Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2242 produtos de "Cromatina/Epigenética"
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JFD00244
CAS:<p>JFD00244 is an inhibitor of sirtuin 2 (SIRT2). It has an anti-tumor effect.</p>Fórmula:C30H26N2O4Pureza:98%Cor e Forma:SolidPeso molecular:478.54JAK-2/3-IN-2
CAS:<p>JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).</p>Fórmula:C19H19ClN2OSCor e Forma:SolidPeso molecular:358.89PARP11 inhibitor ITK7
CAS:<p>ITK7 is a potent, selective PARP11 inhibitor with an IC50 of 14 nM, useful for cellular localization research.</p>Fórmula:C17H14N4OSCor e Forma:SolidPeso molecular:322.38HDAC6-IN-11
CAS:<p>HDAC6-IN-11 (Compound 9) is a cancer cell growth blocker, selectively inhibiting HDAC6 (>300-fold) with an IC50 of 20.7 nM.</p>Fórmula:C19H16N2O4Cor e Forma:SolidPeso molecular:336.34PI3K/HDAC-IN-1
CAS:<p>PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively).</p>Fórmula:C22H25FN4O4Pureza:98%Cor e Forma:SolidPeso molecular:428.46ART-IN-1
CAS:<p>ART-IN-1 (compound 7) is a selective inhibitor of PARP with IC 50 s of 19, 22, 2.4, >100, 1.1 μM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively [1].</p>Fórmula:C14H13NO2SCor e Forma:SolidPeso molecular:259.32BNS
CAS:<p>BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.</p>Fórmula:C18H16N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:420.46HDAC-IN-41
CAS:<p>HDAC-IN-41 is a selective class I HDAC inhibiting HDAC1, 2, & 3 with IC50: 0.62-1.46 µM; oral use; has NO-release.</p>Fórmula:C20H22N4O6SCor e Forma:SolidPeso molecular:446.48BI-831266
CAS:<p>BI-831266 is a potent and selective Aurora kinase B inhibitor.</p>Fórmula:C27H38ClN7O2Cor e Forma:SolidPeso molecular:528.09A2B57
CAS:<p>A2B57 is a selective SIRT2 inhibitor.</p>Fórmula:C22H19N5OPureza:98%Cor e Forma:SolidPeso molecular:369.42CBHA
CAS:<p>m-Carboxycinnamic bishydroxamide: HDAC inhibitor, ID50 = 10 nM (HDAC1), 70 nM (HDAC3), induces apoptosis and tumor growth suppression.</p>Fórmula:C10H10N2O4Cor e Forma:SolidPeso molecular:222.2A2AAR/HDAC-IN-1
CAS:<p>A2AAR/HDAC-IN-1 (compound 14c) is an orally active, balanced A2AAR/HDAC dual inhibitor of A2AAR (Ki: 163.5 nM), HDAC1 (IC50: 145.3 nM). effect.</p>Fórmula:C24H21N7O2Cor e Forma:SolidPeso molecular:439.47JAK-IN-11
CAS:<p>JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.</p>Fórmula:C23H22FN5O4SPureza:99.75%Cor e Forma:SolidPeso molecular:483.52MARK-IN-4
CAS:<p>MARK-IN-4 inhibits microtubule kinase (MARK) effectively (IC50: 1 nM), a target for Alzheimer's therapy.</p>Fórmula:C21H23N7OSCor e Forma:SolidPeso molecular:421.52HDAC6-IN-14
<p>HDAC6-IN-14, an inhibitor of HDAC6 (HDAC), exhibits high selectivity with an IC50 value of 42 nM, demonstrating over 100-fold selectivity compared to HDAC1,</p>Fórmula:C24H30FN3O4Cor e Forma:SolidPeso molecular:443.51PIM1-IN-6
CAS:<p>PIM1-IN-6 (5h) inhibits PIM-1 (IC50: 0.60 μM) and is cytotoxic to HCT-116 (IC50: 1.51 μM) and MCF-7 cells (IC50: 15.2 μM).</p>Fórmula:C21H18N6O4Cor e Forma:SolidPeso molecular:418.41HDAC8/BRPF1-IN-1
