Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2252 produtos de "Cromatina/Epigenética"
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HDAC-IN-29
CAS:<p>HDAC-IN-29 (compound 13b) is a potent pan- HDAC inhibitor with antitumor activity.</p>Fórmula:C20H23N3O4SCor e Forma:SolidPeso molecular:401.48PF-739
CAS:<p>PF-739 is an AMPK agonist that has been shown to activate AMPK in hepatocytes and skeletal muscle.</p>Fórmula:C23H23ClN2O5Pureza:98%Cor e Forma:SolidPeso molecular:442.89HIF-1α-IN-3
CAS:<p>HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].</p>Fórmula:C19H17N5O2Cor e Forma:SolidPeso molecular:347.37NVS-BET-1
CAS:<p>NVS-BET-1 is a BET bromodomain inhibitor. NVS-BET-1 can regulate keratinocyte plasticity.</p>Fórmula:C22H21ClN4O2Cor e Forma:SolidPeso molecular:408.88ZIKV-IN-3
CAS:<p>ZIKV-IN-3, an andrographolide derivative, inhibits ZIKV NS5 MTase (IC50: 18.34 μM) and replication. Used for Zika virus research.</p>Fórmula:C39H41NO4Cor e Forma:SolidPeso molecular:587.75Thi-DPPY
CAS:<p>Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.</p>Fórmula:C28H28ClN5O4SCor e Forma:SolidPeso molecular:566.07HPB
CAS:<p>HPB is a selective HDAC6 deacetylase inhibitor</p>Fórmula:C18H20N2O4Cor e Forma:SolidPeso molecular:328.36NSD3-IN-1
CAS:<p>NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.</p>Fórmula:C13H13N5OSCor e Forma:SolidPeso molecular:287.34BiBET
CAS:<p>BiBET is a potent, selective, bivalent inhibitor of BET bromodomains.</p>Fórmula:C26H30N10O3Cor e Forma:SolidPeso molecular:530.58HIF-1/2α-IN-2
CAS:<p>HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.</p>Fórmula:C16H11FN4O2SCor e Forma:SolidPeso molecular:342.35SHP2/HDAC-IN-1
CAS:<p>SHP2/HDAC-IN-1: dual SHP2/HDAC inhibitor, IC50: 20.4 nM/25.3 nM, boosts antitumor immunity, aids cancer immunotherapy research.</p>Fórmula:C34H35Cl2N7O3Cor e Forma:SolidPeso molecular:660.59BI-9321
CAS:<p>BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.</p>Fórmula:C22H21FN4Pureza:98%Cor e Forma:SolidPeso molecular:360.43LSD1-IN-13
CAS:<p>LSD1-IN-13, an oral LSD1 blocker (IC50: 24.43 nM), boosts CD86 (EC50: 470 nM), and triggers AML cell line differentiation.</p>Fórmula:C23H29N3O2SCor e Forma:SolidPeso molecular:411.56SIRT2-IN-11
CAS:<p>SIRT2-IN-11 (AEM1), a SIRT2 inhibitor (IC50 18.5μM), induces apoptosis and affects p53, used in cancer research.</p>Fórmula:C21H22N2OCor e Forma:SolidPeso molecular:318.41TUL01101
CAS:<p>TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.</p>Fórmula:C22H25F2N5O2Cor e Forma:SolidPeso molecular:429.46Galegine hydrochloride
CAS:<p>Galegine hydrochloride, from G. officinalis, leads to weight loss, activates AMPK in various cells, and has antibacterial properties.</p>Fórmula:C6H14ClN3Cor e Forma:SolidPeso molecular:163.651,2-Didecanoylglycerol
CAS:<p>1,2-Didecanoylglycerol has functions as bioregulator of protein kinase C in human platelets.</p>Fórmula:C23H44O5Cor e Forma:SolidPeso molecular:400.59KDM2B-IN-3
