Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2238 produtos de "Cromatina/Epigenética"
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HDAC6-IN-27
CAS:<p>HDAC6-IN-27 (compound 8C), an HDAC inhibitor, exhibits IC 50 values of 15.9 nM, 136.5 nM, and 6180.2 nM against HDAC6, HDAC8, and HDAC1, respectively. It also demonstrates potent antiparasitic effects [1].</p>Fórmula:C15H15N3O4Cor e Forma:SolidPeso molecular:301.3AdipoR agonist 1
CAS:<p>AdipoR agonist 1 (Compound 112254), acting as an agonist for the adiponectin receptor (AdipoR), stimulates transcriptional regulators including peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). It is employed in the field of preventive doping research.</p>Fórmula:C26H35N3O3Cor e Forma:SolidPeso molecular:437.57GSK-J1 lithium salt
CAS:<p>GSK-J1 lithium salt is an effective inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with an IC 50 of 60 nM for KDM6B.</p>Fórmula:C22H22LiN5O2Pureza:98%Cor e Forma:SolidPeso molecular:395.38I-BET787
CAS:<p>I-BET787, an orally active pan-BET bromodomain inhibitor, has demonstrated efficacy in murine inflammation models.</p>Fórmula:C16H20ClN3O2Cor e Forma:SolidPeso molecular:321.80BG14
CAS:<p>BG14: High-res optical epigenetic control; photo-inhibits human histone deacetylases with visible light.</p>Fórmula:C21H21N5OCor e Forma:SolidPeso molecular:359.433CrBKA
CAS:<p>CrBKA is a fluorogenic small-molecule substrate of SIRT6 with weak activity [1] .</p>Fórmula:C28H31N3O6Cor e Forma:SolidPeso molecular:505.56KR-39038
CAS:<p>KR-39038 is an oral GRK5 inhibitor for heart failure research; blocks HDAC5 pathway, IC50: 0.02 μM, fights cardiac hypertrophy.</p>Fórmula:C24H32ClFN6OCor e Forma:SolidPeso molecular:475.00BG47
CAS:<p>BG47: a COMET probe for precise optical epigenetic control, inhibits histone deacetylases with light.</p>Fórmula:C25H22N4O2SCor e Forma:SolidPeso molecular:442.54KAT6-IN-1
CAS:<p>KAT6-IN-1 is a potent KAT6 inhibitor. KAT6-IN-1 can be used in research of cancer [1] .</p>Fórmula:C19H18N4O5SCor e Forma:SolidPeso molecular:414.43(3S,4S)-Tofacitinib
CAS:<p>(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.</p>Fórmula:C16H20N6OPureza:98%Cor e Forma:SolidPeso molecular:312.37MY-1B
CAS:<p>MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.</p>Fórmula:C22H18BrN3O2Pureza:99.81% - >99.99%Cor e Forma:SoildPeso molecular:436.3TMPA
CAS:<p>TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.</p>Fórmula:C21H32O6Pureza:99.21%Cor e Forma:SolidPeso molecular:380.48GSK-1268997
CAS:<p>GSK-1268997 is a bio-active chemical.</p>Fórmula:C21H23N7O3SPureza:99.33% - 99.81%Cor e Forma:SolidPeso molecular:453.52UNC0224
CAS:<p>UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.</p>Fórmula:C26H43N7O2Pureza:99.80%Cor e Forma:SolidPeso molecular:485.67E3330
CAS:<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Fórmula:C21H30O6Pureza:99.52%Cor e Forma:SolidPeso molecular:378.46GSK360A
