Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2235 produtos de "Cromatina/Epigenética"
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HIF1-IN-3
CAS:<p>HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in</p>Fórmula:C26H24N2O3Pureza:99.59%Cor e Forma:SolidPeso molecular:412.48DB008
<p>DB008 is a selective PARP16 inhibitor with IC50 of 0.27 μM, has acrylamide, and is membrane-permeable.</p>Fórmula:C25H21FN4O3Cor e Forma:SolidPeso molecular:444.46Ep300/CREBBP-IN-2
CAS:<p>Ep300/CREBBP-IN-2: Potent, oral Ep300 & CREBBP inhibitor; IC50s: 0.052μM & 0.148μM; cancer research.</p>Fórmula:C26H27F3N4O4Cor e Forma:SolidPeso molecular:516.51PROTAC BET Degrader-1
CAS:<p>PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.</p>Fórmula:C44H45N11O9Pureza:98%Cor e Forma:SolidPeso molecular:871.9JHDM-IN-1
CAS:<p>JHDM-IN-1 inhibits JHDMs; IC50: 3.4 μM JMJD2C, 4.3 μM JMJD2A, 5.9 μM JMJD2E, 10 μM PHF8, 43 μM JMJD3.</p>Fórmula:C27H29N3O6Cor e Forma:SolidPeso molecular:491.54BETd-246
CAS:<p>BETd-246 is an inhibitor of second-generation and PROTAC-based BET bromodomain (BRD), show antitumor activity.</p>Fórmula:C48H55N11O10Pureza:98%Cor e Forma:SolidPeso molecular:946.02PROTAC BRD4 Degrader-20
CAS:<p>PROTAC BRD4 Degrader-20 (compound 195) is a bifunctional degrader of BRD4 [1].</p>Fórmula:C55H58ClN9O7S2Cor e Forma:SolidPeso molecular:1056.69CDD-1102 HCl
<p>CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.</p>Fórmula:C32H31ClN6O3Pureza:98.30%Cor e Forma:SoildPeso molecular:583.08OKI-006
CAS:<p>OKI-006 is an oral HDAC inhibitor with potential for cancer research, derived from largazole.</p>Fórmula:C21H30N4O5S2Cor e Forma:SolidPeso molecular:482.62MZP-54
CAS:<p>MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)</p>Fórmula:C55H66ClN7O9SPureza:98%Cor e Forma:SolidPeso molecular:1036.67PROTAC BRD4 Degrader-19
CAS:<p>PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utility</p>Fórmula:C44H38N8O5S2Cor e Forma:SolidPeso molecular:822.95JPS016
CAS:<p>JPS016: benzamide VHL E3-ligase PROTAC, degrades HDAC1/2, triggers apoptosis in HCT116 cells.</p>Fórmula:C48H63N7O8SCor e Forma:SolidPeso molecular:898.12SYY-B085-1
CAS:<p>SYY-B085-1 is a histone acetyltransferase (HAT) inhibitor.</p>Fórmula:C27H23F4N5O4Cor e Forma:SolidPeso molecular:557.506CW-3308
<p>CW-3308 is an orally active PROTAC that targets BRD9. It is composed of the PROTAC target protein ligand Naphthyridin-Me-dimethoxybenzene-COOH, the linker 3-Azaspiro[5.5]undecane-9-methanol, and the E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine. The coupling of the E3 ubiquitin ligase ligand with the linker results in the conjugate Thalidomide-pyrrolidine-C-azaspiro.</p>Fórmula:C45H48N6O8Cor e Forma:SolidPeso molecular:800.9Lyngbyatoxin A
CAS:<p>Lyngbyatoxin A is an indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as &quot;swimmers' itch&quot; in Hawaii.</p>Fórmula:C27H39N3O2Cor e Forma:SolidPeso molecular:437.62TNKS-2-IN-2
CAS:<p>TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.</p>Fórmula:C26H23N3O6Pureza:99.45%Cor e Forma:SoildPeso molecular:473.48WDR5-MYC-IN-1
<p>WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.</p>Cor e Forma:Odour SolidFDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Cor e Forma:LiquidJQ1-TCO
CAS:<p>JQ1-TCO, a BET inhibitor derivative, enables click chemistry for molecular probing in vivo and in vitro.</p>Fórmula:C31H37ClN6O3SCor e Forma:SolidPeso molecular:609.18CPI-1328
CAS:<p>CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.</p>Fórmula:C28H36ClN3O4SCor e Forma:SolidPeso molecular:546.12Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
CAS:<p>Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].</p>Fórmula:C34H43N3O7Cor e Forma:SolidPeso molecular:605.72Malantide TFA
<p>Malantide TFA: synthetic dodecapeptide, PKA-specific with Km 15 μM, >90% PKI blockage, also PKC substrate, Km 16 μM.</p>Fórmula:C74H125F3N22O23Cor e Forma:SolidPeso molecular:1747.91CM112
<p>CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.</p>Fórmula:C39H61N5O7Cor e Forma:SolidPeso molecular:711.4571EZH2-IN-5
CAS:<p>EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).</p>Fórmula:C26H37BrN4O2Cor e Forma:SolidPeso molecular:517.512DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Cor e Forma:Odour SolidTyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Cor e Forma:Odour SolidPAD2-IN-1
CAS:<p>PAD2-IN-1 is a selective benzimidazole-derived inhibitor with a 95-fold and 79-fold higher affinity for PAD2 over PAD4 and PAD3, respectively.</p>Fórmula:C25H29FN6O3Cor e Forma:SolidPeso molecular:480.544PROTAC SMARCA2/4-degrader-25