CAS:<p>KDM2B-IN-3, from patent WO2016112284A1 as compound 183c, potently inhibits histone demethylase KDM2B, with cancer research potential.</p>Fórmula:C25H30N2O2Cor e Forma:SolidPeso molecular:390.52KD 5170
CAS:<p>KD 5170, a pan inhibitor of histone deacetylases (HDACs), demonstrates widespread antitumor activity both in vitro and in vivo [1].</p>Fórmula:C20H25N3O5S2Cor e Forma:SolidPeso molecular:451.56Furamidine dihydrochloride
CAS:<p>Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.</p>Fórmula:C18H18Cl2N4OPureza:98.16%Cor e Forma:SolidPeso molecular:377.27Acefylline piperazine
CAS:<p>Acefylline piperazine, a less toxic theophylline derivative, treats asthma and bronchitis by bronchodilation, stimulating respiration and CNS.</p>Fórmula:C9H10N4O4·xC4H10N2Cor e Forma:SolidPeso molecular:562.54F-amidine
CAS:<p>F-amidine is a bioavailable irreversible PAD4 inactivator.</p>Fórmula:C14H19FN4O2Cor e Forma:SolidPeso molecular:294.32UNC0379 TFA
CAS:<p>UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.</p>Fórmula:C25H36F3N5O4Cor e Forma:SolidPeso molecular:527.589DDO-2093 dihydrochloride
<p>DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.</p>Fórmula:C29H39Cl3FN9O3Cor e Forma:SolidPeso molecular:687.04CPI-4203
CAS:<p>CPI-4203 is a selective inhibitor of KDM5 demethylases.</p>Fórmula:C16H14N4OCor e Forma:SolidPeso molecular:278.31PARP-2/1-IN-2
CAS:<p>PARP-2/1-IN-2, Veliparib's enantiomer, inhibits PARP-1/2 (Ki: 5/2 nM) with 3 nM EC50 in cell assay.</p>Fórmula:C13H16N4OCor e Forma:SolidPeso molecular:244.29BAY-598 R-isomer
CAS:<p>BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.</p>Fórmula:C22H20Cl2F2N6O3Cor e Forma:SolidPeso molecular:525.34BPTF-IN-1
CAS:<p>BPTF-IN-1 (AU1), a BPTF bromodomain inhibitor with 2.8 μM affinity, shows higher selectivity over BRD4 and possesses antimalarial properties.</p>Fórmula:C23H23FN6O3Cor e Forma:SolidPeso molecular:450.47NSC-311068
CAS:<p>NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.</p>Fórmula:C10H6N4O4SCor e Forma:SolidPeso molecular:278.24UNC6212 (Kme2)
<p>UNC6212 (Kme2), a dimethyllysine (Kme2)-containing ligand, has a K D for CBX5 of 5.7 μM .</p>Fórmula:C39H53N7O11Cor e Forma:SolidPeso molecular:795.88CAY10669
CAS:<p>CAY10669 inhibits PCAF (IC50 = 662 μM), is twice as potent as anacardic acid, and reduces H4 acetylation in HepG2 cells at 30-60 μM.</p>Fórmula:C20H22O4Cor e Forma:SolidPeso molecular:326.39TAK-418
CAS:<p>TAK-418 is an orally active LSD1/KDM1A inhibitor with a 2.9 nM IC50, potential for autism therapy.</p>Fórmula:C17H25ClN2O2SPureza:99.69%Cor e Forma:SolidPeso molecular:356.91FNDR-20123 free base
CAS:<p>FNDR-20123 is a safe, oral first-in-class anti-malarial HDAC inhibitor with low IC50s against Plasmodium and human HDACs.</p>Fórmula:C21H23N5O2Cor e Forma:SolidPeso molecular:377.44Bromodomain inhibitor-10
CAS:<p>Bromodomain inhibitor-10 (compound 128) suppresses BRD4-1/2 with Kd 15 nM/2.5 μM and curbs IL12p40 production.</p>Fórmula:C20H20N4O3Cor e Forma:SolidPeso molecular:364.4UMB-32
