Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2242 produtos de "Cromatina/Epigenética"
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Aurora Kinases-IN-2
CAS:<p>Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.</p>Fórmula:C22H18ClN5O3Cor e Forma:SolidPeso molecular:435.86CypD inhibitor C-9
CAS:<p>CypD inhibitor C-9 is a CypD inhibitor, it attenuates mitochondrial and cellular perturbation insulted by Aß and calcium stress.</p>Fórmula:C22H22N4O4S2Cor e Forma:SolidPeso molecular:470.56EZH2-IN-3
CAS:<p>EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.</p>Fórmula:C27H28ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:490HDAC/NAMPT-IN-1
CAS:<p>HDAC/NAMPT-IN-1 (compound 39h) simultaneously inhibits HDAC and NAMPT, exhibiting IC 50 values ranging from 0.72 to 37081 nM for HDAC and 1618 nM for NAMPT [1].</p>Fórmula:C19H21N5O2Cor e Forma:SolidPeso molecular:351.4K00135
CAS:<p>K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.</p>Fórmula:C18H18N4OPureza:98.16%Cor e Forma:SolidPeso molecular:306.36CK2/PIM1-IN-1
CAS:<p>CK2/PIM1-IN-1 inhibits CK2 & PIM1 (IC50s: 3.787 & 4.327 μM), aimed for cancer research.</p>Fórmula:C15H9NO4S2Pureza:98%Cor e Forma:SolidPeso molecular:331.37PIM1-IN-7
CAS:<p>PIM1-IN-7 inhibits PIM-1 (IC50: 0.67μM), toxic to HCT-116/MCF-7 cells (IC50: 42.9/7.68μM).</p>Fórmula:C23H23N5OCor e Forma:SolidPeso molecular:385.46BRD4-BD1/2-IN-1
CAS:<p>BRD4-BD1/2-IN-1 efficiently blocks BRD4 BD-1/2 under 100 nM IC50 (US20150148375A1, cmpd 5).</p>Fórmula:C21H14F2N4O2Cor e Forma:SolidPeso molecular:392.364-iodo-SAHA
CAS:<p>4-Iodo-SAHA (1k), an oral HDAC inhibitor for cancer research, has EC50s from 0.12 to 1.3 μM across various cell lines.</p>Fórmula:C14H19IN2O3Cor e Forma:SolidPeso molecular:390.22A2AAR/HDAC-IN-2
CAS:<p>A2AAR/HDAC-IN-2: potent dual A2AAR/HDAC inhib., Ki 10.3 nM, IC50 18.5 nM, anti-tumor potential.</p>Fórmula:C23H26N6O4Cor e Forma:SolidPeso molecular:450.49LT052
CAS:<p>LT052 is a BET BD1 inhibitor with anti-inflammatory activity. It mediates the BRD4/NF-κB/NLRP3 signaling inflammatory pathway.</p>Fórmula:C22H19N5O4SPureza:98.82%Cor e Forma:SolidPeso molecular:449.48BRD4884
CAS:<p>BRD4884 is a highly selective and efficient HDAC1 and HDAC2 inhibitor that also inhibits HDAC3, used in research on neurological disorders.</p>Fórmula:C18H19FN2O2Pureza:99.19% - 99.21%Cor e Forma:SolidPeso molecular:314.35UNC2327
CAS:<p>UNC2327 is a potent and selective inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50:230 nM).</p>Fórmula:C14H17N5O2SPureza:98%Cor e Forma:SolidPeso molecular:319.38AMPK activator 9
CAS:<p>AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.</p>Fórmula:C31H28F4N4O4Cor e Forma:SolidPeso molecular:596.57JAK-IN-20
CAS:<p>JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.</p>Fórmula:C28H30FN7O2Cor e Forma:SolidPeso molecular:515.58Lorpucitinib