<p>PROTAC SMARCA2/4-degrader-25 is a PROTAC that targets SMARCA2/4. It consists of the E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, a PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid, and the target protein ligand SMARCA2/4-ligand-3. The conjugate of the E3 ubiquitin ligase ligand and Linker is (S,R,S)-AHPC.</p>Fórmula:C44H50N10O9S2Cor e Forma:SolidPeso molecular:927.06Pumecitinib
CAS:<p>Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.</p>Fórmula:C17H20N8O2SPureza:99.94%Cor e Forma:SoildPeso molecular:400.46VinSpinIn
CAS:<p>VinSpinIn is a probe for the Spin family proteins.</p>Fórmula:C42H58N8O4Cor e Forma:SolidPeso molecular:738.98(S)-GNE-987
<p>(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).</p>Fórmula:C56H67F2N9O8S2Pureza:98%Cor e Forma:SolidPeso molecular:1096.31MNK/PIM-IN-1
CAS:<p>MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile.</p>Fórmula:C27H27FN6O2Cor e Forma:SolidPeso molecular:486.551NSC 370284
CAS:<p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>Fórmula:C21H25NO6Pureza:99.74%Cor e Forma:SolidPeso molecular:387.43KDM1A-IN-29
CAS:<p>KDM1A-IN-29 is a histone demethylase inhibitor.</p>Fórmula:C16H16ClN3O4SCor e Forma:SoildPeso molecular:381.83GSK8573
CAS:<p>GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).</p>Fórmula:C20H21NO3Pureza:99.81%Cor e Forma:SolidPeso molecular:323.39Zifcasiran
CAS:<p>Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.</p>Fórmula:C737H972F20N211O349P43S8Cor e Forma:SolidPeso molecular:20339.13Tanshinol borneol ester
CAS:<p>Tanshinol borneol ester stimulates angiogenesis via Akt/MAPK pathways and has anti-ischemic, anti-atherosclerosis effects.</p>Fórmula:C19H26O5Cor e Forma:SolidPeso molecular:334.41GSK J5
CAS:<p>GSK J5: schistosome, helminth inhibitor; trematode insecticide; boosts schistosome death dose/time-wise.</p>Fórmula:C24H27N5O2Pureza:99.81%Cor e Forma:SolidPeso molecular:417.5ZL0590
CAS:<p>ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.</p>Fórmula:C23H27F3N4O4SPureza:99.77%Cor e Forma:SoildPeso molecular:512.55Methylation Compound Library
<p>xnum methylation-related compounds that can be used for high-throughput and high-content screening.</p>Cor e Forma:Odour SolidSW2_110A
CAS:<p>SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.</p>Fórmula:C42H60N6O7Pureza:98%Cor e Forma:SolidPeso molecular:760.96Dihydrochlamydocin analog-1
CAS:<p>Dihydrochlamydocinanalog-1 (compound 2) is a Chlamydocin analog that inhibits the deacetylation of histone H4 peptides, with an IC50 of 30 nM.</p>Fórmula:C28H40N4O6Cor e Forma:SolidPeso molecular:528.64EPZ-719
CAS:<p>EPZ-719: Potent SETD2 inhibitor, IC50=0.005μM, high selectivity, potential for targeted epigenetic therapy.</p>Fórmula:C22H31FN4O3SCor e Forma:SolidPeso molecular:450.57UNC6349 (Ket2)
<p>UNC6349 (Ket2), a ligand containing diethyllysine (Ket2), effectively binds to wild-type CBX5 with a dissociation constant (K D) of 3.2 μM [1].</p>Fórmula:C41H57N7O11Cor e Forma:SolidPeso molecular:823.93HIF-1 inhibitor-5
<p>HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1</p>Fórmula:C28H35NO5Cor e Forma:SolidPeso molecular:465.58ACBI2
CAS:<p>ACBI2: potent, oral VHL PROTAC, EC50=7nM; degrades SMARCA2, DC50=1nM in RKO cells; for lung cancer research.</p>Fórmula:C56H68BrFN8O5SCor e Forma:SolidPeso molecular:1064.16PROTAC BRD4 Degrader-1
CAS:<p>PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).</p>Fórmula:C40H37N9O8Pureza:98%Cor e Forma:SolidPeso molecular:771.78Axl-IN-16
<p>Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor</p>Fórmula:C14H19ClO8Pureza:98%Cor e Forma:SolidPeso molecular:350.75JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Cor e Forma:Odour SolidEPZ-025654
CAS:<p>EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.</p>Fórmula:C29H33ClN8O3Cor e Forma:SolidPeso molecular:577.08QA-68
<p>QA-68 is a potent BRD9 degrader, inhibits cell growth, and has anti-leukemic properties.</p>Fórmula:C61H72N10O10S2Cor e Forma:SolidPeso molecular:1169.42PROTAC BRD4 Degrader-5
CAS:<p>PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.</p>Fórmula:C50H62ClN9O8S2Cor e Forma:SolidPeso molecular:1016.67[Ala107]MBP(104-118)
CAS:<p>Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).</p>Fórmula:C67H104N20O19Pureza:98%Cor e Forma:SolidPeso molecular:1493.68PRMT5-IN-15
CAS:<p>PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM.</p>Fórmula:C24H23F3N6O2Cor e Forma:SolidPeso molecular:484.483Echinomycin
CAS:<p>Echinomycin (Quinomycin A) is a quinoxaline antibiotic and a DNA-intercalating peptide that inhibits hypoxia-inducible factor-1 (HIF-1) DNA binding activity.</p>Fórmula:C51H64N12O12S2Pureza:95%Cor e Forma:SolidPeso molecular:1101.26SIRT1-IN-1
