HSP
Os inibidores de proteínas de choque térmico (HSP) têm como alvo as HSPs, uma família de chaperonas moleculares que auxiliam no dobramento de proteínas, estabilidade e proteção contra danos induzidos por estresse. As HSPs são frequentemente superexpressas em células cancerígenas, ajudando-as a sobreviver em condições estressantes, como hipóxia e quimioterapia. Inibir as HSPs pode interromper esses mecanismos de proteção, levando à morte celular. Portanto, os inibidores de HSP são valiosos na terapia contra o câncer e na pesquisa de respostas ao estresse. Na CymitQuimica, oferecemos uma gama abrangente de inibidores de HSP de alta qualidade para apoiar sua pesquisa em homeostase de proteínas, respostas ao estresse e oncologia.
Foram encontrados 169 produtos de "HSP"
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KW-2478
CAS:<p>KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.</p>Fórmula:C30H42N2O9Pureza:98.68% - 99.52%Cor e Forma:SolidPeso molecular:574.66Alvespimycin
CAS:<p>Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.</p>Fórmula:C32H48N4O8Pureza:99.88%Cor e Forma:SolidPeso molecular:616.75Calenduloside E
CAS:<p>Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and by</p>Fórmula:C36H56O9Pureza:96.16% - 98.99%Cor e Forma:SolidPeso molecular:632.8217-AEP-GA
CAS:<p>17-AEP-GA is an HSP90 antagonist and a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.</p>Fórmula:C34H50N4O8Pureza:97.77% - 99.56%Cor e Forma:SolidPeso molecular:642.78Retaspimycin Hydrochloride
CAS:<p>Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM).</p>Fórmula:C31H46ClN3O8Pureza:98%Cor e Forma:SolidPeso molecular:624.17Bimoclomol
CAS:<p>Bimoclomol is a heat shock protein co-inducer used for the research of cardiovascular diseases.</p>Fórmula:C14H20ClN3O2Cor e Forma:SolidPeso molecular:297.78CH5138303
CAS:<p>CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.</p>Fórmula:C19H18ClN5O2SPureza:98%Cor e Forma:SolidPeso molecular:415.9AMP-PCP
CAS:<p>AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.</p>Fórmula:C11H18N5O12P3Pureza:98%Cor e Forma:SolidPeso molecular:505.21JG-48
CAS:<p>JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in cells, endogenous Tau in neuroblastoma cells.</p>Fórmula:C20H16F3N3OS2Cor e Forma:SolidPeso molecular:435.49Hsp90-IN-15
CAS:<p>Hsp90-IN-15: Hsp90 blocker with anticancer properties; halts S phase, triggers apoptosis, cuts Hsp90 in Hela cells.</p>Fórmula:C23H27F3N4Cor e Forma:SolidPeso molecular:416.48CCT251236
CAS:<p>CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.</p>Fórmula:C32H32N4O5Pureza:98.82% - 99.89%Cor e Forma:SolidPeso molecular:552.62HSP90-IN-12
CAS:<p>VAC, a potent anti-cancer vibsanin A analog, inhibits cell proliferation and affects HSP90 protein levels.</p>Fórmula:C25H36O4Cor e Forma:SolidPeso molecular:400.55YM-01 Tosylate
CAS:<p>YM-01 Tosylate, a potent antitumor agent, selectively targets cancer cells and overcoming tamoxifen resistance.</p>Fórmula:C27H27N3O4S3Cor e Forma:SolidPeso molecular:553.72Displurigen
CAS:<p>Displurigen is an inhibitor of ATPase activity of HSP70.</p>Fórmula:C15H10O4SPureza:98%Cor e Forma:SolidPeso molecular:286.3Malonganenone A