CAS:<p>GSK360A is a novel prolyl hydroxylase (PHD) domain-containing enzyme inhibitor.</p>Fórmula:C17H17FN2O5Pureza:98%Cor e Forma:SolidPeso molecular:348.33JAK-IN-28
CAS:<p>JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].</p>Fórmula:C20H18ClN7OPureza:98%Cor e Forma:SolidPeso molecular:407.86ZYJ-34c
CAS:<p>ZYJ-34c is a potent oral antitumor activities histone deacetylase inhibitor (HDACi).</p>Fórmula:C31H42N4O7Pureza:98%Cor e Forma:SolidPeso molecular:582.69SIRT1-IN-3
CAS:<p>SIRT1-IN-3 (compound 3j) is a potent and selective inhibitor of silent information regulator 1 (SIRT1) with an IC 50 of 4.2 μM [1].</p>Fórmula:C13H15BrN2OCor e Forma:SolidPeso molecular:295.17JAK-IN-30
CAS:<p>JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50</p>Fórmula:C19H26N8SPureza:98%Cor e Forma:SolidPeso molecular:398.53Eleven-Nineteen-Leukemia Protein IN-1
CAS:<p>ENL-IN-1: Potent ENL YEATS domain inhibitor with 14.5 nM IC50, enhances thermal stability in vitro.</p>Fórmula:C27H33N7O2Pureza:98%Cor e Forma:SolidPeso molecular:487.6Angiogenesis agent 1
CAS:<p>Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.</p>Fórmula:C20H24O7Pureza:98%Cor e Forma:SolidPeso molecular:376.4LSD1-IN-5
CAS:<p>LSD1-IN-5, a reversible LSD1 inhibitor, boosts H3K4me2 without affecting LSD1 expression; IC50: 121 nM.</p>Fórmula:C15H13BrN2O3Pureza:98%Cor e Forma:SolidPeso molecular:349.18CM-579
CAS:<p>CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.</p>Fórmula:C29H40N4O3Pureza:99.23%Cor e Forma:SolidPeso molecular:492.65FAK/aurora kinase-IN-1
CAS:<p>FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].</p>Fórmula:C23H24ClN7O3Cor e Forma:SolidPeso molecular:481.93Tripolin A
CAS:<p>Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)</p>Fórmula:C15H11NO3Pureza:98%Cor e Forma:SolidPeso molecular:253.25DC_C66
CAS:<p>DC_C66 selectively inhibits CARM1 with IC50 of 1.8μM; also affects PRMT1, 6, 5. It's cell-permeable.</p>Fórmula:C28H22NO2Pureza:98%Cor e Forma:SolidPeso molecular:404.48DCE_42
CAS:<p>DCE_42 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.</p>Fórmula:C22H19N9O2SPureza:98%Cor e Forma:SolidPeso molecular:473.51BET-IN-7
CAS:<p>BET-IN-7 is a potent BET inhibitor with a Ki of 12.27 μM and Kd of 89.3 μM, useful in sepsis research.</p>Fórmula:C18H12ClN3OSCor e Forma:SolidPeso molecular:353.83Aurora kinase inhibitor-9
CAS:<p>Aurora kinase inhibitor-9 (9d) targets AURKA/B with IC50: 0.093 μM for A and 0.09 μM for B, with wide anti-proliferative effects.</p>Fórmula:C19H17Cl2N3O4SCor e Forma:SolidPeso molecular:454.33KF 13218
CAS:<p>KF 13218 is a selective, potent and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.</p>Fórmula:C20H20N2O3Pureza:98%Cor e Forma:SolidPeso molecular:336.38LP99
CAS:<p>LP99 is an epigenetic probe.</p>Fórmula:C26H30ClN3O4SPureza:99.74%Cor e Forma:SolidPeso molecular:516.05TM6089
CAS:<p>TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.</p>Fórmula:C13H14N4O3SPureza:99.70%Cor e Forma:SolidPeso molecular:306.34PRMT4-IN-1