CAS:<p>Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal diseases.</p>Fórmula:C22H28N6O2Pureza:99.72%Cor e Forma:SolidPeso molecular:408.5VE-465
CAS:<p>VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.</p>Fórmula:C22H28N8OSCor e Forma:SolidPeso molecular:452.58PRMT5-IN-17
CAS:<p>PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.</p>Fórmula:C26H33N7O2Cor e Forma:SolidPeso molecular:475.59CCT077791
CAS:<p>CCT077791 is a potent inhibitor of p300 and PCAF histone acetyltransferase activity for cancer research.</p>Fórmula:C9H5ClN2O3SPureza:98.60%Cor e Forma:SolidPeso molecular:256.67IACS-9571 hydrochloride
CAS:<p>IACS-9571 hydrochloride: potent TRIM24/BRPF1 inhibitor; IC50 = 8 nM (TRIM24); Kd = 31 nM (TRIM24), 14 nM (BRPF1).</p>Fórmula:C32H43ClN4O8SCor e Forma:SolidPeso molecular:679.22ET-JQ1-OH
CAS:<p>ET-JQ1-OH is an allele-specific BET inhibitor.</p>Fórmula:C21H21ClN4O2SCor e Forma:SolidPeso molecular:428.93KU-0058684
CAS:<p>KU-0058684 is a potent PARP and DNA-PK inhibitors.</p>Fórmula:C19H14FN3O3Cor e Forma:SolidPeso molecular:351.33ML753286
CAS:<p>ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.</p>Fórmula:C20H25N3O3Pureza:98%Cor e Forma:SolidPeso molecular:355.43Trotabresib
CAS:<p>Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.</p>Fórmula:C21H21NO4SPureza:99.86%Cor e Forma:SolidPeso molecular:383.46Y02224
CAS:<p>Y02224 is a BET inhibitor. It shows the reasonable antiproliferative effect on leukemia cells.</p>Fórmula:C20H17BrN2O4SPureza:98%Cor e Forma:SolidPeso molecular:461.33CBB1003
CAS:<p>CBB1003 is a new inhibitor of histone demethylase LSD1 (IC50: 10.54 μM).</p>Fórmula:C25H31N9O4Pureza:98%Cor e Forma:SolidPeso molecular:521.57Dot1L-IN-5
CAS:<p>Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].</p>Fórmula:C23H19ClF2N8O5SCor e Forma:SolidPeso molecular:592.96CYP51/HDAC-IN-1
CAS:<p>Orally active CYP51/HDAC-IN-1 dual inhibitor targets virulence factors and resistance genes; effective against Candidiasis and Cryptococcal meningitis.</p>Fórmula:C30H40F2N6O4Cor e Forma:SolidPeso molecular:586.67Helenalin Acetate
CAS:<p>Helenalin Acetate: anti-inflammatory, anti-cancer, hinders C/EBPß and p300 cooperation.</p>Fórmula:C17H20O5Pureza:98%Cor e Forma:SolidPeso molecular:304.34HDAC-IN-45
CAS:<p>HDAC-IN-45, a small HDAC blocker, forms H-bonds with Y303 and shows anticancer properties; IC50 for HDAC1/2/3: 0.108/0.585/0.563 μM.</p>Fórmula:C25H20ClFN8OCor e Forma:SolidPeso molecular:502.93DM-01
CAS:<p>DM-01 is a potent and selective inhibitor of EZH2.</p>Fórmula:C23H24F3N3O2Cor e Forma:SolidPeso molecular:431.45dBRD9-A
CAS:<p>Potent BRD9 degrader that binds selectively, fully degrades BRD9 at low doses, and hinders synovial sarcoma growth in vitro and in mice.</p>Fórmula:C42H49N7O8Cor e Forma:SolidPeso molecular:779.88PB118
<p>PB118 clears Aβ, boosts phagocytosis, enhances tubulin networks, reduces p-tau & inflammation in AD; HDAC6 IC50: 5.6 nM.</p>Fórmula:C18H19FN2O2Cor e Forma:SoildPeso molecular:314.35KBH-A42
