HSP
Os inibidores de proteínas de choque térmico (HSP) têm como alvo as HSPs, uma família de chaperonas moleculares que auxiliam no dobramento de proteínas, estabilidade e proteção contra danos induzidos por estresse. As HSPs são frequentemente superexpressas em células cancerígenas, ajudando-as a sobreviver em condições estressantes, como hipóxia e quimioterapia. Inibir as HSPs pode interromper esses mecanismos de proteção, levando à morte celular. Portanto, os inibidores de HSP são valiosos na terapia contra o câncer e na pesquisa de respostas ao estresse. Na CymitQuimica, oferecemos uma gama abrangente de inibidores de HSP de alta qualidade para apoiar sua pesquisa em homeostase de proteínas, respostas ao estresse e oncologia.
Foram encontrados 169 produtos de "HSP"
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Novobiocin Sodium
CAS:<p>Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.</p>Fórmula:C31H35N2NaO11Pureza:99% - 99.28%Cor e Forma:SolidPeso molecular:634.61CC-99677
CAS:<p>CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.</p>Fórmula:C22H20ClN5O3SPureza:99.59%Cor e Forma:SolidPeso molecular:469.94IPI-493
CAS:<p>IPI-493 is a bioactive chemical.</p>Fórmula:C28H39N3O8Pureza:>99.99%Cor e Forma:SolidPeso molecular:545.62Arimoclomol maleate
CAS:<p>Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.</p>Fórmula:C18H24ClN3O7Pureza:99.44% - 99.98%Cor e Forma:SolidPeso molecular:429.85Ethoxyquin
CAS:<p>Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.</p>Fórmula:C14H19NOPureza:97.15% - 98.73%Cor e Forma:Yellow Liquid Mercaptan-Like Odor (Ntp 1992)Peso molecular:217.31GRP78-IN-3
CAS:<p>GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.</p>Fórmula:C17H18N4O2SPureza:99.11%Cor e Forma:SoildPeso molecular:342.42Rifabutin
CAS:<p>Rifabutin (LM-427), a semisynthetic ansamycin, blocks bacterial RNA synthesis by inhibiting RNA polymerase.</p>Fórmula:C46H62N4O11Pureza:98.87% - 99.7%Cor e Forma:Red-Violet Crystalline PowderPeso molecular:847Col003
CAS:<p>Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).</p>Fórmula:C14H11NO4Pureza:98.67% - 99.03%Cor e Forma:SolidPeso molecular:257.24PROTAC Hsp90α degrader 1
<p>Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research.</p>Fórmula:C43H50N6O7Pureza:98%Cor e Forma:SolidPeso molecular:762.89DN401
CAS:<p>DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.</p>Fórmula:C13H9BrClN5O2Pureza:99.63%Cor e Forma:SolidPeso molecular:382.6NDNA4
<p>NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability.</p>Fórmula:C31H35F3N2O5SPureza:98%Cor e Forma:SolidPeso molecular:604.68Zelavespib hydrochloride
<p>Zelavespib (PU-H71) hydrochloride is a potent inhibitor of Hsp90, exhibiting an IC50 value of 51 nM in MDA-MB-468 cells.</p>Pureza:98%Cor e Forma:Odour SolidTRAP1-IN-2
CAS:<p>TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients.</p>Fórmula:C46H42F6N2O5P2Pureza:98%Cor e Forma:SolidPeso molecular:878.77HSP90-IN-23
<p>HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM.</p>Fórmula:C22H24N2O6SPureza:98%Cor e Forma:SolidPeso molecular:444.5PROTAC HSP90 degrader BP3
CAS:<p>PROTAC BP3 selectively degrades HSP90, inhibits breast cancer growth (DC50=0.99µM), CRBN-dependent.</p>Fórmula:C32H29ClN8O5Cor e Forma:SolidPeso molecular:641.08NPX800
CAS:<p>NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.</p>Fórmula:C32H32FN5O4Pureza:99.29%Cor e Forma:SolidPeso molecular:569.63MPC-0767
CAS:<p>MPC-0767, a potent, selective, and orally active hsp90 inhibitor, is the L-alanine ester prodrug of MPC-3100, exhibiting enhanced chemical stability.</p>Fórmula:C26H36BrN7O9S2Cor e Forma:SolidPeso molecular:734.64HS-27
CAS:<p>HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC.</p>Fórmula:C52H60N6O12SPureza:97.09%Cor e Forma:SolidPeso molecular:993.13MAL3-101
CAS:<p>MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).</p>Fórmula:C54H66N4O10Cor e Forma:SolidPeso molecular:931.12Hsp90-IN-36
<p>Hsp90-IN-36 (compound 5) is an Hsp90 inhibitor with anticancer properties and exhibits an IC50 value of 14.74 μM against MCF-7 cells.</p>Fórmula:C20H13F4N3O4Cor e Forma:SolidPeso molecular:435.328Hsp110-STAT3 interaction-IN-2
<p>Hsp110-STAT3 interaction-IN-2 (compound 10b) is an inhibitor of the Hsp110-STAT3 interaction. It is utilized in research related to pulmonary arterial hypertension (PAH).</p>Fórmula:C24H18F3N5O3Cor e Forma:SolidPeso molecular:481.43HSP90-IN-35
CAS:<p>HSP90-IN-35 is an inhibitor targeting Hsp90, exhibiting anticancer activity. It demonstrates an IC50 ranging from 0.05 to 0.5 μM against Her2. Additionally, HSP90-IN-35 can be utilized in the synthesis of PROTAC.</p>Fórmula:C27H33N5O5Cor e Forma:SolidPeso molecular:507.58p5 Ligand for Dnak and DnaJ