CAS:<p>Compound 23a, dual HDAC8/BRPF1 inhibitor: IC50 HDAC8 = 443 nM, Kd BRPF1 = 67 nM; weak against HDAC1/6.</p>Fórmula:C19H19N3O6SCor e Forma:SolidPeso molecular:417.44PARP1-IN-9
CAS:<p>PARP1-IN-9, potent PARP1 inhibitor with 30.51 nM IC50, outperforms Olaparib in anticancer efficacy.</p>Fórmula:C18H21N3O5Cor e Forma:SolidPeso molecular:359.38J1038
CAS:<p>J1038 is a novel Histone Deacetylase 8 (HDAC8) Inhibitor .</p>Fórmula:C10H10N2O3SCor e Forma:SolidPeso molecular:238.26BRD4 Inhibitor-25
<p>BRD4 Inhibitor-25 blocks BRD4 (BD1: IC50 0.82 μM, BD2: 1.94 μM), induces cell death in ovarian cancer, used in cancer research.</p>Fórmula:C29H27N5O6SCor e Forma:SolidPeso molecular:573.62CAY10685
CAS:<p>CAY10685, a CPTH2 analog with an alkyne for click reactions, inhibits NAT10 to study cancer-related chromatin changes.</p>Fórmula:C17H16ClN3SCor e Forma:SolidPeso molecular:329.85NCDM-32B
CAS:<p>NCDM-32B, a novel potent and selective KDM4 inhibitor, impairs viability and transforms phenotypes of basal breast cancer.</p>Fórmula:C15H30N2O4Pureza:98%Cor e Forma:SolidPeso molecular:302.41MAT2A-IN-7
CAS:<p>MAT2A-IN-7 inhibits MAT2A in various cancers, especially MTAP-deficient cancer cells, with potential for research use.</p>Fórmula:C17H13ClF3N3O2Cor e Forma:SolidPeso molecular:383.75DNMT3A-IN-1
CAS:<p>DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).</p>Fórmula:C30H38N6O4Cor e Forma:SolidPeso molecular:546.66AChE/HDAC-IN-1
CAS:<p>COX-2-IN-23 (A10) inhibits AChE & HDAC (IC50s: 0.12 & 0.23 nM), has antioxidant/metal-binding traits, and is used in Alzheimer's research.</p>Fórmula:C26H27ClN4O3Cor e Forma:SolidPeso molecular:478.97ABT-472
CAS:<p>ABT-472 is a novel PARP inhibitor</p>Fórmula:C20H28N4O5Cor e Forma:SolidPeso molecular:404.46TYK2-IN-11
CAS:<p>TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.</p>Fórmula:C18H17N5O3SCor e Forma:SolidPeso molecular:383.42MAT2A-IN-6
CAS:<p>MAT2A-IN-6 inhibits MAT2A, may slow MTAP-deficient cancer cell growth, has research value in cancer.</p>Fórmula:C18H13ClF3N3O3Cor e Forma:SolidPeso molecular:411.76103D5R
CAS:<p>103D5R selectively inhibits hif-1α, reducing its levels in hypoxia or with cobalt ions, dose- and time-dependently.</p>Fórmula:C20H21N3O2Cor e Forma:SolidPeso molecular:335.4MZ-242
CAS:<p>MZ-242 is an effective and selective inhibitor of Sirt2.</p>Fórmula:C24H27N7O3S2Pureza:98%Cor e Forma:SolidPeso molecular:525.65KDOAM-25
CAS:<p>KDOAM-25, a potent KDM5 inhibitor, enhances H3K4 methylation, hampers MM1S cell growth; IC50: 71 nM (5A), 19 nM (5B), 69 nM (5C/D).</p>Fórmula:C15H25N5O2Pureza:98%Cor e Forma:SolidPeso molecular:307.39HDAC1-IN-4
CAS:<p>HDAC1-IN-4 is a potent inhibitor of Plasmodium falciparum HDAC1 (PfHDAC1) with low cytotoxicity and antimalarial effects (IC50<5 nM).</p>Fórmula:C21H24BrClN6O2Cor e Forma:SolidPeso molecular:507.82CPI703
CAS:<p>CPI703 is a novel potent and specific CBP/EP300 bromodomain inhibitor.</p>Fórmula:C17H22N4OPureza:98%Cor e Forma:SolidPeso molecular:298.38CP-690550A
