Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2235 produtos de "Cromatina/Epigenética"
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(Z)-SMI-4a
CAS:<p>(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.</p>Fórmula:C11H6F3NO2SPureza:97.66% - 99.93%Cor e Forma:SolidPeso molecular:273.23Oclacitinib
CAS:<p>Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000</p>Fórmula:C15H23N5O2SPureza:98% - 98.45%Cor e Forma:White To Off-White SolidPeso molecular:337.44lutidinic acid
CAS:<p>lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.</p>Fórmula:C7H5NO4Pureza:98.06%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:167.12RG108
CAS:<p>RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).</p>Fórmula:C19H14N2O4Pureza:98% - 99.43%Cor e Forma:SolidPeso molecular:334.33SGC-CBP30
CAS:<p>SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).</p>Fórmula:C28H33ClN4O3Pureza:99.05% - >99.99%Cor e Forma:SolidPeso molecular:509.04AZD-1480
CAS:<p>AZD1480: JAK2 inhibitor, IC50 0.26 nM; selective vs Tyk2, JAK3; less on JAK1. Used in solid tumors, PPV, PMF, ET trials.</p>Fórmula:C14H14ClFN8Pureza:98.25% - 99.47%Cor e Forma:SolidPeso molecular:348.77JAK-IN-5 hydrochloride
CAS:<p>JAK-IN-5 hydrochloride is a JAK inhibitor [1].</p>Fórmula:C27H32ClFN6OCor e Forma:SolidPeso molecular:511.03Barasertib-HQPA
CAS:<p>Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.</p>Fórmula:C26H30FN7O3Pureza:98.43% - 99.29%Cor e Forma:SolidPeso molecular:507.56ARV-825
CAS:<p>ARV-825: PROTAC recruits BRD4 to cereblon for rapid BRD4 degradation in all tested BL cells.</p>Fórmula:C46H47ClN8O9SPureza:97.15% - 98%Cor e Forma:SolidPeso molecular:923.43UNC6934
CAS:<p>UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.</p>Fórmula:C24H21N5O4Pureza:98.67%Cor e Forma:SolidPeso molecular:443.45Annaosanchun
CAS:<p>Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).</p>Fórmula:C19H32O3Pureza:99.58%Cor e Forma:SolidPeso molecular:308.46GS-829845
CAS:<p>GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life</p>Fórmula:C17H19N5O2SPureza:99.93%Cor e Forma:SolidPeso molecular:357.43CX-6258 hydrochloride
CAS:<p>CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).</p>Fórmula:C26H24ClN3O3·HClPureza:96.03% - 98.60%Cor e Forma:SolidPeso molecular:498.4CBHcy
CAS:<p>CBHcy, a dual substrate analog, is a specific BHMT inhibitor that may induce cysteinemia.</p>Fórmula:C9H17NO4SPureza:>99.99% - >99.99%Cor e Forma:SolidPeso molecular:235.3TNG-462
CAS:<p>TNG-462 is a oral, potent and selective PRMT5 inhibitor for the treatment of MTAP-deficient and/or MTA-accumulating cancers (e.g., pancreatic & bladder).</p>Fórmula:C28H36N6O2SPureza:98.7%Cor e Forma:SolidPeso molecular:520.69MIV-6R
CAS:<p>MIV-6R inhibits Menin-MLL interaction (IC50: 56 nM) and can be used to study leukemia.</p>Fórmula:C27H35N3OPureza:99.81% - 99.88%Cor e Forma:SolidPeso molecular:417.59Talazoparib tosylate
CAS:<p>PF-3882845 is an MR antagonist that binds to the progesterone receptor (PR) and is used in the study of endocrine disorders and urogenital disorders.</p>Fórmula:C26H22F2N6O4SPureza:99.79%Cor e Forma:SolidPeso molecular:552.55Zavondemstat
CAS:<p>Zavondemstat (QC8222 free base) is a KDM4 inhibitor with anticancer and antitumor activity for the study of triple-negative and breast cancers.</p>Fórmula:C26H29N3O3Pureza:99.43% - 99.53%Cor e Forma:SolidPeso molecular:431.53MS023 dihydrochloride
CAS:<p>MS023 dihydrochloride (MS023 2HCl) is a human type I protein arginine methyltransferase inhibitor with antitumour activity for the study of breast cancer.</p>Fórmula:C17H27Cl2N3OPureza:99.52%Cor e Forma:SolidPeso molecular:360.32Cerdulatinib hydrochloride
CAS:<p>Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.</p>Fórmula:C20H28ClN7O3SPureza:99.85%Cor e Forma:SolidPeso molecular:482Chromium(III) acetate
CAS:<p>Chromium(III) acetate （Chromium acetate） is a small molecule ionic crosslinker that is used as a feedstock for the synthesis of other compounds.</p>Fórmula:C2H3O2CrPureza:99.9%Cor e Forma:Blue-Green Powder Environment Immediate Steps Should Be Taken To Limit Its Spread To The Environment It Is Used InPeso molecular:76.37(S)-HH2853
CAS:<p>(S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune research.</p>Fórmula:C31H36F3N7O3Pureza:97.18% - 99.74%Cor e Forma:SolidPeso molecular:611.66MRK-740
CAS:<p>MRK-740 is a PRDM9 histone methyltransferase inhibitor that inhibits H3K4 methylation.</p>Fórmula:C25H32N6O3Pureza:99.66%Cor e Forma:SolidPeso molecular:464.56BI-9321 trihydrochloride
