HSP
Os inibidores de proteínas de choque térmico (HSP) têm como alvo as HSPs, uma família de chaperonas moleculares que auxiliam no dobramento de proteínas, estabilidade e proteção contra danos induzidos por estresse. As HSPs são frequentemente superexpressas em células cancerígenas, ajudando-as a sobreviver em condições estressantes, como hipóxia e quimioterapia. Inibir as HSPs pode interromper esses mecanismos de proteção, levando à morte celular. Portanto, os inibidores de HSP são valiosos na terapia contra o câncer e na pesquisa de respostas ao estresse. Na CymitQuimica, oferecemos uma gama abrangente de inibidores de HSP de alta qualidade para apoiar sua pesquisa em homeostase de proteínas, respostas ao estresse e oncologia.
Foram encontrados 176 produtos para "HSP".
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Iroxanadine hydrobromide
CAS:Iroxanadine hydrobromide is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Fórmula:C14H21BrN4OCor e Forma:SolidPeso molecular:341.25C086
CAS:C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.Fórmula:C29H28O8Cor e Forma:SolidPeso molecular:504.53Hsp110-STAT3 interaction-IN-1
CAS:Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.Fórmula:C23H31N3O4SCor e Forma:SolidPeso molecular:445.58ETB
CAS:ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.Fórmula:C24H33NO6Cor e Forma:SolidPeso molecular:431.52DDO-6691
CAS:DDO-6691 is an inhibitor of heat shock protein 90 (HSP90). It exhibits antiproliferative effects against various tumor cells, with the highest sensitivity observed in HCT-116 colon cancer cells (IC50: 1.08 μM). DDO-6691 also demonstrates potent tumor growth inhibition in HCT-116 xenograft mouse models.Fórmula:C22H17N3O2SCor e Forma:SolidPeso molecular:387.45Onalespib lactate
CAS:Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.Fórmula:C27H37N3O6Cor e Forma:SolidPeso molecular:499.6HSP90-IN-11
HSP90-IN-11: potent HSP90 inhibitor, akin to AUY-922; hinders CRC/NSCLC cell proliferation; degrades EGFR, Akt proteins.Fórmula:C27H30FN3O6Cor e Forma:SolidPeso molecular:511.54HSP90-IN-32
CAS:HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.Fórmula:C33H40N2O4Cor e Forma:SolidPeso molecular:528.68HSP90α-IN-1
CAS:HSP90α-IN-1 is an HSP90α inhibitor (IC50= 111 nM) that demonstrates anti-aging activity across various cellular senescence models. Belonging to the xanthine family, HSP90α-IN-1 is involved in research focused on combating age-related inflammation, senescence, and diseases (including cancer), and it may contribute to extending healthy lifespan.Fórmula:C19H16N4O2Cor e Forma:SolidPeso molecular:332.356Hsp90-IN-34
CAS:Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.Fórmula:C22H14F2N6OCor e Forma:SolidPeso molecular:416.38DCEM1
CAS:DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.Fórmula:C22H23N3O2SCor e Forma:SolidPeso molecular:393.50KU-32
CAS:KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.Fórmula:C20H25NO8Pureza:98%Cor e Forma:SolidPeso molecular:407.41Cemdomespib
CAS:Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.Fórmula:C24H30FNO6Cor e Forma:SolidPeso molecular:447.5TRAP1-IN-2
CAS:TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients.Fórmula:C46H42F6N2O5P2Pureza:98%Cor e Forma:SolidPeso molecular:878.77Monorden diacetate
CAS:Monorden diacetate a Hsp90 Inhibitor. Monorden diacetate is a Promising Lead Compound for the Development of Novel Fungicides.Fórmula:C22H21ClO8Cor e Forma:SolidPeso molecular:448.85
