Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2235 produtos de "Cromatina/Epigenética"
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EHMT2-IN-2
CAS:<p>EHMT2-IN-2 Used in the research of blood disease or cancer. EHMT2-IN-2 is a potent EHMT inhibitor, with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.</p>Fórmula:C21H22N6OCor e Forma:SolidPeso molecular:374.44(8R,9S)-Talazoparib
CAS:<p>(8R,9S)-Talazoparib is Talazoparib enantiomer , less active than Talazoparib on the inhibition of PARP1 (IC50: 144 nM).</p>Fórmula:C19H14F2N6OCor e Forma:SolidPeso molecular:380.35Cercosporin
CAS:<p>Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).</p>Fórmula:C29H26O10Pureza:98%Cor e Forma:SolidPeso molecular:534.51BD-9136
<p>BD-9136, a highly selective BRD4 degrader, demonstrates the capability to inhibit tumor growth without inducing adverse effects in mice, showing potential for</p>Fórmula:C44H44N10O5SPureza:98%Cor e Forma:SolidPeso molecular:824.95HIF-PHD-IN-1
CAS:<p>HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising.</p>Fórmula:C17H12Cl2N6O3Cor e Forma:SolidPeso molecular:419.22CARM1-IN-1 hydrochloride
CAS:<p>CARM1-IN-1 hydrochloride is a potent and selective inhibitor of CARM1 (IC50: 8.6 μM) with minimal inhibition of PRMT1 and SET7.</p>Fórmula:C26H22Br2ClNO3Cor e Forma:SolidPeso molecular:591.72PLK1-IN-6
<p>PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.</p>Fórmula:C28H37N9O3Cor e Forma:SolidPeso molecular:547.6520-HETE
CAS:<p>20-HETE is a CYP450 product, vasoconstrictor, modulates K+ channels, affects NADPH, ROS, NF-κB, NO synthase, and cell apoptosis/proliferation.</p>Fórmula:C20H32O3Pureza:99.79%Cor e Forma:SolidPeso molecular:320.47(3R,4S)-Tofacitinib
CAS:<p>(3R,4S)-Tofacitinib, the less active enantiomer of Tofacitinib, is a JAK3 inhibitor with an IC50 of 1 nM.</p>Fórmula:C16H20N6OPureza:98%Cor e Forma:SolidPeso molecular:312.37HJB97
CAS:<p>HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively).</p>Fórmula:C26H28N8O3Pureza:98%Cor e Forma:SolidPeso molecular:500.55Ref: TM-T15484
Produto descontinuadoAmredobresib
CAS:<p>Amredobresib is a potent BET inhibitor that impedes the interaction between bromodomains and acetylated lysines on histone H3 and H4, thereby serving as crucial regulators of gene transcription. It proves valuable in the investigation of acute myeloid leukemia (AML) and cancer.</p>Fórmula:C26H29N9Cor e Forma:SolidPeso molecular:467.581YF-2 hydrochloride
CAS:<p>YF-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. It specifically acetylates H3 in the hippocampus, with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM for CBP, PCAF, and GCN5, respectively. Notably, it does not affect HDAC activity. Moreover, YF-2 hydrochloride demonstrates promising anti-cancer and anti-Alzheimer's disease properties.</p>Fórmula:C20H23Cl2F3N2O3Cor e Forma:SolidPeso molecular:467.31SIRT-IN-3
CAS:<p>SIRT-IN-3: potent SIRT1 inhibitor (IC50=17μM), 4x selective over SIRT2, 14x over SIRT3 (IC50s: 74μM & 235μM).</p>Fórmula:C13H12N2OCor e Forma:SolidPeso molecular:212.25Desidustat
CAS:<p>Desidustat is an inhibitor of HIF hydroxylase.</p>Fórmula:C16H16N2O6Pureza:98%Cor e Forma:SolidPeso molecular:332.31CTB
CAS:<p>CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.</p>Fórmula:C16H13ClF3NO2Pureza:99.82%Cor e Forma:SolidPeso molecular:343.73AMPK activator C2
CAS:<p>AMPK activator C2 is an AMPK allosteric activator.</p>Fórmula:C7H6NO6PPureza:98%Cor e Forma:SolidPeso molecular:231.1BLL5 Maleate
CAS:<p>BLL5 Maleate is a first-in-class selective PRMT5 inhibitor, it blocks EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected.</p>Fórmula:C21H21N3Pureza:98%Cor e Forma:SolidPeso molecular:315.41Bisindolylmaleimide I HCl
CAS:<p>Bisindolylmaleimide I HCl is a specific ATP-competitive PKC inhibitor.</p>Fórmula:C25H25ClN4O2Pureza:98%Cor e Forma:SolidPeso molecular:448.95BET-IN-15
