Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2252 produtos de "Cromatina/Epigenética"
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Izencitinib
CAS:<p>Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.</p>Fórmula:C22H26N8Pureza:99.82%Cor e Forma:SolidPeso molecular:402.50Corin
CAS:<p>Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).</p>Fórmula:C26H28N4O2Pureza:99.6%Cor e Forma:SolidPeso molecular:428.53β-NF-JQ1
CAS:<p>β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins.</p>Fórmula:C45H42ClN5O6SPureza:97.58% - 99.15%Cor e Forma:SolidPeso molecular:816.36TGP-377/421
CAS:<p>TGP-377/421 (Targapre-miR-377/421) is a potent miR-377 and miR-421 dual inhibitor that inhibits miR-377 and miR-421 by binding to their functional sites.</p>Fórmula:C20H16N6Pureza:98.48%Cor e Forma:SolidPeso molecular:340.38PF-249
CAS:PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.Fórmula:C17H16ClN3O3Pureza:97.01%Cor e Forma:SolidPeso molecular:345.78BAY-299
CAS:<p>BAY-299 inhibits BRPF2, TAF1, and TAF1L with IC50s of 67, 8, and 106 nM.</p>Fórmula:C25H23N3O4Pureza:99.53%Cor e Forma:SolidPeso molecular:429.47R 59-022 hydrochloride
CAS:<p>R 59-022 hydrochloride is a 5-HT antagonist, PKC activator, DGK inhibitor (IC50: 2.8 µM), and modulates lipid production in platelets and neutrophils.</p>Fórmula:C27H27ClFN3OSPureza:97.7%Cor e Forma:SolidPeso molecular:496.04SRX3177
CAS:<p>SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.</p>Fórmula:C31H32N6O4SPureza:99.16%Cor e Forma:SolidPeso molecular:584.69LSD1-IN-20
CAS:<p>LSD1-IN-20: Dual LSD1/G9a inhibitor, Ki 0.44/0.68 μM; hampers THP-1, MDA-MB-231 cell growth with IC50 0.51/1.60 μM at 72h.</p>Fórmula:C27H38N6O2Pureza:98.44% - 99.57%Cor e Forma:SolidPeso molecular:478.63LEM-14
CAS:<p>LEM-14 is a potent NSD2-specific inhibitor (IC50:132 μM).LEM-14 may be used in the study of multiple myeloma.</p>Fórmula:C25H26N4O4SPureza:98.3%Cor e Forma:SolidPeso molecular:478.56HDAC6 degrader 9c
CAS:<p>HDAC6 degrader 9c is a small molecule histone deacetylase 6 (HDAC6) degrader that can be used to study cancer or other diseases.</p>Fórmula:C37H45N9O10Pureza:>99.99%Cor e Forma:SolidPeso molecular:775.81Bobcat339 hydrochloride
CAS:<p>Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.</p>Fórmula:C16H13Cl2N3OPureza:99.22%Cor e Forma:SolidPeso molecular:334.2Crebinostat
CAS:<p>Crebinostat: potent HDAC inhibitor, boosts synapsin-1 in neurons, enhances memory and gene Egr1 expression in mice.</p>Fórmula:C20H23N3O3Pureza:94.96%Cor e Forma:SolidPeso molecular:353.41Flosequinan
CAS:<p>Flosequinan is an arteriovenous vasodilator, which can effectively treat acute heart failure.</p>Fórmula:C11H10FNO2SPureza:99.95%Cor e Forma:SolidPeso molecular:239.27EZH2-IN-13
CAS:<p>EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.</p>Fórmula:C34H45N5O3Pureza:98.3%Cor e Forma:SolidPeso molecular:571.75OUL232
CAS:OUL232 is a potent single ARTs PARP7, PARP10, PARP11, PARP12, PARP14 and PARP15 inhibitor for cancer and tumour research.Fórmula:C10H10N4O2SPureza:99.04%Cor e Forma:SolidPeso molecular:250.28ZEN-3219