CAS:<p>Malonganenone A is a selective plasmodial Hsp70s modulator. It also has antimalarial activity.</p>Fórmula:C26H38N4O2Cor e Forma:SolidPeso molecular:438.616BrCaQ
CAS:<p>6BrCaQ inhibits TRAP1, has antiproliferative effects, and is used in 6BrCaQ-TPP synthesis.</p>Fórmula:C18H15BrN2O3Cor e Forma:SolidPeso molecular:387.23HSP90-IN-22
CAS:<p>HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM in</p>Fórmula:C25H30N4O3Pureza:98%Cor e Forma:SolidPeso molecular:434.53PU3
CAS:<p>PU3 is an inhibitor of Hsp90.</p>Fórmula:C19H25N5O3Pureza:98%Cor e Forma:SolidPeso molecular:371.43SEW84
CAS:<p>SEW84, an Aha1-stimulated Hsp90 inhibitor, has an IC50 of 0.3 μM, aiding protein deposition disease research.</p>Fórmula:C19H14F4N4OSCor e Forma:SolidPeso molecular:422.4HSP90-IN-14
CAS:<p>HSP90-IN-14 inhibits Hsp90 (Kd=0.26 μM) and fights influenza A/H3N2, A/H1N1, B with EC50 of 2.6, 3.9, 17 μM in MDCK cells.</p>Fórmula:C14H8Cl2N4O4SCor e Forma:SolidPeso molecular:399.21CH5164840
CAS:<p>CH5164840: strong HSP90 blocker; excels in NSCLC treatment; boosts erlotinib efficacy on EGFR-mutant tumors.</p>Fórmula:C19H23N5O2SCor e Forma:SolidPeso molecular:385.48Hsp90-Cdc37-IN-1
CAS:<p>Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.</p>Fórmula:C43H57FN2O6SPureza:98%Cor e Forma:SolidPeso molecular:748.99Vibsanin A
CAS:<p>Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.</p>Fórmula:C25H38O4Cor e Forma:SolidPeso molecular:402.57YM-1
CAS:<p>YM-1, a stable MKT-077 analog, inhibits Hsp70 orally, kills HeLa cells, and boosts p53 and p21 proteins.</p>Fórmula:C20H20ClN3OS2Cor e Forma:SolidPeso molecular:417.98BIIB028
CAS:<p>BIIB028: Hsp90 inhibitor, may degrade oncogenic proteins, potentially hindering tumor growth.</p>Fórmula:C19H21ClN5O5PCor e Forma:SolidPeso molecular:465.83Retaspimycin
CAS:<p>Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9).</p>Fórmula:C31H45N3O8Pureza:98%Cor e Forma:SolidPeso molecular:587.7KUNB31
CAS:<p>KUNB31 is a potent and selective inhibitor of Hsp90β.</p>Fórmula:C19H18N2O3Cor e Forma:SolidPeso molecular:322.36HSP90-IN-20
CAS:<p>HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.</p>Fórmula:C26H32N4O4Cor e Forma:SolidPeso molecular:464.56Hsp90-IN-17
CAS:<p>Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.</p>Fórmula:C21H20N4O7Cor e Forma:SolidPeso molecular:440.41Heat Shock Protein Inhibitor II
CAS:<p>Hsp inhibitor II, an active benzylidene lactam, blocks inducible Hsp synthesis, reduces tumor thermotolerance, and enhances AmB effects on A. fumigatus.</p>Fórmula:C12H11NO3Cor e Forma:SolidPeso molecular:217.22SW02
CAS:<p>SW02 is a potent ATPase activator of Hsp70 (EC50: 150 μM). SW02 is able to accumulate total tau and phosphorylated tau (pTau).</p>Fórmula:C19H23BrN2O5Cor e Forma:SolidPeso molecular:439.3PU24FCl
CAS:<p>PU24FCl is a specific inhibitor of tumor Hsp90.</p>Fórmula:C20H21ClFN5O3Cor e Forma:SolidPeso molecular:433.86BMS-358233
CAS:<p>BMS-358233 is an effective LCK inhibitor with excellent cell activity against T cell proliferation.</p>Fórmula:C25H25ClN6O2SCor e Forma:SolidPeso molecular:509.02EC 144
CAS:<p>EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.</p>Fórmula:C21H24ClN5O2Cor e Forma:SolidPeso molecular:413.9MPC-3100
