Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2598 produtos para "Cromatina/Epigenética".
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Chloramphenicol
CAS:Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.Fórmula:C11H12Cl2N2O5Pureza:99.6% - 99.90%Cor e Forma:White SolidPeso molecular:323.13EBI-2511
CAS:EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).Fórmula:C34H48N4O4Pureza:99.74%Cor e Forma:SolidPeso molecular:576.77M-89
CAS:M-89, a potent menin inhibitor (Kd 1.4 nM), disrupts Menin-MLL interaction, offering possible MLL leukemia treatment.Fórmula:C37H47N5O4SPureza:98.38%Cor e Forma:SolidPeso molecular:657.87Ref: TM-T11925
1mg158,00€5mg385,00€10mg532,00€1mL*10mM (DMSO)538,00€25mg782,00€50mg1.063,00€100mg1.468,00€Nimucitinib
CAS:Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.Fórmula:C25H26F2N6O2Pureza:99.58%Cor e Forma:Yellow SolidPeso molecular:480.51Ref: TM-T67907
1mg90,00€2mg132,00€5mg215,00€10mg334,00€25mg620,00€50mg888,00€100mg1.378,00€500mg2.673,00€Enarodustat
CAS:Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.Fórmula:C17H16N4O4Pureza:99.73% - 99.75%Cor e Forma:SolidPeso molecular:340.33Ref: TM-T15219
1mg37,00€2mg52,00€5mg74,00€1mL*10mM (DMSO)86,00€10mg109,00€25mg178,00€50mg295,00€100mg439,00€MOZ-IN-2
CAS:MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).Fórmula:C17H13FN4O3SPureza:99.17%Cor e Forma:SolidPeso molecular:372.37Ref: TM-T12098
2mg34,00€5mg57,00€1mL*10mM (DMSO)63,00€10mg90,00€25mg178,00€50mg268,00€100mg409,00€500mg888,00€PARP10-IN-3
CAS:PARP10-IN-3: selective inhibitor for mono-ADP-ribotransferase PARP10 (IC50: 480nM), also affects PARP2 and PARP15 (IC50: 1.7μM).Fórmula:C14H12N2O3Pureza:97.79%Cor e Forma:White SolidPeso molecular:256.26Valemetostat
CAS:Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor, which can be used to study T-cell lymphoma.Cost-effective and quality-assured.Fórmula:C26H34ClN3O4Pureza:98.38% - 99.83%Cor e Forma:SolidPeso molecular:488.02Ref: TM-T13279L
1mg89,00€5mg177,00€1mL*10mM (DMSO)197,00€10mg313,00€25mg520,00€50mg742,00€100mg982,00€Glucosamine
CAS:Glucosamine (Chitosamine) is used as a dietary supplement. Glucosamine has pharmacological effects on osteoarthritis cartilage. High-Quality, Low-Cost!Fórmula:C6H13NO5Pureza:99.68% - 99.8%Cor e Forma:SolidPeso molecular:179.17Ziftomenib
CAS:Ziftomenib (KO-539) is an inhibitor of menin-MLL interaction with antitumor activity and can be used to study leukemia.Fórmula:C33H42F3N9O2S2Pureza:99.65% - 99.99%Cor e Forma:Yellow SolidPeso molecular:717.871Lin28-let-7a antagonist 1
CAS:Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction，and shows a clear antagonistic effect against the Lin28-let-7a interaction.Fórmula:C31H29N5O7Pureza:99.44%Cor e Forma:SolidPeso molecular:583.59Ref: TM-T11851
1mg96,00€5mg205,00€1mL*10mM (DMSO)266,00€10mg313,00€25mg562,00€50mg845,00€100mg1.243,00€Pim-1 kinase inhibitor 8
CAS:Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.Fórmula:C14H17N3O3Pureza:99.92%Cor e Forma:SolidPeso molecular:275.3Molidustat
CAS:Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。Fórmula:C13H14N8O2Pureza:98.79% - 99.79%Cor e Forma:White SolidPeso molecular:314.3AW68
CAS:AW68 is a potential small molecule BRD4 inhibitor that prevents and treats BRD4-related diseases and can be used in cancer research.Fórmula:C22H21ClN6Pureza:98.52% - 99.72%Cor e Forma:SolidPeso molecular:404.89MAK683
CAS:MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).Fórmula:C20H17FN6OPureza:98.25% - 99.92%Cor e Forma:SolidPeso molecular:376.39N-(3-Aminopropyl)cyclohexylamine