CAS:ZEN-3219 is a BET inhibitor, which has inhibitory effect on BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).Fórmula:C19H18N2O3Pureza:99.86%Cor e Forma:SolidPeso molecular:322.36OXFBD04
CAS:<p>OXFBD04: Potent BRD4 inhibitor, IC50=166nM, acts on BET bromodomains; moderate CREBBP affinity; anti-cancer properties.</p>Fórmula:C17H16N2O3Pureza:99.56%Cor e Forma:SolidPeso molecular:296.32DC-BPi-03
CAS:<p>DC-BPi-03 is a potent BPTF-BRD inhibitor with an IC 50 of 698.3 nM and a K d of 2.81 μM .</p>Fórmula:C14H14N4O2SPureza:98.96%Cor e Forma:SolidPeso molecular:302.35Raxofelast
CAS:<p>Raxofelast (IRFI-016), a vitamin-like, hydrophilic antioxidant, mitigates ischemia-reperfusion in testis and may treat diabetic issues and atherosclerosis.</p>Fórmula:C15H18O5Pureza:99.74% - 99.97%Cor e Forma:SolidPeso molecular:278.3DW14800
CAS:<p>DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.</p>Fórmula:C31H36N4O3Pureza:99.55% - 99.68%Cor e Forma:SolidPeso molecular:512.64PARP10-IN-2
CAS:<p>PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and</p>Fórmula:C14H10N2O2Pureza:99.27%Cor e Forma:SolidPeso molecular:238.24EB-47
CAS:<p>EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).</p>Fórmula:C24H27N9O6Pureza:99.81%Cor e Forma:SolidPeso molecular:537.53OXF BD 02
CAS:<p>OXF BD 02 is a potent and selective BRD4(1) inhibitor (IC50: 382 nM) with anticancer and anti-inflammatory activity.</p>Fórmula:C18H17NO3Pureza:98.25%Cor e Forma:SolidPeso molecular:295.33Chiauranib
CAS:<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Fórmula:C27H21N3O3Pureza:99.22%Cor e Forma:SolidPeso molecular:435.47AGI-43192
CAS:<p>AGI-43192: potent MAT2A inhibitor, crosses blood-brain barrier, may help study SAM in CNS and treat cancer.</p>Fórmula:C23H16ClF3N6OPureza:99.89%Cor e Forma:SolidPeso molecular:484.86NSC 694623
CAS:<p>NSC 694623: Potent HAT inhibitor, IC50=15.9 μM against PCAF, anti-cancer properties.</p>Fórmula:C16H16N2OSPureza:99.9%Cor e Forma:SolidPeso molecular:284.38CPUY074020
CAS:<p>CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.</p>Fórmula:C25H28N4O2Pureza:98.64%Cor e Forma:SolidPeso molecular:416.52MAT2A-IN-9
CAS:<p>MAT2A-IN-9, a 2-oxoquinazoline, inhibits MAT2A with antitumor effects on lymphomas and solid cancers.</p>Fórmula:C14H8ClF3N4OPureza:99.17%Cor e Forma:SolidPeso molecular:340.69GSK-690
CAS:<p>GSK-690 is a potent, reversible and selective inhibitors of Lysine Specific Demethylase 1.</p>Fórmula:C24H23N3OPureza:98.65%Cor e Forma:SolidPeso molecular:369.46CARM1-IN-1
CAS:CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.Fórmula:C26H21Br2NO3Pureza:98.24%Cor e Forma:SolidPeso molecular:555.26DCPLA-ME
CAS:DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be used to treat neurodegenerativeFórmula:C21H38O2Pureza:99.80%Cor e Forma:SolidPeso molecular:322.53AGI-24512
CAS:<p>AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in</p>Fórmula:C24H24N4O2Pureza:98.55%Cor e Forma:SolidPeso molecular:400.47Butyzamide