CAS:<p>MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with significant antitumor activity [1].</p>Fórmula:C22H25BrN6O4SCor e Forma:SolidPeso molecular:549.44Iroxanadine
CAS:<p>Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation in</p>Fórmula:C14H20N4OPureza:98.04% - 99.04%Cor e Forma:SolidPeso molecular:260.33AMP-PCP disodium
CAS:<p>AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.</p>Fórmula:C11H16N5Na2O12P3Pureza:99.32%Cor e Forma:SolidPeso molecular:549.17SNX0723
CAS:<p>SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.</p>Fórmula:C22H26FN3O3Pureza:99.85%Cor e Forma:SolidPeso molecular:399.46Arimoclomol
CAS:<p>Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (</p>Fórmula:C14H20ClN3O3Pureza:99.15%Cor e Forma:SolidPeso molecular:313.78JG-231
CAS:<p>JG-231, a JG-98 analog, shows anticancer properties by blocking Hsp70-BAG3 interaction and hindering TNBC in MDA-MB-231 models.</p>Fórmula:C22H18BrCl2N3OS4Pureza:99.79%Cor e Forma:SolidPeso molecular:619.47KU-177
CAS:<p>KU-177 is an Aha1 inhibitor that disrupts the interaction between Hsp90 and Aha1, eliminating cell proliferation and PI resistance induced by elevated AHSA1.</p>Fórmula:C27H23NO8Pureza:96.92% - 98.54%Cor e Forma:SolidPeso molecular:489.47HSP90-IN-29
CAS:<p>HSP90-IN-29 (Compound 13), a benzoxazole derivative, serves as a potent and selective HSP-90 inhibitor, exhibiting a low IC50 value of 30 nM. This compound demonstrates significant antitumor activity [1].</p>Fórmula:C19H20ClN3O4Cor e Forma:SolidPeso molecular:389.83GRP78-IN-2
CAS:<p>GRP78-IN-2 inhibits surface GRP78, showing anti-angiogenic and anti-cancer properties, sparing normal cells.</p>Fórmula:C29H29NO6Cor e Forma:SolidPeso molecular:487.54HSP90-IN-27
CAS:<p>HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].</p>Fórmula:C18H21N3O2SPureza:98%Cor e Forma:SolidPeso molecular:343.44Flavokawain 1i
CAS:<p>Flavokawain 1i, a derivative of chalcones flavokawain A, flavokawain B, and flavokawain C, exhibits anticancer and antiviral properties.</p>Fórmula:C21H18O4Cor e Forma:SolidPeso molecular:334.37MAO A/HSP90-IN-2
CAS:<p>MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90.</p>Fórmula:C25H31ClN2O4Pureza:98%Cor e Forma:SolidPeso molecular:458.98HSP70/SIRT2-IN-2
CAS:<p>HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].</p>Fórmula:C17H13N3S3Pureza:98%Cor e Forma:SolidPeso molecular:355.5Colletofragarone A2
CAS:<p>Colletofragarone A2 from Colletotrichum sp. blocks mutant p53 and HSP90, aiding cancer treatment.</p>Fórmula:C22H26O6Cor e Forma:SolidPeso molecular:386.44YM-08
CAS:<p>YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].</p>Fórmula:C19H17N3OS2Pureza:98%Cor e Forma:SolidPeso molecular:367.49HSP90-IN-19
CAS:<p>HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.</p>Fórmula:C29H38O7Pureza:98%Cor e Forma:SolidPeso molecular:498.61MAO A/HSP90-IN-1
CAS:<p>MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α.</p>Fórmula:C24H29ClN2O4Pureza:98%Cor e Forma:SolidPeso molecular:444.95Iroxanadine sulfate
CAS:<p>Iroxanadine sulfate is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.</p>Fórmula:C14H22N4O5SCor e Forma:SolidPeso molecular:358.41BX-2819
