Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2242 produtos de "Cromatina/Epigenética"
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JAK2-IN-4
CAS:<p>JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.</p>Fórmula:C23H27N5O4SPureza:98%Cor e Forma:SolidPeso molecular:469.56F-Amidine TFA
CAS:<p>F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.</p>Fórmula:C14H19FN4O2CF3COOHCor e Forma:SolidPeso molecular:408.4ZINC08792355
CAS:<p>ZINC08792355 is a novel inhibitor of SIRT1.</p>Fórmula:C31H24N4O3Cor e Forma:SolidPeso molecular:500.55CBP/p300-IN-5
CAS:P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).Fórmula:C29H27F5N6O4Pureza:98%Cor e Forma:SolidPeso molecular:618.55FHT-1204
CAS:<p>FHT-1204 is a potent inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) (IC50 ≤ 10 nM).</p>Fórmula:C24H23N5O5S2Cor e Forma:SolidPeso molecular:525.6RTS-V5
CAS:<p>RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).</p>Fórmula:C27H35N5O6Pureza:98%Cor e Forma:SolidPeso molecular:525.6CLB-016
CAS:<p>CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.</p>Fórmula:C17H20N6O3Pureza:98%Cor e Forma:SolidPeso molecular:356.38A1B11
CAS:<p>A1B11 is a selective SIRT2 inhibitor.</p>Fórmula:C22H25N5OCor e Forma:SolidPeso molecular:375.47PARP-2-IN-1
CAS:<p>PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM).</p>Fórmula:C21H19F4N5O3Pureza:98%Cor e Forma:SolidPeso molecular:465.4Luteolin 7-sulfate
CAS:<p>Luteolin 7-sulfate from Phyllospadix iwatensis inhibits melanin production by disrupting CREB/MITF signaling.</p>Fórmula:C15H10O9SPureza:98%Cor e Forma:SolidPeso molecular:366.3PARPYnD
CAS:<p>PARPYnD: Photoaffinity PARP probe; inhibits PARP2, PARP1, PARP6 (IC50: 6, 38, 230 nM); tags PARP1/2 with N3 fluorescent probe.</p>Fórmula:C34H31N9O3Cor e Forma:SolidPeso molecular:613.67NSC756093
CAS:<p>NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.</p>Fórmula:C20H19NO4Pureza:99.92%Cor e Forma:SolidPeso molecular:337.37I-BET762 carboxylic acid
CAS:<p>I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).</p>Fórmula:C20H17ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:396.83KP-544
CAS:<p>KP-544 is an agent of neurotrophin potentiator.</p>Fórmula:C18H19ClN4OPureza:98%Cor e Forma:SolidPeso molecular:342.82L-Moses
CAS:L-45 is the first potent and cell-active bromodomain (Brd) inhibitor of p300/CBP-associated factor (PCAF) (Kd: 126±15 nM).Fórmula:C21H24N6Pureza:98%Cor e Forma:SolidPeso molecular:360.46HDAC-IN-38
CAS:<p>HDAC-IN-38: Potent HDAC1-3,5,6,8 inhibitor, boosts H3K14/H4K5 acetylation, elevates CBF, lessens cognitive decline & hippocampal atrophy.</p>Fórmula:C27H28ClN3O2Cor e Forma:SolidPeso molecular:461.98ZINC08792229
CAS:<p>ZINC08792229 is a novel inhibitor of SIRT1.</p>Fórmula:C30H22N4O3Pureza:98%Cor e Forma:SolidPeso molecular:486.52HA-1004 dihydrochloride
CAS:<p>HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein</p>Fórmula:C12H16ClN5O2SPureza:98%Cor e Forma:White Crystalline SolidPeso molecular:329.81MS67
CAS:<p>MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.</p>Fórmula:C52H59F4N9O7SCor e Forma:SolidPeso molecular:1030.14CBP/p300-IN-19 hydrochloride
CAS:<p>CBP/p300-IN-19 HCl is a p300/CBP HAT inhibitor (IC50: p300 1.4 μM, CBP 2.2 μM) with antitumor properties.</p>Fórmula:C30H28ClN3O3Cor e Forma:SolidPeso molecular:514.02KT-531
CAS:<p>KT-531 (KT531) is a highly potent and selective HDAC6 inhibitor with an IC50 value of 8.5 nM and is 39-fold more selective against other HDAC isoenzymes.</p>Fórmula:C17H14F4N2O4SCor e Forma:SolidPeso molecular:418.36TCS 21311
CAS:<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Fórmula:C27H25F3N4O4Pureza:99.39% - ≥98%Cor e Forma:SolidPeso molecular:526.51Bisegliptin
CAS:<p>Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.</p>Fórmula:C18H26FN3O3Pureza:98%Cor e Forma:SolidPeso molecular:351.42KDM2A/7A-IN-1
CAS:<p>KDM2A/7A-IN-1 is a KDM2A/7A inhibitor with potential anti-tumour activity for the study of duodenal adenomas and ossifying fibromucoid tumours.</p>Fórmula:C33H38N4OPureza:99.59%Cor e Forma:SolidPeso molecular:506.68GNE-955
CAS:<p>GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).</p>Fórmula:C22H24N8OPureza:98%Cor e Forma:SolidPeso molecular:416.48UNC8153 TFA
CAS:<p>UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating a</p>Fórmula:C35H38F3N5O7Pureza:96.44%Cor e Forma:SolidPeso molecular:697.7Nezulcitinib
