Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2603 produtos para "Cromatina/Epigenética". São mostrados os primeiros 500.
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JMJD6 inhibitor WL12
CAS:WL12 (ZINC6733033): First-in-class JMJD6 inhibitor; halts JMJD6-dependent cervical/liver cancer cell growth.Fórmula:C16H11N3O2Pureza:98.57%Cor e Forma:Yellow SolidPeso molecular:277.28Ref: TM-T9939
1mg37,00€5mg75,00€1mL*10mM (DMSO)75,00€10mg110,00€25mg180,00€50mg269,00€100mg374,00€200mg530,00€Tulmimetostat
CAS:Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advancedFórmula:C28H36ClN3O5SPureza:98.04% - 99.87%Cor e Forma:SolidPeso molecular:562.12Tranylcypromine (2-PCPA) hydrochloride
CAS:Tranylcypromine (2-PCPA) HCl, a MAO inhibitor, treats major, dysthymic, and atypical depression.Fórmula:C9H11N·HClPureza:99.48% - 99.86%Cor e Forma:SolidPeso molecular:169.66(R)-CR8
CAS:(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.Fórmula:C24H29N7OPureza:98.41%Cor e Forma:SolidPeso molecular:431.53Ref: TM-T12617L
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg200,00€25mg268,00€50mg409,00€100mg580,00€Nicotinamide riboside
CAS:Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-Fórmula:C11H15N2O5Pureza:99.58% - 99.89%Cor e Forma:White SolidPeso molecular:255.25TAK-901
CAS:TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among othersFórmula:C28H32N4O3SPureza:99.02% - 99.59%Cor e Forma:SolidPeso molecular:504.64Ref: TM-T2709
1mg34,00€5mg66,00€1mL*10mM (DMSO)74,00€10mg99,00€25mg192,00€50mg313,00€100mg497,00€200mg710,00€Uzansertib phosphate
CAS:Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.Fórmula:C26H29F3N5O7PPureza:99.75% - 99.79%Cor e Forma:SolidPeso molecular:611.51Pulrodemstat benzenesulfonate
CAS:Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally inhibitor of lysine specific demethylase-1 (LSD1) with anticancer effect.Fórmula:C30H29F2N5O5SPureza:97.67%Cor e Forma:White SolidPeso molecular:609.64Ref: TM-T11882
1mg57,00€2mg81,00€5mg117,00€1mL*10mM (DMSO)167,00€10mg178,00€25mg313,00€50mg464,00€100mg672,00€Ilginatinib hydrochloride
CAS:Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.Fórmula:C21H21ClFN7Pureza:99.55%Cor e Forma:SolidPeso molecular:425.89Ref: TM-T12266L2
1mg70,00€5mg150,00€1mL*10mM (DMSO)166,00€10mg215,00€25mg358,00€50mg517,00€100mg707,00€200mg973,00€PT2399
CAS:PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.Fórmula:C17H10F5NO4SPureza:98.8% - 99.45%Cor e Forma:White SolidPeso molecular:419.32Ref: TM-T12675L
1mg88,00€5mg212,00€1mL*10mM (DMSO)233,00€10mg318,00€25mg575,00€50mg848,00€100mg1.189,00€A-485
CAS:A-485 is a p300/CBP histone acetyltransferase (HAT) inhibitor that inhibits p300 and CBP. A-485 has antitumor effects. Cost effective and quality assured.Fórmula:C25H24F4N4O5Pureza:98.01% - 99.98%Cor e Forma:White SolidPeso molecular:536.48Ref: TM-T14073
1mg88,00€5mg159,00€1mL*10mM (DMSO)187,00€10mg273,00€25mg339,00€50mg404,00€100mg698,00€DC-05
CAS:DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).Fórmula:C25H25N3OPureza:98.95%Cor e Forma:SolidPeso molecular:383.49Ref: TM-T15080
1mg66,00€5mg145,00€1mL*10mM (DMSO)158,00€10mg236,00€25mg515,00€50mg858,00€100mg1.251,00€200mg1.684,00€WDR5-IN-6
CAS:WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6Fórmula:C13H8Cl2N2O2SPureza:99.69%Cor e Forma:SoildPeso molecular:327.19EHP-101
CAS:EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.Fórmula:C28H35NO3Pureza:98.36%Cor e Forma:SolidPeso molecular:433.58Ref: TM-T13289
1mg101,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg295,00€25mg485,00€50mg677,00€100mg888,00€A-395