CAS:<p>BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM .</p>Fórmula:C21H24N4O4SPureza:98%Cor e Forma:SolidPeso molecular:428.51EV206
CAS:<p>EV206 is an effective inhibitor of Hsp70, exhibiting antiproliferative properties. This compound induces cell apoptosis (apoptosis) and enhances the protein expression of cleaved PARP and caspase-3. Additionally, EV206 demonstrates antitumor activity.</p>Fórmula:C21H19N3OCor e Forma:SolidPeso molecular:329.40DDO-6691
CAS:<p>DDO-6691 is an inhibitor of heat shock protein 90 (HSP90). It exhibits antiproliferative effects against various tumor cells, with the highest sensitivity observed in HCT-116 colon cancer cells (IC50: 1.08 μM). DDO-6691 also demonstrates potent tumor growth inhibition in HCT-116 xenograft mouse models.</p>Fórmula:C22H17N3O2SCor e Forma:SolidPeso molecular:387.45Onalespib lactate
CAS:<p>Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.</p>Fórmula:C27H37N3O6Cor e Forma:SolidPeso molecular:499.6Cemdomespib
CAS:<p>Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.</p>Fórmula:C24H30FNO6Cor e Forma:SolidPeso molecular:447.5Hsp90-IN-37
CAS:<p>Hsp90-IN-37 (Z-2) is an inhibitor of heat shock protein 90 (Hsp90), demonstrating a 69% inhibition rate on Hsp90 enzyme activity. It exhibits antitumor properties.</p>Fórmula:C12H15N3O2Cor e Forma:SolidPeso molecular:233.266ETB
CAS:<p>ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.</p>Fórmula:C24H33NO6Peso molecular:431.52Hsp110-STAT3 interaction-IN-1
CAS:<p>Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.</p>Fórmula:C23H31N3O4SCor e Forma:SolidPeso molecular:445.58DCEM1
CAS:<p>DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.</p>Fórmula:C22H23N3O2SCor e Forma:SolidPeso molecular:393.50KUNG65
CAS:<p>KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.</p>Fórmula:C23H20ClFO4Cor e Forma:SolidPeso molecular:414.85KU-32
CAS:<p>KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.</p>Fórmula:C20H25NO8Pureza:98%Cor e Forma:SolidPeso molecular:407.41Macbecin I
CAS:<p>Hsp90 inhibitor</p>Fórmula:C30H42N2O8Pureza:98%Cor e Forma:SolidPeso molecular:558.66C086
CAS:<p>C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.</p>Fórmula:C29H28O8Cor e Forma:SolidPeso molecular:504.53Hsp90-IN-34
CAS:<p>Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.</p>Fórmula:C22H14F2N6OCor e Forma:SolidPeso molecular:416.38HSP90-IN-11
<p>HSP90-IN-11: potent HSP90 inhibitor, akin to AUY-922; hinders CRC/NSCLC cell proliferation; degrades EGFR, Akt proteins.</p>Fórmula:C27H30FN3O6Cor e Forma:SolidPeso molecular:511.54HSP90-IN-32
CAS:<p>HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.</p>Fórmula:C33H40N2O4Cor e Forma:SolidPeso molecular:528.68HSP90α-IN-1
CAS:<p>HSP90α-IN-1 is an HSP90α inhibitor (IC50= 111 nM) that demonstrates anti-aging activity across various cellular senescence models. Belonging to the xanthine family, HSP90α-IN-1 is involved in research focused on combating age-related inflammation, senescence, and diseases (including cancer), and it may contribute to extending healthy lifespan.</p>Fórmula:C19H16N4O2Cor e Forma:SolidPeso molecular:332.356
