HSP
Os inibidores de proteínas de choque térmico (HSP) têm como alvo as HSPs, uma família de chaperonas moleculares que auxiliam no dobramento de proteínas, estabilidade e proteção contra danos induzidos por estresse. As HSPs são frequentemente superexpressas em células cancerígenas, ajudando-as a sobreviver em condições estressantes, como hipóxia e quimioterapia. Inibir as HSPs pode interromper esses mecanismos de proteção, levando à morte celular. Portanto, os inibidores de HSP são valiosos na terapia contra o câncer e na pesquisa de respostas ao estresse. Na CymitQuimica, oferecemos uma gama abrangente de inibidores de HSP de alta qualidade para apoiar sua pesquisa em homeostase de proteínas, respostas ao estresse e oncologia.
Foram encontrados 176 produtos para "HSP".
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BIIB028
CAS:BIIB028: Hsp90 inhibitor, may degrade oncogenic proteins, potentially hindering tumor growth.Fórmula:C19H21ClN5O5PCor e Forma:SolidPeso molecular:465.83Retaspimycin
CAS:Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9).Fórmula:C31H45N3O8Pureza:98%Cor e Forma:SolidPeso molecular:587.7KUNB31
CAS:KUNB31 is a potent and selective inhibitor of Hsp90β.Fórmula:C19H18N2O3Cor e Forma:SolidPeso molecular:322.36Hsp90-IN-17
CAS:Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.Fórmula:C21H20N4O7Cor e Forma:SolidPeso molecular:440.41Heat Shock Protein Inhibitor II
CAS:Hsp inhibitor II, an active benzylidene lactam, blocks inducible Hsp synthesis, reduces tumor thermotolerance, and enhances AmB effects on A. fumigatus.Fórmula:C12H11NO3Cor e Forma:SolidPeso molecular:217.22SW02
CAS:SW02 is a potent ATPase activator of Hsp70 (EC50: 150 μM). SW02 is able to accumulate total tau and phosphorylated tau (pTau).Fórmula:C19H23BrN2O5Cor e Forma:SolidPeso molecular:439.3PU24FCl
CAS:PU24FCl is a specific inhibitor of tumor Hsp90.Fórmula:C20H21ClFN5O3Cor e Forma:SolidPeso molecular:433.86BMS-358233
CAS:BMS-358233 is an effective LCK inhibitor with excellent cell activity against T cell proliferation.Fórmula:C25H25ClN6O2SCor e Forma:SolidPeso molecular:509.02CH5138303
CAS:CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.Fórmula:C19H18ClN5O2SPureza:98%Cor e Forma:SolidPeso molecular:415.9JG-48
CAS:JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in cells, endogenous Tau in neuroblastoma cells.Fórmula:C20H16F3N3OS2Cor e Forma:SolidPeso molecular:435.49CCT251236
CAS:CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.Fórmula:C32H32N4O5Pureza:98.82% - 99.89%Cor e Forma:White SolidPeso molecular:552.62Ref: TM-T14905
1mg34,00€5mg105,00€1mL*10mM (DMSO)130,00€10mg200,00€25mg414,00€50mg662,00€100mg1.054,00€Icapamespib HCl
CAS:Icapamespib (PU-HZ151) is an HSP90 inhibitor; EC50 of 5 nM, logD of 2.37; targets epichaperomes, effective in cells, mice, and humans.Fórmula:C19H25Cl2IN6O2SCor e Forma:SolidPeso molecular:599.31CH5015765
CAS:CH5015765: potent, selective HSP90 inhibitor with high affinity and antitumor effects in human cancer mouse models.Fórmula:C16H13ClN4OSCor e Forma:SolidPeso molecular:344.82Grp94-IN-2
CAS:Grp94-IN-2 is a inhibitor of Grp94.Fórmula:C22H23ClN2O5Cor e Forma:SolidPeso molecular:430.88BF844
CAS:BF844 chemical counters USH3-induced hearing loss by transporting mutated CLRN1 to cell membranes, effectively preserving hearing in vivo.Fórmula:C21H19ClN4OCor e Forma:SolidPeso molecular:378.85STA-2842
CAS:STA-2842 is an inhibitor of heat shock protein 90 (HSP90).Fórmula:C29H38N6O5Cor e Forma:SolidPeso molecular:550.65EC 144
CAS:EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.Fórmula:C21H24ClN5O2Cor e Forma:SolidPeso molecular:413.9Retaspimycin Hydrochloride
CAS:Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM).Fórmula:C31H46ClN3O8Pureza:98%Cor e Forma:SolidPeso molecular:624.17MPC-3100
CAS:MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with significant antitumor activity [1].Fórmula:C22H25BrN6O4SCor e Forma:SolidPeso molecular:549.44HSP90-IN-22
CAS:HSP90-IN-22 is a potent HSP90 inhibitor; client protein degrader; blocks oncogenic signaling; cancer research tool.Fórmula:C25H30N4O3Pureza:99.90%Cor e Forma:White SolidPeso molecular:434.53