CAS:A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.Fórmula:C26H35FN4O2SPureza:98.43%Cor e Forma:SolidPeso molecular:486.65Fenbendazole
CAS:Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.Fórmula:C15H13N3O2SPureza:99.74%Cor e Forma:White To Yellowish PowderPeso molecular:299.35Glucosamine hydrochloride
CAS:Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.Fórmula:C6H13NO5·HClPureza:99.77% - 99.96%Cor e Forma:White Solid CrystallinePeso molecular:215.63SNDX-5613
CAS:Revumenib (SNDX-5613) is a potent and selective oral inhibitor of menin-KMT2A interaction.Cost-effective and quality-assured.Fórmula:C32H47FN6O4SPureza:99.12% - 99.97%Cor e Forma:SolidPeso molecular:630.82Ref: TM-T12943
1mg70,00€2mg92,00€5mg152,00€1mL*10mM (DMSO)207,00€10mg259,00€25mg513,00€50mg737,00€100mg1.018,00€SW2_110A
CAS:SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.Fórmula:C42H60N6O7Pureza:98%Cor e Forma:SolidPeso molecular:760.96PKC β pseudosubstrate acetate
PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.Pureza:95.42%Cor e Forma:Soildiso-Azalansta
CAS:(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.Fórmula:C22H24ClN3O2SPureza:99.53% - 99.89%Cor e Forma:SoildPeso molecular:429.96Bufexamac
CAS:Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.Fórmula:C12H17NO3Pureza:99.73%Cor e Forma:Acicular CrystalPeso molecular:223.27SMARCA-BD ligand 1 for Protac
CAS:SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2Fórmula:C14H17N5OPureza:99.99%Cor e Forma:SolidPeso molecular:271.32Diflunisal
CAS:Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.Fórmula:C13H8F2O3Pureza:98.92% - 99.42%Cor e Forma:SolidPeso molecular:250.20Miltefosine
CAS:Miltefosine (HePC), effective oral drug for both visceral and cutaneous leishmaniasis, in clinical trials worldwide.Fórmula:C21H46NO4PPureza:98% - 99.94%Cor e Forma:White SolidPeso molecular:407.57Amifostine
CAS:Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.Fórmula:C5H15N2O3PSPureza:99.59% - 99.91%Cor e Forma:White SolidPeso molecular:214.22Lin28-let-7a antagonist 1
CAS:Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction，and shows a clear antagonistic effect against the Lin28-let-7a interaction.Fórmula:C31H29N5O7Pureza:99.44%Cor e Forma:SolidPeso molecular:583.59Ref: TM-T11851
1mg96,00€5mg205,00€1mL*10mM (DMSO)266,00€10mg313,00€25mg562,00€50mg845,00€100mg1.243,00€ZEN-3694
CAS:ZEN-3694 (ZEN 3694) is a bromo-structural domain extra-terminal inhibitor (BETi) with activity in androgen signaling inhibitor (ASI) resistance models and canFórmula:C19H19N5OPureza:98.94% - 99.76%Cor e Forma:SolidPeso molecular:333.39ZL0580
CAS:ZL0580 suppresses HIV by blocking Tat activation, halting transcription, and promoting repressive chromatin at the HIV promoter.Fórmula:C25H23F3N4O4SPureza:99.70%Cor e Forma:White SolidPeso molecular:532.53NU6140
CAS:NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).Fórmula:C23H30N6O2Pureza:98.33%Cor e Forma:SolidPeso molecular:422.52Ref: TM-T16359
2mg39,00€5mg60,00€1mL*10mM (DMSO)67,00€10mg92,00€25mg177,00€50mg285,00€100mg414,00€200mg580,00€BMS-986158
CAS:BMS-986158: BET inhibitor, IC50 of 6.6 nM in SCLC, 5 nM in TNBC cells.Fórmula:C30H33N5O2Pureza:98.78%Cor e Forma:White SolidPeso molecular:495.62Ref: TM-T14685
1mg82,00€5mg245,00€1mL*10mM (DMSO)268,00€10mg356,00€25mg700,00€50mg954,00€100mg1.305,00€LIN28 inhibitor LI71
CAS:LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM.Fórmula:C21H21NO3Pureza:95.14%Cor e Forma:Purple LiquidPeso molecular:335.4Ref: TM-T11850
1mg107,00€5mg255,00€1mL*10mM (DMSO)341,00€10mg414,00€25mg745,00€50mg1.063,00€100mg1.459,00€MAK683