CAS:<p>BET-IN-15 (compound 1) is a potent, orally active inhibitor of BET, demonstrating inhibitory IC50 values of 0.64 nM for BRD4-BD1 and 0.25 nM for BRD4-BD2.</p>Fórmula:C21H18F2N4O3SPureza:98%Cor e Forma:SolidPeso molecular:444.45Ref: TM-T79167
Produto descontinuadoJAK2-IN-9
CAS:<p>Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 nM.</p>Fórmula:C20H24N6O2SPureza:98%Cor e Forma:SolidPeso molecular:412.51Ref: TM-T79581
Produto descontinuadoJAK1-IN-10
CAS:<p>JAK1-IN-10 (compound 9), a cyano-substituted cyclic hydrazine derivative, functions as a potent and selective inhibitor of JAK1 [1].</p>Fórmula:C15H17N7Pureza:98%Cor e Forma:SolidPeso molecular:295.34Igermetostat
CAS:<p>Igermetostat, an EZH2 inhibitor, is utilized both in vivo and in vitro for cancer research [1].</p>Fórmula:C32H46N4O4Pureza:98%Cor e Forma:SolidPeso molecular:550.73BBDDL2059
CAS:<p>BBDDL2059 is a selective covalent inhibitor targeting EZH2, exhibiting an IC50 of 1.5 nM against the EZH2-Y641F mutant.</p>Fórmula:C27H36N4O4SPureza:98%Cor e Forma:SolidPeso molecular:512.66Ref: TM-T79200
Produto descontinuadoJAK-IN-27
CAS:<p>JAK-IN-27, also known as compound 1, is an orally active, potent inhibitor of the JAKS family kinases, displaying inhibitory concentrations (IC50s) of 3.0 nM</p>Fórmula:C20H21F2N7OPureza:98%Cor e Forma:SolidPeso molecular:413.42BET-IN-14
CAS:<p>BET-IN-14 is a pan BET inhibitor with an IC50 of 5.35 nM, demonstrating oral activity and anticancer properties [1].</p>Fórmula:C30H37N7O2Pureza:98%Cor e Forma:SolidPeso molecular:527.66JAK1-IN-11
CAS:<p>JAK1-IN-11 (compound 11) serves as a potent inhibitor of Janus kinases, exhibiting nanomolar inhibitory concentrations with IC50 values of 0.02 nM (JAK1) and 0.</p>Fórmula:C26H36N6O4SPureza:98%Cor e Forma:SolidPeso molecular:528.67DPP
CAS:<p>DPP, a Platinum(IV) complex with a pterostilbene-derived axial ligand, inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, demonstrating</p>Fórmula:C36H40Cl2N2O10PtPureza:98%Cor e Forma:SolidPeso molecular:926.7Lerzeparib
CAS:<p>Lerzeparib is a PARP (ADP-ribose polymerase) inhibitor that exhibits antineoplastic activity [1].</p>Fórmula:C21H20FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:365.4Antitumor agent-104
CAS:<p>Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzyme</p>Fórmula:C31H33FN6O3Pureza:98%Cor e Forma:SolidPeso molecular:556.63JAK-IN-34
CAS:<p>JAK-IN-34 (compound 11n) is a potent inhibitor of Janus kinases (JAKs), demonstrating IC50 values of 0.40 nM for JAK1, 0.83 nM for JAK2, 2.10 nM for JAK3,</p>Fórmula:C27H26N6OPureza:98%Cor e Forma:SolidPeso molecular:450.53BAZ2-ICR
CAS:<p>BAZ2-ICR is an epigenetic chemical probe and it also is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains.</p>Fórmula:C20H19N7Pureza:98%Cor e Forma:SolidPeso molecular:357.41STAT3-IN-18
CAS:<p>STAT3-IN-18 (compound SPP), a platinum (IV) complex featuring an axial ligand from sandalwood, suppresses the JAK2-STAT3 pathway in breast cancer (BC) cells and</p>Fórmula:C18H24Cl2N2O6PtPureza:98%Cor e Forma:SolidPeso molecular:630.38BET BD2-IN-3
CAS:<p>BET BD2-IN-3 (compound I-58), a BET inhibitor specifically targeting the BD2 domain, can be radiolabeled with [11C] for use in positron emission tomography (PET) imaging. PET studies with [11C]BD2-IN-3 in mice have demonstrated appropriate biodistribution in peripheral organs and tissues.</p>Fórmula:C29H30N4OCor e Forma:SolidPeso molecular:450.58PARP7-IN-16 free base
CAS:<p>PARP7-IN-16 free base is the freebase form of PARP7-IN-16. As a selective oral inhibitor of PARP-1/2/7, it demonstrates IC50 values of 0.94, 0.87, and 0.21 nM, respectively. This compound is utilized in the research of breast and prostate cancer.</p>Fórmula:C25H27FN4O4Cor e Forma:SolidPeso molecular:466.50Ref: TM-T200703
Produto descontinuadoBB-Cl-Amidine hydrochloride
CAS:<p>BB-Cl-Amidine hydrochloride is an inhibitor of peptidylarginine deminase (PAD) [1].</p>Fórmula:C26H27Cl2N5OPureza:98%Cor e Forma:SolidPeso molecular:496.43
