HSP
Os inibidores de proteínas de choque térmico (HSP) têm como alvo as HSPs, uma família de chaperonas moleculares que auxiliam no dobramento de proteínas, estabilidade e proteção contra danos induzidos por estresse. As HSPs são frequentemente superexpressas em células cancerígenas, ajudando-as a sobreviver em condições estressantes, como hipóxia e quimioterapia. Inibir as HSPs pode interromper esses mecanismos de proteção, levando à morte celular. Portanto, os inibidores de HSP são valiosos na terapia contra o câncer e na pesquisa de respostas ao estresse. Na CymitQuimica, oferecemos uma gama abrangente de inibidores de HSP de alta qualidade para apoiar sua pesquisa em homeostase de proteínas, respostas ao estresse e oncologia.
Foram encontrados 200 produtos para "HSP".
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GRP78-IN-3
CAS:GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.Fórmula:C17H18N4O2SPureza:99.49%Cor e Forma:SolidPeso molecular:342.415Ethoxyquin
CAS:Produto ControladoEthoxyquin (Santoflex) is an antioxidant used in animal feeds.Fórmula:C14H19NOPureza:97.15% - 98.73%Cor e Forma:Yellow LiquidPeso molecular:217.3068IPI-493
CAS:IPI-493 is a bioactive chemical.Fórmula:C28H39N3O8Pureza:99.86%Cor e Forma:SolidPeso molecular:545.62Novobiocin Sodium
CAS:Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.Fórmula:C31H35N2NaO11Pureza:98.46% - 99.51%Cor e Forma:SolidPeso molecular:634.6062CC-99677
CAS:CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.Fórmula:C22H20ClN5O3SPureza:99.59%Cor e Forma:SolidPeso molecular:469.944Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Fórmula:C18H24ClN3O7Pureza:99.44% - 99.98%Cor e Forma:SolidPeso molecular:429.852Col003
CAS:Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).Fórmula:C14H11NO4Pureza:99.03% - 99.96%Cor e Forma:SolidPeso molecular:257.2414Palmitic acid-13C2
CAS:13C-labeled Palmitic acid is a saturated fatty acid in animals/plants influencing GRP78 and CHOP in mouse cells.Fórmula:C16H32O2Peso molecular:258.415Palmitic acid-D4
CAS:Palmitic acid-D4 is the deuterated form of Palmitic acid. This compound is a long-chain saturated fatty acid commonly found in animals and plants. Palmitic acid (T2908) is known to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) in murine granulosa cells.Fórmula:C16H32O2Peso molecular:260.45trans-Dehydrocurvularin
CAS:trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.Fórmula:C16H18O5Cor e Forma:SolidPeso molecular:290.315Grp94-IN-3
Grp94-IN-3 (Compound 47) is a selective Grp94 ATP-competitive inhibitor with a dissociation constant (Kd) of 76 nM. It exhibits significantly lower affinity for Hsp90α, with a Kd of 9.17 μM. Grp94-IN-3 induces degradation of Integrin α2 (Integrinα2) in MDA-MB-231 cells and reduces intracellular accumulation of mutant myocilin in human trabecular meshwork cells. This compound is useful in research on metastatic cancers and open-angle glaucoma.Grp94 Inhibitor-2
Grp94 Inhibitor-2 (compound 23) is a cyclopropane analog that exhibits high affinity for Glucose Regulated Protein 94 (Grp94), with dissociation constants (Kd) of 0.48 µM for Grp94 and 0.65 µM for Hsp90α.Fórmula:C26H25ClFNO4Peso molecular:469.94NMS-E973
CAS:NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Fórmula:C22H22N4O7Pureza:99.84%Cor e Forma:Yellow SolidPeso molecular:454.4327TBPH
TBPH exacerbates liver steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It induces phospholipid metabolism disorders, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH causes lung injury through mitochondrial-derived ds-DNA-mediated inflammatory responses. TBPH is utilized to study the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.Palmitic acid-13C sodium
CAS:13C-labeled Palmitic acid, a common long-chain fatty acid in flora/fauna, induces GRP78/CHOP in mouse cells.Fórmula:CC15H31NaO2Peso molecular:279.4HEMTAC WEE1 degrader-1
CAS:HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.Fórmula:C57H71N15O6Cor e Forma:SolidPeso molecular:1062.27Shepherdin (79-87)
CAS:Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.Fórmula:C41H64N12O12SPureza:98%Cor e Forma:SolidPeso molecular:949.09[Au(TPP)]Cl
CAS:[Au(TPP)]Cl inhibits the refolding activity of the Hsp60-Hsp10 complex and exhibits anticancer properties.'Fórmula:C44H28AuClN4Peso molecular:845.14Hsp90β-IN-2
Hsp90β-IN-2 (Compound 16B) is a selective inhibitor of Hsp90β, with dissociation constants (KD) of 225 nM for Hsp90β and 73.32 μM for Hsp90α. KUNB106 exhibits antiproliferative activity against MDA-MB-231, A549, and SKOV-3 cells, and is applicable in research on triple-negative breast cancer.JD-13
CAS:JD-13 is a selective GPR119 agonist; promotes insulin and GLP-1 release; glucose homeostasis; diabetes research tool.Fórmula:C25H32N4O3Pureza:99.32% - 99.69%Cor e Forma:White SolidPeso molecular:436.56
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