Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2242 produtos de "Cromatina/Epigenética"
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Vafidemstat
CAS:<p>Vafidemstat (ORY-2001) is a lysine-histone demethylase (LSD1)/MAO-B inhibitor for the study of neurological disorders.</p>Fórmula:C19H20N4O2Pureza:99.53%Cor e Forma:SolidPeso molecular:336.39CD235
CAS:<p>CD235 is a structurally similar analog of CD161. CD161 is an orally bioavailable inhibitor of BET bromodomain.</p>Fórmula:C26H20FN5O2Pureza:98%Cor e Forma:SolidPeso molecular:453.47CAY10398
CAS:<p>CAY10398 is a compound that serves as an isoform-selective inhibitor of histone deacetylase (HDAC1).</p>Fórmula:C15H23N3O3Cor e Forma:SolidPeso molecular:293.367GSK-3484862
CAS:<p>Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.</p>Fórmula:C19H19N5OSPureza:99.87% - 99.963%Cor e Forma:SolidPeso molecular:365.45YM-08
CAS:<p>YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].</p>Fórmula:C19H17N3OS2Pureza:98%Cor e Forma:SolidPeso molecular:367.49MAK683-CH2CH2COOH
CAS:<p>MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.</p>Fórmula:C23H21FN6O3Pureza:98%Cor e Forma:SolidPeso molecular:448.45dBRD4-BD1
CAS:<p>dBRD4-BD1 selectively inhibits and degrades BRD4 (DC50=280nM), upregulates BRD2/3, and aids in creating BRD4-specific probes.</p>Fórmula:C50H53F3N8O9Cor e Forma:SolidPeso molecular:967GSK761
<p>GSK761 inhibits SP140 (IC50: 77.79 nM), hinders monocyte-to-macrophage differentiation, and prompts CD206+ regulatory macrophages.</p>Fórmula:C40H46N4O4Cor e Forma:SolidPeso molecular:646.82KDM5-IN-1
CAS:<p>KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.</p>Fórmula:C17H20N6OPureza:99.50%Cor e Forma:SolidPeso molecular:324.38Tubulin/JAK2-IN-1
CAS:<p>Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant</p>Fórmula:C22H20N6O3Cor e Forma:SolidPeso molecular:416.43(1s,4s)-Menin-MLL inhibitor-23
<p>(1s,4s)-Menin-MLL Inhibitor-23, an enantiomer of Menin-MLL Inhibitor-23 (Example 99A), functions as an inhibitor of the menin-MLL interaction [1].</p>Fórmula:C36H53FN6O4Cor e Forma:SolidPeso molecular:652.84PHD2/HDACs-IN-1
CAS:<p>PHD2/HDACs-IN-1: strong PHD2/HDAC inhibitor (IC50: 1.15-26.60 μM), low-toxicity, protects kidneys from cisplatin-induced AKI.</p>Fórmula:C18H19N9O4Cor e Forma:SolidPeso molecular:425.4BRD-IN-3
CAS:<p>BRD-IN-3 is a highly potent PCAF bromodomain (BRD) inhibitor (IC50: 7 nM). It also exhibits activity against GCN5 and FALZ.</p>Fórmula:C21H25N5O3Pureza:98%Cor e Forma:SolidPeso molecular:395.45SMYD3-IN-1
CAS:<p>SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).</p>Fórmula:C28H31ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:507.02TCS HDAC6 20b
CAS:<p>TCS HDAC6 20b (HDAC6-IN-7) is an HDAC6 inhibitor that blocks the growth of breast cancer cells and can be used in cancer research.</p>Fórmula:C26H44N2O4SPureza:>99.99%Cor e Forma:SolidPeso molecular:480.7KDM4-IN-2
CAS:<p>KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.</p>Fórmula:C25H26N6OPureza:98%Cor e Forma:SolidPeso molecular:426.51MK-0626
CAS:<p>MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.</p>Fórmula:C22H24F2N6O2Pureza:99.47% - >99.99%Cor e Forma:SolidPeso molecular:442.46Tankyrase-IN-5
