Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2238 produtos de "Cromatina/Epigenética"
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DPQ
CAS:<p>DPQ inhibits PARP-1, aids in neuroprotection, restores ATP, and lessens neuronal injury from NMDA.</p>Fórmula:C18H26N2O2Pureza:98%Cor e Forma:SolidPeso molecular:302.41Aurora Kinases-IN-2
CAS:<p>Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.</p>Fórmula:C22H18ClN5O3Cor e Forma:SolidPeso molecular:435.86HDAC1-IN-4
CAS:<p>HDAC1-IN-4 is a potent inhibitor of Plasmodium falciparum HDAC1 (PfHDAC1) with low cytotoxicity and antimalarial effects (IC50<5 nM).</p>Fórmula:C21H24BrClN6O2Cor e Forma:SolidPeso molecular:507.82HDAC/CK2-IN-1
CAS:<p>HDAC/CK2-IN-1 (compound 38) acts as an inhibitor of HDAC1 (IC 50 = 1.46 μM), HDAC6 (IC 50 = 0.66 μM), and CK2 (IC 50 = 3.67 μM). It demonstrates promising antiproliferative effects on various cell lines, including Jurkat, MCF-7, HCT-116, and HL-60.</p>Fórmula:C15H18Br4N4O2Cor e Forma:SolidPeso molecular:605.95BRM/BRG1 ATP Inhibitor-4
CAS:<p>BRM/BRG1 ATP Inhibitor-4, a potent inhibitor of BRG1/BRM, is utilized in the research of cancers and BAF complex-related disorders.</p>Fórmula:C25H32N6O3SCor e Forma:SolidPeso molecular:496.62KDM2/7-IN-1
CAS:<p>KDM2/7-IN-1 is a selective histone demethylase inhibitor (IC50s: 0.2–>120 μM) that inhibits HeLa and KYSE-150 cell proliferation, epigenetic and cancer.</p>Fórmula:C15H27NO4Pureza:99.87%Cor e Forma:SolidPeso molecular:285.38EZH2-IN-3
CAS:<p>EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.</p>Fórmula:C27H28ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:490OHM1
CAS:<p>OHM1, an analog of HIF1α CTAD, effectively inhibits the interaction between HIF1α CTAD and p300/CBP by targeting the CH1 domain with a binding affinity of 0.53</p>Fórmula:C24H42N6O5Cor e Forma:SolidPeso molecular:494.63CypD inhibitor C-9
CAS:<p>CypD inhibitor C-9 is a CypD inhibitor, it attenuates mitochondrial and cellular perturbation insulted by Aß and calcium stress.</p>Fórmula:C22H22N4O4S2Cor e Forma:SolidPeso molecular:470.56PIM1-IN-7
CAS:<p>PIM1-IN-7 inhibits PIM-1 (IC50: 0.67μM), toxic to HCT-116/MCF-7 cells (IC50: 42.9/7.68μM).</p>Fórmula:C23H23N5OCor e Forma:SolidPeso molecular:385.46HDAC/NAMPT-IN-1
CAS:<p>HDAC/NAMPT-IN-1 (compound 39h) simultaneously inhibits HDAC and NAMPT, exhibiting IC 50 values ranging from 0.72 to 37081 nM for HDAC and 1618 nM for NAMPT [1].</p>Fórmula:C19H21N5O2Cor e Forma:SolidPeso molecular:351.4BRD4-BD1/2-IN-1
CAS:<p>BRD4-BD1/2-IN-1 efficiently blocks BRD4 BD-1/2 under 100 nM IC50 (US20150148375A1, cmpd 5).</p>Fórmula:C21H14F2N4O2Cor e Forma:SolidPeso molecular:392.36CK2/PIM1-IN-1
CAS:<p>CK2/PIM1-IN-1 inhibits CK2 & PIM1 (IC50s: 3.787 & 4.327 μM), aimed for cancer research.</p>Fórmula:C15H9NO4S2Pureza:98%Cor e Forma:SolidPeso molecular:331.37AMPK activator 9
CAS:<p>AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.</p>Fórmula:C31H28F4N4O4Cor e Forma:SolidPeso molecular:596.57UNC2327
CAS:<p>UNC2327 is a potent and selective inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50:230 nM).</p>Fórmula:C14H17N5O2SPureza:98%Cor e Forma:SolidPeso molecular:319.384-iodo-SAHA
CAS:<p>4-Iodo-SAHA (1k), an oral HDAC inhibitor for cancer research, has EC50s from 0.12 to 1.3 μM across various cell lines.</p>Fórmula:C14H19IN2O3Cor e Forma:SolidPeso molecular:390.22ARTD10/PARP10-IN-2
CAS:<p>ARTD10/PARP10-IN-2: A potent, non-selective PARP inhibitor, IC50: ARTD10/PARP10 (2.0μM), ARTD1/PARP1 (9.7μM).</p>Fórmula:C12H13N3O3Cor e Forma:SolidPeso molecular:247.25VE-465
CAS:<p>VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.</p>Fórmula:C22H28N8OSCor e Forma:SolidPeso molecular:452.58LT052
CAS:<p>LT052 is a BET BD1 inhibitor with anti-inflammatory activity. It mediates the BRD4/NF-κB/NLRP3 signaling inflammatory pathway.</p>Fórmula:C22H19N5O4SPureza:98.82%Cor e Forma:SolidPeso molecular:449.48JAK-IN-20
CAS:<p>JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.</p>Fórmula:C28H30FN7O2Cor e Forma:SolidPeso molecular:515.58