CAS:<p>BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.</p>Fórmula:C22H24Cl3FN4Pureza:99.12% - 99.34%Cor e Forma:SolidPeso molecular:469.81R 59-022
CAS:<p>R 59-022 (DKGI-I) is a DGK inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells.</p>Fórmula:C27H26FN3OSPureza:98.55%Cor e Forma:SolidPeso molecular:459.58PFI-2
CAS:<p>PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other</p>Fórmula:C23H25F4N3O3SPureza:99.38%Cor e Forma:SolidPeso molecular:499.52NVP-BSK805
CAS:<p>NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.</p>Fórmula:C27H28F2N6OPureza:98%Cor e Forma:SolidPeso molecular:490.55MK-5108
CAS:<p>MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.</p>Fórmula:C22H21ClFN3O3SPureza:99.22%Cor e Forma:SolidPeso molecular:461.94Dehydrocorydaline nitrate
CAS:<p>DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.</p>Fórmula:C22H24N2O7Pureza:99.79% - 99.92%Cor e Forma:SolidPeso molecular:428.44SCH-1473759 hydrochloride
CAS:<p>SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).</p>Fórmula:C20H27ClN8OSPureza:98.29%Cor e Forma:SolidPeso molecular:463GSK2807 Trifluoroacetate
CAS:<p>GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).</p>Fórmula:C21H33F3N8O7Pureza:99.95%Cor e Forma:SolidPeso molecular:566.53(R)-Dihydrolipoic acid
CAS:<p>(R)-Dihydrolipoic acid, the biochemically significant R-enantiomer, partakes in biochemical transformations.</p>Fórmula:C8H16O2S2Pureza:98%Cor e Forma:SolidPeso molecular:208.33Solrikitug
CAS:<p>Solrikitug,Anti-CRLF2 humanized IgG1κ monoclonal antibody.</p>Pureza:95%Cor e Forma:LiquidTazemetostat trihydrochloride
CAS:<p>Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in peptide and nucleosome assays.</p>Fórmula:C34H47Cl3N4O4Pureza:98%Cor e Forma:SolidPeso molecular:682.12Acedapsone
CAS:<p>Acedapsone has antimalarial and antimicrobial action, but is mainly used as a depot leprostatic agent.</p>Fórmula:C16H16N2O4SPureza:98%Cor e Forma:SolidPeso molecular:332.37Diethyl bipy55'DC
CAS:<p>"Diethyl bipy55'DC blocks CP4H, crucial for collagen stability via hydroxylation in cells."</p>Fórmula:C16H16N2O4Pureza:98%Cor e Forma:SolidPeso molecular:300.312-PADQZ
CAS:<p>DPQ is an antiviral compound.</p>Fórmula:C14H19N5O2Pureza:98%Cor e Forma:White PowderPeso molecular:289.33Nicotinamide-d4
CAS:<p>Nicotinamide-d4 is a deuterium-labelled compound of nicotinamide for isotope tracing. Nicotinamide, a vitamin B3 derivative, inhibits SIRT1 and SIRT2.</p>Fórmula:C6H2D4N2OPureza:99.746%Cor e Forma:SolidPeso molecular:126.15193 D7
CAS:<p>193 D7 is an inhibitor of histone demethylase JMJD1C (IC50= 0.59 μM in in vitro demethylation assay). In vivo, 193 D7 suppresses tumors by targeting intratumoral Treg cells in mouse tumor models.</p>Fórmula:C16H15NO4SCor e Forma:SolidPeso molecular:317.36GSK 4027
CAS:<p>GSK 4027 is a PCAF/GCN5 bromodomain chemical probe. In a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, it has a pIC50 of 7.4±0.11 for PCAF.</p>Fórmula:C17H21BrN4OCor e Forma:SolidPeso molecular:377.28I-BET787
CAS:<p>I-BET787, an orally active pan-BET bromodomain inhibitor, has demonstrated efficacy in murine inflammation models.</p>Fórmula:C16H20ClN3O2Cor e Forma:SolidPeso molecular:321.80CrBKA
CAS:<p>CrBKA is a fluorogenic small-molecule substrate of SIRT6 with weak activity [1] .</p>Fórmula:C28H31N3O6Cor e Forma:SolidPeso molecular:505.56AdipoR agonist 1
CAS:<p>AdipoR agonist 1 (Compound 112254), acting as an agonist for the adiponectin receptor (AdipoR), stimulates transcriptional regulators including peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). It is employed in the field of preventive doping research.</p>Fórmula:C26H35N3O3Cor e Forma:SolidPeso molecular:437.57HDAC6-IN-27
CAS:<p>HDAC6-IN-27 (compound 8C), an HDAC inhibitor, exhibits IC 50 values of 15.9 nM, 136.5 nM, and 6180.2 nM against HDAC6, HDAC8, and HDAC1, respectively. It also demonstrates potent antiparasitic effects [1].</p>Fórmula:C15H15N3O4Cor e Forma:SolidPeso molecular:301.3BG47
CAS:<p>BG47: a COMET probe for precise optical epigenetic control, inhibits histone deacetylases with light.</p>Fórmula:C25H22N4O2SCor e Forma:SolidPeso molecular:442.54Guanosine-5'-triphosphate disodium salt
CAS:<p>5'-GTP disodium salt boosts myogenic differentiation and fuels cellular processes.</p>Fórmula:C10H14N5Na2O14P3Pureza:95.69% - 99.96%Cor e Forma:Odorless White SolidPeso molecular:567.14GSK-J1 lithium salt