CAS:<p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>Fórmula:C14H16N2OPureza:99.58%Cor e Forma:SolidPeso molecular:228.29Axltide
CAS:<p>Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.</p>Fórmula:C63H107N19O20S2Pureza:98%Cor e Forma:SolidPeso molecular:1514.777-Hydroxyneolamellarin A
CAS:<p>7-Hydroxyneolamellarin A, from Dendrilla nigra, inhibits HIF-1α and VEGF in cancer research.</p>Fórmula:C24H19NO5Cor e Forma:SolidPeso molecular:401.41MACTIDE-V
<p>MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. This compound delivers Verteporfin to CD206+ tumor-associated macrophages (TAM), thereby inhibiting the YAP/TAZ signaling pathway. It facilitates YAP exclusion from the nucleus, induces TAM polarization toward an anti-tumor phenotype, enhances phagocytosis and antigen presentation, and promotes T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models.</p>Fórmula:C109H156N22O27S2Cor e Forma:SolidPeso molecular:2269.09517CPI-268456
CAS:<p>CPI-268456 is a compound which has bioactive.</p>Fórmula:C20H15Cl2N3O2Cor e Forma:SolidPeso molecular:400.26JAK-2/3-IN-1
CAS:<p>JAK-2/3-IN-1 inhibits JAK-2/3 isoforms with sub-250 nM Ki; from US patent US8163732B2.</p>Fórmula:C20H12ClN3OCor e Forma:SolidPeso molecular:345.79GSK097
CAS:<p>GSK097: Potent, selective BD2 inhibitor in BET proteins; 2000x more selective for BD2 than BD1; soluble >1 mg/mL in FaSSIF.</p>Fórmula:C19H21N3O3Cor e Forma:SolidPeso molecular:339.395GSK3735967
CAS:<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Fórmula:C25H31N7OSCor e Forma:SolidPeso molecular:477.62DS-103
<p>DS-103 is an HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 0.029, 0.123, 0.022, 0.367, and 9.26 μM, respectively. It also inhibits the malignant malaria parasite [Plasmodium falciparum 3D7] with an IC50 of 5.08 μM. In A2780 and Cal27 cells, DS-103 exhibits cytotoxicity with IC50 values of 1.48 μM and 1.47 μM, respectively, and reverses cisplatin resistance in these cells with IC50 values of 4.62 μM and 2.23 μM. DS-103 acts synergistically with cisplatin, enhancing apoptosis induced by cisplatin.</p>Fórmula:C28H33N5O3Cor e Forma:SolidPeso molecular:487.59coumarin-SAHA
CAS:<p>SAHA inhibits class I/II HDAC; c-SAHA, a fluorescent derivative, excites at 325 nm and emits at 400 nm.</p>Fórmula:C18H22N2O5Cor e Forma:SolidPeso molecular:346.383Okicenone
CAS:<p>Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.</p>Fórmula:C15H14O4Cor e Forma:SolidPeso molecular:258.27HDAC6 ligand-3
<p>HDAC6ligand-3 serves as a ligand for HDAC6 and can be utilized as a target protein ligand in the synthesis of [PROTAC] HDAC6 degrader4.</p>Fórmula:C20H21N3O3Cor e Forma:SolidPeso molecular:351.399dBRD9
CAS:<p>dBRD9 is a PROTAC.</p>Fórmula:C40H45N7O10Pureza:99.81%Cor e Forma:SolidPeso molecular:783.83iRucaparib-AP6
CAS:<p>iRucaparib-AP6: a specific, non-trapping PARP1 degrader; inhibits the enzyme's activity and scaffolding.</p>Fórmula:C46H55FN6O11Pureza:98%Cor e Forma:SolidPeso molecular:886.96GSK973
CAS:<p>GSK973 is a selective oral BET inhibitor, 1600x more for BRD4 BD2 (pIC50 7.8, pKd 8.7) than BD1, effective against other BD2s.</p>Fórmula:C23H23FN2O4Cor e Forma:SolidPeso molecular:410.445PRMT5 ligand 1
CAS:<p>PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.</p>Fórmula:C20H26N6O2Cor e Forma:SolidPeso molecular:382.459Go6976
CAS:<p>Go6976 is a PKC inhibitor, widely used in research to probe PKC functions in health and disease.</p>Fórmula:C24H18N4OPureza:95.89%Cor e Forma:Off-White To Yellow SolidPeso molecular:378.43JAK1/STAT3-IN-1
<p>JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).</p>Fórmula:C30H33FN4O3SCor e Forma:SolidPeso molecular:548.67AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Fórmula:C28H32FN9O2Cor e Forma:SolidPeso molecular:545.61Antidiabetic agent 7
<p>Antidiabetic agent 7 (Compound 5m) functions as a potent hyperglycemia inhibitor. It effectively stimulates GLUT4 translocation in skeletal muscle cells by activating the AMPK-dependent pathway. Additionally, this compound is capable of reducing blood glucose levels and exhibits favorable pharmacokinetic properties. Antidiabetic agent 7 is suitable for research related to antihyperglycemic treatments.</p>Fórmula:C27H21Cl2N5O3Cor e Forma:SolidPeso molecular:534.39Myelin Basic Protein
CAS:<p>Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.</p>Fórmula:C60H103N21O17Pureza:98%Cor e Forma:SolidPeso molecular:1390.59CEM114