CAS:<p>Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.</p>Fórmula:C30H37N7O2Cor e Forma:SolidPeso molecular:527.66SIRT5 inhibitor 7
CAS:<p>SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.</p>Fórmula:C28H32ClN7O3SPureza:99.77%Cor e Forma:SolidPeso molecular:582.12GNE-207
CAS:<p>GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM).</p>Fórmula:C29H30N6O3Pureza:98%Cor e Forma:SolidPeso molecular:510.59FT895
CAS:<p>FT895 is a selective and potent HDAC11 inhibitor with antifungal and antitumor activity that inhibits HDAC11 expression and limits EV71 replication in vitro.</p>Fórmula:C16H15F3N4O2Pureza:98.95% - >99.99%Cor e Forma:SolidPeso molecular:352.31Gö 7874
CAS:<p>Gö 7874 is a potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC50 = 4 nM for rat brain PKC).</p>Fórmula:C27H26N4O4Cor e Forma:SolidPeso molecular:470.52CW 008
CAS:<p>CW 008 is an agonist of the cAMP/PKA/CREB pathway, promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs).a PKA activator.</p>Fórmula:C21H14F2N6O2Pureza:97.39%Cor e Forma:SolidPeso molecular:420.37JAK-IN-26
CAS:<p>JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in</p>Fórmula:C22H24N6O3Pureza:98%Cor e Forma:SolidPeso molecular:420.46NHWD-870
CAS:<p>NHWD-870 selectively inhibits BET bromodomains BRD2-4, BRDT; potent anti-cancer effect by inducing apoptosis, halting cell growth.</p>Fórmula:C29H29N7OPureza:98%Cor e Forma:SolidPeso molecular:491.59Itacnosertib (hydrocholide)
CAS:<p>Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].</p>Fórmula:C26H29ClN8OCor e Forma:SolidPeso molecular:505.01JBI-589
CAS:<p>JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.</p>Fórmula:C29H28FN5OCor e Forma:SolidPeso molecular:481.56T-448 free base
CAS:<p>T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).</p>Fórmula:C17H20N4OSPureza:98%Cor e Forma:SolidPeso molecular:328.43Ginsenoside Rk1
CAS:<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Fórmula:C42H70O12Pureza:98.46% - 99.13%Cor e Forma:SolidPeso molecular:767(S)-Ro 32-0432
CAS:<p>(S)-Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKCα, 28 nM for PKCβI, 30 nM for PKCβII, 36.5 nM for PKCγ, and 108.3 nM for PKCε, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S)-Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].</p>Fórmula:C28H29ClN4O2Cor e Forma:SolidPeso molecular:489.01CBB1007 hydrochloride
CAS:<p>CBB1007 Hcl inhibits LSD1 selectively (IC50=5.27μM), blocks H3K4 demethylation, activates genes; less effect on other cells/tissues.</p>Fórmula:C27H39Cl5N8O4Cor e Forma:SoildPeso molecular:716.91HDAC6/HSP90-IN-1
CAS:<p>HDAC6/HSP90-IN-1 is a potent dual inhibitor of HDAC6 and HSP90 with IC50s 4.3 nM & 46.8 nM, respectively; curbs PD-L1 and tumor growth in H1975 mice.</p>Fórmula:C28H37N3O6Cor e Forma:SolidPeso molecular:511.61KH-3
CAS:<p>KH-3: HuR inhibitor, IC50 0.35 μM, halts cell growth, blocks HuR-FOXQ1 mRNA, curbs breast cancer invasion, slows lung colony growth.</p>Fórmula:C21H22N2O4S2Cor e Forma:SolidPeso molecular:430.54FHT-2344
CAS:<p>FHT-2344, a SMARCA4/SMARCA2 ATPase inhibitor, exhibits anticancer activity with half-maximal inhibitory concentrations (IC 50 ) of 0.026 μM for SMARCA4 and 0.013 μM for SMARCA2, respectively [1].</p>Fórmula:C23H24N6O5S2Cor e Forma:SolidPeso molecular:528.6MS023 trihydrochloride
CAS:<p>MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.</p>Fórmula:C17H28Cl3N3OPureza:99.81%Cor e Forma:SolidPeso molecular:396.78JAK-IN-1
CAS:<p>JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.</p>Fórmula:C20H24N6O2Pureza:98%Cor e Forma:SolidPeso molecular:380.44QC6352
CAS:<p>QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).</p>Fórmula:C24H25N3O2Pureza:98%Cor e Forma:SolidPeso molecular:387.47GNE-049
CAS:<p>GNE-049 is a highly selective CBP inhibitor (IC50=1.1 nM) that blocks prostate cancer cell proliferation.</p>Fórmula:C27H32F2N6O2Pureza:98.67%Cor e Forma:SolidPeso molecular:510.58JAK-IN-4
CAS:<p>JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.</p>Fórmula:C18H21N4Na2O6PPureza:98%Cor e Forma:SolidPeso molecular:466.341CM-579 trihydrochloride (1846570-40-8 free base)
<p>CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide</p>Fórmula:C29H43Cl3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:602.04PIM1-IN-1
CAS:<p>PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.</p>Fórmula:C25H30N8O2Pureza:98%Cor e Forma:SolidPeso molecular:474.56
