dihydrochloride
CAS:Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor.Fórmula:C14H19Cl2N3O2SPureza:99.81%Cor e Forma:White Crystalline SolidPeso molecular:364.29PKC ζ pseudosubstrate acetate
PKC ζ pseudosubstrate acetate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide.Fórmula:C78H132N30O18Pureza:98.78%Cor e Forma:SolidPeso molecular:1778.10PKC-iota inhibitor 1
CAS:PKC-iota inhibitor 1 is an inhibitor of protein kinase C-iota (PKC-ι ; IC50 : 0.34 μM)Fórmula:C21H22N6OPureza:98.82%Cor e Forma:SolidPeso molecular:374.44Ref: TM-T8764
1mg107,00€2mg152,00€5mg219,00€10mg349,00€25mg583,00€50mg833,00€100mg1.134,00€500mg2.268,00€1mL*10mM (DMSO)226,00€Taurochenodeoxycholic Acid
CAS:Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.Fórmula:C26H45NO6SPureza:99.53% - 99.86%Cor e Forma:SolidPeso molecular:499.7Valrubicin
CAS:Valrubicin (AD-32) (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.Fórmula:C34H36F3NO13Pureza:98.63%Cor e Forma:SolidPeso molecular:723.64Go 6983
CAS:Go 6983 is a PKC inhibitor with IC50 values of 7, 7, 6, 10, and 60 nM for PKCα, PKCβ, PKCγ, PKCδ, and PKCζ, respectively. High-Quality, Low-Cost!Fórmula:C26H26N4O3Pureza:98.41% - 99.85%Cor e Forma:SolidPeso molecular:442.51Ref: TM-T6313
1mg40,00€2mg52,00€5mg79,00€10mg119,00€25mg233,00€50mg368,00€100mg533,00€1mL*10mM (DMSO)84,00€Darovasertib
CAS:Darovasertib (LXS196) is a potent PKC inhibitor, orally active, with IC50 of 1.9 nM (PKCα), 0.4 nM (PKCθ), 3.1 μM (GSK3β).Fórmula:C22H23F3N8OPureza:98.72% - ≥95%Cor e Forma:SolidPeso molecular:472.47Taurochenodeoxycholic acid sodium
CAS:Sodium taurochenodeoxycholate: induces apoptosis, anti-inflammatory, boosts insulin, stimulates α2-cells, increases [Ca(2+)](c).Fórmula:C26H44NNaO6SPureza:98.23% - 99.56%Cor e Forma:White To Off-White PowderPeso molecular:521.68Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Fórmula:C14H18ClN3O2SPureza:99.54% - ≥95%Cor e Forma:White SolidPeso molecular:327.83Verbascoside
CAS:Verbascoside (Kusaginin) is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.Fórmula:C29H36O15Pureza:97.46% - 99.55%Cor e Forma:SolidPeso molecular:624.59Ref: TM-T3375
2mg39,00€5mg58,00€10mg88,00€25mg168,00€50mg255,00€100mg359,00€200mg525,00€1mL*10mM (DMSO)81,00€Phorbol 12-myristate 13-acetate
CAS:Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.Fórmula:C36H56O8Pureza:98.55% - >99.99%Cor e Forma:White To Off-White SolidPeso molecular:616.83Afuresertib hydrochloride
CAS:Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
Fórmula:C18H18Cl3FN4OSPureza:99.96%Cor e Forma:SolidPeso molecular:463.8TAS-301
CAS:TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries.Fórmula:C23H19NO3Pureza:99.55%Cor e Forma:SolidPeso molecular:357.4Midostaurin
CAS:PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.Fórmula:C35H30N4O4Pureza:97.61% - >99.99%Cor e Forma:SolidPeso molecular:570.64Ref: TM-T3211
1mg49,00€5mg84,00€10mg119,00€25mg205,00€50mg310,00€100mg462,00€500mg1.035,00€1mL*10mM (DMSO)90,00€Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),
Fórmula:C9H6O4Pureza:97.47% - 99.8%Cor e Forma:SolidPeso molecular:178.14Sotrastaurin
CAS:Sotrastaurin (AEB071) is a potent pan-PKC inhibitor (Kis: 0.95/0.64/2.1/3.2/1.8/0.22 nM for PKCα/βI/δ/ε/η/θ).Fórmula:C25H22N6O2Pureza:98% - 99.70%Cor e Forma:SolidPeso molecular:438.48Ref: TM-T6278
1mg44,00€5mg86,00€10mg135,00€25mg254,00€50mg423,00€100mg605,00€200mg845,00€1mL*10mM (DMSO)94,00€Decursin
CAS:Decursin: potential antiepileptic, hepatoprotective, anti-cancer, anti-amnesic; affects NOX activation, PKCα/MAPK/NF-κB pathways, AChE.Fórmula:C19H20O5Pureza:97.22% - 99.91%Cor e Forma:SolidPeso molecular:328.36Ref: TM-T3S1416
1mg40,00€5mg84,00€10mg113,00€25mg245,00€50mg439,00€100mg627,00€500mg1.288,00€1mL*10mM (DMSO)93,00€Ζ-Stat
CAS:ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis inFórmula:C10H8O10S3Pureza:99.85%Cor e Forma:SolidPeso molecular:384.36Chelerythrine chloride
CAS:Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect toFórmula:C21H18ClNO4Pureza:95% - 99.19%Cor e Forma:Yellow To Orange SolidPeso molecular:383.83Ref: TM-T3419
2mg34,00€5mg50,00€10mg84,00€25mg145,00€50mg205,00€100mg289,00€200mg432,00€1mL*10mM (DMSO)65,00€R59949
CAS:R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.Fórmula:C28H25F2N3OSPureza:97.04%Cor e Forma:SolidPeso molecular:489.58Ref: TM-T26019