CAS:<p>Tankyrase-IN-5 (Compound 30f), structurally related to MSC2504877, effectively inhibits tankyrase isoforms TNKS1 and TNKS2, with half-maximal inhibitory</p>Fórmula:C17H18N2O2Pureza:98%Cor e Forma:SolidPeso molecular:282.34Brepocitinib
CAS:<p>Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).</p>Fórmula:C18H21F2N7OPureza:99.82%Cor e Forma:SolidPeso molecular:389.4PRMT5-IN-28
CAS:<p>PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processes</p>Fórmula:C18H19ClN4O5Pureza:98%Cor e Forma:SolidPeso molecular:406.82JAK-IN-5
CAS:<p>JAK-IN-5 is a JAK inhibitor.</p>Fórmula:C27H31FN6OPureza:98.1% - 99.37%Cor e Forma:SolidPeso molecular:474.57PHD-IN-2
CAS:<p>PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 of</p>Fórmula:C26H27N7O4Pureza:98%Cor e Forma:SolidPeso molecular:501.54PRMT5-IN-29
CAS:<p>PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].</p>Fórmula:C18H20Cl3N5O5Pureza:98%Cor e Forma:SolidPeso molecular:492.74CBP/p300-IN-19
CAS:<p>CBP/p300-IN-19 inhibits p300/CBP HAT (IC50: 1.4μM), less effective on PCAF/Myst3, shows anti-tumor properties.</p>Fórmula:C30H27N3O3Cor e Forma:SolidPeso molecular:477.55PRMT5-IN-25
CAS:<p>PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1</p>Fórmula:C24H21F3N6OPureza:98%Cor e Forma:SolidPeso molecular:466.46PARP7-IN-15
CAS:<p>PARP7-IN-15 (Compound 18) is a potent PARP7 inhibitor exhibiting an IC50 of 0.56 nM and demonstrates antitumor activity [1].</p>Fórmula:C23H24F6N6O4Pureza:98%Cor e Forma:SolidPeso molecular:562.46KDM5-C70
CAS:<p>KDM5-C70 is an ethyl ester derivative of KDM5-C49.</p>Fórmula:C17H28N4O3Pureza:97.63% - 99.86%Cor e Forma:SolidPeso molecular:336.43Pim-1 kinase inhibitor 5
CAS:<p>Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-</p>Fórmula:C22H13Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:406.26Sirtuin-1 inhibitor 1
CAS:<p>Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.</p>Fórmula:C20H17N3O2Pureza:99.1%Cor e Forma:SolidPeso molecular:331.37BRD7-IN-1
CAS:<p>BRD7-IN-1, a BI7273 derivative, forms PROTAC VZ185, targeting BRD7/9 with DC50s of 4.5/1.8 nM via VHL ligand linkage.</p>Fórmula:C22H28Cl2N4O3Pureza:98.95%Cor e Forma:SolidPeso molecular:467.39Aurora Kinases-IN-4
CAS:<p>Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.</p>Fórmula:C26H28N8OPureza:98%Cor e Forma:SolidPeso molecular:468.55Physachenolide C
CAS:<p>Physachenolide C, a selective BET inhibitor, induces apoptosis and arrests the cell cycle at the G0-G1 phase, exhibiting antitumor activity [1].</p>Fórmula:C30H40O9Pureza:98%Cor e Forma:SolidPeso molecular:544.63PHD2-IN-1
CAS:<p>PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].</p>Fórmula:C21H23ClN4O5Pureza:98%Cor e Forma:SolidPeso molecular:446.88BET-IN-16
CAS:<p>BET-IN-16 (Comp I), a bromodomain and extra-terminal (BET) inhibitor, demonstrates anticancer activity by impeding the growth of prostate cancer cells.</p>Fórmula:C31H25N5O3Pureza:98%Cor e Forma:SolidPeso molecular:515.56Antitumor agent-101
CAS:<p>Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of 8.5 nM for G9a and 5.5 nM for</p>Fórmula:C26H38N6O3Pureza:98%Cor e Forma:SolidPeso molecular:482.62SJ1461
