Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2547 produtos de "Cromatina/Epigenética"
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Menin-MLL inhibitor 4
CAS:Menin-MLL inhibitor 4 has antitumor activity.Menin-MLL inhibitor 4 is an inhibitor of Menin- MLL (mixed-lineage leukemia protein) interaction .Fórmula:C32H38FN7O3Pureza:98%Cor e Forma:SolidPeso molecular:587.69LSD1-IN-16
LSD1-IN-16 (4b) inhibits LSD1, MAO-A/B; IC50: 0.015-0.366 μM. Halts prostate cancer cell growth; IC50: 15.2 μM.Fórmula:C20H18N2OSCor e Forma:SolidPeso molecular:334.43SMARCA2/4-ligand-5
CAS:SMARCA2/4-ligand-5 is the target protein ligand of PROTAC SMARCA2/4 degrader-37 (Example 4). PROTAC SMARCA2/4 degrader-37 (Example 4) is a PROTAC degrader of SMARCA2/4, with an IC50 value of ≤0.1 μM.Fórmula:C20H13ClN4O3Cor e Forma:SolidPeso molecular:392.795CBP/p300-IN-18
CBP/p300-IN-18 (compound 8) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.056 μM) and LK2 H3K27 (IC50: 0.46 μM).Fórmula:C25H27FN4O3Cor e Forma:SolidPeso molecular:450.51GSK789
CAS:GSK789 is a selective inhibitor of the first bromodomains (BD1) of the bromo and extra terminal domain (BET) proteins.Fórmula:C26H33N5O3Cor e Forma:SolidPeso molecular:463.575-Ph-IAA-AM
5-Ph-IAA-AM, eggshell-permeable analog of 5-Ph-IAA, boosts protein degradation in embryos, useful for studying proteins in C. elegans.Fórmula:C19H17NO4Cor e Forma:SolidPeso molecular:323.34PRMT5-IN-1
CAS:PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).Fórmula:C19H19ClN4O5Pureza:98%Cor e Forma:SolidPeso molecular:418.83HDAC6-IN-51
CAS:HDAC6-IN-51 (Compound 7e) is a selective inhibitor of HDAC6, exhibiting an IC50 value of 42.9 nM. This compound demonstrates effective anti-pulmonary fibrosis activity.Fórmula:C24H24ClN5O3Cor e Forma:SolidPeso molecular:465.93PARP1/2-IN-4
CAS:PARP1/2-IN-4 (compound 3) is an inhibitor of PARP1/2.Fórmula:C23H30FN5O6Cor e Forma:SolidPeso molecular:491.51Pim-1 kinase inhibitor 6
CAS:Pim-1 kinase inhibitor 6 (Compound 4d) is a robust inhibitor of Pim-1 kinase, demonstrating an IC 50 of 0.46 μM. It significantly exhibits cytotoxic effects on cancer cells [1].Fórmula:C21H10BrCl2N3Cor e Forma:SolidPeso molecular:455.13JAK3 covalent inhibitor-1
CAS:JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM andFórmula:C22H17FN6O2SPureza:98%Cor e Forma:SolidPeso molecular:448.47XP-524
CAS:XP-524: BET & EP300 inhibitor, suppresses KRAS tumors in vivo, targets PDAC, boosts immune response.Fórmula:C30H28N6O3SCor e Forma:SolidPeso molecular:552.65W4275
CAS:W4275 (Compound 42) is a selective NSD2 inhibitor with oral activity and an IC50 of 17 nM. It exhibits antiproliferative activity, with an IC50 of 230 nM against RS411 cells, and significantly inhibits tumor growth in an RS411 tumor xenograft model. Pharmacokinetic analysis in mice shows that W4275 has a favorable oral bioavailability (F is 27.34%). W4275 holds potential for use in cancer research.Fórmula:C25H36N6O3Cor e Forma:SolidPeso molecular:468.59MC3138
CAS:MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.Fórmula:C25H25NO6Pureza:99.57%Cor e Forma:SolidPeso molecular:435.47Sirtuin-IN-2
Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.Fórmula:C28H46N8O6SCor e Forma:SolidPeso molecular:622.786K465
CAS:6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.Fórmula:C26H33ClFN9OPureza:99.78%Cor e Forma:SolidPeso molecular:542.05Balomenib
CAS:Balomenib is an inhibitor of the menin-MLL interaction, effectively blocking the men1-MLL4-43 interaction with an IC50 of less than 0.075 μM. It inhibits cell growth in MV4-11 (CC50 < 0.1 μM), MOLM-13 (CC50 0.1~0.5 μM), and HEK293 (CC50 < 2 μM) cells. Balomenib also exhibits antitumor activity.Fórmula:C33H34F3N7O2Cor e Forma:SolidPeso molecular:617.664SIRT6 activator 2
CAS:SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.Fórmula:C23H23N3O6Cor e Forma:SolidPeso molecular:437.45BSI-401
CAS:BSI-401 is an oral inhibitor of PARP-1. It can inhibit pancreatic cancer either when used alone or in synergy with Oxaliplatin.Fórmula:C9H4INO4Cor e Forma:SolidPeso molecular:317.037YTH-IN-1
CAS:YTH-IN-1 is an inhibitor of the five YTH structural domains in the human.The YTH family of proteins is an N 6-methyladenosine (m6A) reader in gene expression.Fórmula:C18H24N6O3Pureza:98.46% - 99.94%Cor e Forma:SolidPeso molecular:372.42