CAS:<p>KBH-A42 is an inhibitor of histone deacetylase.</p>Fórmula:C17H22N2O3Pureza:98%Cor e Forma:SolidPeso molecular:302.37JAK1-IN-4
CAS:<p>JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).</p>Fórmula:C26H32FN9O2Pureza:98%Cor e Forma:SolidPeso molecular:521.59CeMMEC2
CAS:<p>CeMMEC2, a novel inhibitor of BRD4, binds both the first and the second bromodomain of BRD4.</p>Fórmula:C14H19N5Cor e Forma:SolidPeso molecular:257.33(1S,2R)-Tranylcypromine hydrochloride
CAS:<p>(1S,2R)-Tranylcypromine hydrochloride ((1S,2R)-SKF 385), a potent antidepressant, functions by inhibiting both MAO and LSD1.</p>Fórmula:C9H12ClNCor e Forma:SolidPeso molecular:169.651HAT-IN-1
CAS:<p>HAT-IN-1 is an inhibitor of HAT used in the research of cancer.</p>Fórmula:C23H18BrF4N3O4Pureza:98%Cor e Forma:SolidPeso molecular:556.3HDAC3-IN-T326
CAS:<p>HDAC3-IN-T326: potent, selective HDAC3 inhibitor, boosts NF-κB acetylation, activates latent HIV gene expression.</p>Fórmula:C21H18N6O3SPureza:98%Cor e Forma:SolidPeso molecular:434.47Gue1654
CAS:<p>Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.</p>Fórmula:C23H17N3OS3Pureza:98.02% - 98.04%Cor e Forma:SolidPeso molecular:447.6LSD1-IN-6
CAS:<p>LSD1-IN-6, a potent LSD1 inhibitor (IC50: 123 nM), enhances H3K4me2 without altering LSD1 expression. Reversible.</p>Fórmula:C15H13BrN2O3Pureza:98%Cor e Forma:SolidPeso molecular:349.18Guadecitabine sodium
CAS:<p>Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .</p>Fórmula:C18H24N9NaO10PPureza:98%Cor e Forma:SolidPeso molecular:580.407PS432
CAS:<p>PS432 inhibits atypical PKCs, targets PIF-pocket, reduces tumors in mice sans side effects.</p>Fórmula:C25H19ClN2O5SPureza:98%Cor e Forma:SolidPeso molecular:494.95SMYD2-IN-1
CAS:<p>SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).</p>Fórmula:C25H25Cl2F2N7O2Pureza:98%Cor e Forma:SolidPeso molecular:564.41EZH2-IN-7
CAS:<p>EZH2-IN-7 inhibits EZH2, reducing H3K27me3 and tumor growth (e.g., breast, prostate cancer, leukemia). Potential in cancer research.</p>Fórmula:C31H37D2N5O3SCor e Forma:SolidPeso molecular:563.75Akt Inhibitor X
CAS:<p>Akt Inhibitor X is a cell-permeable and reversible inhibitor of Akt phosphorylation.</p>Fórmula:C20H25ClN2OPureza:98%Cor e Forma:SolidPeso molecular:344.88SC-9
CAS:<p>SC-9 is a protein kinase C activator.</p>Fórmula:C22H24ClNO2SPureza:98%Cor e Forma:SolidPeso molecular:401.95KDM5B-IN-3
CAS:<p>KDM5B-IN-3 inhibits KDM5B/JARID1B with IC50 of 9.32 μM, useful in gastric cancer studies.</p>Fórmula:C19H25ClN4O2Cor e Forma:SolidPeso molecular:376.88CID-4785700
CAS:CID-4785700 is a potent pan-GTPase inhibitor that inhibits Rab7 and inhibits the fungal histone acetyltransferase Rtt109 that binds to Asf1 and Vps75Fórmula:C22H23ClFN3O3Pureza:98.16%Cor e Forma:SolidPeso molecular:431.89Kgp-IN-1
CAS:<p>Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.</p>Fórmula:C19H24F4N4O3Pureza:98%Cor e Forma:SolidPeso molecular:432.41
