Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2242 produtos de "Cromatina/Epigenética"
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NN-390
CAS:<p>NN-390: selective HDAC6 inhibitor, IC50 9.8 μM, blood-brain barrier penetrant, potential for metastatic group 3 neural tube cancer research.</p>Fórmula:C17H16F4N2O4SCor e Forma:SolidPeso molecular:420.38BI-9321
CAS:<p>BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.</p>Fórmula:C22H21FN4Pureza:98%Cor e Forma:SolidPeso molecular:360.43OTS186935
CAS:OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).Fórmula:C25H26ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:463.96AA-CW236
CAS:<p>AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).</p>Fórmula:C17H16ClF3N4O2Cor e Forma:SolidPeso molecular:400.78Antiproliferative agent-17
CAS:Antiproliferative Agent-17 exhibits both antimicrobial properties against Gram-positive bacteria and anticancer activity [1].Fórmula:C26H28N2OSCor e Forma:SolidPeso molecular:416.58IACS-9571
CAS:<p>IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).</p>Fórmula:C32H42N4O8SPureza:98%Cor e Forma:SolidPeso molecular:642.76103D5R
CAS:<p>103D5R selectively inhibits hif-1α, reducing its levels in hypoxia or with cobalt ions, dose- and time-dependently.</p>Fórmula:C20H21N3O2Cor e Forma:SolidPeso molecular:335.4TYK2-IN-11
CAS:<p>TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.</p>Fórmula:C18H17N5O3SCor e Forma:SolidPeso molecular:383.42AChE/HDAC-IN-1
CAS:<p>COX-2-IN-23 (A10) inhibits AChE & HDAC (IC50s: 0.12 & 0.23 nM), has antioxidant/metal-binding traits, and is used in Alzheimer's research.</p>Fórmula:C26H27ClN4O3Cor e Forma:SolidPeso molecular:478.97LSD1-IN-13
CAS:<p>LSD1-IN-13, an oral LSD1 blocker (IC50: 24.43 nM), boosts CD86 (EC50: 470 nM), and triggers AML cell line differentiation.</p>Fórmula:C23H29N3O2SCor e Forma:SolidPeso molecular:411.56DNMT3A-IN-1
CAS:<p>DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).</p>Fórmula:C30H38N6O4Cor e Forma:SolidPeso molecular:546.66CAY10685
CAS:<p>CAY10685, a CPTH2 analog with an alkyne for click reactions, inhibits NAT10 to study cancer-related chromatin changes.</p>Fórmula:C17H16ClN3SCor e Forma:SolidPeso molecular:329.85CP-690550A
CAS:<p>Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.</p>Fórmula:C15H21N5O2Cor e Forma:SolidPeso molecular:303.36BRD4 Inhibitor-25
<p>BRD4 Inhibitor-25 blocks BRD4 (BD1: IC50 0.82 μM, BD2: 1.94 μM), induces cell death in ovarian cancer, used in cancer research.</p>Fórmula:C29H27N5O6SCor e Forma:SolidPeso molecular:573.62PIM1-IN-6
CAS:<p>PIM1-IN-6 (5h) inhibits PIM-1 (IC50: 0.60 μM) and is cytotoxic to HCT-116 (IC50: 1.51 μM) and MCF-7 cells (IC50: 15.2 μM).</p>Fórmula:C21H18N6O4Cor e Forma:SolidPeso molecular:418.41J1038
CAS:<p>J1038 is a novel Histone Deacetylase 8 (HDAC8) Inhibitor .</p>Fórmula:C10H10N2O3SCor e Forma:SolidPeso molecular:238.26HDAC8/BRPF1-IN-1
CAS:<p>Compound 23a, dual HDAC8/BRPF1 inhibitor: IC50 HDAC8 = 443 nM, Kd BRPF1 = 67 nM; weak against HDAC1/6.</p>Fórmula:C19H19N3O6SCor e Forma:SolidPeso molecular:417.44HDAC6-IN-14
<p>HDAC6-IN-14, an inhibitor of HDAC6 (HDAC), exhibits high selectivity with an IC50 value of 42 nM, demonstrating over 100-fold selectivity compared to HDAC1,</p>Fórmula:C24H30FN3O4Cor e Forma:SolidPeso molecular:443.51YUKA1
CAS:<p>YUKA1, a cell-permeable KDM5A inhibitor with a weak effect on KDM5C, increase H3K4me3 and inhibit the proliferation, prevent drug-resistant.</p>Fórmula:C13H16N4O2SPureza:99.85%Cor e Forma:SolidPeso molecular:292.36PRMT5-IN-C17
CAS:<p>PRMT5-IN-C17 is a novel potent, selective, and cell active protein arginine methyltransferase 5 (PRMT5) inhibitor.</p>Fórmula:C18H17N3O4SCor e Forma:SolidPeso molecular:371.41