CAS:N-(3-Aminopropyl)cyclohexylamine inhibits spermine synthase; used in neuro disease research.Fórmula:C9H20N2Pureza:98.05% - 98.82%Cor e Forma:SolidPeso molecular:156.2685Nefiracetam
CAS:Nefiracetam (DM9384), in Phase 2 trials, enhances GABA, choline, monoamine systems, and treats Ro 5-4864 convulsions.Fórmula:C14H18N2O2Pureza:97.37%Cor e Forma:SolidPeso molecular:246.3PKC β pseudosubstrate acetate
PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.Pureza:95.42%Cor e Forma:SoildTAK-901
CAS:TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among othersFórmula:C28H32N4O3SPureza:99.02% - 99.59%Cor e Forma:Yellow SolidPeso molecular:504.64Ref: TM-T2709
1mg34,00€5mg66,00€1mL*10mM (DMSO)74,00€10mg99,00€25mg192,00€50mg313,00€100mg497,00€200mg710,00€EHP-101
CAS:EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.Fórmula:C28H35NO3Pureza:98.36%Cor e Forma:SolidPeso molecular:433.58Ref: TM-T13289
1mg101,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg295,00€25mg485,00€50mg677,00€100mg888,00€Fenbendazole
CAS:Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.Fórmula:C15H13N3O2SPureza:99.74%Cor e Forma:SolidPeso molecular:299.35WDR5-IN-6
CAS:WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6Fórmula:C13H8Cl2N2O2SPureza:99.69%Cor e Forma:SoildPeso molecular:327.19Pumecitinib
CAS:Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.Fórmula:C17H20N8O2SPureza:99.93%Cor e Forma:SoildPeso molecular:400.46A-485
CAS:A-485 is a p300/CBP histone acetyltransferase (HAT) inhibitor that inhibits p300 and CBP. A-485 has antitumor effects. Cost effective and quality assured.Fórmula:C25H24F4N4O5Pureza:98.01% - 99.98%Cor e Forma:White SolidPeso molecular:536.48Ref: TM-T14073
1mg88,00€5mg159,00€1mL*10mM (DMSO)187,00€10mg273,00€25mg339,00€50mg404,00€100mg698,00€JAK2 Inhibitor V
CAS:JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.Fórmula:C23H24N2OPureza:98.36% - 99.15%Cor e Forma:SolidPeso molecular:344.45Ref: TM-T3042
2mg37,00€5mg54,00€1mL*10mM (DMSO)59,00€10mg80,00€25mg148,00€50mg259,00€100mg477,00€500mg1.063,00€(R)-CR8
CAS:(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.Fórmula:C24H29N7OPureza:98.41%Cor e Forma:SolidPeso molecular:431.53Ref: TM-T12617L
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg200,00€25mg268,00€50mg409,00€100mg580,00€BMS-986158
CAS:BMS-986158: BET inhibitor, IC50 of 6.6 nM in SCLC, 5 nM in TNBC cells.Fórmula:C30H33N5O2Pureza:98.78%Cor e Forma:White SolidPeso molecular:495.62Ref: TM-T14685
1mg82,00€5mg245,00€1mL*10mM (DMSO)268,00€10mg356,00€25mg700,00€50mg954,00€100mg1.305,00€KDM1A-IN-29
CAS:KDM1A-IN-29 is a histone demethylase inhibitor.Fórmula:C16H16ClN3O4SCor e Forma:Yellow SolidPeso molecular:381.83MNN-02-155
CAS:MNN-02-155 is a bivalent molecular glue that can simultaneously interact with both p300/CBP and BCL6. It effectively induces the activation of BCL6-targeted reporter genes and promotes cell death. This compound is used in the research of diffuse large B-cell lymphoma (DLBCL).Fórmula:C56H68ClF2N15O7Cor e Forma:SolidPeso molecular:1136.69PF-03622905
CAS:PF-03622905: potent ATP-competitive PKC inhibitor, IC50: 5.6-74.1 nM for PKCα/βI/βII/γ/θ, high specificity for PKC.Fórmula:C24H35N7O3Cor e Forma:SolidPeso molecular:469.59ZL0590
CAS:ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.Fórmula:C23H27F3N4O4SPureza:99.77%Cor e Forma:SolidPeso molecular:512.55Ref: TM-T60072
