Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2441 produtos de "Cromatina/Epigenética"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
MR44397
<p>MR44397 is a ligand for WD40 repeat (WDR) 5 and is applicable in cancer research.</p>Fórmula:C23H26N4O2SCor e Forma:SolidPeso molecular:422.54Biguanide
CAS:Biguanide can reduce oxidative stress in rats with hyperglycemia.Fórmula:C2H7N5Cor e Forma:SolidPeso molecular:101.11BRD3067
CAS:BRD3067, a Tubacin derivative, inhibits HDAC6 (IC50 15 nM) and acts as a negative control for Tubacin A, showing anticancer and anti-inflammatory effects.Fórmula:C21H23N3O2Pureza:98%Cor e Forma:SolidPeso molecular:349.43Bryostatin 3
CAS:Bryostatin 3 is a protein kinase C activator.Fórmula:C46H64O17Pureza:98%Cor e Forma:SolidPeso molecular:888.99MSC2504877
CAS:<p>MSC2504877 inhibits tankyrase, boosts CDK4/6 inhibitors, blocks Cyclin D2/E2 upregulation, and strengthens phospho-Rb suppression.</p>Fórmula:C17H18N2O2Pureza:99.72%Cor e Forma:SoildPeso molecular:282.34pan-BET/BD2-IN-1
Pan-BET/BD2-IN-1 (compound 6b) is a selective BET protein inhibitor with BRDT-1Ki of 1.05 μM and BRD4-1Ki of 0.68 μM. It effectively inhibits the growth of MM.1S cancer cells with an IC50 value of 2.6 μM.Cor e Forma:Odour SolidGo6976
CAS:Go6976 is a PKC inhibitor, widely used in research to probe PKC functions in health and disease.Fórmula:C24H18N4OPureza:95.89%Cor e Forma:Off-White To Yellow SolidPeso molecular:378.43SJ1008030
CAS:<p>SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.</p>Fórmula:C42H43N13O7SCor e Forma:SolidPeso molecular:873.94Ep300/CREBBP-IN-8
CAS:Ep300/CREBBP-IN-8, IC50: 0.014/0.018 μM, potent Ep300/CREBBP inhibitor, oral, for cancer research.Fórmula:C25H27F2N5O3Cor e Forma:SolidPeso molecular:483.51Malantide
CAS:Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.Fórmula:C72H124N22O21Pureza:98%Cor e Forma:SolidPeso molecular:1633.89SJ10542
CAS:SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Fórmula:C41H46N12O5SCor e Forma:SolidPeso molecular:818.95Lys-CoA TFA
Lys-CoA TFA: p300 HAT inhibitor, IC50 50-500 nM, >100x selective vs PCAF, inhibits p300-dependent transcription.Fórmula:C33H54F3N10O21P3SCor e Forma:SolidPeso molecular:1108.82C 21
CAS:PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.Fórmula:C90H161ClN36O24Pureza:98%Cor e Forma:SolidPeso molecular:2166.94FTX-6058 hydrochloride
CAS:FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.Fórmula:C22H19ClFN5O2Cor e Forma:SolidPeso molecular:439.87HDAC-IN-26
CAS:HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC 50 value of 4.7 nM.Fórmula:C24H28FN5O3Cor e Forma:SolidPeso molecular:453.518BRD4-IN-2
CAS:BRD4-IN-2 is a bromodomain BRD4 inhibitor with an IC 50 value of 9.9 nM.Fórmula:C43H48N8O11Cor e Forma:SolidPeso molecular:852.902MZP-55
CAS:MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)Fórmula:C57H70ClN7O10SPureza:98%Cor e Forma:SolidPeso molecular:1080.73Ref: TM-T13786
5mg434,00€10mg663,00€25mg1.254,00€50mgA consultar100mgA consultar1mL*10mM (DMSO)472,00€HDAC-IN-68 hydrochloride
HDAC-IN-68 (hydrochloride) (Compound 29) is an HDACs inhibitor with an IC50 value of 0.04 μM and induces microtubule fragmentation by activating katanin, a microtubule-severing protein. It is applicable in cancer research.Fórmula:C27H25ClN8O6Peso molecular:592.15856PROTAC SMARCA2/4-degrader-26
PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.Fórmula:C38H47N9O5SCor e Forma:SolidPeso molecular:741.9MACTIDE-V
MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. This compound delivers Verteporfin to CD206+ tumor-associated macrophages (TAM), thereby inhibiting the YAP/TAZ signaling pathway. It facilitates YAP exclusion from the nucleus, induces TAM polarization toward an anti-tumor phenotype, enhances phagocytosis and antigen presentation, and promotes T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models.Fórmula:C109H156N22O27S2Cor e Forma:SolidPeso molecular:2269.09517