CAS:<p>GSK-J1 lithium salt is an effective inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with an IC 50 of 60 nM for KDM6B.</p>Fórmula:C22H22LiN5O2Pureza:98%Cor e Forma:SolidPeso molecular:395.38BG14
CAS:<p>BG14: High-res optical epigenetic control; photo-inhibits human histone deacetylases with visible light.</p>Fórmula:C21H21N5OCor e Forma:SolidPeso molecular:359.433KAT6-IN-1
CAS:<p>KAT6-IN-1 is a potent KAT6 inhibitor. KAT6-IN-1 can be used in research of cancer [1] .</p>Fórmula:C19H18N4O5SCor e Forma:SolidPeso molecular:414.43ZM39923
CAS:<p>ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).</p>Fórmula:C23H25NOPureza:98%Cor e Forma:SolidPeso molecular:331.45KR-39038
CAS:<p>KR-39038 is an oral GRK5 inhibitor for heart failure research; blocks HDAC5 pathway, IC50: 0.02 μM, fights cardiac hypertrophy.</p>Fórmula:C24H32ClFN6OCor e Forma:SolidPeso molecular:475.00BChE/HDAC6-IN-2
CAS:<p>BChE/HDAC6-IN-2 is an inhibitor of BChE and HDAC6 with neuroprotective and ROS scavenging activity and a metal ion co-agonist and inhibits tau phosphorylation.</p>Fórmula:C27H30N4O4Pureza:98.47%Cor e Forma:SoildPeso molecular:474.55BG48
CAS:<p>BG48, a COMET probe, enables precise optical epigenetic control and photochromically blocks human histone deacetylases with visible light.</p>Fórmula:C25H23N5OSCor e Forma:SolidPeso molecular:441.55(3S,4S)-Tofacitinib
CAS:<p>(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.</p>Fórmula:C16H20N6OPureza:98%Cor e Forma:SolidPeso molecular:312.37Asteltoxin
CAS:<p>Asteltoxin is a useful organic compound for research related to life sciences. The catalog number is T124203 and the CAS number is 79663-49-3.</p>Fórmula:C23H30O7Cor e Forma:SolidPeso molecular:418.486HDAC2-IN-2
CAS:<p>HDAC2-IN-2 (compound 124) acts as an HDAC2 inhibitor, exhibiting a Kd value ranging from 0.1-1 μM.</p>Fórmula:C18H15N3O3SCor e Forma:SolidPeso molecular:353.40E3330
CAS:<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Fórmula:C21H30O6Pureza:99.52%Cor e Forma:SolidPeso molecular:378.46TMPA
CAS:<p>TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.</p>Fórmula:C21H32O6Pureza:99.21%Cor e Forma:SolidPeso molecular:380.48GSK-1268997
CAS:<p>GSK-1268997 is a bio-active chemical.</p>Fórmula:C21H23N7O3SPureza:99.33% - 99.81%Cor e Forma:SolidPeso molecular:453.52UNC0224
CAS:<p>UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.</p>Fórmula:C26H43N7O2Pureza:99.80%Cor e Forma:SolidPeso molecular:485.67MY-1B
CAS:<p>MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.</p>Fórmula:C22H18BrN3O2Pureza:99.81% - >99.99%Cor e Forma:SoildPeso molecular:436.3JAK-IN-30
CAS:<p>JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50</p>Fórmula:C19H26N8SPureza:98%Cor e Forma:SolidPeso molecular:398.53ZYJ-34c
CAS:<p>ZYJ-34c is a potent oral antitumor activities histone deacetylase inhibitor (HDACi).</p>Fórmula:C31H42N4O7Pureza:98%Cor e Forma:SolidPeso molecular:582.69SIRT1-IN-3
CAS:<p>SIRT1-IN-3 (compound 3j) is a potent and selective inhibitor of silent information regulator 1 (SIRT1) with an IC 50 of 4.2 μM [1].</p>Fórmula:C13H15BrN2OCor e Forma:SolidPeso molecular:295.17Eleven-Nineteen-Leukemia Protein IN-1
CAS:<p>ENL-IN-1: Potent ENL YEATS domain inhibitor with 14.5 nM IC50, enhances thermal stability in vitro.</p>Fórmula:C27H33N7O2Pureza:98%Cor e Forma:SolidPeso molecular:487.6Angiogenesis agent 1
CAS:<p>Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.</p>Fórmula:C20H24O7Pureza:98%Cor e Forma:SolidPeso molecular:376.4LSD1-IN-5
CAS:<p>LSD1-IN-5, a reversible LSD1 inhibitor, boosts H3K4me2 without affecting LSD1 expression; IC50: 121 nM.</p>Fórmula:C15H13BrN2O3Pureza:98%Cor e Forma:SolidPeso molecular:349.18EZH2-IN-7
CAS:<p>EZH2-IN-7 inhibits EZH2, reducing H3K27me3 and tumor growth (e.g., breast, prostate cancer, leukemia). Potential in cancer research.</p>Fórmula:C31H37D2N5O3SCor e Forma:SolidPeso molecular:563.75CM-579
CAS:<p>CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.</p>Fórmula:C29H40N4O3Pureza:99.23%Cor e Forma:SolidPeso molecular:492.655-Aza-4'-thio-2'-deoxycytidine
CAS:<p>5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].</p>Fórmula:C8H12N4O3SCor e Forma:SolidPeso molecular:244.27Tripolin A
CAS:<p>Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)</p>Fórmula:C15H11NO3Pureza:98%Cor e Forma:SolidPeso molecular:253.25DC_C66
CAS:<p>DC_C66 selectively inhibits CARM1 with IC50 of 1.8μM; also affects PRMT1, 6, 5. It's cell-permeable.</p>Fórmula:C28H22NO2Pureza:98%Cor e Forma:SolidPeso molecular:404.48Aurora kinase inhibitor-9