CAS:<p>CEM114 is a potent chemical compound known as a chemical epigenetic modifier (CEM).</p>Fórmula:C84H122FN9O19SCor e Forma:SolidPeso molecular:1613.0JWZ-7-7-Neg1
CAS:<p>JWZ-7-7-Neg1, a neighboring transcription chemical inducer (TCIP), serves as a negative control. It exhibits reduced binding capabilities to BRD4 or BCL6 compared to JWZ-7-7, resulting in lower cytotoxicity towards DLBCL cells.</p>Fórmula:C50H58Cl2N12O6SCor e Forma:SolidPeso molecular:1026.045H-BENZO[E]PYRIDO[3,2-B][1,4]DIAZEPIN-6(11H)-ONE
CAS:Fórmula:C12H9N3OCor e Forma:SolidPeso molecular:211.21ZMF-23
<p>ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis and</p>Fórmula:C22H23Cl2N5O3Pureza:98%Cor e Forma:SolidPeso molecular:476.36Cath-L-dBET1
<p>Cath-L-dBET1 is a PROTAC degrader targeting BRD4. It has an IC50 value of 2.8 μM in MDA-MB-231 cells. Activated by cathepsin L (Cath-L), Cath-L-dBET1 recruits E3 ubiquitin ligase to degrade BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable for antitumor research.</p>Cor e Forma:Odour Solid(rel)-Tranylcypromine D5 hydrochloride
CAS:<p>(rel)-Tranylcypromine D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride.</p>Fórmula:C9H12ClNPureza:98%Cor e Forma:SolidPeso molecular:174.682TAT-cyclo-CLLFVY
CAS:<p>Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).</p>Fórmula:C111H188N42O24S2Pureza:98%Cor e Forma:SolidPeso molecular:2559.1Sirtuin modulator 5
CAS:<p>Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.</p>Fórmula:C24H23N3O4Cor e Forma:SolidPeso molecular:417.46Izilendustat
CAS:<p>Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.</p>Fórmula:C22H28ClN3O4Pureza:99.95%Cor e Forma:SolidPeso molecular:433.93Mz325
<p>Mz325 serves as a dual inhibitor of both HDAC and Sirt2, exhibiting an IC50 of 9.7 µM against Sirt2, which are implicated in the pathogenesis of cancer and</p>Pureza:98%Cor e Forma:Odour SolidTYK2 activator-1
<p>TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.</p>Fórmula:C23H21FN4O2Cor e Forma:SolidPeso molecular:404.16485mUNO
CAS:<p>mUNO is a tumor-homing peptide (mUNO, sequence: "CSPGAK") that specifically binds to murine CD206, targeting tumor-associated macrophages that express CD206/MRC1. Additionally, mUNO can interact with human recombinant CD206.</p>Fórmula:C22H39N7O8SCor e Forma:SolidPeso molecular:561.652E67-2
CAS:<p>E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.</p>Fórmula:C21H36N6O2Cor e Forma:SolidPeso molecular:404.559PROTAC HDAC6 degrader 4
<p>PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]</p>Fórmula:C39H42FN9O7Cor e Forma:SolidPeso molecular:767.81TYD-68
<p>TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.</p>Cor e Forma:Odour SolidPROTAC EED degrader-2
<p>PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.</p>Fórmula:C50H58FN11O6SPureza:98%Cor e Forma:SolidPeso molecular:960.13SJ10542
CAS:<p>SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.</p>Fórmula:C41H46N12O5SCor e Forma:SolidPeso molecular:818.95SAH-EZH2
CAS:<p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>Fórmula:C155H256N48O40Pureza:98%Cor e Forma:SolidPeso molecular:3432.05HD-TAC7
<p>HD-TAC7 is a PROTAC HDAC degrader; IC50s: HDAC1 (3.6μM), HDAC2 (4.2μM), HDAC3 (1.1μM); reduces NF-κB p65; researched for asthma, COPD.</p>Fórmula:C33H32FN7O7Cor e Forma:SolidPeso molecular:657.65PF-03622905
CAS:<p>PF-03622905: potent ATP-competitive PKC inhibitor, IC50: 5.6-74.1 nM for PKCα/βI/βII/γ/θ, high specificity for PKC.</p>Fórmula:C24H35N7O3Cor e Forma:SolidPeso molecular:469.59A-893
CAS:<p>A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .</p>Fórmula:C29H38Cl2N4O4Cor e Forma:SolidPeso molecular:577.54Biotinylated-JQ1
CAS:<p>Biotin-JQ1 is a bromodomain BRD4 binder; inhibits MM1.S cell growth with EC50 of 0.4μM.</p>Fórmula:C39H53ClN8O6S2Cor e Forma:SolidPeso molecular:829.47CAY10591
CAS:<p>SIRT1 activated by CAY10591, mimics caloric restriction, extends lifespan, inhibits apoptosis, suppresses TNF-α, and promotes fat mobilization.</p>Fórmula:C20H25N5O2Cor e Forma:SolidPeso molecular:367.44BTR2004
<p>BTR2004 is a selective PROTAC degrader targeting the BET family (BRD2/3/4) proteins. It facilitates the formation of a ternary complex with BRD proteins and KLHL20, leading to ubiquitination and proteasomal degradation via the UPS pathway. BTR2004 shows potential for research in PC3 prostate cancer and MDA-MB-231 breast cancer cell lines.</p>Cor e Forma:Odour SolidPRO-HD1
<p>PRO-HD1, a PROTAC (proteolysis-targeting chimera) HDAC6 degrader, effectively degrades HDAC6 in A549 cells and inhibits Jurkat cell proliferation with an IC50</p>Pureza:98%Cor e Forma:Odour SolidTDI-012804