CAS:<p>Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.</p>Fórmula:C15H21N5O2Cor e Forma:SolidPeso molecular:303.36Antiproliferative agent-17
CAS:<p>Antiproliferative Agent-17 exhibits both antimicrobial properties against Gram-positive bacteria and anticancer activity [1].</p>Fórmula:C26H28N2OSCor e Forma:SolidPeso molecular:416.58BET-IN-2
CAS:BET-IN-2 is a BET inhibitor (IC50: 52 nM for BRD4-BD1).Fórmula:C23H29N3OPureza:98%Cor e Forma:SolidPeso molecular:363.5AA-CW236
CAS:<p>AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).</p>Fórmula:C17H16ClF3N4O2Cor e Forma:SolidPeso molecular:400.78SDR-04
CAS:<p>SDR-04 inhibits BRD4-BD1 with high affinity, suppressing MV4;11 cancer cell growth as a BET inhibitor.</p>Fórmula:C19H16N4O2Cor e Forma:SolidPeso molecular:332.36NN-390
CAS:<p>NN-390: selective HDAC6 inhibitor, IC50 9.8 μM, blood-brain barrier penetrant, potential for metastatic group 3 neural tube cancer research.</p>Fórmula:C17H16F4N2O4SCor e Forma:SolidPeso molecular:420.38EZH2-IN-9
CAS:<p>EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.</p>Fórmula:C28H32ClF2N3O5SCor e Forma:SolidPeso molecular:596.09EZH2-IN-11
CAS:<p>EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.</p>Fórmula:C28H36ClN3O5SCor e Forma:SolidPeso molecular:562.12DC-BPi-11
CAS:<p>DC-BPi-11 inhibits BPTF at IC50 698 nM and significantly reduces leukemia cell growth.</p>Fórmula:C20H23N5O2SCor e Forma:SolidPeso molecular:397.49MC-1353
CAS:<p>MC-1353 is a potent, selective inhibitor of HDAC class I.</p>Fórmula:C16H16N2O3Cor e Forma:SolidPeso molecular:284.31TNKS-IN-41
CAS:TNKS-IN-41 highly potent and selective inhibitor of tankyrase.Fórmula:C24H22N10O2Pureza:98%Cor e Forma:SolidPeso molecular:482.5DPQ
CAS:<p>DPQ inhibits PARP-1, aids in neuroprotection, restores ATP, and lessens neuronal injury from NMDA.</p>Fórmula:C18H26N2O2Pureza:98%Cor e Forma:SolidPeso molecular:302.41HDAC/CK2-IN-1
CAS:<p>HDAC/CK2-IN-1 (compound 38) acts as an inhibitor of HDAC1 (IC 50 = 1.46 μM), HDAC6 (IC 50 = 0.66 μM), and CK2 (IC 50 = 3.67 μM). It demonstrates promising antiproliferative effects on various cell lines, including Jurkat, MCF-7, HCT-116, and HL-60.</p>Fórmula:C15H18Br4N4O2Cor e Forma:SolidPeso molecular:605.95PBRM1-BD2-IN-1
CAS:<p>PBRM1-BD2-IN-1: Selective PBRM1 inhibitor with Kd 0.7μM, IC50 0.2μM, useful in cancer research.</p>Fórmula:C17H19ClN2OCor e Forma:SolidPeso molecular:302.8BRM/BRG1 ATP Inhibitor-4
CAS:<p>BRM/BRG1 ATP Inhibitor-4, a potent inhibitor of BRG1/BRM, is utilized in the research of cancers and BAF complex-related disorders.</p>Fórmula:C25H32N6O3SCor e Forma:SolidPeso molecular:496.62KDM2/7-IN-1
CAS:<p>KDM2/7-IN-1 is a selective histone demethylase inhibitor (IC50s: 0.2–>120 μM) that inhibits HeLa and KYSE-150 cell proliferation, epigenetic and cancer.</p>Fórmula:C15H27NO4Pureza:99.87%Cor e Forma:SolidPeso molecular:285.38PARP1-IN-11
CAS:<p>PARP1-IN-11 is a potent PARP1 inhibitor (IC50=0.082 μM), also reducing PARP3, TNKS1, and TNKS2 activity.</p>Fórmula:C16H12N2O4Cor e Forma:SolidPeso molecular:296.28
