Aurora Quinase
Os inibidores da quinase Aurora têm como alvo as quinasas Aurora, uma família de quinasas serina/treonina que desempenham um papel crucial na regulação da mitose. Essas quinasas são essenciais para o alinhamento adequado dos cromossomos, segregação e citocinese durante a divisão celular. A atividade anormal da quinase Aurora pode levar à proliferação celular descontrolada e ao câncer. Ao inibir as quinasas Aurora, esses compostos podem induzir a parada do ciclo celular e a apoptose em células cancerígenas, tornando-os ferramentas valiosas na pesquisa e terapia do câncer. Na CymitQuimica, oferecemos uma ampla gama de inibidores de quinasas Aurora de alta qualidade para apoiar sua pesquisa em regulação do ciclo celular, mitose e oncologia.
Foram encontrados 94 produtos de "Aurora Quinase"
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dAURK-4 hydrochloride
<p>dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].</p>Fórmula:C52H53Cl2FN8O12Pureza:99.44%Cor e Forma:SolidPeso molecular:1071.93NU6140
CAS:<p>NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).</p>Fórmula:C23H30N6O2Pureza:98.33%Cor e Forma:SolidPeso molecular:422.52TAK-901
CAS:<p>TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others</p>Fórmula:C28H32N4O3SPureza:99.02% - 99.59%Cor e Forma:SolidPeso molecular:504.64Aurora A inhibitor 3
<p>Aurora A Inhibitor 3 (Compound 5h) effectively inhibits Aurora-A kinase, exhibiting an IC50 of 0.78 μM, and demonstrates cytotoxicity against MCF-7 and MDA-MB-</p>Pureza:98%Cor e Forma:Odour SolidCD532 hydrochloride
<p>CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.</p>Cor e Forma:SolidAKI603
CAS:<p>AKI603: Aurora A kinase blocker; IC50 12.3 nM; targets BCR-ABL-T315I resistance; halts leukemia cell growth.</p>Fórmula:C19H23N9O2Pureza:99.81%Cor e Forma:SolidPeso molecular:409.45HLB-0532259
CAS:<p>HLB-0532259 is a PROTAC degrader that targets the degradation of Aurora-A and N-Myc. In non-MYCN amplified MCF-7 cells, it degrades Aurora-A with a DC50 of 20.2 nM, and in MYCN amplified SK-N-BE and Kelly cells, it degrades N-Myc with DC50 values of 179 nM and 229 nM, respectively. HLB-0532259 has demonstrated antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)</p>Fórmula:C40H44N8O7Cor e Forma:SolidPeso molecular:748.827CAM2602
<p>CAM2602 is an inhibitor of Aurora A-TPX2 interaction, demonstrating a binding affinity of 19 nM with Aurora A. This compound has been shown to inhibit the growth of pancreatic cancer cells. In solid tumor xenograft models, CAM2602 increases the proportion of PH3-positive cells while decreasing the ratio of P-Thr288Aurora A-positive cells, ultimately inhibiting tumor growth.</p>Cor e Forma:Odour SolidPROTAC MPS1 degrader 1
<p>PROTAC MPS1 degrader 1 (Compound 19) acts as a potent degrader of Monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB, with DC50 values of 17.7, 108.7, and 570.3 nM respectively. It is utilized in the study of acute myeloid leukemia. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase)</p>Fórmula:C41H46N12O7Cor e Forma:SolidPeso molecular:818.88Aurora-A ligand 1
CAS:<p>Aurora-A ligand 1 is a potent and selective inhibitor of Aurora-A, exhibiting a dissociation constant (Kd) of 0.85 nM. It serves as a target protein ligand [PROTAC target protein ligand] in the development of PROTAC Aurora-A degraders with antitumor activity. Additionally, Aurora-A ligand 1 is utilized in the synthesis of HLB-0532259, which exhibits antitumor effects against neuroblastoma.</p>Fórmula:C21H23N5O3Cor e Forma:SolidPeso molecular:393.439GSK-1070916
CAS:<p>GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.</p>Fórmula:C30H33N7OPureza:99.73%Cor e Forma:SolidPeso molecular:507.63Barasertib
CAS:<p>AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.</p>Fórmula:C26H31FN7O6PPureza:99.63% - 99.92%Cor e Forma:SolidPeso molecular:587.54Retreversine
CAS:<p>Retreversine serves as an inactive control counterpart to Reversine, a pioneering class of ATP-competitive Aurora kinase inhibitor.</p>Fórmula:C21H27N7OCor e Forma:SolidPeso molecular:393.49JB170
CAS:<p>JB170 is a specific Aurora A degradator. Alisertib and Thalidomide, induces S-phase arrest in cell growth and inhibits the non-catalytic function.</p>Fórmula:C48H44ClFN8O11Pureza:99.82%Cor e Forma:SolidPeso molecular:963.36AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Fórmula:C28H32FN9O2Cor e Forma:SolidPeso molecular:545.61dAURK-4
CAS:<p>dAURK-4, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].</p>Fórmula:C52H52ClFN8O12Cor e Forma:SolidPeso molecular:1035.47TAS-119
CAS:<p>TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95</p>Fórmula:C23H22Cl2FN5O3Pureza:99.65%Cor e Forma:SolidPeso molecular:506.36JB300
CAS:<p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>Fórmula:C43H45ClFN7O10SCor e Forma:SolidPeso molecular:906.375SP-96
CAS:<p>SP-96: Aurora B inhibitor, IC50=0.316 nM, selectively hinders MDA-MD-468 growth, GI50=107 nM, for triple-negative breast cancer research.</p>Fórmula:C25H20FN7OPureza:99.54%Cor e Forma:SolidPeso molecular:453.47PROTAC MPS1 degrader 2
<p>PROTAC MPS1 Degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB with DC50 values of 42.0, 2.1, and 154.0 nM respectively. It is utilized in the research of acute myeloid leukemia.</p>Fórmula:C41H41N11O8SCor e Forma:SolidPeso molecular:847.90