<p>TDI-012804 is a TNKS2 inhibitor that selectively inhibits endogenous TNKS2 protein within cells. It enhances the expression of AXIN1 protein in Tnks1 heterozygous (Tnks1HET) and knockout (Tnks1KO) cells. TDI-012804 suppresses the proliferation of ApcQ1405X/Tnks1KO organoids with an EC50 of 59.1 nM and exhibits selective toxicity towards Tnks1KO AKP-G12D and AKP-G13D organoids.</p>Cor e Forma:Odour SolidPROTAC CBP/P300 Degrader-1
CAS:<p>PROTAC CBP/P300 Degrader-1 effectively reduces cancer cell viability by degrading CBP/P300.</p>Fórmula:C46H53F2N11O6Cor e Forma:SolidPeso molecular:893.998BRD4 degrader AT1
CAS:<p>BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.</p>Fórmula:C48H58ClN9O5S3Pureza:98%Cor e Forma:SolidPeso molecular:972.68UNC2399
CAS:<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Fórmula:C67H104N10O17SCor e Forma:SolidPeso molecular:1353.68HIV-1 protease-IN-10
<p>HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) and</p>Fórmula:C23H40O5Pureza:98%Cor e Forma:SolidPeso molecular:396.56Fluorescein-NAD+
<p>Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.</p>Cor e Forma:SolidHDAC-IN-26
CAS:<p>HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC 50 value of 4.7 nM.</p>Fórmula:C24H28FN5O3Cor e Forma:SolidPeso molecular:453.518PRO-HD2
<p>PRO-HD2 is a selective, PROTAC-based degrader of HDAC6 [1].</p>Pureza:98%Cor e Forma:Odour SolidZIP
CAS:<p>Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.</p>Fórmula:C90H154N30O17Pureza:98%Cor e Forma:SolidPeso molecular:1928.4M-808
CAS:<p>M-808, a strong covalent Menin-MLL inhibitor, binds tightly with a 2.6 nM IC50.</p>Fórmula:C45H63FN6O5SCor e Forma:SolidPeso molecular:819.09PROTAC SMARCA2/4-degrader-26
<p>PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.</p>Fórmula:C38H47N9O5SCor e Forma:SolidPeso molecular:741.9(S,R,S)-AHPC-C5-COOH
CAS:<p>E3 ligase ligand-linker '(S,R,S)-AHPC-C5-COOH' for PROTACs, VH032 inhibits VHL/HIF-1α with 185 nM Kd, may aid anemia and ischemic disease research.</p>Fórmula:C29H42N4O5SPureza:98%Cor e Forma:SolidPeso molecular:558.73PROTAC SMARCA2/4-degrader-27
CAS:<p>PROTAC SMARCA2/4-degrader-27 (PROTAC 2) serves as a targeted degrader, utilizing PROTAC technology to degrade both SMARCA2 and SMARCA4.</p>Fórmula:C49H58FN9O6SCor e Forma:SolidPeso molecular:920.11MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Cor e Forma:Odour SolidSIRT1/2/3-IN-1
CAS:<p>Potent SIRT1/2/3-IN-1 inhibits SIRT1/2/3 with IC50: 0.54, 0.25, 0.72 μM; used in cancer research.</p>Fórmula:C46H63N9O8S2Cor e Forma:SolidPeso molecular:934.18MZP-55
CAS:<p>MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)</p>Fórmula:C57H70ClN7O10SPureza:98%Cor e Forma:SolidPeso molecular:1080.73Dihydrochlamydocin
CAS:<p>Dihydrochlamydocin, an inhibitor of histone deacetylases (HDAC), exhibits potent cytostatic activity against mastocytoma cells.</p>Fórmula:C28H40N4O6Cor e Forma:SolidPeso molecular:528.65MS2133
<p>MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.</p>Fórmula:C58H66ClF3N14O11S2Cor e Forma:SolidPeso molecular:1290.41175PROTAC SMARCA2/4-degrader-31
CAS:<p>PROTAC SMARCA2/4-degrader-31 (Compound I-280) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in A549 cells and SMARCA4 in MV411 cells, both with a degradation concentration (DC50) of less than 100 nM.</p>Fórmula:C44H51N11O4Cor e Forma:SolidPeso molecular:797.95JB300
CAS:<p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>Fórmula:C43H45ClFN7O10SCor e Forma:SolidPeso molecular:906.375TAS-119
CAS:<p>TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95</p>Fórmula:C23H22Cl2FN5O3Pureza:99.65%Cor e Forma:SolidPeso molecular:506.36KDM4 ligand-1
<p>KDM4ligand-1 is a ligand targeting the protein (histone lysine demethylase KDM4) in PROTACs. It can be utilized for the synthesis of PROTACs.</p>Cor e Forma:Odour SolidZSNI-21
<p>ZSNI-21 is a dual inhibitor targeting ADAM17 and HDAC2. It effectively suppresses the proliferation of Bel-7402 cells and exhibits significant anti-metastatic properties against HCC-LM3 cells, making it a promising candidate for hepatocellular carcinoma (HCC) research.</p>Fórmula:C26H25N3O5Cor e Forma:SolidPeso molecular:459.49C 21
CAS:<p>PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.</p>Fórmula:C90H161ClN36O24Pureza:98%Cor e Forma:SolidPeso molecular:2166.94Nicotinamide riboside tartrate
CAS:<p>NRT is an oral NAD+ precursor, boosts NAD+, activates SIRT1/3, provides vitamin B3, enhances metabolism, and may mitigate Alzheimer's.</p>Fórmula:C15H20N2O11Cor e Forma:SolidPeso molecular:404.33PROTAC SMARCA2/4-degrader-30