CAS:<p>UMB-32: Potent, selective BRD4 inhibitor, Kd 550 nM, IC50 637 nM, also targets TAF1.</p>Fórmula:C21H23N5OCor e Forma:SolidPeso molecular:361.44Aurora A/PKC-IN-1
CAS:<p>Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.</p>Fórmula:C16H14N6OSe2Cor e Forma:SolidPeso molecular:464.24Binucleine 2
CAS:<p>Binucleine 2: Drosophila Aurora B kinase inhibitor (Ki=0.36μM), dose-dependent, minimal effect on human/X. laevis kinases, disrupts mitosis in fly cells.</p>Fórmula:C13H11ClFN5Cor e Forma:SolidPeso molecular:291.71CPI-905
CAS:<p>CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.</p>Fórmula:C18H20N2O5Cor e Forma:SolidPeso molecular:344.36iBRD4-BD1
CAS:<p>iBRD4-BD1 inhibits BRD4 bromodomain selectively with 12 nM IC50, useful in inflammation and cancer research.</p>Fórmula:C29H30F3N5OCor e Forma:SolidPeso molecular:521.58Sirtuin modulator 4
CAS:<p>Sirtuin modulator 4 inhibits SIRT1 (EC50: 51-100 μM), may extend cell life and prevent diseases like diabetes and cancer.</p>Fórmula:C18H10N2O2SCor e Forma:SolidPeso molecular:318.35HPCG
CAS:<p>HPCG is an inhibitor of HIF-1α prolyl hydroxylase.</p>Fórmula:C8H8N2O4Cor e Forma:SolidPeso molecular:196.16SPC-180002
CAS:<p>SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.</p>Fórmula:C18H23NO4Pureza:98%Cor e Forma:SolidPeso molecular:317.38NSC 698600
CAS:<p>NSC 698600 is a potent inhibitor of PCAF(p300/CBP-associated factor) with IC 50 of 6.51 μM that shows good inhibition activity of cancer cell proliferation [1].</p>Fórmula:C14H12N2O2SCor e Forma:SolidPeso molecular:272.32NR-160
CAS:<p>NR-160 is a selective HDAC6 inhibitor (IC50=0.03μM), weaker on HDAC1-4,8, toxic to 7 cancer lines, boosts bortezomib and anthracycline effects.</p>Fórmula:C25H21F3N6O3Cor e Forma:SolidPeso molecular:510.47NCGC00247743
CAS:NCGC00247743 is an inhibitor of histone lysine demethylase KDM4.Fórmula:C24H29N3O2Pureza:98%Cor e Forma:SolidPeso molecular:391.51SIRT6-IN-1
CAS:<p>SIRT6-IN-1, a novel SIRT6 inhibitor, reduces glycemia and improves oral glucose tolerance in unfed wild-type mice.</p>Fórmula:C19H14N4O5SCor e Forma:SolidPeso molecular:410.4MAT2A-IN-5
CAS:<p>MAT2A-IN-5 inhibits MAT2A in tumors, curbing growth in gastric, colon, liver, and pancreatic cancers.</p>Fórmula:C17H12ClF3N2OCor e Forma:SolidPeso molecular:352.74ST7710AA1
CAS:<p>ST7710AA1 inhibits PARP-1, effectively targets in vitro, and overcomes Pgp-associated multidrug resistance.</p>Fórmula:C20H22N4OCor e Forma:SolidPeso molecular:334.41HDAC6-IN-10
CAS:<p>HDAC6-IN-10 is a potent HDAC6 inhibitor with 0.73 nM IC50, highly selective, and hinders multiple myeloma cell growth.</p>Fórmula:C21H20N4O4Cor e Forma:SolidPeso molecular:392.41JAK-IN-18
CAS:<p>"JAK-IN-18: potent JAK inhibitor for eye, skin, respiratory disease research (WO2018204238A1, comp 1)."</p>Fórmula:C27H28F2N6O3Cor e Forma:SolidPeso molecular:522.55
