Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2252 produtos de "Cromatina/Epigenética"
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Sirt2-IN-7
<p>Sirt2-IN-7, a selective SIRT2 inhibitor, has IC50 and Ki values of 178.2 nM and 154.3 nM, useful in cancer research.</p>Fórmula:C22H38Cl2K3N3OSCor e Forma:SolidPeso molecular:831.98PBRM1-BD2-IN-7
CAS:<p>PBRM1-BD2-IN-7, a PBRM1 bromodomain inhibitor with an IC50 of 0.29 μM, is used in cancer research.</p>Fórmula:C16H15ClN2OPureza:99.31% - 99.41%Cor e Forma:SoildPeso molecular:286.76IHMT-EZH2-426
<p>IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5</p>Fórmula:C31H35FN4O4SPureza:98%Cor e Forma:SolidPeso molecular:578.7PRMT5-IN-11
CAS:<p>PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.</p>Fórmula:C13H17N5O4Cor e Forma:SolidPeso molecular:307.31Foenumoside B
CAS:<p>Foenumoside B, a triterpene saponin extracted from Lysimachia foenum-graecum, stimulates AMPK signaling, suppresses PPARγ-induced adipogenesis, and promotes</p>Fórmula:C60H96O25Pureza:98%Cor e Forma:SolidPeso molecular:1217.39BBDDL2204
<p>BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.</p>Fórmula:C37H47N5O5SCor e Forma:SolidPeso molecular:673.32979JAK-IN-33
<p>JAK-IN-33 (Compound 3 (R)) is a selective inhibitor of the Janus kinase (JAK) family [1].</p>Pureza:98%Cor e Forma:Odour SolidJMJD6 inhibitor WL12
CAS:<p>WL12 (ZINC6733033): First-in-class JMJD6 inhibitor; halts JMJD6-dependent cervical/liver cancer cell growth.</p>Fórmula:C16H11N3O2Pureza:98.57%Cor e Forma:SolidPeso molecular:277.28UNC7096
<p>UNC7096 is a potent, selective degrader of NSD2-PWWP1, exhibiting a dissociation constant (Kd) of 46 nM, and shows promise for treating NSD2-related diseases [1</p>Fórmula:C61H87N7O18SPureza:98%Cor e Forma:SolidPeso molecular:1238.44Izilendustat
CAS:<p>Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.</p>Fórmula:C22H28ClN3O4Pureza:99.95%Cor e Forma:SolidPeso molecular:433.93NPC-15437 dihydrochloride
CAS:<p>NPC-15437 dihydrochloride is a PKC inhibitor blocking enzyme activity and phorbol ester binding, selective over other kinases, in cellular signaling research.</p>Fórmula:C25H52Cl2N4O2Cor e Forma:SolidPeso molecular:511.62TO-1187
<p>TO-1187 is a selective HDAC6 PROTAC degrader with a DC50 of 5.81 nM. It enhances the ubiquitination and subsequent degradation of HDAC6, making it useful for research in hematological malignancies and solid tumors.</p>Cor e Forma:Odour SolidMersalyl
CAS:Mersalyl is an organic mercurial diuretic.Fórmula:C13H16HgNNaO6Cor e Forma:SolidPeso molecular:505.854HDAC6 ligand-2
<p>HDAC6 ligand-2 (Compound 15) is a ligand of HDAC6 and can be used in the synthesis of PROTAC HDAC6 degrader2.</p>Fórmula:C23H20F2N6O3Cor e Forma:SolidPeso molecular:466.44PROTAC BRD9-binding moiety 1
CAS:PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.Fórmula:C23H25N3O7S2Pureza:98%Cor e Forma:SolidPeso molecular:519.59PROTAC SMARCA2/4-degrader-25
<p>PROTAC SMARCA2/4-degrader-25 is a PROTAC that targets SMARCA2/4. It consists of the E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, a PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid, and the target protein ligand SMARCA2/4-ligand-3. The conjugate of the E3 ubiquitin ligase ligand and Linker is (S,R,S)-AHPC.</p>Fórmula:C44H50N10O9S2Cor e Forma:SolidPeso molecular:927.06CPI-268456
CAS:<p>CPI-268456 is a compound which has bioactive.</p>Fórmula:C20H15Cl2N3O2Cor e Forma:SolidPeso molecular:400.26XF056-132
CAS:<p>XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .</p>Fórmula:C51H57F4N9O7SCor e Forma:SolidPeso molecular:1016.11MT1
CAS:<p>MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).</p>Fórmula:C54H66Cl2N10O9S2Cor e Forma:SolidPeso molecular:1134.2FY-21
FY-21 is a selective LSD1 inhibitor (IC50= 340 nM) that inhibits proliferation and colony formation of leukemia cells, decreases mRNA levels of the transcription factors HOXA9 and MEIS1, and can be used in the study of leukemia.Fórmula:C17H15F3N2O6Pureza:99.88%Cor e Forma:SolidPeso molecular:400.31