CAS:<p>Compound I-291, also known as PROTAC SMARCA2/4-degrader-30, targets the catalytic subunits of the SWI/SNF complex, specifically SMARCA2 and SMARCA4. It effectively degrades SMARCA2 in A549 and MV411 cells, as well as SMARCA4 in MV411 cells, with a degradation concentration (DC50) of less than 100 nM.</p>Fórmula:C44H51N11O4Cor e Forma:SolidPeso molecular:797.95EP300/CBP ligand 2
<p>EP300/CBP ligand 2 (compound S19) serves as a specific ligand for the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). It plays a critical role in PROTAC technology by acting as a target protein ligand. By linking to an E3 ubiquitin ligase ligand via the PROTAC Linker, it facilitates the synthesis of PROTAC molecules capable of targeted protein degradation. For instance, when EP300/CBP ligand 2 is connected to the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc, it results in the formation of the PROTAC molecule dCE-2.</p>Fórmula:C20H18N6OCor e Forma:SolidPeso molecular:358.4PROTAC BRD4 Degrader-13
CAS:<p>PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.</p>Fórmula:C68H85F2N11O17P2S2Cor e Forma:SolidPeso molecular:1492.55PRO-HD3
<p>PRO-HD3 is a cell-specific, PROTAC-based degrader targeting HDAC6 [1].</p>Pureza:98%Cor e Forma:Odour SolidHIF-PHD-IN-4
<p>HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.</p>Cor e Forma:Odour SolidProtein Kinase C (19-36)
CAS:<p>Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.</p>Fórmula:C93H159N35O24Pureza:98%Cor e Forma:SolidPeso molecular:2151.48PROTAC SMARCA2/4-degrader-29
CAS:<p>PROTAC SMARCA2/4-degrader-29 (Compound I-279) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. In A549 cells, this compound effectively degrades SMARCA2 with a DC50 value of less than 100 nM, and similarly degrades SMARCA4 in MV411 cells with a DC50 under 100 nM.</p>Fórmula:C44H51N11O4Cor e Forma:SolidPeso molecular:797.95Nicotinamide riboside malate
CAS:<p>Orally active NAD+ booster, NR malate enhances metabolism, supports cognitive function, and is a vitamin B3 source.</p>Fórmula:C15H20N2O10Cor e Forma:SolidPeso molecular:388.33SNIPER(BRD)-1
CAS:<p>SNIPER(BRD)-1 has LCL-161, (+)-JQ1 linked; degrades BRD4, cIAP1/2, XIAP; IC50s: 6.8, 17, 49nM.</p>Fórmula:C53H66ClN9O8S2Pureza:98%Cor e Forma:SolidPeso molecular:1056.73SMARCA2 degrader-17
CAS:<p>SMARCA2 degrader-17 is a degrader of SMARCA2, exhibiting synergistic antiproliferative effects with Adagrasib in cancer cells and capable of inhibiting tumor growth.</p>Fórmula:C47H58N10O6SCor e Forma:SolidPeso molecular:891.09Malantide
CAS:<p>Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.</p>Fórmula:C72H124N22O21Pureza:98%Cor e Forma:SolidPeso molecular:1633.89GXH-II-052
<p>GXH-II-052: Potent BET inhibitor, binds BRD4/BRDT (Kd 0.6-28 nM), anti-proliferative, reduces c-Myc expression.</p>Fórmula:C62H76Cl2F2N14O11S2Cor e Forma:SolidPeso molecular:1366.39Thalidomide-NH-CBP/p300 ligand 2
CAS:<p>Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).</p>Fórmula:C48H57F2N11O6Cor e Forma:SolidPeso molecular:922.052PROTAC BET Degrader-10
CAS:<p>PROTAC BET Degrader-10 targets and degrades BRD4 with a DC50 of 49 nM, using Cereblon ligands.</p>Fórmula:C39H39ClN8O6SCor e Forma:SolidPeso molecular:783.3HDAC6-IN-56
<p>HDAC6-IN-56 (compound 18d) is an inhibitor of HDAC6, with an IC50 of 1.3 nM. This compound can inhibit the S phase and induce apoptosis in HCT-116 colon cancer cells.</p>Fórmula:C25H27ClN4O4SCor e Forma:SolidPeso molecular:514.14415PROTAC BRD4 Degrader-27
CAS:<p>PROTAC BRD4 Degrader-27 is a selective PROTAC targeting BRD4, distinguished from BRD2/BRD3. This compound is composed of the E3 ubiquitinase ligand Thalidomide-4-OH, the PROTAC Linker γ-Aminobutyric acid, and the PROTAC target protein ligand PROTAC BRD4 ligand-3. The active control for this target protein ligand is Mivebresib, while the conjugate of the E3 ubiquitin ligase ligand and Linker is identified as Pomalidomide 4'-alkylC3-acid.</p>Fórmula:C37H30F2N6O7Cor e Forma:SolidPeso molecular:708.67MS049 2HCl (1502816-23-0(free base))
<p>MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.</p>Fórmula:C15H26Cl2N2OPureza:99.9%Cor e Forma:SolidPeso molecular:321.28FTX-6058
CAS:<p>FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.</p>Fórmula:C22H18FN5O2Cor e Forma:SolidPeso molecular:403.417Mersalyl
CAS:<p>Mersalyl is an organic mercurial diuretic.</p>Fórmula:C13H16HgNNaO6Cor e Forma:SolidPeso molecular:505.854KB02-JQ1
CAS:<p>KB02-JQ1: potent BRD4-degrading PROTAC, stable, specific; doesn't affect BRD2/3, modifies DCAF16 for action.</p>Fórmula:C38H43Cl2N7O6SPureza:98%Cor e Forma:SoildPeso molecular:796.76PKC β pseudosubstrate