CAS:<p>PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].</p>Fórmula:C23H28FN3OPureza:98%Cor e Forma:SolidPeso molecular:381.49HDAC1/MAO-B-IN-1
CAS:<p>HDAC1/MAO-B-IN-1 is a selective Alzheimer’s research inhibitor with IC50s: HDAC1 (21.4 nM) & MAO-B (99 nM); crosses the blood-brain barrier.</p>Fórmula:C18H17ClN2O2Cor e Forma:SolidPeso molecular:328.79BET bromodomain inhibitor 3
CAS:<p>BET Bromodomain Inhibitor 3 is a BET bromodomain inhibitor with an inhibitory Ki value of >40 µM against BrdT.</p>Fórmula:C18H17N3O4Pureza:98%Cor e Forma:SolidPeso molecular:339.35HDAC-IN-30
CAS:<p>HDAC-IN-30 is a potent HDAC inhibitor targeting HDAC1, 2, 3, 6, and 8 with strong antitumor efficacy.</p>Fórmula:C22H23N5O3Cor e Forma:SolidPeso molecular:405.45SGC6870
CAS:<p>SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases.</p>Fórmula:C23H21BrN2O2SCor e Forma:SolidPeso molecular:469.39PARP11 inhibitor ITK7
CAS:<p>ITK7 is a potent, selective PARP11 inhibitor with an IC50 of 14 nM, useful for cellular localization research.</p>Fórmula:C17H14N4OSCor e Forma:SolidPeso molecular:322.38Y06036
CAS:<p>Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).</p>Fórmula:C16H15BrN2O5SPureza:99.97%Cor e Forma:SolidPeso molecular:427.27BRD4 Inhibitor-19
CAS:<p>BRD4 inhibitors -19 are BET inhibitors that act on BRD4-BD1 (IC50: 55 nM) and can be used to study multiple myeloma.</p>Fórmula:C29H25N5O3Cor e Forma:SolidPeso molecular:491.54PRMT5-IN-2
CAS:<p>PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.</p>Fórmula:C17H16ClFN4O4Pureza:98%Cor e Forma:SolidPeso molecular:394.78NCD38
CAS:<p>NCD38 is a potent, selective LSD1 inhibitor.</p>Fórmula:C37H37ClF3N3O4Pureza:98.21% - 98.86%Cor e Forma:SolidPeso molecular:680.16(Rac)-BAY1238097
CAS:<p>(Rac)-BAY1238097 is a inhibitor of BET(IC50 of 1.02 μM for BRD4),used in cancer research.</p>Fórmula:C25H33N5O3Pureza:98%Cor e Forma:SolidPeso molecular:451.56HDAC-IN-41
CAS:<p>HDAC-IN-41 is a selective class I HDAC inhibiting HDAC1, 2, & 3 with IC50: 0.62-1.46 µM; oral use; has NO-release.</p>Fórmula:C20H22N4O6SCor e Forma:SolidPeso molecular:446.48EZM 2302
CAS:<p>EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.</p>Fórmula:C29H37ClN6O5Pureza:97.47% - ≥98%Cor e Forma:SolidPeso molecular:585.09HDAC6-IN-11
CAS:<p>HDAC6-IN-11 (Compound 9) is a cancer cell growth blocker, selectively inhibiting HDAC6 (>300-fold) with an IC50 of 20.7 nM.</p>Fórmula:C19H16N2O4Cor e Forma:SolidPeso molecular:336.34Furamidine
CAS:<p>Furamidine is a PRMT1-selective, cell-permeable inhibitor (IC50: 9.4μM), also targeting TDP-1, and is an antiparasitic bisbenzamidine derivative.</p>Fórmula:C18H16N4OPureza:98%Cor e Forma:SolidPeso molecular:304.35BI-831266
CAS:<p>BI-831266 is a potent and selective Aurora kinase B inhibitor.</p>Fórmula:C27H38ClN7O2Cor e Forma:SolidPeso molecular:528.09JFD00244
CAS:<p>JFD00244 is an inhibitor of sirtuin 2 (SIRT2). It has an anti-tumor effect.</p>Fórmula:C30H26N2O4Pureza:98%Cor e Forma:SolidPeso molecular:478.54