CAS:<p>Aurora kinase inhibitor-9 (9d) targets AURKA/B with IC50: 0.093 μM for A and 0.09 μM for B, with wide anti-proliferative effects.</p>Fórmula:C19H17Cl2N3O4SCor e Forma:SolidPeso molecular:454.33G9a-IN-2
CAS:<p>G9a-IN-2 (Compound 7i) is an inhibitor of the histone methyltransferase G9a, with an IC50 of 0.024 μM. It can reduce the levels of H3K9me2 and induce the expression of γ-globin mRNA. G9a-IN-2 shows potential for improving Sickle Cell Disease (SCD).</p>Fórmula:C30H42N4O4Cor e Forma:SolidPeso molecular:522.68HDAC1/MAO-B-IN-1
CAS:<p>HDAC1/MAO-B-IN-1 is a selective Alzheimer’s research inhibitor with IC50s: HDAC1 (21.4 nM) & MAO-B (99 nM); crosses the blood-brain barrier.</p>Fórmula:C18H17ClN2O2Cor e Forma:SolidPeso molecular:328.79Tankyrase-IN-4
<p>Tankyrase-IN-4 is a potent inhibitor of tankyrase 1 (TNKS1), exhibiting an IC50 of 0.8 nM, and is utilized in cancer research.</p>Fórmula:C25H24N6O5Cor e Forma:SolidPeso molecular:488.5LP99
CAS:<p>LP99 is an epigenetic probe.</p>Fórmula:C26H30ClN3O4SPureza:99.74%Cor e Forma:SolidPeso molecular:516.05TM6089
CAS:<p>TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.</p>Fórmula:C13H14N4O3SPureza:99.70%Cor e Forma:SolidPeso molecular:306.34FAK/aurora kinase-IN-1
CAS:<p>FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].</p>Fórmula:C23H24ClN7O3Cor e Forma:SolidPeso molecular:481.93BET bromodomain inhibitor 3
CAS:<p>BET Bromodomain Inhibitor 3 is a BET bromodomain inhibitor with an inhibitory Ki value of >40 µM against BrdT.</p>Fórmula:C18H17N3O4Pureza:98%Cor e Forma:SolidPeso molecular:339.35PRMT4-IN-1
CAS:<p>PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].</p>Fórmula:C23H28FN3OPureza:98%Cor e Forma:SolidPeso molecular:381.49PARP11 inhibitor ITK7
CAS:<p>ITK7 is a potent, selective PARP11 inhibitor with an IC50 of 14 nM, useful for cellular localization research.</p>Fórmula:C17H14N4OSCor e Forma:SolidPeso molecular:322.38HDAC-IN-41
CAS:<p>HDAC-IN-41 is a selective class I HDAC inhibiting HDAC1, 2, & 3 with IC50: 0.62-1.46 µM; oral use; has NO-release.</p>Fórmula:C20H22N4O6SCor e Forma:SolidPeso molecular:446.48BI-831266
CAS:<p>BI-831266 is a potent and selective Aurora kinase B inhibitor.</p>Fórmula:C27H38ClN7O2Cor e Forma:SolidPeso molecular:528.09KF 13218
CAS:<p>KF 13218 is a selective, potent and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.</p>Fórmula:C20H20N2O3Pureza:98%Cor e Forma:SolidPeso molecular:336.38YUKA1
CAS:<p>YUKA1, a cell-permeable KDM5A inhibitor with a weak effect on KDM5C, increase H3K4me3 and inhibit the proliferation, prevent drug-resistant.</p>Fórmula:C13H16N4O2SPureza:99.85%Cor e Forma:SolidPeso molecular:292.36HDAC-IN-30
CAS:<p>HDAC-IN-30 is a potent HDAC inhibitor targeting HDAC1, 2, 3, 6, and 8 with strong antitumor efficacy.</p>Fórmula:C22H23N5O3Cor e Forma:SolidPeso molecular:405.45HDAC6-IN-14
<p>HDAC6-IN-14, an inhibitor of HDAC6 (HDAC), exhibits high selectivity with an IC50 value of 42 nM, demonstrating over 100-fold selectivity compared to HDAC1,</p>Fórmula:C24H30FN3O4Cor e Forma:SolidPeso molecular:443.51JFD00244
CAS:<p>JFD00244 is an inhibitor of sirtuin 2 (SIRT2). It has an anti-tumor effect.</p>Fórmula:C30H26N2O4Pureza:98%Cor e Forma:SolidPeso molecular:478.54Y06036
CAS:<p>Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).</p>Fórmula:C16H15BrN2O5SPureza:99.97%Cor e Forma:SolidPeso molecular:427.27PRMT5-IN-2
CAS:<p>PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.</p>Fórmula:C17H16ClFN4O4Pureza:98%Cor e Forma:SolidPeso molecular:394.78NCD38
CAS:<p>NCD38 is a potent, selective LSD1 inhibitor.</p>Fórmula:C37H37ClF3N3O4Pureza:98.21% - 98.86%Cor e Forma:SolidPeso molecular:680.16(Rac)-BAY1238097
CAS:<p>(Rac)-BAY1238097 is a inhibitor of BET(IC50 of 1.02 μM for BRD4),used in cancer research.</p>Fórmula:C25H33N5O3Pureza:98%Cor e Forma:SolidPeso molecular:451.56JAK-2/3-IN-2
CAS:<p>JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).</p>Fórmula:C19H19ClN2OSCor e Forma:SolidPeso molecular:358.89EZM 2302
CAS:<p>EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.</p>Fórmula:C29H37ClN6O5Pureza:97.47% - ≥98%Cor e Forma:SolidPeso molecular:585.09HDAC6-IN-11
CAS:<p>HDAC6-IN-11 (Compound 9) is a cancer cell growth blocker, selectively inhibiting HDAC6 (>300-fold) with an IC50 of 20.7 nM.</p>Fórmula:C19H16N2O4Cor e Forma:SolidPeso molecular:336.34HDAC8/BRPF1-IN-1
CAS:<p>Compound 23a, dual HDAC8/BRPF1 inhibitor: IC50 HDAC8 = 443 nM, Kd BRPF1 = 67 nM; weak against HDAC1/6.</p>Fórmula:C19H19N3O6SCor e Forma:SolidPeso molecular:417.44OHM1