CAS:<p>Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).</p>Fórmula:C177H294N62O38S3Pureza:98%Cor e Forma:SolidPeso molecular:3994.84PROTAC BRD2/BRD4 degrader-1
<p>Compound 15: Potent PROTAC, selectively degrades BRD4/BRD2, has low toxicity, and is built of a BET inhibitor, linker, and CRBN ligand.</p>Fórmula:C39H38N6O9SPureza:98%Cor e Forma:SolidPeso molecular:766.82M-1211
CAS:<p>M 1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression.</p>Fórmula:C42H57FN6O6SCor e Forma:SolidPeso molecular:793.01SIM1
<p>SIM1, a potent PROTAC®Degrader, preferentially degrades BET proteins (BRD4, BRD2, BRD3) and induces apoptosis in prostate cancer cells.</p>Cor e Forma:LiquidSW2_110A acetate
<p>SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).</p>Fórmula:C44H64N6O9Pureza:98%Cor e Forma:SoildPeso molecular:821.01MS33
CAS:<p>MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.</p>Fórmula:C64H84F3N11O7SCor e Forma:SolidPeso molecular:1208.5Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS:<p>Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.</p>Fórmula:C56H110N22O14Pureza:98%Cor e Forma:SolidPeso molecular:1315.61Larsucosterol Ammonium salt
CAS:<p>Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.</p>Fórmula:C27H49NO5SPureza:>99.99% - >99.99%Cor e Forma:SoildPeso molecular:499.75JAK3-IN-15
<p>JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.</p>Cor e Forma:Odour SolidBAY-184
CAS:<p>BAY-184,KAT6A/B inhibitor (IC50=71/83 nM). Suppresses ERα activity. Impedes breast cancer proliferation.</p>Fórmula:C23H20N2O4SPureza:98.87%Cor e Forma:SolidPeso molecular:420.48JAK1/TYK2-IN-1
CAS:<p>JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).</p>Fórmula:C18H20F3N7OCor e Forma:SolidPeso molecular:407.401LSD1/HDAC6-IN-1
<p>LSD1/HDAC6-IN-1 is an oral dual inhibitor of LSD1/HDAC6 with anti-tumor effects, useful for multiple myeloma research.</p>Cor e Forma:SolidHDAC6 degrader-3
CAS:<p>HDAC6 degrader-3: potent, selective, degrades HDAC6 at 19.4 nM, weakens HDAC1 at 0.647 μM, induces α-tubulin hyperacetylation.</p>Fórmula:C41H41F4N7O11Cor e Forma:SolidPeso molecular:883.8Uzansertib
CAS:<p>Uzansertib (INCB053914) is a potent pan-PIM kinase inhibitor with low IC50s: 0.24, 30, 0.12 nM for PIM1, 2, 3; hinders hematologic tumor growth.</p>Fórmula:C26H26F3N5O3Cor e Forma:SolidPeso molecular:513.51dBAZ2
<p>dBAZ2 is a pioneering PROTAC degrader targeting BAZ2A and BAZ2B, with DC50 values of 180 nM for BAZ2A and 250 nM for BAZ2B.</p>Fórmula:C54H64FN11O5S2Cor e Forma:SolidPeso molecular:1030.29GSK040
CAS:<p>GSK040: Potent BET BD2 inhibitor, pIC50 8.3, 5000x selectivity over BD1, for oncology & immunology research.</p>Fórmula:C29H34N4O4Cor e Forma:SolidPeso molecular:502.6PF-04577806
CAS:<p>PF-04577806: potent & selective PKC inhibitor, ATP competitive, blocks PKCα/βI/βII/γ/θ (IC50: 2.4-45.9 nM), may reverse diabetic retinal leakage.</p>Fórmula:C26H37N7O3Cor e Forma:SolidPeso molecular:495.628PRMT5-IN-9
CAS:<p>PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.</p>Fórmula:C25H23F3N6OCor e Forma:SolidPeso molecular:480.495BRD4 degrader-6
CAS:<p>BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.</p>Fórmula:C61H71BClN9O7S2Cor e Forma:SolidPeso molecular:1152.67CARM1/IKZF3 ligand 1
<p>CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.</p>Fórmula:C27H35ClN6O3Cor e Forma:SolidPeso molecular:527.06PRMT5-IN-12
CAS:<p>PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .</p>Fórmula:C32H40N4O4Cor e Forma:SolidPeso molecular:544.696HIF-1 α (556-574)
CAS:<p>HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.</p>Fórmula:C101H150D2N20O34S2Pureza:98%Cor e Forma:SolidPeso molecular:2254.6PROTAC BRD4 Degrader-8
<p>PROTAC BRD4 Degrader-8: BRD4 inhibitor with IC50s of 1.1/1.4 nM for BD1/BD2, degrades BRD4 in PC3 cells.</p>Cor e Forma:LiquidNamoline
CAS:<p>Namoline, a γ-pyrone, inhibits LSD1 with a 51 μM IC50, blocking cell growth and showing potential in prostate cancer studies.</p>Fórmula:C10H3ClF3NO4Cor e Forma:SolidPeso molecular:293.58Eldocasiran
CAS:<p>Eldocasiran, a micro-RNA-193a-3p analogue, exhibits anticancer properties. It is utilized in cancer research [1].</p>Fórmula:C423H529N161O305P42Cor e Forma:SolidPeso molecular:14049.5SJ1008030
CAS:<p>SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.</p>Fórmula:C42H43N13O7SCor e Forma:SolidPeso molecular:873.94PROTAC BET degrader-3
<p>PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.</p>Fórmula:C53H64N12O9SPureza:98%Cor e Forma:SolidPeso molecular:1045.22BRD3067