CAS:<p>Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.</p>Fórmula:C29H32Cl2N2O5SPureza:99.51% - 99.83%Cor e Forma:SoildPeso molecular:591.55ZEN-3411
CAS:<p>ZEN-3411 is an BET inhibitor that inhibits BRD4(BD1), BRD4(BD2), and BRD4(BD1BD2) and suppresses the growth of tumor cells overproducing BET proteins.</p>Fórmula:C21H20N4O2Pureza:97.51% - 98.84%Cor e Forma:SolidPeso molecular:360.41ZEN-2759
CAS:<p>ZEN-2759 is a potent BET small molecule inhibitor of BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).</p>Fórmula:C17H16N2O2Pureza:99.36%Cor e Forma:SolidPeso molecular:280.32Cedazuridine
CAS:<p>Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.</p>Fórmula:C9H14F2N2O5Pureza:99.66%Cor e Forma:SolidPeso molecular:268.21Bisaramil hydrochloride
CAS:Bisaramil hydrochloride (Bisaramil) is an antiarrhythmic compound that inhibits free radical production.Fórmula:C17H24Cl2N2O2Pureza:98.64% - 99.48%Cor e Forma:SolidPeso molecular:359.29KRH102140
CAS:<p>KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.</p>Fórmula:C25H24FNOPureza:98.31% - 99.61%Cor e Forma:SolidPeso molecular:373.46GRK6-IN-1
CAS:GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.Fórmula:C22H23ClN6O2Pureza:99.37%Cor e Forma:SolidPeso molecular:438.91Butyrolactone 3
CAS:Butyrolactone 3 (MB-3) is a Gcn5 inhibitor with weak affinity for CBP.Butyrolactone 3 has antimicrobial activity and can be used in cancer.Fórmula:C9H12O4Pureza:98.99% - 99.5%Cor e Forma:SolidPeso molecular:184.19Procainamide
CAS:<p>Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.</p>Fórmula:C13H21N3OPureza:99.92% - 99.92%Cor e Forma:SolidPeso molecular:235.33STS-E412
CAS:<p>STS-E412 is a tissue-protective and selective EPOR/CD131 receptor activator for the study of neurological disorders.</p>Fórmula:C15H15ClN4O2Pureza:99.01%Cor e Forma:SolidPeso molecular:318.76ZEN-3862
CAS:<p>ZEN-3862, a BET inhibitor, blocks BRD4(BD1) at 0.16 μM & BRD4(BD2) at 0.13 μM; usable in PROTACs for BRD4 degradation.</p>Fórmula:C19H17FN2O3Pureza:97.1%Cor e Forma:SolidPeso molecular:340.35CMP-5
CAS:<p>CMP-5 is a PRMT5 inhibitor with antiviral activity, inhibits PRMT5 methyltransferase activity, and can be used in the study of SARS virus infection.</p>Fórmula:C21H21N3Pureza:98.68%Cor e Forma:SolidPeso molecular:315.41JAK1-IN-8
CAS:<p>JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).</p>Fórmula:C22H23FN4O3SPureza:98.4%Cor e Forma:SolidPeso molecular:442.51TNG908
CAS:TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, useful in cancer studies.Fórmula:C21H23N5O2SPureza:98.08% - 98.24%Cor e Forma:SolidPeso molecular:409.51MARK-IN-2
CAS:<p>MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).</p>Fórmula:C18H18ClF2N5OSPureza:98%Cor e Forma:SolidPeso molecular:425.88CBP/p300-IN-19
CAS:CBP/p300-IN-19 inhibits p300/CBP HAT (IC50: 1.4μM), less effective on PCAF/Myst3, shows anti-tumor properties.Fórmula:C30H27N3O3Cor e Forma:SolidPeso molecular:477.55Sirtuin-1 inhibitor 1
CAS:<p>Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.</p>Fórmula:C20H17N3O2Pureza:99.1%Cor e Forma:SolidPeso molecular:331.37