CAS:<p>P5 is a nonapeptide ligand for DnaK/DnaJ, mimicking the key sites of mitochondrial aspartate aminotransferase presequence.</p>Fórmula:C44H81N15O11SPureza:98%Cor e Forma:SolidPeso molecular:1028.27Arimoclomol citrate
CAS:<p>Arimoclomol citrate boosts Hsp expression, aiding protein aggregation and neuron protection.</p>Fórmula:C20H28ClN3O10Cor e Forma:SolidPeso molecular:505.913-Phenyltoxoflavin
CAS:<p>3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.</p>Fórmula:C13H11N5O2Pureza:99.88%Cor e Forma:SolidPeso molecular:269.26Gamitrinib TPP
CAS:<p>Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.</p>Fórmula:C52H65N3O8PPureza:98%Cor e Forma:SolidPeso molecular:891.0786BrCaQ-C10-TPP
<p>6BrCaQ-C10-TPP inhibits TRAP1, halts cancer cell growth (IC50=0.008-0.30µM), disrupts mitochondrial membrane.</p>Fórmula:C45H47Br2N2O3PCor e Forma:SolidPeso molecular:854.65HSP90-IN-25
<p>HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].</p>Fórmula:C29H48O10Pureza:98%Cor e Forma:SolidPeso molecular:556.69Hsp70-derived octapeptide
CAS:<p>TPR proteins including CHIP, TPR1, and hSGT affect luciferase refolding by DnaJ and hsc70.</p>Fórmula:C36H58N8O16Pureza:98%Cor e Forma:SolidPeso molecular:858.89NDNA3
<p>NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10A</p>Fórmula:C28H32N2O3SPureza:98%Cor e Forma:SolidPeso molecular:476.63TRAP1-IN-1
CAS:<p>TRAP1-IN-1 is a selective TRAP1 inhibitor, induces degradation of TRAP1 downstream proteins, inhibits OXPHOS, and disrupts mitochondrial membrane potential.</p>Fórmula:C45H39F7N2O4P2Pureza:98%Cor e Forma:SolidPeso molecular:866.74Myrtucommulone
CAS:<p>Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.</p>Fórmula:C38H52O10Pureza:98%Cor e Forma:SolidPeso molecular:668.81Chetomin
CAS:<p>Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar</p>Fórmula:C31H30N6O6S4Pureza:98%Cor e Forma:Off-White To Fawn SolidPeso molecular:710.87Grp94 Inhibitor-3
<p>Grp94 Inhibitor-3 (Compound C6) is a selective inhibitor of glucose-regulated protein 94 (Grp94), with an affinity of 5.52 μM. It shows potential for research in primary open-angle glaucoma and metastatic cancer.</p>Fórmula:C24H20ClNO4Cor e Forma:SolidPeso molecular:421.8717-DMAP-GA
CAS:<p>17-DMAP-GA, a Geldanamycin analogue, acts as an HSP90 inhibitor, leading to cell cycle abnormalities.</p>Fórmula:C33H50N4O8Cor e Forma:SolidPeso molecular:630.783Shepherdin (79-87)
CAS:<p>Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.</p>Fórmula:C41H64N12O12SPureza:98%Cor e Forma:SolidPeso molecular:949.09JG-258
CAS:<p>JG-258 is an inactive negative control for Hsp70 inhibitors [1] .</p>Fórmula:C20H22ClN3OS3Cor e Forma:SolidPeso molecular:452.06trans-Dehydrocurvularin
CAS:<p>trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.</p>Fórmula:C16H18O5Cor e Forma:SolidPeso molecular:290.315HSP70/SIRT2-IN-1
<p>HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.</p>Pureza:98%Cor e Forma:Odour SolidHA15-Biotin
CAS:<p>HA15-Biotin, a synthetic HA15-biotin conjugate, shows similar activity and may aid in proteomics.</p>Fórmula:C37H45N7O5S3Cor e Forma:SolidPeso molecular:763.99NMS-E973
CAS:<p>NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.</p>Fórmula:C22H22N4O7Pureza:99.84%Cor e Forma:SolidPeso molecular:454.43HEMTAC WEE1 degrader-1
CAS:<p>HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.</p>Fórmula:C57H71N15O6Cor e Forma:SolidPeso molecular:1062.27PU-H71 HCl
CAS:<p>PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.</p>Fórmula:C18H22ClIN6O2SPureza:98.95%Cor e Forma:SoildPeso molecular:548.83Alvespimycin TFA
<p>Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.</p>Fórmula:C34H49F3N4O10Cor e Forma:SolidPeso molecular:730.34008PU-H71
CAS:<p>PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.</p>Fórmula:C18H21IN6O2SPureza:98.31% - 99.937%Cor e Forma:SolidPeso molecular:512.37CCT245232
CAS:<p>CCT245232 is a potent HSF1 inhibitor, possibly used for researching cancer.</p>Fórmula:C27H23N3O4Cor e Forma:SolidPeso molecular:453.49Palmitic acid-1-13C
CAS:<p>Palmitic acid-13C, a 16-C saturated fatty acid internal standard for GC/LC-MS, is prevalent in plasma lipids and influences protein acylation and COX-2 levels.</p>Fórmula:C16H32O2Cor e Forma:SolidPeso molecular:257.422Debio 0932
CAS:<p>Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.</p>Fórmula:C22H30N6O2SPureza:98.98%Cor e Forma:SolidPeso molecular:442.58L-Alanyl-L-glutamine
CAS:<p>L-Alanyl-L-glutamine (Ala-Gln), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals.</p>Fórmula:C8H15N3O4Pureza:99.71% - 99.97%Cor e Forma:SolidPeso molecular:217.22YUM70
CAS:<p>YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.</p>Fórmula:C21H19ClN2O4Pureza:97.25%Cor e Forma:SolidPeso molecular:398.84