CAS:<p>BRD3067, a Tubacin derivative, inhibits HDAC6 (IC50 15 nM) and acts as a negative control for Tubacin A, showing anticancer and anti-inflammatory effects.</p>Fórmula:C21H23N3O2Pureza:98%Cor e Forma:SolidPeso molecular:349.43pan-BET/BD2-IN-1
<p>Pan-BET/BD2-IN-1 (compound 6b) is a selective BET protein inhibitor with BRDT-1Ki of 1.05 μM and BRD4-1Ki of 0.68 μM. It effectively inhibits the growth of MM.1S cancer cells with an IC50 value of 2.6 μM.</p>Cor e Forma:Odour SolidCB1R/AMPK modulator 1
<p>Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R.</p>Fórmula:C25H22Cl2N6O3SPureza:98%Cor e Forma:SolidPeso molecular:557.45MAK-683 hydrochloride
CAS:<p>MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.</p>Fórmula:C20H18ClFN6OPureza:97.02% - >99.99%Cor e Forma:SolidPeso molecular:412.85GSK9311 hydrochloride
CAS:<p>GSK9311 hydrochloride is a less active GSK6853 analog, serving as a negative control, inhibiting BRPF1/2 (pIC50: 6.0/4.3).</p>Fórmula:C24H32ClN5O3Pureza:98%Cor e Forma:SolidPeso molecular:474Bryostatin 3
CAS:<p>Bryostatin 3 is a protein kinase C activator.</p>Fórmula:C46H64O17Pureza:98%Cor e Forma:SolidPeso molecular:888.99CBB1007 trihydrochloride (1379573-92-8 free base)
CAS:<p>CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).</p>Fórmula:C27H37Cl3N8O4Pureza:98%Cor e Forma:SoildPeso molecular:643.99PROTAC EED degrader-1
<p>PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.</p>Fórmula:C55H60FN11O8SPureza:98%Cor e Forma:SolidPeso molecular:1054.2FKBP12 PROTAC dTAG-7
CAS:<p>dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.</p>Fórmula:C63H79N5O19Pureza:98%Cor e Forma:SolidPeso molecular:1210.32AUR1545
CAS:<p>AUR1545 is a selective KAT2A/KAT2B degradator exhibiting inhibitory activity against cancer models including AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.</p>Fórmula:C41H50BrN9O5Pureza:98.84%Cor e Forma:SolidPeso molecular:828.8PROTAC BRD4 Degrader-30
<p>PROTACBRD4 degrader-30 is an ISOX-DUAL-based PROTAC degrader, targeting BRD4 with an IC50 value of 65 nM. It is used in research studies related to c-Myc oncoproteins and the pathophysiology of cancer cells.</p>Cor e Forma:Odour SolidEXQ-2d
<p>EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.</p>Fórmula:C18H17N3O3Cor e Forma:SolidPeso molecular:323.35SIRT5 inhibitor 8
CAS:<p>SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.</p>Fórmula:C22H25ClN8O2SPureza:99.56%Cor e Forma:SolidPeso molecular:501PROTAC BET degrader-2
CAS:<p>PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).</p>Fórmula:C41H42N10O6Pureza:98%Cor e Forma:SolidPeso molecular:770.84Anemonin (6CI)
CAS:<p>Anemonin, a furanone dimer from Buttercups, may help manage melanocytes and osteoarthritis.</p>Fórmula:C10H8O4Cor e Forma:SolidPeso molecular:192.17SMD-3040 TFA
<p>SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis.</p>Pureza:98%Cor e Forma:Odour SolidGNE-987
CAS:<p>GNE-987 is a potent chimeric BET degrader, binding BRD4 BD1/BD2 at IC50: 4.7/4.4 nM & has a DC50: 0.03 nM in EOL-1 AML cells.</p>Fórmula:C56H67F2N9O8S2Pureza:98%Cor e Forma:SolidPeso molecular:1096.31(+)-JQ-1-aldehyde
<p>(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1].</p>Cor e Forma:SolidMRS2698
CAS:<p>MRS2698: potent P2Y2 agonist, EC50 8 nM, >300x selectivity over P2Y4/P2Y6.</p>Fórmula:C9H16N3O13P3SPureza:98%Cor e Forma:SolidPeso molecular:499.22UNC4976
<p>UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.</p>Fórmula:C47H70N6O8Pureza:98%Cor e Forma:SolidPeso molecular:847.09PI3Kα/HDAC6-IN-1
<p>PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.</p>Fórmula:C27H30F3N7O6S2Pureza:98%Cor e Forma:SolidPeso molecular:669.7HDAC/CD13-IN-1
<p>HDAC/CD13-IN-1 (Compound 12) is an inhibitor of both HDAC and CD13, with IC50 values of 0.34 μM for hCD13, 0.53 μM for porcine CD13, and 0.03, 0.06, and 0.02 μM</p>Fórmula:C27H41Cl2N5O4Pureza:98%Cor e Forma:SolidPeso molecular:570.55JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
<p>JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a BRD4 ligand and a PROTAC linker, and is used in the synthesis of PROTAC BRD4 Degrader-29.</p>Fórmula:C43H51ClN8O3S2Cor e Forma:SolidPeso molecular:827.5UNC6864 (Kei)
<p>UNC6864, an ethylisopropyllysine-containing ligand, exhibits binding affinity to wild-type CBX5, demonstrating a dissociation constant (K D) of 3.3 μM.</p>Fórmula:C42H59N7O11Cor e Forma:SolidPeso molecular:837.96WDR5 ligand 2
CAS:<p>WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.</p>Fórmula:C29H31F3N4O4Cor e Forma:SolidPeso molecular:556.576HDAC11-IN-1
<p>HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.</p>Fórmula:C43H63F3N6O6S2Cor e Forma:SolidPeso molecular:881.12
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