CAS:<p>OHM1, an analog of HIF1α CTAD, effectively inhibits the interaction between HIF1α CTAD and p300/CBP by targeting the CH1 domain with a binding affinity of 0.53</p>Fórmula:C24H42N6O5Cor e Forma:SolidPeso molecular:494.63J1038
CAS:<p>J1038 is a novel Histone Deacetylase 8 (HDAC8) Inhibitor .</p>Fórmula:C10H10N2O3SCor e Forma:SolidPeso molecular:238.26A2B57
CAS:<p>A2B57 is a selective SIRT2 inhibitor.</p>Fórmula:C22H19N5OPureza:98%Cor e Forma:SolidPeso molecular:369.42BRD4-BD1-IN-1
CAS:<p>BRD4-BD1-IN-1 (Compound 9a) is a BRD4-BD1 inhibitor(IC50= 38.20 μM).</p>Fórmula:C16H15BrN4O4Cor e Forma:SolidPeso molecular:407.22A2AAR/HDAC-IN-1
CAS:<p>A2AAR/HDAC-IN-1 (compound 14c) is an orally active, balanced A2AAR/HDAC dual inhibitor of A2AAR (Ki: 163.5 nM), HDAC1 (IC50: 145.3 nM). effect.</p>Fórmula:C24H21N7O2Cor e Forma:SolidPeso molecular:439.47ARTD10/PARP10-IN-2
CAS:<p>ARTD10/PARP10-IN-2: A potent, non-selective PARP inhibitor, IC50: ARTD10/PARP10 (2.0μM), ARTD1/PARP1 (9.7μM).</p>Fórmula:C12H13N3O3Cor e Forma:SolidPeso molecular:247.25BNS
CAS:<p>BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.</p>Fórmula:C18H16N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:420.46MARK-IN-4
CAS:<p>MARK-IN-4 inhibits microtubule kinase (MARK) effectively (IC50: 1 nM), a target for Alzheimer's therapy.</p>Fórmula:C21H23N7OSCor e Forma:SolidPeso molecular:421.52DCE_42
CAS:<p>DCE_42 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.</p>Fórmula:C22H19N9O2SPureza:98%Cor e Forma:SolidPeso molecular:473.51JAK-IN-11
CAS:<p>JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.</p>Fórmula:C23H22FN5O4SPureza:99.75%Cor e Forma:SolidPeso molecular:483.52PARP1-IN-9
CAS:<p>PARP1-IN-9, potent PARP1 inhibitor with 30.51 nM IC50, outperforms Olaparib in anticancer efficacy.</p>Fórmula:C18H21N3O5Cor e Forma:SolidPeso molecular:359.38BRD4 Inhibitor-25
<p>BRD4 Inhibitor-25 blocks BRD4 (BD1: IC50 0.82 μM, BD2: 1.94 μM), induces cell death in ovarian cancer, used in cancer research.</p>Fórmula:C29H27N5O6SCor e Forma:SolidPeso molecular:573.62CAY10685
CAS:<p>CAY10685, a CPTH2 analog with an alkyne for click reactions, inhibits NAT10 to study cancer-related chromatin changes.</p>Fórmula:C17H16ClN3SCor e Forma:SolidPeso molecular:329.85DNMT3A-IN-1
CAS:<p>DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).</p>Fórmula:C30H38N6O4Cor e Forma:SolidPeso molecular:546.66NCDM-32B
CAS:<p>NCDM-32B, a novel potent and selective KDM4 inhibitor, impairs viability and transforms phenotypes of basal breast cancer.</p>Fórmula:C15H30N2O4Pureza:98%Cor e Forma:SolidPeso molecular:302.41AChE/HDAC-IN-1
CAS:<p>COX-2-IN-23 (A10) inhibits AChE & HDAC (IC50s: 0.12 & 0.23 nM), has antioxidant/metal-binding traits, and is used in Alzheimer's research.</p>Fórmula:C26H27ClN4O3Cor e Forma:SolidPeso molecular:478.97TYK2-IN-11
CAS:<p>TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.</p>Fórmula:C18H17N5O3SCor e Forma:SolidPeso molecular:383.42SGC6870
CAS:<p>SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases.</p>Fórmula:C23H21BrN2O2SCor e Forma:SolidPeso molecular:469.39BRD4 Inhibitor-26
<p>BRD4 Inhibitor-26: blocks BRD4 (BD1 and BD2) with IC50 of 0.82 μM & 1.94 μM; used in ovarian cancer research.</p>Fórmula:C29H27N5O6SCor e Forma:SolidPeso molecular:573.62103D5R
CAS:<p>103D5R selectively inhibits hif-1α, reducing its levels in hypoxia or with cobalt ions, dose- and time-dependently.</p>Fórmula:C20H21N3O2Cor e Forma:SolidPeso molecular:335.4MAT2A-IN-6
CAS:<p>MAT2A-IN-6 inhibits MAT2A, may slow MTAP-deficient cancer cell growth, has research value in cancer.</p>Fórmula:C18H13ClF3N3O3Cor e Forma:SolidPeso molecular:411.76CP-690550A
CAS:<p>Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.</p>Fórmula:C15H21N5O2Cor e Forma:SolidPeso molecular:303.36MZ-242
CAS:<p>MZ-242 is an effective and selective inhibitor of Sirt2.</p>Fórmula:C24H27N7O3S2Pureza:98%Cor e Forma:SolidPeso molecular:525.65Antiproliferative agent-17
CAS:<p>Antiproliferative Agent-17 exhibits both antimicrobial properties against Gram-positive bacteria and anticancer activity [1].</p>Fórmula:C26H28N2OSCor e Forma:SolidPeso molecular:416.58KDOAM-25
CAS:<p>KDOAM-25, a potent KDM5 inhibitor, enhances H3K4 methylation, hampers MM1S cell growth; IC50: 71 nM (5A), 19 nM (5B), 69 nM (5C/D).</p>Fórmula:C15H25N5O2Pureza:98%Cor e Forma:SolidPeso molecular:307.39HDAC6/8/BRPF1-IN-1
CAS:<p>HDAC6/8/BRPF1-IN-1 is a cancer-research inhibitor for HDAC6, HDAC8, BRPF1 with IC50: 344-908 nM and Kd: 175.2 nM.</p>Fórmula:C18H17N3O5SCor e Forma:SolidPeso molecular:387.41UNC2327