1mg71,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg222,00€25mg401,00€50mg602,00€100mg887,00€A-893
CAS:A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Fórmula:C29H38Cl2N4O4Cor e Forma:SolidPeso molecular:577.54PRO-HD1
PRO-HD1, a PROTAC (proteolysis-targeting chimera) HDAC6 degrader, effectively degrades HDAC6 in A549 cells and inhibits Jurkat cell proliferation with an IC50Pureza:98%Cor e Forma:Odour SolidJAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Cor e Forma:Odour SolidPROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.Fórmula:C50H58FN11O6SPureza:98%Cor e Forma:SolidPeso molecular:960.13SIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Fórmula:C22H25ClN8O2SPureza:99.56%Cor e Forma:SolidPeso molecular:501ALKBH1-IN-1
ALKBH1-IN-1 (Compound 13h) is a selective ALKBH1 inhibitor with IC50 values of 0.026 μM in fluorescence polarization assays and 1.39 μM in enzyme activity assays. It can regulate the levels of DNA 6mA modifications and is useful for studying the functions of ALKBH1 and DNA 6mA.Fórmula:C16H11F3N4O4Peso molecular:380.07324PROTAC CBP/P300 Degrader-1
CAS:PROTAC CBP/P300 Degrader-1 effectively reduces cancer cell viability by degrading CBP/P300.Fórmula:C46H53F2N11O6Cor e Forma:SolidPeso molecular:893.998(S,R,S)-AHPC-C5-COOH
CAS:E3 ligase ligand-linker '(S,R,S)-AHPC-C5-COOH' for PROTACs, VH032 inhibits VHL/HIF-1α with 185 nM Kd, may aid anemia and ischemic disease research.Fórmula:C29H42N4O5SPureza:98%Cor e Forma:SolidPeso molecular:558.73HIF-PHD-IN-4
HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.Cor e Forma:Odour SolidSJ988497
CAS:SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.Fórmula:C36H36N10O5Cor e Forma:SolidPeso molecular:688.74RMM23
RMM23 is an inhibitor that targets PfBDP1, exhibiting a Kd of 1.24 μM. In vitro, it shows EC50 values of 18 μM against the 3D7 wild-type strain, 14 μM against the NF54 wild-type strain, and 20 μM against the multidrug-resistant K1 strain during the blood stage.Cor e Forma:Odour SolidNCT-TFP
CAS:NCT-TFP is PARP probe used to identifying Poly(ADP-ribose) polymerases (PARP) inhibitors[1].Fórmula:C41H34F4N2O5Cor e Forma:SolidPeso molecular:710.71Sulfo SMCC R-phycoerythrin
SulfoSMCCR-phycoerythrin is a conjugate composed of the protein crosslinker SMCC and R-PE (R-Phycoerythrin), designed for labeling proteins to carry red fluorescence. SMCC functions to bind antigen-coupled spleen cells, thereby inducing antigen-specific immune responses.Cor e Forma:Odour SolidPROTAC HDAC6 degrader 3
PROTACHDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader of HDAC6, with an IC50 of 686 nM and a DC50 of 171 nM. It enhances the acetylation of α-tubulin. [Pink: ligand for target protein; Blue: ligand for E3ligaseVHL.]Fórmula:C46H56F2N10O9SCor e Forma:SolidPeso molecular:963.06SIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Fórmula:C24H29ClN8O4SPureza:98.68%Cor e Forma:SolidPeso molecular:561.06DNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Cor e Forma:Odour SolidCDD-1102 HCl
CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.Fórmula:C32H31ClN6O3Pureza:98.30%Cor e Forma:SoildPeso molecular:583.08ML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Cor e Forma:Odour SolidBET-IN-26
BET-IN-26 (compound 13a) is a potent, selective, and orally active BD1 inhibitor, exhibiting IC50 values of 0.0055 µM for BD1 and 9.0 µM for BD2. It effectively reduces serum IL-6 and MCP-1 levels induced by LPS.Fórmula:C26H36N6O2SCor e Forma:SolidPeso molecular:496.26205