1mg39,00€2mg52,00€5mg87,00€10mg138,00€25mg281,00€50mg425,00€100mg625,00€200mg883,00€1mL*10mM (DMSO)95,00€Taurolithocholic acid sodium salt
CAS:Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, butFórmula:C26H44NNaO5SPureza:99.79% - 99.93%Cor e Forma:SolidPeso molecular:505.69Desmethylglycitein
CAS:Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which hasFórmula:C15H10O5Pureza:97.93%Cor e Forma:SolidPeso molecular:270.24Hypocrellin A
CAS:Hypocrellin A is a natural PKC inhibitor with light-induced antitumor, antifungal and antiviral activities.Cost-effective and quality-assured.Fórmula:C30H26O10Pureza:98% - 99.95%Cor e Forma:SolidPeso molecular:546.52Bisindolylmaleimide V
CAS:Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor.Fórmula:C21H15N3O2Pureza:90%Cor e Forma:Red SolidPeso molecular:341.36Staurosporine
CAS:Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFórmula:C28H26N4O3Pureza:99.24% - 99.82%Cor e Forma:Off-White PowderPeso molecular:466.53Ref: TM-T6680
1mg58,00€2mg82,00€5mg92,00€10mg138,00€25mg234,00€50mg380,00€100mg565,00€500mg1.215,00€1mL*10mM (DMSO)103,00€1,2-Dimyristoyl-sn-glycerol
CAS:1,2-Dimyristoyl-sn-glycerol (1,2-DMG) is able to increase AChE activity by 35-40% at concentrations of 25 micrograms/ml in the parasite S. mansoni..Fórmula:C31H60O5Pureza:99.96%Cor e Forma:White Powder With LumpsPeso molecular:512.81Hispidin
CAS:Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective propertiesFórmula:C13H10O5Pureza:98.27%Cor e Forma:White Crystalline PowderPeso molecular:246.22Ref: TM-T7792
1mg88,00€5mg187,00€10mg298,00€25mg533,00€50mg747,00€100mg1.017,00€1mL*10mM (DMSO)207,00€[Ala107]-MBP (104-118) acetate
[Ala107]-MBP (104-118) acetate ([Ala107]-MBP ) is synthetic peptide analog of bovine myelin basic protein (MBP).Fórmula:C59H108N20O21Pureza:99.23%Cor e Forma:SolidPeso molecular:1553.72HA-100
CAS:HA-100 is an inhibitor of protein kinaseFórmula:C13H15N3O2SPureza:99.44%Cor e Forma:Pale Yellow Crystalline SolidPeso molecular:277.34Bisindolylmaleimide I
CAS:Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.Fórmula:C25H24N4O2Pureza:97.51% - 98.75%Cor e Forma:Orange SolidPeso molecular:412.48Mitoxantrone
CAS:Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.Fórmula:C22H28N4O6Pureza:96.29% - 98.74%Cor e Forma:Blue PowderPeso molecular:444.48PKC-θ inhibitor hcl
CAS:PKC-theta inhibitor hcl is a selective PKC-θinhibitor(IC50:12 nM).Fórmula:C20H26ClF3N6O3Pureza:98.93%Cor e Forma:SolidPeso molecular:490.91Ref: TM-T5817
1mg88,00€2mg114,00€5mg220,00€10mg356,00€25mg595,00€50mg848,00€100mg1.153,00€500mg2.305,00€N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine
CAS:Novel 2,6-naphthyridine inhibits PKC/PKD, identified by HTS.Fórmula:C23H28N6Pureza:98.35%Cor e Forma:SolidPeso molecular:388.51Pep2m, myristoylated acetate
Pep2m, a myristoylated acetate, inhibits GluA2-NSF interaction, reducing AMPA receptor function and expression in neurons.Fórmula:C65H122N18O16SPureza:99.62%Cor e Forma:SolidPeso molecular:1443.96Aurothiomalate sodium
CAS:Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.Fórmula:C4H3AuNa2O4SPureza:99.66%Cor e Forma:SoildPeso molecular:390.07Decursinol angelate
CAS:Decursinol angelate is anti-tumor, anti-inflammatory, anti-oxidant, hepatoprotective, and inhibits VEGF and cancer cell invasion.Fórmula:C19H20O5Pureza:99.93%Cor e Forma:SolidPeso molecular:328.36Rottlerin
CAS:Rottlerin (NSC-56346), a Mallotus Philippinensis extract, inhibits PKC (3-100 μM IC50); triggers apoptosis by activating caspase 3.Fórmula:C30H28O8Pureza:97.41% - 99.44%Cor e Forma:Orange To Brown PowderPeso molecular:516.54D-ERYTHRO-SPHINGOSINE
CAS:D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activatorFórmula:C18H37NO2Pureza:98% - 99.85%Cor e Forma:SolidPeso molecular:299.49Procyanidin A1
CAS:Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+.Fórmula:C30H24O12Pureza:99.52%Cor e Forma:SolidPeso molecular:576.50Afuresertib
CAS:Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplasticFórmula:C18H17Cl2FN4OSPureza:97.51% - 99.51%Cor e Forma:SolidPeso molecular:427.32Ref: TM-T1911
1mg37,00€2mg52,00€5mg74,00€10mg92,00€25mg166,00€50mg259,00€100mg452,00€500mg982,00€1mL*10mM (DMSO)74,00€Bisindolylmaleimide IV
CAS:Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)
Fórmula:C20H13N3O2Pureza:98.83%Cor e Forma:Dark Red SolidPeso molecular:327.34
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