CAS:MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).Fórmula:C20H17FN6OPureza:98.25% - 99.92%Cor e Forma:SolidPeso molecular:376.39Levetiracetam
CAS:Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onsetFórmula:C8H14N2O2Pureza:99.67% - 99.86%Cor e Forma:SolidPeso molecular:170.21Oltipraz
CAS:Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.Fórmula:C8H6N2S3Pureza:98.79% - 99.77%Cor e Forma:SolidPeso molecular:226.34GNE-781
CAS:GNE-781: potent CBP inhibitor (IC50: 0.94 nM), also targets BRET/BRD4(1) (IC50: 6.2/5100 nM).Fórmula:C27H33F2N7O2Pureza:99.25% - 99.64%Cor e Forma:SolidPeso molecular:525.59Ref: TM-T15405
1mg131,00€5mg281,00€1mL*10mM (DMSO)324,00€10mg460,00€25mg765,00€50mg1.035,00€100mg1.404,00€ODM-207
CAS:ODM-207 (BET-IN-4) is a potent BRD4 inhibitor.Fórmula:C22H21N3O3Pureza:99.75%Cor e Forma:White SolidPeso molecular:375.42Ref: TM-T10521
1mg44,00€1mL*10mM (DMSO)90,00€5mg92,00€10mg133,00€25mg235,00€50mg339,00€100mg480,00€200mg660,00€VTP50469
CAS:VTP50469 is a highly selective and orally active small molecule inhibitor of the Menin-MLL protein-protein interaction.Cost-effective and quality-assured.Fórmula:C32H47FN6O4SPureza:98.31% - 99.55%Cor e Forma:SolidPeso molecular:630.82Ref: TM-T13336
1mg164,00€5mg334,00€10mg401,00€1mL*10mM (DMSO)465,00€25mg560,00€50mg715,00€100mg964,00€MAT2A inhibitor 2
CAS:MAT2A inhibitor 2 is an inhibitor of methionine adenosyltransferase 2A (MAT2A).Fórmula:C18H24ClN3O3Pureza:99.52%Cor e Forma:White SolidPeso molecular:365.85Minocycline hydrochloride
CAS:Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.Fórmula:C23H28ClN3O7Pureza:99.71% - >99.99%Cor e Forma:Yellow SolidPeso molecular:493.94Golidocitinib
CAS:Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).Fórmula:C25H31N9O2Pureza:98.87% - 99.88%Cor e Forma:Yellow SolidPeso molecular:489.57MS417
CAS:MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weakFórmula:C20H19ClN4O2SPureza:99.87%Cor e Forma:White SolidPeso molecular:414.91N-Desmethyltamoxifen hydrochloride
CAS:N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.Fórmula:C25H28ClNOPureza:99.15%Cor e Forma:SolidPeso molecular:393.95FIDAS-5
CAS:FIDAS-5 is an orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. Cost-effective and quality-assured.Fórmula:C15H13ClFNPureza:98.3% - 99.17%Cor e Forma:SolidPeso molecular:261.72Ref: TM-T11285
1mg56,00€2mg80,00€5mg110,00€10mg177,00€25mg314,00€50mg485,00€100mg700,00€500mg1.341,00€MS402
CAS:MS402 is a novel BD1-selective BET BrD inhibitor.Fórmula:C20H19ClN2O3Pureza:99.72%Cor e Forma:White SolidPeso molecular:370.83MSC2504877
CAS:MSC2504877 inhibits tankyrase, boosts CDK4/6 inhibitors, blocks Cyclin D2/E2 upregulation, and strengthens phospho-Rb suppression.Fórmula:C17H18N2O2Pureza:99.72%Cor e Forma:White SolidPeso molecular:282.34JAK2 Inhibitor V
CAS:JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.Fórmula:C23H24N2OPureza:98.36% - 99.15%Cor e Forma:SolidPeso molecular:344.45Ref: TM-T3042
2mg37,00€5mg54,00€1mL*10mM (DMSO)59,00€10mg80,00€25mg148,00€50mg259,00€100mg477,00€500mg1.063,00€TRIM24/BRPF1-IN-2
CAS:TRIM24/BRPF1-IN-2 is a TRIM24/BRPF1 dual inhibitor with anticancer activity that inhibits the proliferation of prostate cancer cells.Fórmula:C20H22N2O4SPureza:98.69% - 99.13%Cor e Forma:White SolidPeso molecular:386.47Pumecitinib
CAS:Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.
Fórmula:C17H20N8O2SPureza:99.94%Cor e Forma:SoildPeso molecular:400.46Brepocitinib P-Tosylate
CAS:Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).Fórmula:C25H29F2N7O4SPureza:99.82% - 99.97%Cor e Forma:SolidPeso molecular:561.6