CAS:<p>UNC2327 is a potent and selective inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50:230 nM).</p>Fórmula:C14H17N5O2SPureza:98%Cor e Forma:SolidPeso molecular:319.38AA-CW236
CAS:<p>AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).</p>Fórmula:C17H16ClF3N4O2Cor e Forma:SolidPeso molecular:400.78NN-390
CAS:<p>NN-390: selective HDAC6 inhibitor, IC50 9.8 μM, blood-brain barrier penetrant, potential for metastatic group 3 neural tube cancer research.</p>Fórmula:C17H16F4N2O4SCor e Forma:SolidPeso molecular:420.38EZH2-IN-9
CAS:<p>EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.</p>Fórmula:C28H32ClF2N3O5SCor e Forma:SolidPeso molecular:596.09EZH2-IN-11
CAS:<p>EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.</p>Fórmula:C28H36ClN3O5SCor e Forma:SolidPeso molecular:562.12Aurora Kinases-IN-2
CAS:<p>Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.</p>Fórmula:C22H18ClN5O3Cor e Forma:SolidPeso molecular:435.86DC-BPi-11
CAS:<p>DC-BPi-11 inhibits BPTF at IC50 698 nM and significantly reduces leukemia cell growth.</p>Fórmula:C20H23N5O2SCor e Forma:SolidPeso molecular:397.49JS1310
CAS:<p>JS1310 is a selective PRMT7 inhibitor (IC50: 5 μM against human PRMT7). JS1310 has shown anti-cancer effects on different cancer cells.</p>Fórmula:C23H22FN5O3Cor e Forma:SolidPeso molecular:435.45CypD inhibitor C-9
CAS:<p>CypD inhibitor C-9 is a CypD inhibitor, it attenuates mitochondrial and cellular perturbation insulted by Aß and calcium stress.</p>Fórmula:C22H22N4O4S2Cor e Forma:SolidPeso molecular:470.56BET-IN-2
CAS:<p>BET-IN-2 is a BET inhibitor (IC50: 52 nM for BRD4-BD1).</p>Fórmula:C23H29N3OPureza:98%Cor e Forma:SolidPeso molecular:363.5PIM1-IN-6
CAS:<p>PIM1-IN-6 (5h) inhibits PIM-1 (IC50: 0.60 μM) and is cytotoxic to HCT-116 (IC50: 1.51 μM) and MCF-7 cells (IC50: 15.2 μM).</p>Fórmula:C21H18N6O4Cor e Forma:SolidPeso molecular:418.41TNKS-IN-41
CAS:<p>TNKS-IN-41 highly potent and selective inhibitor of tankyrase.</p>Fórmula:C24H22N10O2Pureza:98%Cor e Forma:SolidPeso molecular:482.5K00135
CAS:<p>K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.</p>Fórmula:C18H18N4OPureza:98.16%Cor e Forma:SolidPeso molecular:306.36MC-1353
CAS:<p>MC-1353 is a potent, selective inhibitor of HDAC class I.</p>Fórmula:C16H16N2O3Cor e Forma:SolidPeso molecular:284.31PBRM1-BD2-IN-1
CAS:<p>PBRM1-BD2-IN-1: Selective PBRM1 inhibitor with Kd 0.7μM, IC50 0.2μM, useful in cancer research.</p>Fórmula:C17H19ClN2OCor e Forma:SolidPeso molecular:302.84-iodo-SAHA
CAS:<p>4-Iodo-SAHA (1k), an oral HDAC inhibitor for cancer research, has EC50s from 0.12 to 1.3 μM across various cell lines.</p>Fórmula:C14H19IN2O3Cor e Forma:SolidPeso molecular:390.22HDAC1-IN-4
CAS:<p>HDAC1-IN-4 is a potent inhibitor of Plasmodium falciparum HDAC1 (PfHDAC1) with low cytotoxicity and antimalarial effects (IC50<5 nM).</p>Fórmula:C21H24BrClN6O2Cor e Forma:SolidPeso molecular:507.82JAK-IN-20
CAS:<p>JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.</p>Fórmula:C28H30FN7O2Cor e Forma:SolidPeso molecular:515.58PIM1-IN-7
CAS:<p>PIM1-IN-7 inhibits PIM-1 (IC50: 0.67μM), toxic to HCT-116/MCF-7 cells (IC50: 42.9/7.68μM).</p>Fórmula:C23H23N5OCor e Forma:SolidPeso molecular:385.46HDAC/CK2-IN-1
CAS:<p>HDAC/CK2-IN-1 (compound 38) acts as an inhibitor of HDAC1 (IC 50 = 1.46 μM), HDAC6 (IC 50 = 0.66 μM), and CK2 (IC 50 = 3.67 μM). It demonstrates promising antiproliferative effects on various cell lines, including Jurkat, MCF-7, HCT-116, and HL-60.</p>Fórmula:C15H18Br4N4O2Cor e Forma:SolidPeso molecular:605.95BRD4-BD1/2-IN-1
CAS:<p>BRD4-BD1/2-IN-1 efficiently blocks BRD4 BD-1/2 under 100 nM IC50 (US20150148375A1, cmpd 5).</p>Fórmula:C21H14F2N4O2Cor e Forma:SolidPeso molecular:392.36DPQ
CAS:<p>DPQ inhibits PARP-1, aids in neuroprotection, restores ATP, and lessens neuronal injury from NMDA.</p>Fórmula:C18H26N2O2Pureza:98%Cor e Forma:SolidPeso molecular:302.41AMPK activator 9
CAS:<p>AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.</p>Fórmula:C31H28F4N4O4Cor e Forma:SolidPeso molecular:596.57ART-IN-1
CAS:<p>ART-IN-1 (compound 7) is a selective inhibitor of PARP with IC 50 s of 19, 22, 2.4, >100, 1.1 μM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively [1].</p>Fórmula:C14H13NO2SCor e Forma:SolidPeso molecular:259.32Peficitinib hydrochloride
CAS:<p>Peficitinib HCl (ASP015K) is an oral JAK inhibitor with IC50s: JAK1 (3.9 nM), JAK2 (5.0 nM), JAK3 (0.7 nM), Tyk2 (4.8 nM).</p>Fórmula:C18H23ClN4O2Cor e Forma:SolidPeso molecular:362.86VE-465
