Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2238 produtos de "Cromatina/Epigenética"
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JAK-2/3-IN-2
CAS:<p>JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).</p>Fórmula:C19H19ClN2OSCor e Forma:SolidPeso molecular:358.89YUKA1
CAS:<p>YUKA1, a cell-permeable KDM5A inhibitor with a weak effect on KDM5C, increase H3K4me3 and inhibit the proliferation, prevent drug-resistant.</p>Fórmula:C13H16N4O2SPureza:99.85%Cor e Forma:SolidPeso molecular:292.36HDAC6/8/BRPF1-IN-1
CAS:<p>HDAC6/8/BRPF1-IN-1 is a cancer-research inhibitor for HDAC6, HDAC8, BRPF1 with IC50: 344-908 nM and Kd: 175.2 nM.</p>Fórmula:C18H17N3O5SCor e Forma:SolidPeso molecular:387.41BNS
CAS:<p>BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.</p>Fórmula:C18H16N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:420.46HDAC6-IN-14
<p>HDAC6-IN-14, an inhibitor of HDAC6 (HDAC), exhibits high selectivity with an IC50 value of 42 nM, demonstrating over 100-fold selectivity compared to HDAC1,</p>Fórmula:C24H30FN3O4Cor e Forma:SolidPeso molecular:443.51JAK-IN-11
CAS:<p>JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.</p>Fórmula:C23H22FN5O4SPureza:99.75%Cor e Forma:SolidPeso molecular:483.52A2B57
CAS:<p>A2B57 is a selective SIRT2 inhibitor.</p>Fórmula:C22H19N5OPureza:98%Cor e Forma:SolidPeso molecular:369.42HDAC8/BRPF1-IN-1
CAS:<p>Compound 23a, dual HDAC8/BRPF1 inhibitor: IC50 HDAC8 = 443 nM, Kd BRPF1 = 67 nM; weak against HDAC1/6.</p>Fórmula:C19H19N3O6SCor e Forma:SolidPeso molecular:417.44A2AAR/HDAC-IN-1
CAS:<p>A2AAR/HDAC-IN-1 (compound 14c) is an orally active, balanced A2AAR/HDAC dual inhibitor of A2AAR (Ki: 163.5 nM), HDAC1 (IC50: 145.3 nM). effect.</p>Fórmula:C24H21N7O2Cor e Forma:SolidPeso molecular:439.47MARK-IN-4
CAS:<p>MARK-IN-4 inhibits microtubule kinase (MARK) effectively (IC50: 1 nM), a target for Alzheimer's therapy.</p>Fórmula:C21H23N7OSCor e Forma:SolidPeso molecular:421.52J1038
CAS:<p>J1038 is a novel Histone Deacetylase 8 (HDAC8) Inhibitor .</p>Fórmula:C10H10N2O3SCor e Forma:SolidPeso molecular:238.26PARP1-IN-9
CAS:<p>PARP1-IN-9, potent PARP1 inhibitor with 30.51 nM IC50, outperforms Olaparib in anticancer efficacy.</p>Fórmula:C18H21N3O5Cor e Forma:SolidPeso molecular:359.38PIM1-IN-6
CAS:<p>PIM1-IN-6 (5h) inhibits PIM-1 (IC50: 0.60 μM) and is cytotoxic to HCT-116 (IC50: 1.51 μM) and MCF-7 cells (IC50: 15.2 μM).</p>Fórmula:C21H18N6O4Cor e Forma:SolidPeso molecular:418.41BRD4 Inhibitor-25
<p>BRD4 Inhibitor-25 blocks BRD4 (BD1: IC50 0.82 μM, BD2: 1.94 μM), induces cell death in ovarian cancer, used in cancer research.</p>Fórmula:C29H27N5O6SCor e Forma:SolidPeso molecular:573.62CAY10685
CAS:<p>CAY10685, a CPTH2 analog with an alkyne for click reactions, inhibits NAT10 to study cancer-related chromatin changes.</p>Fórmula:C17H16ClN3SCor e Forma:SolidPeso molecular:329.85DNMT3A-IN-1
CAS:<p>DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).</p>Fórmula:C30H38N6O4Cor e Forma:SolidPeso molecular:546.66NCDM-32B
CAS:<p>NCDM-32B, a novel potent and selective KDM4 inhibitor, impairs viability and transforms phenotypes of basal breast cancer.</p>Fórmula:C15H30N2O4Pureza:98%Cor e Forma:SolidPeso molecular:302.41AChE/HDAC-IN-1
CAS:<p>COX-2-IN-23 (A10) inhibits AChE & HDAC (IC50s: 0.12 & 0.23 nM), has antioxidant/metal-binding traits, and is used in Alzheimer's research.</p>Fórmula:C26H27ClN4O3Cor e Forma:SolidPeso molecular:478.97CP-690550A
CAS:<p>Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.</p>Fórmula:C15H21N5O2Cor e Forma:SolidPeso molecular:303.36ART-IN-1
CAS:<p>ART-IN-1 (compound 7) is a selective inhibitor of PARP with IC 50 s of 19, 22, 2.4, >100, 1.1 μM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively [1].</p>Fórmula:C14H13NO2SCor e Forma:SolidPeso molecular:259.32
