Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2252 produtos de "Cromatina/Epigenética"
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GDC-4379
CAS:<p>GDC-4379 is a JAK1 inhibitor that can be used to study asthma.</p>Fórmula:C21H18ClF2N7O3Cor e Forma:SolidPeso molecular:489.86BET bromodomain inhibitor 2
CAS:<p>BET bromodomain inhibitor 2 is a potent inhibitor of the BET-type bromodomain (IC50: 14.1 μM).</p>Fórmula:C23H30N2O5SCor e Forma:SolidPeso molecular:446.56HDAC-IN-44
CAS:<p>HDAC-IN-44 is an HDAC inhibitor (IC50: 61.2 nM) with strong anti-cancer effects.</p>Fórmula:C26H27BrN4O4Cor e Forma:SolidPeso molecular:539.42INCB054329 Racemate
CAS:INCB054329 Racemate is an inhibitor of BET protein.Fórmula:C19H16N4O3Pureza:98%Cor e Forma:SolidPeso molecular:348.36NC-III-49-1
CAS:<p>NC-III-49-1: potent BET inhibitor, binds BRD4/BRDT, inhibits cell growth, reduces c-Myc expression.</p>Fórmula:C44H50N4O11S2Cor e Forma:SoildPeso molecular:875.02NSD3-IN-3
CAS:<p>"NSD3-IN-3, a potent anticancer agent, inhibits NSD3 (IC50: 1.86 μM) and hampers H460 lung cancer cell growth."</p>Fórmula:C15H17N5O2SCor e Forma:SolidPeso molecular:331.39NSD3-IN-2
CAS:<p>NSD3-IN-2: Potent NSD3 inhibitor, IC50 17.97μM, halts NSCLC growth (H460, H1299, H1650) with anticancer effects.</p>Fórmula:C17H15N5OSCor e Forma:SolidPeso molecular:337.4BRM/BRG1 ATP Inhibitor-3
CAS:<p>BRM/BRG1 ATP Inhibitor-3 targets BRM/BRG1 (IC50: 10.4/19.3 nM) for cancer/BAF disorder research.</p>Fórmula:C26H25N5O2S2Cor e Forma:SolidPeso molecular:503.64RSC-133
CAS:promotes the reprogramming of human somatic cells to pluripotent stem cellsFórmula:C18H15N3O2Pureza:98%Cor e Forma:SolidPeso molecular:305.33SIRT2-IN-10
CAS:<p>SIRT2-IN-10 (Compound 12) is a potent inhibitor of SIRT2 (IC50: 1.3 μM), which can be used in the study of cancer and neurodegenerative diseases.</p>Fórmula:C28H21N5OSCor e Forma:SolidPeso molecular:475.56KCN1
CAS:<p>KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.</p>Fórmula:C26H27NO5SCor e Forma:SolidPeso molecular:465.56UMB-136
CAS:<p>UMB-136 is a bromodomain BRD4 inhibitor that acts by significantly inducing HIV-1 reactivation.</p>Fórmula:C24H27N5O2Pureza:98%Cor e Forma:SolidPeso molecular:417.5PBRM1-BD2-IN-6
CAS:PBRM1-BD2-IN-6: potent PBRM1 inhibitor with 0.22 µM IC50, anti-cancer research potential.Fórmula:C16H15ClN2OCor e Forma:SolidPeso molecular:286.76Aurora Kinases-IN-3
CAS:<p>Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.</p>Fórmula:C20H16F3N3O4Cor e Forma:SolidPeso molecular:419.35SRTCX1003
CAS:<p>SRTCX1003, a SIRT1 activator, suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.</p>Fórmula:C23H23N5O3SCor e Forma:SolidPeso molecular:449.53Povorcitinib
CAS:<p>Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).</p>Fórmula:C23H22F5N7OCor e Forma:SolidPeso molecular:507.469(2R,5S)-Ritlecitinib
CAS:<p>(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].</p>Fórmula:C15H19N5OCor e Forma:SolidPeso molecular:285.34CSV0C018875
CAS:<p>CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].</p>Fórmula:C18H17ClN2OCor e Forma:SolidPeso molecular:312.79KDM5-C49
CAS:<p>KDM5-C49 is a potent and selective inhibitor of KDM5, which regulates cell proliferation and stem cell self-renewal and differentiation.</p>Fórmula:C15H24N4O3Pureza:98%Cor e Forma:SolidPeso molecular:308.38SMTIN-T140
CAS:<p>SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.</p>Fórmula:C36H34BrClFN5OPPureza:98%Cor e Forma:SolidPeso molecular:718.02IND 1316
CAS:<p>IND 1316 is an activator of AMP-activated protein kinase (AMPK).</p>Fórmula:C22H17NO3Cor e Forma:SolidPeso molecular:343.38BETi-211
CAS:<p>BETi-211 is a selective inhibitor BET bromodomain.</p>Fórmula:C26H29N7O3Cor e Forma:SolidPeso molecular:487.55RET-IN-19
CAS:<p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>Fórmula:C28H28N6O4SCor e Forma:SolidPeso molecular:544.62Dihydro-5-azacytidine acetate
CAS:<p>Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1</p>Fórmula:C10H18N4O7Pureza:98%Cor e Forma:SolidPeso molecular:306.27AMPK activator 8
CAS:<p>AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.</p>Fórmula:C25H21ClN2O6Cor e Forma:SolidPeso molecular:480.9KDM2B-IN-4