CAS:<p>VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.</p>Fórmula:C22H28N8OSCor e Forma:SolidPeso molecular:452.58PRMT5-IN-17
CAS:<p>PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.</p>Fórmula:C26H33N7O2Cor e Forma:SolidPeso molecular:475.59HDAC/NAMPT-IN-1
CAS:<p>HDAC/NAMPT-IN-1 (compound 39h) simultaneously inhibits HDAC and NAMPT, exhibiting IC 50 values ranging from 0.72 to 37081 nM for HDAC and 1618 nM for NAMPT [1].</p>Fórmula:C19H21N5O2Cor e Forma:SolidPeso molecular:351.4IACS-9571 hydrochloride
CAS:<p>IACS-9571 hydrochloride: potent TRIM24/BRPF1 inhibitor; IC50 = 8 nM (TRIM24); Kd = 31 nM (TRIM24), 14 nM (BRPF1).</p>Fórmula:C32H43ClN4O8SCor e Forma:SolidPeso molecular:679.22KDM2B-IN-4
CAS:<p>KDM2B-IN-4, from patent WO2016112284A1 as 182b, is a potent KDM2B inhibitor used in cancer research.</p>Fórmula:C24H28N2O2Cor e Forma:SolidPeso molecular:376.49CEP-8983
CAS:<p>CEP-8983 is a PARP inhibitor potentially for the treatment of solid tumours.</p>Fórmula:C18H14N2O3Pureza:98%Cor e Forma:SolidPeso molecular:306.32BRM/BRG1 ATP Inhibitor-4
CAS:<p>BRM/BRG1 ATP Inhibitor-4, a potent inhibitor of BRG1/BRM, is utilized in the research of cancers and BAF complex-related disorders.</p>Fórmula:C25H32N6O3SCor e Forma:SolidPeso molecular:496.62MAT2A-IN-7
CAS:<p>MAT2A-IN-7 inhibits MAT2A in various cancers, especially MTAP-deficient cancer cells, with potential for research use.</p>Fórmula:C17H13ClF3N3O2Cor e Forma:SolidPeso molecular:383.75Dihydro-5-azacytidine acetate
CAS:<p>Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1</p>Fórmula:C10H18N4O7Pureza:98%Cor e Forma:SolidPeso molecular:306.27LT052
CAS:<p>LT052 is a BET BD1 inhibitor with anti-inflammatory activity. It mediates the BRD4/NF-κB/NLRP3 signaling inflammatory pathway.</p>Fórmula:C22H19N5O4SPureza:98.82%Cor e Forma:SolidPeso molecular:449.48Sirt2-IN-6
CAS:<p>Sirt2-IN-6 is a potent and selective inhibitor of SIRT2 (IC50: 0.815 μM) and can be used to study cancer.</p>Fórmula:C26H26N6O3SCor e Forma:SolidPeso molecular:502.59BRD4884
CAS:<p>BRD4884 is a highly selective and efficient HDAC1 and HDAC2 inhibitor that also inhibits HDAC3, used in research on neurological disorders.</p>Fórmula:C18H19FN2O2Pureza:99.19% - 99.21%Cor e Forma:SolidPeso molecular:314.35Lorpucitinib
CAS:<p>Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal diseases.</p>Fórmula:C22H28N6O2Pureza:99.72%Cor e Forma:SolidPeso molecular:408.5KDM2/7-IN-1
CAS:<p>KDM2/7-IN-1 is a selective histone demethylase inhibitor (IC50s: 0.2–>120 μM) that inhibits HeLa and KYSE-150 cell proliferation, epigenetic and cancer.</p>Fórmula:C15H27NO4Pureza:99.87%Cor e Forma:SolidPeso molecular:285.38BETi-211
CAS:<p>BETi-211 is a selective inhibitor BET bromodomain.</p>Fórmula:C26H29N7O3Cor e Forma:SolidPeso molecular:487.55ZYJ-25e
CAS:<p>ZYJ-25e is an oral histone deacetylase inhibitor (HDACi) with potent antitumor activities.</p>Fórmula:C30H40N4O8Pureza:98%Cor e Forma:SolidPeso molecular:584.66IND 1316
CAS:<p>IND 1316 is an activator of AMP-activated protein kinase (AMPK).</p>Fórmula:C22H17NO3Cor e Forma:SolidPeso molecular:343.38CCT077791
CAS:<p>CCT077791 is a potent inhibitor of p300 and PCAF histone acetyltransferase activity for cancer research.</p>Fórmula:C9H5ClN2O3SPureza:98.60%Cor e Forma:SolidPeso molecular:256.67ZIKV-IN-2
CAS:<p>ZIKV-IN-2 blocks ZIKV replication, is a strong NS5 MTase inhibitor (IC50: 38.86 μM), and aids Zika virus research.</p>Fórmula:C39H42O4Cor e Forma:SolidPeso molecular:574.75KU-0058684
CAS:<p>KU-0058684 is a potent PARP and DNA-PK inhibitors.</p>Fórmula:C19H14FN3O3Cor e Forma:SolidPeso molecular:351.33ML753286
CAS:<p>ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.</p>Fórmula:C20H25N3O3Pureza:98%Cor e Forma:SolidPeso molecular:355.43Trotabresib
CAS:<p>Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.</p>Fórmula:C21H21NO4SPureza:99.86%Cor e Forma:SolidPeso molecular:383.46JAK1-IN-4
CAS:<p>JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).</p>Fórmula:C26H32FN9O2Pureza:98%Cor e Forma:SolidPeso molecular:521.59Y02224
CAS:<p>Y02224 is a BET inhibitor. It shows the reasonable antiproliferative effect on leukemia cells.</p>Fórmula:C20H17BrN2O4SPureza:98%Cor e Forma:SolidPeso molecular:461.33Dot1L-IN-5
CAS:<p>Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].</p>Fórmula:C23H19ClF2N8O5SCor e Forma:SolidPeso molecular:592.96HAT-IN-1
CAS:<p>HAT-IN-1 is an inhibitor of HAT used in the research of cancer.</p>Fórmula:C23H18BrF4N3O4Pureza:98%Cor e Forma:SolidPeso molecular:556.3Helenalin Acetate