CAS:<p>SJ1461 is a potent, orally active inhibitor of the BET family, selectively targeting and inhibiting BRD2 (BD1), BRD2 (BD2), BRD4 (BD1), and BRD4 (BD2) with</p>Fórmula:C21H18ClN7OS2Pureza:98%Cor e Forma:SolidPeso molecular:484CBP-IN-1
CAS:<p>CBP-IN-1 (compound 12) acts as a potent CBP inhibitor exhibiting an IC50 of 1.5 nM and additionally suppresses CBP BRET and BRD4(1) with IC50 values of 690 nM</p>Fórmula:C27H33F2N7OPureza:98%Cor e Forma:SolidPeso molecular:509.59Eleven-Nineteen-Leukemia Protein IN-2
CAS:<p>Eleven-Nineteen-Leukemia Protein IN-2 (compound 23), an ENL inhibitor, exhibits an IC50 of 10.7 nM and is utilized for leukemia research [1].</p>Fórmula:C22H23N5O2Pureza:98%Cor e Forma:SolidPeso molecular:389.45LSD1-UM-109
CAS:<p>LSD1-UM-109 is a highly potent and reversible inhibitor of LSD1, demonstrating an IC50 of 3.1 nM.</p>Fórmula:C29H27FN6Pureza:98%Cor e Forma:SolidPeso molecular:478.56Bromodomain inhibitor-12
CAS:<p>Bromodomain Inhibitor-12 (example 303) is a research compound utilized in the study of autoimmune and inflammatory diseases [1].</p>Fórmula:C28H38N4O5Pureza:98%Cor e Forma:SolidPeso molecular:510.63MAT2A-IN-10
CAS:<p>MAT2A-IN-10 (Compound 28), an orally active inhibitor of MAT2A, exhibits an IC50 of 26 nM and is utilized in cancer research [1].</p>Fórmula:C27H24F2N6O4Pureza:98%Cor e Forma:SolidPeso molecular:534.51PIM1-IN-4
CAS:<p>PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.</p>Fórmula:C27H25BrCl2CuN6OPureza:98%Cor e Forma:SolidPeso molecular:663.88Eleven-Nineteen-Leukemia Protein IN-3
CAS:<p>ENL YEATS inhibitor Eleven-Nineteen-Leukemia Protein IN-3, IC50 15.4 nM, orally active, suppresses MYC, stabilizes ENL in vitro.</p>Fórmula:C28H27N5O2Pureza:98%Cor e Forma:SolidPeso molecular:465.55MAT2A-IN-12
CAS:<p>MAT2A Allosteric Inhibitor 2 is a potent, selective inhibitor exhibiting an IC50 of 5 nM and demonstrates nanomolar efficacy (IC50 = 5 μM) in proliferation</p>Fórmula:C20H17NO3Pureza:98%Cor e Forma:SolidPeso molecular:319.35CBP/p300-IN-21
CAS:<p>CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibits</p>Fórmula:C19H16ClNO4Pureza:98%Cor e Forma:SolidPeso molecular:357.79BRD4 Inhibitor-28
CAS:<p>BRD4 Inhibitor-28 (Compound 18), an orally active molecule, selectively inhibits the bromodomains of BRD4 (BRD4-BD1 and BRD4-BD2) with IC50 values of 15 and 55</p>Fórmula:C23H21N3O3Pureza:98%Cor e Forma:SolidPeso molecular:387.43Bromodomain inhibitor-12 (edisylate)
CAS:<p>Bromodomain Inhibitor-12 Edisylate (example 303) serves as a bromodomain inhibitor applicable to autoimmune and inflammatory disease research [1].</p>Fórmula:C30H44N4O11S2Pureza:98%Cor e Forma:SolidPeso molecular:700.82HIF-2α-IN-9
CAS:<p>HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes within</p>Fórmula:C12H13F5O4S2Pureza:98%Cor e Forma:SolidPeso molecular:380.35(S,R)-CFT8634
CAS:<p>(S,R)-CFT8634 is a selective and orally active BRD9 protein degrader with potential for researching BRD9-mediated disorders, such as abnormal cellular</p>Fórmula:C37H45F3N6O5Pureza:98%Cor e Forma:SolidPeso molecular:710.79FM-479
CAS:<p>FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.</p>Fórmula:C25H26N6O2Pureza:98%Cor e Forma:SolidPeso molecular:442.523