CAS:<p>KDM2B-IN-4, from patent WO2016112284A1 as 182b, is a potent KDM2B inhibitor used in cancer research.</p>Fórmula:C24H28N2O2Cor e Forma:SolidPeso molecular:376.49IACS-9571 hydrochloride
CAS:<p>IACS-9571 hydrochloride: potent TRIM24/BRPF1 inhibitor; IC50 = 8 nM (TRIM24); Kd = 31 nM (TRIM24), 14 nM (BRPF1).</p>Fórmula:C32H43ClN4O8SCor e Forma:SolidPeso molecular:679.22PRMT5-IN-17
CAS:<p>PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.</p>Fórmula:C26H33N7O2Cor e Forma:SolidPeso molecular:475.59VE-465
CAS:<p>VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.</p>Fórmula:C22H28N8OSCor e Forma:SolidPeso molecular:452.58AMPK activator 9
CAS:<p>AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.</p>Fórmula:C31H28F4N4O4Cor e Forma:SolidPeso molecular:596.57BRD4-BD1/2-IN-1
CAS:<p>BRD4-BD1/2-IN-1 efficiently blocks BRD4 BD-1/2 under 100 nM IC50 (US20150148375A1, cmpd 5).</p>Fórmula:C21H14F2N4O2Cor e Forma:SolidPeso molecular:392.36PIM1-IN-7
CAS:<p>PIM1-IN-7 inhibits PIM-1 (IC50: 0.67μM), toxic to HCT-116/MCF-7 cells (IC50: 42.9/7.68μM).</p>Fórmula:C23H23N5OCor e Forma:SolidPeso molecular:385.46CK2/PIM1-IN-1
CAS:CK2/PIM1-IN-1 inhibits CK2 & PIM1 (IC50s: 3.787 & 4.327 μM), aimed for cancer research.Fórmula:C15H9NO4S2Pureza:98%Cor e Forma:SolidPeso molecular:331.37EZH2-IN-3
CAS:<p>EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.</p>Fórmula:C27H28ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:490KDM2/7-IN-1
CAS:<p>KDM2/7-IN-1 is a selective histone demethylase inhibitor (IC50s: 0.2–>120 μM) that inhibits HeLa and KYSE-150 cell proliferation, epigenetic and cancer.</p>Fórmula:C15H27NO4Pureza:99.87%Cor e Forma:SolidPeso molecular:285.38HDAC1-IN-4
CAS:<p>HDAC1-IN-4 is a potent inhibitor of Plasmodium falciparum HDAC1 (PfHDAC1) with low cytotoxicity and antimalarial effects (IC50<5 nM).</p>Fórmula:C21H24BrClN6O2Cor e Forma:SolidPeso molecular:507.82PBRM1-BD2-IN-1
CAS:<p>PBRM1-BD2-IN-1: Selective PBRM1 inhibitor with Kd 0.7μM, IC50 0.2μM, useful in cancer research.</p>Fórmula:C17H19ClN2OCor e Forma:SolidPeso molecular:302.8BRM/BRG1 ATP Inhibitor-4
CAS:<p>BRM/BRG1 ATP Inhibitor-4, a potent inhibitor of BRG1/BRM, is utilized in the research of cancers and BAF complex-related disorders.</p>Fórmula:C25H32N6O3SCor e Forma:SolidPeso molecular:496.62DPQ
CAS:<p>DPQ inhibits PARP-1, aids in neuroprotection, restores ATP, and lessens neuronal injury from NMDA.</p>Fórmula:C18H26N2O2Pureza:98%Cor e Forma:SolidPeso molecular:302.41MC-1353
CAS:<p>MC-1353 is a potent, selective inhibitor of HDAC class I.</p>Fórmula:C16H16N2O3Cor e Forma:SolidPeso molecular:284.31DC-BPi-11
CAS:<p>DC-BPi-11 inhibits BPTF at IC50 698 nM and significantly reduces leukemia cell growth.</p>Fórmula:C20H23N5O2SCor e Forma:SolidPeso molecular:397.49EZH2-IN-11
CAS:<p>EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.</p>Fórmula:C28H36ClN3O5SCor e Forma:SolidPeso molecular:562.12EZH2-IN-9
CAS:<p>EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.</p>Fórmula:C28H32ClF2N3O5SCor e Forma:SolidPeso molecular:596.09NN-390
CAS:<p>NN-390: selective HDAC6 inhibitor, IC50 9.8 μM, blood-brain barrier penetrant, potential for metastatic group 3 neural tube cancer research.</p>Fórmula:C17H16F4N2O4SCor e Forma:SolidPeso molecular:420.38AA-CW236
CAS:<p>AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).</p>Fórmula:C17H16ClF3N4O2Cor e Forma:SolidPeso molecular:400.78Antiproliferative agent-17
CAS:Antiproliferative Agent-17 exhibits both antimicrobial properties against Gram-positive bacteria and anticancer activity [1].Fórmula:C26H28N2OSCor e Forma:SolidPeso molecular:416.58103D5R
CAS:<p>103D5R selectively inhibits hif-1α, reducing its levels in hypoxia or with cobalt ions, dose- and time-dependently.</p>Fórmula:C20H21N3O2Cor e Forma:SolidPeso molecular:335.4TYK2-IN-11
CAS:<p>TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.</p>Fórmula:C18H17N5O3SCor e Forma:SolidPeso molecular:383.42AChE/HDAC-IN-1
CAS:<p>COX-2-IN-23 (A10) inhibits AChE & HDAC (IC50s: 0.12 & 0.23 nM), has antioxidant/metal-binding traits, and is used in Alzheimer's research.</p>Fórmula:C26H27ClN4O3Cor e Forma:SolidPeso molecular:478.97DNMT3A-IN-1
CAS:<p>DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).</p>Fórmula:C30H38N6O4Cor e Forma:SolidPeso molecular:546.66