CAS:<p>Helenalin Acetate: anti-inflammatory, anti-cancer, hinders C/EBPß and p300 cooperation.</p>Fórmula:C17H20O5Pureza:98%Cor e Forma:SolidPeso molecular:304.34HDAC-IN-45
CAS:<p>HDAC-IN-45, a small HDAC blocker, forms H-bonds with Y303 and shows anticancer properties; IC50 for HDAC1/2/3: 0.108/0.585/0.563 μM.</p>Fórmula:C25H20ClFN8OCor e Forma:SolidPeso molecular:502.93DM-01
CAS:<p>DM-01 is a potent and selective inhibitor of EZH2.</p>Fórmula:C23H24F3N3O2Cor e Forma:SolidPeso molecular:431.45dBRD9-A
CAS:<p>Potent BRD9 degrader that binds selectively, fully degrades BRD9 at low doses, and hinders synovial sarcoma growth in vitro and in mice.</p>Fórmula:C42H49N7O8Cor e Forma:SolidPeso molecular:779.88PB118
<p>PB118 clears Aβ, boosts phagocytosis, enhances tubulin networks, reduces p-tau & inflammation in AD; HDAC6 IC50: 5.6 nM.</p>Fórmula:C18H19FN2O2Cor e Forma:SoildPeso molecular:314.35Dot1L-IN-7
CAS:<p>Dot1L-IN-7 (compound 25), a potent DOT1L inhibitor with an IC50 of 1.0 μM, selectively kills MLL-AF9, sparing E2A-HLF cells.</p>Fórmula:C23H27N9O2Cor e Forma:SolidPeso molecular:461.52CeMMEC2
CAS:<p>CeMMEC2, a novel inhibitor of BRD4, binds both the first and the second bromodomain of BRD4.</p>Fórmula:C14H19N5Cor e Forma:SolidPeso molecular:257.33(1S,2R)-Tranylcypromine hydrochloride
CAS:<p>(1S,2R)-Tranylcypromine hydrochloride ((1S,2R)-SKF 385), a potent antidepressant, functions by inhibiting both MAO and LSD1.</p>Fórmula:C9H12ClNCor e Forma:SolidPeso molecular:169.651Guadecitabine sodium
CAS:<p>Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .</p>Fórmula:C18H24N9NaO10PPureza:98%Cor e Forma:SolidPeso molecular:580.407HDAC6-IN-46
CAS:<p>HDAC6-IN-46 (compound 12) is a selective inhibitor of histone deacetylase 6 (HDAC6), exhibiting an IC50 of 6.2 nM. It is utilized in research related to Alzheimer's disease.</p>Fórmula:C26H21N3O4Cor e Forma:SolidPeso molecular:439.46HDAC3-IN-T326
CAS:<p>HDAC3-IN-T326: potent, selective HDAC3 inhibitor, boosts NF-κB acetylation, activates latent HIV gene expression.</p>Fórmula:C21H18N6O3SPureza:98%Cor e Forma:SolidPeso molecular:434.47Gue1654
CAS:<p>Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.</p>Fórmula:C23H17N3OS3Pureza:98.02% - 98.04%Cor e Forma:SolidPeso molecular:447.6LSD1-IN-6
CAS:<p>LSD1-IN-6, a potent LSD1 inhibitor (IC50: 123 nM), enhances H3K4me2 without altering LSD1 expression. Reversible.</p>Fórmula:C15H13BrN2O3Pureza:98%Cor e Forma:SolidPeso molecular:349.18SC-9
CAS:<p>SC-9 is a protein kinase C activator.</p>Fórmula:C22H24ClNO2SPureza:98%Cor e Forma:SolidPeso molecular:401.95PS432
CAS:<p>PS432 inhibits atypical PKCs, targets PIF-pocket, reduces tumors in mice sans side effects.</p>Fórmula:C25H19ClN2O5SPureza:98%Cor e Forma:SolidPeso molecular:494.95SMYD2-IN-1
CAS:<p>SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).</p>Fórmula:C25H25Cl2F2N7O2Pureza:98%Cor e Forma:SolidPeso molecular:564.41Piribedil dihydrochloride
CAS:<p>dopamine agonist</p>Fórmula:C16H20Cl2N4O2Pureza:98%Cor e Forma:SolidPeso molecular:371.26Akt Inhibitor X
CAS:<p>Akt Inhibitor X is a cell-permeable and reversible inhibitor of Akt phosphorylation.</p>Fórmula:C20H25ClN2OPureza:98%Cor e Forma:SolidPeso molecular:344.88KDM5B-IN-3
CAS:<p>KDM5B-IN-3 inhibits KDM5B/JARID1B with IC50 of 9.32 μM, useful in gastric cancer studies.</p>Fórmula:C19H25ClN4O2Cor e Forma:SolidPeso molecular:376.88DDP-38003 dihydrochloride
CAS:<p>DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM).</p>Fórmula:C21H28Cl2N4OPureza:99.76%Cor e Forma:SolidPeso molecular:423.38CID-4785700
CAS:<p>CID-4785700 is a potent pan-GTPase inhibitor that inhibits Rab7 and inhibits the fungal histone acetyltransferase Rtt109 that binds to Asf1 and Vps75</p>Fórmula:C22H23ClFN3O3Pureza:98.16%Cor e Forma:SolidPeso molecular:431.89Kgp-IN-1
CAS:<p>Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.</p>Fórmula:C19H24F4N4O3Pureza:98%Cor e Forma:SolidPeso molecular:432.41PARP-1/2-IN-1
CAS:<p>PARP-1-/2-IN-1 is a potent inhibitor of PARP-1 (IC50: 0.51 nM) and PARP-2 (IC50: 23.11 nM).</p>Fórmula:C24H27FN4O3Cor e Forma:SolidPeso molecular:438.49NSC-636819
CAS:<p>NSC-636819 is a novel inhibitor of KDM4A/KDM4B.</p>Fórmula:C22H12Cl4N2O4Pureza:98%Cor e Forma:SolidPeso molecular:510.15M-110
CAS:<p>M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).</p>Fórmula:C22H28ClN5O3Pureza:99.55%Cor e Forma:SolidPeso molecular:445.94MI-1
CAS:<p>MI-1 inhibits Menin-MLL interaction with an IC 50 of 1.9 μM [1].</p>Fórmula:C19H25N5S2Cor e Forma:SolidPeso molecular:387.57
